Clinical trials: Uremic Toxin
Kidney Disease, Chronic, Renal Insufficiency, Chronic
Probiotic Supplementation and Disease Progression in CKD: A Randomized Trial
The goal of this clinical trial is to learn whether probiotic supplementation can slow disease progression in patients with moderate to severe chronic kidney disease (CKD).
- Conditions
- Kidney Disease, Chronic, Renal Insufficiency, Chronic, Gut Dysbiosis, Uremic Toxins
- Trial name
- PRO-CKD (NCT06863194)
- Testing
- Probiotic Supplementation (Lactobacillus plantarum)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis
National Registry of Rare Kidney Diseases
The goal of this National Registry is to is to collect information from patients with rare kidney diseases, so that it that can be used for research.
- Conditions
- Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis, AHL Amyloidosis, AL Amyloidosis
- Trial name
- RaDaR (NCT06065852)
- Where
- United Kingdom
- Volunteers
- 35,000 people
- Sponsor
- UK Kidney Association
End Stage Renal Failure on Dialysis
Effect of Prebiotics and/or Probiotics on Uremic Toxins and Inflammation Markers in Peritoneal Dialysis Patients
End-stage renal disease (ESRD) is a world public health problem, with high morbidity and mortality. Cardiovascular disease is the main cause of mortality in ESRD; uremic toxin retention and inflammation are considered…
- Trial name
- NCT03770611
- Testing
- Probiotic, Prebiotic, Symbiotic
- Where
- Mexico
- Volunteers
- 112 people
- Sponsor
- Unidad de Investigacion Medica en Enfermedades Renales
Hemolytic-Uremic Syndrome
Shiga Toxin Producing Escherichia Coli (STEC) Volume Expansion
This study will provide feasibility data regarding the conduct of a clinical trail evaluating the use of early aggressive inpatient intravenous rehydration in children with Shiga Toxin producing E. coli infection.
- Trial name
- NCT03275792
- Testing
- D5-0.9%NS, Routine home oral rehydration
- Where
- Canada
- Sponsor
- University of Calgary
Acute Kidney Injury
A Uremic Toxin Absorbent (AST-120) to Treat Hospital Acquired Acute Kidney Injury
Hospital acquired acute kidney injury is an important negative outcome predictor for hospitalized patients. Uremic toxins accumulated after a given renal insult.
- Trial name
- NCT02687841
- Testing
- AST-120and pentoxyphylline (PTX), pentoxyphylline (PTX)
- Where
- Taiwan
- Volunteers
- 206 people
- Sponsor
- National Taiwan University Hospital
End Stage Renal Disease (ESRD)
Comparison of the Removal of Uremic Toxins With Medium Cut-off and Super High-flux Vitamin E-coated Dialyzers
End-stage renal disease (ESRD) induces an accumulation of uremic toxins responsible for increased morbidity and mortality. These toxins cover a wide range of molecules, classified according to their molecular weight as small-size…
- Trial name
- E-FLUX (NCT05610683)
- Testing
- Hemodialysis sessions using SHFVE dialyzer (VieX™) or the MCO (Theranova 500™) dialyzer
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Poitiers University Hospital
End Stage Renal Disease
Evaluation Of The Efficacy of a Strain-Specific Probiotic Formulation in Hemodialysis Patients
Previous studies found that lactic acid bacteria could inhibit the activity of the performance of aristolochic acids (AAs) and improve apoptosis of proximal tubular epithelial cells (NRK-52E) and renal fibrosis on rats.
- Trial name
- NCT03066921
- Testing
- Probiotic packet
- Where
- Taiwan
- Volunteers
- 52 people
- Sponsor
- Paik Seong Lim
Kidney Failure, Acute
Uremic Toxins of Patients With Acute Kidney Failure
Determination of the concentration of uremic toxins of sepsis patients with or without acute kidney failure compared to the concentrations of uremic toxins of chronically uremic patients
- Trial name
- NCT00148044
- Testing
- Blood sampling for determination of uremic toxins
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Ghent
Chronic Kidney Disease (Stages 4 and 5), Peritoneal Dialysis (PD)
Probiotic and Prebiotic Supplementation in Peritoneal Dialysis Patients
The goal of this clinical trial is to learn if synbiotics work to lower inflammation in adults with chronic kidney disease who are on peritoneal dialysis.
