Clinical trials: Urethra Stenosis
Urethral Strictures in Males
Effectiveness and Safety of Autologous Adipose-Derived Regenerative Cells for the Treatment of Urethral Strictures
Autologous adipose-derived regenerative cells (ADRC) extracted using Celution 800/CRS System (Cytori Therapeutics Inc)from a portion of the fat harvested from the patient's front abdominal wall.
- Trial name
- NCT01889888
- Testing
- Submucosal injection of ADRC
- Where
- Russia
- Volunteers
- 12 people
- Sponsor
- Burnasyan Federal Medical Biophysical Center
Urethral Stricture, Fat Graft
Feasibility and Therapeutic Potential of Free Fat Grafts in the Treatment of Urethral Strictures
In this study the investigators investigate the feasibility and therapeutic potential of free autologous fat grafting combined to direct visual urethrotomy (DVIU) in the treatment of urethral strictures.
- Trial name
- UREGRAFT (NCT04161365)
- Testing
- Direct visual urethrotomy, Autologous fat grafting
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Hannes Kortekangas
Benign Prostate Obstruction (BPO)
The Effects of Holmium Laser Enucleation and Thulium Laser Enucleation on Continence, Urethral Stricture, and Sexual Function in Benign Prostatic Hyperplasia
This study aims to evaluate the effects of Holmium Laser Enucleation of the Prostate (HoLEP) and Thulium Laser Enucleation of the Prostate (ThuLEP), performed for the treatment of benign prostatic hyperplasia (BPH), on the…
- Trial name
- EHTCUS (NCT07334730)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- TC Erciyes University
Penile Skin, Buccal Mucosal Graft
Penile Skin Versus Buccal Mucosal Graft in Augmentation Urethroplasty for Long Anterior Urethral Stricture
The aim of this study is to analyze the outcomes of dorsal onlay buccal mucosal graft (BMG) and penile skin graft (PSG) urethroplasty in the management of long segment bulbar urethral stricture.
- Conditions
- Penile Skin, Buccal Mucosal Graft, Augmentation, Urethroplasty
- Trial name
- NCT07074717
- Testing
- Buccal Mucosal Graft (BMG) Urethroplasty, Penile Skin Graft (PSG) Urethroplasty
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Urethral Meatal Stenosis
The Improvement in Uroflow and Postvoid Residual Urine After Urethral Meatotomy in Children With Meatal Stenosis
The improvement in uroflow and postvoid residual urine in children after urethral meatotomy for meatal stenosis. The hypothesis is that there is an improvement in both parameters, thus justifying the procedure.
- Trial name
- NCT01214525
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Meir Medical Center
Urethral Stricture Disease
Diagnosis of Urethral Stricture With Sono-urethrography vs Conventional Urethrography (SONO-URETHRA)
Conventional urethrography is the standard diagnostic evaluation for patients with a suspicion of urethral stricture. The radiation dose of this examination is 5-9 mSV. Sono-urethrography was introduced in 1988 (McAninch et al.
- Trial name
- SONO-URETHRA (NCT01790776)
- Testing
- Urografin 30%, NaCl 0,9 % in aqua
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Traumatic Urethral Stricture, Male, Overlapping Sites
Vessel-sparing Technique Versus Conventional Repair of PFUI: A Prospective Comparative Study
Pelvic fracture is associated with urethral injury in about 10% of patients . The common site of injury is at the bulbomembranous Junction and anastomotic urethroplasty with a tension free anastomosis remains the gold standard…
- Trial name
- NCT06248047
- Testing
- uretheroplasty
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Assiut University
Urethral Stricture
Tissue-engineered Construct Based on Buccal Mucosa Cells and Matrix From Collagen and Polylactoglycolide Fibers
This study investigates safety and efficacy of surgical treatment of patients with anterior urethral stricture using a tissue-engineered construct based on autologous buccal mucosa cells and matrix from reconstituted collagen and…
- Trial name
- NCT03205670
- Testing
- Urethroplasty with a tissue-engineered construct
- Where
- Russia
- Volunteers
- 6 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Urethral Stricture, Surgery
VeSpAR: Comparing Vessel-Sparing Anastomotic Repair and Transecting Anastomotic Repair in Isolated Short Bulbar Strictures.
The investigators want to verify whether the surgical outcome of vessel-sparing anastomotic repair in isolated short bulbar urethral strictures is not inferior to the surgical outcome of transecting anastomotic repair.
- Conditions
- Urethral Stricture, Surgery, Urologic Diseases
- Trial name
- VeSpAR (NCT03572348)
- Testing
- Transecting anastomotic repair (tAR), Vessel-sparing anastomotic repair (vsAR)
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Gastric Foreign Body, Nos, Disorder of Abdomen (Disorder)
Transluminal Flexible Endoscopic Procedure in Foregut and Urologic Surgery
NOTES access is safe and feasible in the controlled human setting and comparable to standard-of-care surgical techniques. NOTES exploration of the abdomen provides adequate visualization comparable to laparoscopy.
