Clinical trials: Uremic Toxins
Symbiotic, Uremic Toxins
Alterations of Gut Derived Uremic Toxins and Microbiome Metabolites by Multispecies Synbiotic
Patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis frequently exhibit significant gut microbiota dysbiosis and increased intestinal permeability.
- Conditions
- Symbiotic, Uremic Toxins, Gut -Microbiota
- Trial name
- NCT07443280
- Testing
- Multispecies Synbiotic Supplementation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Symbiotic, Uremic Toxins
Modulation of Gut Microbiota Composition and Gut Permeability Profiles by Multispecies Synbiotic Supplementation in Hemodialysis Patients
Chronic kidney disease (CKD) patients undergoing maintenance hemodialysis experience profound alterations in their gut microbiota, leading to dysbiosis and increased gut permeability.
- Conditions
- Symbiotic, Uremic Toxins, Gut -Microbiota, Gut Permeability
- Trial name
- NCT07461233
- Testing
- Multispecies Synbiotic Supplementation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E.
- Trial name
- HIKO-STEC (NCT05219110)
- Testing
- Infusion of 200% maintenance fluids as balanced crystalloid IV solution, Oral fluids; infusion of up to 110% maintenance fluids as balanced crystalloid IV solution
- Where
- 26 sites in United States, Canada
- Volunteers
- 1,040 people
- Sponsor
- University of Calgary
Oral Uremic Toxin Absorbent
Study of Oral Uremic Toxin Absorbent/Probiotics to Modulate Systemic Inflammation and Retard the Progression of Chronic Kidney Disease in Patients With Diabetes.
Diabetes mellitus (DM) is a chronic inflammatory disease characterized by insufficient insulin secretion or insulin resistance, leading to hyperglycemia.
- Trial name
- NCT07333313
- Testing
- oral uremic toxin absorbent, probiotics, oral uremic toxin absorbent + probiotics
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Kidney Disease, Chronic, Renal Insufficiency, Chronic
Probiotic Supplementation and Disease Progression in CKD: A Randomized Trial
The goal of this clinical trial is to learn whether probiotic supplementation can slow disease progression in patients with moderate to severe chronic kidney disease (CKD).
- Conditions
- Kidney Disease, Chronic, Renal Insufficiency, Chronic, Gut Dysbiosis, Uremic Toxins
- Trial name
- PRO-CKD (NCT06863194)
- Testing
- Probiotic Supplementation (Lactobacillus plantarum)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Acute Renal Failure, Iatrogenic Effect
Detection of Acute Renal Failure Using Hospital Coding Data
AKI is a rapid and usually reversible impairment of kidney function that is life-threatening in the short term well described by the "Kidney Disease: Improving Global Outcomes - KDIGO" classification of 2012.
- Conditions
- Acute Renal Failure, Iatrogenic Effect, Uremic Toxin
- Trial name
- IRA-PMSI (NCT04923750)
- Where
- France
- Volunteers
- 498 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis
National Registry of Rare Kidney Diseases
The goal of this National Registry is to is to collect information from patients with rare kidney diseases, so that it that can be used for research.
- Conditions
- Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis, AHL Amyloidosis, AL Amyloidosis
- Trial name
- RaDaR (NCT06065852)
- Where
- United Kingdom
- Volunteers
- 35,000 people
- Sponsor
- UK Kidney Association
To Evaluate the Clearance Rate of Uremic Toxin by HFR
Hemodiafiltration With Endogenous Reinfusion on Uremic Toxins Clearance of Maintenance Hemodialysis Patients
1.1Primary Objective To evaluate the clearance rate of uremic toxin β2-microglobulin (β2-MG), indoxyl sulfate and λ-free light chain (λFLC) by HFR.
- Trial name
- NCT06002529
- Testing
- HFR
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Uremic Toxin
Evaluation of Protective Effect of Activated Charcoal and Probiotic Against Progression of Chronic Kidney Disease
Investigate the nephroprotective effect of Activated Charcoal and Probiotic in limiting the progression of renal impairment in patients with chronic kidney disease and improving of renal function test and phosphate level.
- Trial name
- NCT05540431
- Testing
- Activated Charcoal, Probiotic, No intervention
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Waleed Khaild Rahman Kareem Al-kabi
Uremic Toxins, Haemodynamic Stability
Uremic Toxin Removal and Hemodynamics in Long-hour Hemodialysis and Hemodiafiltration
Rationale: The mortality of end-stage renal disease (ESRD) patients on dialysis remains high. This may at least be partly due to the insufficient removal of (especially protein-bound) uremic toxins which have been associated with…
- Trial name
- NCT01328119
- Testing
- 4-hour HD, 4-hour HDF, 8-hour HD and 8-hour HDF
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center
End-stage Kidney Disease, CD4 T Cells
Effects of High Cut-off (HCO) Hemodialysis on Central Memory CD4+ T and Treg Cells in Patients With End-stage Kidney Disease
In this study, the investigators will evaluate whether CD4+ TCM producing effector cytokines can be distinguished on the basis of their expression of the IL-7 receptor alpha-chain (CD127).
- Conditions
- End-stage Kidney Disease, CD4 T Cells, Central Memory T Cells, Regulatory T Cells
- Trial name
- NCT01103076
- Testing
- Polyamide HD membrane
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier du Centre du Valais