- Trial name
- NCT07694791
- Testing
- Synbiotic
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Hemolytic-uremic Syndrome, Escherichia Coli Infections
Outbreak of Hemolytic Uremic Syndrome Linked to Escherichia Coli of Serotype O104:H4
The Hemolytic Uremic Syndrome (HUS) in its typical form occurs after a food born infection with a shiga-toxin secreting bacteria, usually Escherichia coli of the O157H7 serotype.
- Trial name
- SHU O104 CUB (NCT01406288)
- Testing
- HUS standard coverage care (including in ICU)
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Bordeaux
Haemodialysis Complication
Cooler Dialysis and Liver Perfusion and Function
Having hemodialysis affects the blood supply to various organs in the body including the heart and the brain. With time, these effects build up and can affect the way these organs function.
- Trial name
- NCT02997774
- Testing
- Cooler dialysis, Standard Dialysis
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Chris McIntyre
End Stage Renal Disease on Dialysis
Dietary Therapy in Dialysis Patients
Patients with end-stage kidney disease have hyperphosphatemia and accumulated uremic toxin level due to decreased urine excretion ability.
- Trial name
- NCT04505462
- Testing
- Therapeutic diet
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- Far Eastern Memorial Hospital
End-stage Renal Disease, Hemodialysis
Protein-bound Toxin Removal Between Limited Blood Flow Super High-flux Online HDF and High-Efficiency Online HDF
High-efficiency post-dilution online hemodiafiltration (OL-HDF) using high-flux dialyzer and requiring high blood flow rate (BF ≥400 mL/min) has been reported to enhance protein-bound toxin and middle molecular toxin removal and…
- Trial name
- NCT03288922
- Testing
- Limited BF OL-HDF with SHF, High-efficiency OL-HDF
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Chulalongkorn University
Arterial Stiffness, CHRONIC RENAL FAILURE
Pulse Wave Analysis and Velocity in Patients With Chronic Renal Failure: a Cross-sectional Observational Study to Assess Association With Left Ventricular Hypertrophy, Uremic Toxins and Inflammation.
The aims of the presented study are as follows: 1. To evaluate the endothelial function and arterial stiffness in a large cohort of prevalent CKD patients by means of non-invasive applantion tonometry. 2.
- Conditions
- Arterial Stiffness, CHRONIC RENAL FAILURE, Left Ventricular Hypertrophy
- Trial name
- NCT01579032
- Where
- 2 sites in Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Renal Failure
Serum Uremic Toxins and Histological Findings of the Blood Vessels in Dialysis Patients
Patients treated by chronic renal replacement therapy are exposed to cardiovascular problems and suffer from an accelerated and sever atherosclerosis.
- Trial name
- NCT00412139
- Where
- North Macedonia
- Volunteers
- 100 people
- Sponsor
- University of Skopje
Kidney Failure, Chronic
The Correlation Between Gut Microbiome/Metabolite and End Stage Renal Disease (ESRD)
The purpose of this study is to investigate the differences of gut Microbiome/Metabolite between ESRD patients and healthy subjects.
- Trial name
- NCT03010696
- Testing
- No interventions, questionnaire, collect specimen
- Where
- 4 sites in China
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- China Agricultural University
Symbiotic, Uremic Toxins
Alterations of Gut Derived Uremic Toxins and Microbiome Metabolites by Multispecies Synbiotic
Patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis frequently exhibit significant gut microbiota dysbiosis and increased intestinal permeability.
- Conditions
- Symbiotic, Uremic Toxins, Gut -Microbiota
- Trial name
- NCT07443280
- Testing
- Multispecies Synbiotic Supplementation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital