Clinical trials: Uremic Toxin
Healthy, Chronic Kidney Diseases
Innovative Approach to Fecal Microbiota Transplantation (FMT) Applied for Chronic Kidney Disease (CKD)
The aim of this PhD project focuses on the relationship between intestinal microbiota and health in the background of Chronic Kidney Disease (CKD).
- Trial name
- NCT04222153
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Acute Kidney Disease, Acute Kidney Injury (AKI)
AST-120 (Kremezin®) for the Renal Protection and Attenuation of Decline in Acute Kidney Disease
The primary goal of this clinical trial is to evaluate the efficacy of AST-120 (Kremezin®) in combination with standard care in reducing the levels of protein-bound uremic toxins (PBUTs), specifically indoxyl sulfate (IS) and…
- Trial name
- ASTRA-AKD (NCT07182422)
- Testing
- AST-120 (Kremezin®)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Kidney Diseases, Healthy
NATURE 3.1_New Approach for the Reduction of REnal Uremic Toxins
The objective of the pilot study is to validate the clinical use of an innovative symbiotic in patients with chronic kidney disease (CKD) stage 3b-4 and in healthy subjects.
- Trial name
- NATURE31 (NCT03815786)
- Testing
- Symbiotic
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
End Stage Renal Disease on Dialysis
Coated Aldehyde Oxystarch for Protein-Bound Uremic Toxin Reduction in End-Stage Renal Disease
The goal of this clinical trial is to learn if Coated Aldehyde Oxystarch (Xiqing) works to reduce protein-bound uremic toxins (PBUTs) in adults with end-stage renal disease (ESRD).
- Trial name
- NCT07653711
- Testing
- Coated Aldehyde Oxystarch
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
End Stage Renal Disease
Efficacy of Uremic Toxins Clearance With Expanded Hemodialysis
The aim of this study is to quantify the B2-microglobulin reduction rate based on the type of extracorporeal therapy (ET) used: HDx (expanded hemodialysis), HDc (high-flux conventional hemodialysis), or HDF (hemodiafiltration).
- Trial name
- NCT04786535
- Testing
- Expanded Hemodialysis, High-flux Conventional Hemodialysis, Hemodiafiltration
- Where
- Mexico
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hemodialysis Complication
Effect of Lactobacillus Rhamnosus on Serum Uremic Toxins in Hemodialysis
Uremic toxins such as p-cresol and phenol are suggested to be associated with higher mortality in hemodialysis patients. The aim of this study was to investigate the effects of probiotics on serum p-cresol level in hemodialysis…
- Trial name
- NCT03527680
- Testing
- Lactobacillus rhamnosus
- Volunteers
- 42 people
- Sponsor
- nooshin dalili
ESRD (End-Stage Renal Disease), Maintenance Hemodialysis
Efficacy of pHA130 Hemoadsorption on Protein-Bound Uremic Toxins and Quality of Life in Kidney Failure
Patients on maintenance hemodialysis (MHD) face a high risk of cardiovascular mortality and reduced quality of life. Conventional high-flux hemodialysis (HD) is the standard of care but has limited efficacy in clearing…
- Trial name
- PHOENIX (NCT07656168)
- Testing
- pHA130 Hemoadsorption Cartridge, High-flux Hemodialyzer
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Chronic Kidney Diseases, Hemodialysis
Long-term, High Blood Flow Hemoadsorption Therapy in Patients Undergoing Maintenance Hemodialysis
Objective：The purpose of the study is to confirm that extending the duration of hemoadsorption (HA) and increasing blood flow during the HA+hemodialysis (HD) treatment process is safe and feasible, and to verify that extending…
- Trial name
- NCT06574425
- Testing
- long-term, high blood flow hemoadsorption therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Dongliang Zhang, MD
Uremic Toxin
Evaluation of Protective Effect of Activated Charcoal and Probiotic Against Progression of Chronic Kidney Disease
Investigate the nephroprotective effect of Activated Charcoal and Probiotic in limiting the progression of renal impairment in patients with chronic kidney disease and improving of renal function test and phosphate level.
- Trial name
- NCT05540431
- Testing
- Activated Charcoal, Probiotic, No intervention
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Waleed Khaild Rahman Kareem Al-kabi
Acute Renal Failure
Uremic Toxins in the Intensive Care Units (ICU): Patients With Lactate Acidosis
Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients with lactate acidosis.
- Trial name
- NCT00752453
- Testing
- Dialysis during 4 hours, Dialysis during 6 hours, Dialysis during 8 hours
- Where
- Belgium
- Volunteers
- 8 people
- Sponsor
- University Hospital, Ghent
Acute Kidney Injury, Septic Shock
Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients.
The development of acute kidney injury (AKI) during septic shock is frequent and is associated with a high mortality rate. The reason of this increased mortality despite the use of renal replacement therapy is still unknown.
- Conditions
- Acute Kidney Injury, Septic Shock, Uremic; Toxemia, Mortality
- Trial name
- TOX-AKI (NCT03920982)
- Testing
- Determination of the blood concentration of indoxyl sulfate (IS)
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Uremic; Toxemia, Pharmacokinetics
Toxicokinetics of Protein-bound Uremic Toxins in ESRD Patients
Protein-bound uremic toxins (PBUTs) are important uremic toxins, represented by indoxyl sulfate (IS), derived from the fermentation of dietary proteins by gut bacteria.
- Conditions
- Uremic; Toxemia, Pharmacokinetics, Renal Dialysis
- Trial name
- NCT05755503
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Bloody Diarrhea, STEC, Unspecified
Phase 2/3 Study to Evaluate PK, Safety & Efficacy of INM004 in STEC Positive Pediatric Patients for Prevention of HUS
The investigational medicinal product (IMP), INM004, proposes to neutralize the toxin in the bloodstream to prevent the interaction of the Stx with the specific receptor, by means of a polyclonal antibody to be administered upon…
- Conditions
- Bloody Diarrhea, STEC, Unspecified, Hemolytic-Uremic Syndrome, Pediatric Kidney Disease
- Trial name
- NCT04132375
- Testing
- INM004
- Where
- 7 sites in Argentina
- Volunteers
- 11 people
- Sponsor
- Inmunova S.A.
Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5
Healthy Diet Rich in Potassium to Chronic Kidney Disease With Sodium Zirconium Cyclosilicate: A Feasibility Study
This is a descriptive single arm open-label interventional trial lasting 6 weeks aiming to test if a low protein healthy K-rich diet with fruits, vegetables, whole grains, and nuts with concomitant use of new potassium binder…
- Conditions
- Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5, Hyperkalemia
- Trial name
- HELPFUL (NCT04207203)
- Testing
- sodium zirconium cyclosilicate and healthy diet
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Karolinska Institutet
Chronic Kidney Disease
Observational Study of Kibow Biotics in Chronic Kidney Failure Patients on Dialysis
A specifically formulated probiotic product comprised of defined and tested microbial strains may afford renoprotection in what has been generally called "Enteric DialysisTM".
- Trial name
- NCT01450709
- Testing
- Kibow Biotics
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kibow Pharma
Symbiotic, Uremic Toxins
Modulation of Gut Microbiota Composition and Gut Permeability Profiles by Multispecies Synbiotic Supplementation in Hemodialysis Patients
Chronic kidney disease (CKD) patients undergoing maintenance hemodialysis experience profound alterations in their gut microbiota, leading to dysbiosis and increased gut permeability.
- Conditions
- Symbiotic, Uremic Toxins, Gut -Microbiota, Gut Permeability
- Trial name
- NCT07461233
- Testing
- Multispecies Synbiotic Supplementation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Haemodialysis
Uremic Toxin Removal With a New High Flux Cellulose Triacetate Membrane
Comparison of the uremic toxin removal by haemodialysis either with a low flux or a new high flux cellulose triacetate membrane
- Trial name
- NCT00230906
- Testing
- Haemodialysis with either low or high flux membranes
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- University Hospital, Ghent
Uremia
Removal of Protein Bound Uremic Toxins by Modified Plasma Separation and Adsorption Combined With Hemodialysis
The aim of this study is to examine removal of protein bound uremic substances by mFPSA in chronic hemodialysis patients. mFPSA is an extracorporal blood purification system developed for detoxification in acute liver failure by…
- Trial name
- NCT00375635
- Testing
- mFPSA treatment
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Kidney Disease
Intra Individual Evaluation of Uremic Toxin Levels in Hemodialysed Patients
Chronic kidney disease (CKD) is characterized by a irreversible decrease of kidney functions. It is characterized by accumulation of solutes called uremic toxins.
- Trial name
- EVITUPH (NCT02480699)
- Testing
- Recurring blood sample, dietary survey
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Chronic Kidney Disease
The Role of Sodium Bicarbonate Enema in Improving Constipation and Reducing Uremic Toxins in Chronic Kidney Disease Patients.
Chronic kidney disease (CKD) is a progressive condition characterized by a gradual loss of kidney function, often resulting in the accumulation of metabolic waste products.
- Trial name
- NCT07394920
- Testing
- sodium bicarbonate enema
- Volunteers
- 100 people
- Sponsor
- Assiut University