Clinical trials: Urethra Stenosis
Stricture Urethra
Role of Paclitaxel in Stricture Urethra
Stricture urethra is a common disease and has various causing factors. The most common performed procedure is direct visual internal urethrotomy (DVIU), but unfortunately has a high recurrence rates.
- Trial name
- NCT05678413
- Testing
- DVIU with paclitaxel injection, DVIU
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Al-Azhar University
Urethral Stricture
Holmium Laser Uretherotomy in Combination With Intralesional Steroids in Bulbar Uretheral Stricture
the purpose is to evaluate the outcome of visual internal uretherotomy with Holmium laser along with intralesional steroid injection.
- Trial name
- NCT05078788
- Testing
- Laser uretherotomy, Laser uretherotomy with triamcinolone
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Ain Shams University
Urethral Stricture, Urethral Stricture, Anterior
Treatment of Bulbar Urethral Strictures With Optilume Drug-Coated Balloons in an Untreated Population
This randomized controlled trial investigates the effectiveness and safety of the Optilume® drug-coated balloon (DCB) compared to standard direct visual internal urethrotomy (DVIU) in the treatment of bulbar urethral strictures.
- Conditions
- Urethral Stricture, Urethral Stricture, Anterior, Urethral Stricture, Male, Urethral Stricture Less Than 2 cm
- Trial name
- FIRST-CARE (NCT06827210)
- Testing
- Optilume DCB, Standard Direct Visual Internal Urethrotomy (DVIU)
- Where
- 3 sites in Denmark
- Volunteers
- 140 people
- Sponsor
- Aalborg University Hospital
Anterior Urethral Stricture, Male
Anatomical and Functional Outcome of PSG Vs BMG for Urethral Substitution in Long Segment Anterior Urethral Strictures
This study aims to compare the penile skin graft and buccal mucosal graft for substitution of long anterior urethral strictures using one-sided dorsal perineal approach.
- Trial name
- NCT06056856
- Testing
- Penile skin graft substituttion urethroplasty, Buccal Mucosal Graft substitution urethroplasty
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Urethral Stricture, Male
Holmium: YAG Versus Cold Knife Internal Urethrotomy in Management of Short Urethral Strictures
Urethral stricture disease is defined as narrowing of the urethral lumen because of fibrosis, which occurs in urethral mucosa and surrounding tissues. The etiology could be congenital, iatrogenic, infectious, or idiopathic.
- Trial name
- NCT04650347
- Testing
- visualized internal urethrotomy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Anterior Urethral Stricture, Male
Optilume Registry for Treatment of Stricture of the Anterior Urethra
The purpose of this registry is verifying the continued safety and effectiveness of the Optilume DCB clinical use in patients undergoing dilation of the urethral stricture.
- Trial name
- NCT05479422
- Where
- 13 sites in Belgium, Italy and 3 more
- Volunteers
- 150 people
- Sponsor
- European Association of Urology Research Foundation
Urethral Stricture Less Than 2 cm
Treatment of Urethral Stricture With Urethral Drug Ball
To evaluate the safety and efficacy of urethral drug balloon catheter in the treatment of urethral stricture.
- Trial name
- NCT05812482
- Testing
- Drug balloon dilatation, Direct vision internal urethrotomy (DVIU)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Lepu Medical Technology (Beijing) Co., Ltd.
Urethral Stricture
The Nanofat Regenerative Surgery for Management of Genital Lichen Sclerosus in Male and Female Patients
Regenerative surgery is an emerging multidisciplinary field actually based on derived adipose tissue. Autologous fat grafting was first described by Neuber in 1893 and since then it has developed over the next century.
- Trial name
- LSNanofat (NCT05464290)
- Testing
- NANOfat grafting
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Elective Penile Surgeries, Hypospadias
Effects of Dexmedetomidine as Adjunct to Pudendal Block for Pediatric Penile Surgery
Caudal block is often performed to relieve postoperative pain in pediatric urological surgery. Recently, pudendal block is also used in penile surgery and it has advantage because of less side effects such as transient weakness…
- Conditions
- Elective Penile Surgeries, Hypospadias, Urethral Fistula or Stricture After Hypospadias Repair, Penile Curvature
- Trial name
- NCT02848157
- Testing
- Dexmedetomidine, plain ropivacaine, Ropivacaine
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Urethral Stricture
Urethral Resistive Index (URI): A New Parameter for Diagnosing Urethral Obstruction
This prospective observational study aims to evaluate the diagnostic accuracy of a new, non-invasive uroflowmetry parameter called the Urethral Resistive Index (URI) for detecting urethral stricture in men.
- Trial name
- URI (NCT07403786)
- Testing
- Uroflowmetry with URI Calculation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Urethral Stricture
Dorsal vs. Ventral Buccal Graft Dorsal vs. Ventral Buccal Graft
This is a randomized non-blinded comparison of dorsal vs. ventral approach for buccal mucosa graft urethroplasty in the bulbar urethra. Buccal mucosa graft is a common method of repairing the strictured urethra.
- Trial name
- DoVeBuG (NCT02551783)
- Testing
- Urethroplasty with buccal mucosa graft, Ventral Buccal
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Minnesota
Urethra Stricture
LishitonglinUS-01 Trial
This study intends to conduct a prospective, randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of Lishi Tonglin Granule (a hospital-formulated innovative prescription) developed in our…
- Trial name
- NCT07769060
- Testing
- Lishitonglin Formula granules
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University First Hospital
Pain, Postoperative, Urethral Stricture
Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty
The investigator's study aims to see if an enhanced recovery regimen of pain medications before and during surgery will decrease the use and risk of opioid pain medications as well as improve pain control in anterior…
- Trial name
- NCT03859024
- Testing
- Oxycodone, Acetaminophen, Gabapentin
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Urethral Stricture
Intraoperative Lidocaine or Dexmedetomidine for Postoperative Pain Modulation After Urethral Reconstruction.
The development of chronic postoperative pain (CPP) following surgery is influenced by several factors, among which the intensity of acute postoperative pain in the immediate perioperative period and mechanisms related to nerve…
- Trial name
- NCT07676942
- Testing
- Perioperative lidocaine infusion, Perioperative dexmedetomidine infusion
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Centre of Postgraduate Medical Education
Urethral Stricture, Urethral Stricture, Anterior
Re-Establishing Flow Via Drug Coated Balloon for the Treatment of Urethral Stricture Disease - Registry Study
The ROBUST IV study is designed to collect and better understand "real-world" outcomes for men undergoing urethral dilation using the Optilume Drug Coated Balloon (DCB) for treatment of urethral stricture.
- Conditions
- Urethral Stricture, Urethral Stricture, Anterior, Lower Urinary Tract Symptoms, Anterior Urethral Stricture
- Trial name
- ROBUST IV (NCT03851952)
- Testing
- Optilume Drug Coated Balloon
- Sponsor
- Urotronic Inc.
Urethral Stricture
Memokath® 044TW Stent for Treatment of Urethral Stricture
The purpose of this study is to evaluate if the placement of a temporary urethral stent for up to 12 months, following dilation or internal urethrotomy (cutting open), results in a higher rate of urethral patency during the first…
- Trial name
- NCT00270504
- Testing
- Memokath stenting
- Where
- 7 sites in United States
- Volunteers
- 92 people
- Sponsor
- Pnn Medical DK
Urethra Stenosis, Urethral Stricture
Multi-stage Urethroplasty with Augmentation Using a Dorsal Graft Inlay Technique Comparing Graft Use in First or Second Stage
The principal aim of this pilot study is to directly compare both approaches and analyze the failure rate after one year of follow-up.
- Trial name
- MAGIC I (NCT04965025)
- Testing
- Multi-stage urethroplasty with graft inlay in first stage, Multi-stage urethroplasty with graft inlay in second stage
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Ghent
Urethral Stricture, Urethral Diseases
REDUCER Trial (TXA in Urethroplasty)
This study will test whether tranexamic acid (TXA), a medication used to reduce bleeding, can decrease blood loss in patients having urethroplasty.
- Trial name
- REDUCER (NCT07501884)
- Testing
- Tranexamic Acid, Urethroplasty
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Amjad Alwaal, MD, MSc, FRCSC, FACS
Recurrence
Role of Oral Steroids in Reducing Recurrence of Urethral Stricture After Direct Vision Internal Urethrotomy
It was a randomized controlled trial conducted at department of Urology, Armed Forces Institute of Urology, Rawalpindi from 1st January, 2018 July 2019 to 31st March 2021 to determine the role of oral steroids after Direct Vision…
- Trial name
- NCT05069883
- Testing
- Steroid Drug, No steroid
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Services Hospital, Lahore
Urethral Stricture, Bulbar
Optimal Duration of Foley Catheter After Bulbar Urethroplasty
The goal of this clinical trial is to learn when is the best time to remove a Foley catheter (tube used to drain urine from the bladder) after surgery in adult men who have a specific type of urethral stricture disease (narrowing…
- Trial name
- NCT07220980
- Testing
- Early catheter removal, Later catheter removal
- Where
- 4 sites in United States
- Volunteers
- 320 people
- Sponsor
- Jane Kurtzman