- Conditions
- Gastric Foreign Body, Nos, Disorder of Abdomen (Disorder), Foreign Body in Esophagus, Prostatic Diseases
- Trial name
- NOTES (NCT00484783)
- Testing
- Natural Orifice Transluminal Endoscopic Surgery (NOTES), Natural Orifice Translumenal Endoscopic Surgery (NOTES)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University Hospitals Cleveland Medical Center
Joshi's Step, Buccal Mucosal Graft
Joshi's Step With Buccal Mucosal Graft Urethroplasty in Nearly Obliterated Bulbar Urethral Stricture
This study aims to evaluate the functional and surgical outcome of Joshi's step with buccal graft urethroplasty for the management of nearly obliterated bulbar urethral stricture.
- Conditions
- Joshi's Step, Buccal Mucosal Graft, Urethroplasty, Obliterated Bulbar Urethral Stricture
- Trial name
- NCT07088198
- Testing
- Joshi's step
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Urethral Stricture
Liposomal Bupivacaine To Control Post-Operative Pain Following BMG
This is a single blinded-randomized controlled trial that recruit male patients for substitution urethroplasty using buccal mucosal graft.
- Trial name
- NCT03720223
- Testing
- Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Urology of Virginia
Urologic Diseases, Male Urogenital Diseases
Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures
This is a Phase I clinical study to determine the safety and efficacy of using autologous, engineered urethral constructs for the treatment of urethral strictures in adult males.
- Conditions
- Urologic Diseases, Male Urogenital Diseases, Urethral Stricture, Urethral Injury
- Trial name
- NCT03258658
- Testing
- Autologous Engineered Urethral Construct
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Urethral Stricture
ROBUST III- Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease
ROBUST III is a prospective, multi-center, randomized controlled adaptive sample size clinical trial to establish the safety and effectiveness for the Optilume Stricture Drug Coated Balloon (DCB).
- Trial name
- ROBUST-III (NCT03499964)
- Testing
- Optilume Drug Coated Balloon (DCB), Control Treatment
- Where
- 22 sites in United States, Canada
- Volunteers
- 127 people
- Sponsor
- Urotronic Inc.
Urethral Stricture
Urethral Stricture Database
Establishment of a clinical urethral stricture database for a prospective longitudinal cohort study.
- Trial name
- NCT06362083
- Testing
- Questionnaires and data collection
- Where
- Austria
- Volunteers
- 500 people
- Sponsor
- Medical University of Graz
Urethral Stricture
Mobile Health Application to Improve Patient Satisfaction After Urethroplasty
Create a custom urethroplasty mobile application that will guide patients through through the surgical process.
- Trial name
- NCT06384066
- Testing
- GetWell Mobile Application, Standard of Care
- Where
- United States
- Sponsor
- Northwestern University
Urethral Stricture
Liquid Buccal Mucosa Graft Urethroplasty
Study Objectives The current definitive treatment options for urethral stricture disease include endoscopic urethrotomy known as Direct Vision Internal Urethrotomy (DVIU) or open reconstruction known as urethroplasty (1-6).
- Trial name
- LBMG (NCT03061344)
- Testing
- DVIU treated with liquid buccal mucosal graft
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- State University of New York - Upstate Medical University
Urethral Stricture
A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty
The investigators propose a randomized non-blinded comparison of dorsal vs. ventral approach for buccal mucosa graft urethroplasty in the bulbar urethra. Buccal mucosa graft is a common method of repairing the strictured urethra.
- Trial name
- DvV (NCT02634619)
- Testing
- Ventral buccal mucosa onlay urethroplasty, Dorsal buccal mucosa onlay urethroplasty
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- University of California, San Francisco
Urethral Stricture
A Comparative Study of the Antibacterial Effects of Two Preoperative Hair Removal Methods in Male Patients With Urethral Stricture
Male urethral stricture is one of the common diseases in urology, with risk factors including a history of hypospadias surgery, indwelling urinary catheterization or instrumental manipulation, trauma, transurethral surgery, and…
- Trial name
- NCT07508566
- Testing
- Wiping with wet wipes containing 2% chlorhexidine gluconate (CHG).
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Urethral Stricture
Role of Uttarbasti in the Management of Mutra Marga Sankoch (Urethral Stricture)
Uttarbasti is per urethral administration of medicated oil which has been recommended by Sushrut for urinary track disorders. As far as conventional surgery is concerned urethral stricture still remains a challenge due to post…
- Trial name
- NCT00535717
- Testing
- uttarbasti (per urethral administration of medicated oil )
- Volunteers
- healthy volunteers welcome
- Sponsor
- Maharashtra University of Health Sciences