Clinical trials: Urethral Obstruction
Cystocele
Detrusor Underactivity and Bladder Outlet Obstruction in Women With Cystocele
Women with cystocele may be associated with detrusor underactivity (DU) or bladder outlet obstruction (BOO). However, the impact of cystocele repair on the rates of DU and BOO remained obscure.
- Trial name
- NCT04184128
- Testing
- Urodynamic study
- Where
- Taiwan
- Volunteers
- 623 people
- Sponsor
- National Taiwan University Hospital
Prostate Hyperplasia, Prostatic Hypertrophy
Low Energy HoLEP on IPSS
The purpose of this study is to prove that low-energy (30W) Holmium laser prostatectomy (Holeb) is not inferior to high-energy (100W) Holmium laser prostatectomy (safety and effectiveness)
- Conditions
- Prostate Hyperplasia, Prostatic Hypertrophy, Surgery, Bladder Outlet Obstruction
- Trial name
- NCT04514718
- Testing
- Holmium laser
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Urethra Stenosis
DoVe Trial: Dorsal Onlay Versus Ventral Onlay in Isolated Bulbar Urethral Strictures
For bulbar urethral strictures, it remains unclear whether ventral onlay graft urethroplasty is non-inferior to dorsal onlay graft urethroplasty in terms of patency rates.
- Trial name
- DoVe (NCT04551417)
- Testing
- Free graft urethroplasty
- Where
- Belgium
- Volunteers
- 240 people
- Sponsor
- University Hospital, Ghent
HoLEP, Trifecta Achievement
Predictors of Trifecta Achievement After HoLEP
Holmium laser enucleation of the prostate (HoLEP) is a surgical treatment option for men experiencing bothersome lower urinary tract symptoms due to an enlarged prostate.
- Conditions
- HoLEP, Trifecta Achievement, Urinary Incontinence Following Surgical Procedure, Clavien Dindo Surgical Complication Scale
- Trial name
- ReMIUS-BPO (NCT07429994)
- Testing
- Transurethral Holmium Laser Enuclation of the Prostate
- Where
- Turkey (Türkiye)
- Volunteers
- 604 people
- Sponsor
- Ondokuz Mayıs University
Urethral Stricture
The Accuracy of Pulsed Fluoroscopy Retrograde Urethrogram Vs the Traditional Retrograde Urethrogram In Diagnosing Urethral Stricture
This study is designed as a prospective comparative randomized clinical study to determine the diagnostic accuracy (sensitivity, specificity, positive predictive value, and negative predictive value) of pulsed fluoroscopy…
- Trial name
- NCT05519566
- Testing
- Retrograde Urethrogram
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Northern Ontario School of Medicine
Urethral Stricture
Tissue-engineered Construct Based on Buccal Mucosa Cells and Matrix From Collagen and Polylactoglycolide Fibers
This study investigates safety and efficacy of surgical treatment of patients with anterior urethral stricture using a tissue-engineered construct based on autologous buccal mucosa cells and matrix from reconstituted collagen and…
- Trial name
- NCT03205670
- Testing
- Urethroplasty with a tissue-engineered construct
- Where
- Russia
- Volunteers
- 6 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Bladder Outlet Obstruction
Diagnosis of Bladder Outlet Obstruction Using Dynamic Urine Vibration "Holter" in Comparison to Pressure Flow Study
Current gold standard of bladder outlet diagnosis is pressure flow study. This study is invasive time consuming and requires expensive and complex set-up.
- Trial name
- NCT01388348
- Testing
- Dynamic Urine Vibration "Holter"
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Meir Medical Center
Benign Prostatic Hyperplasia
Comparison of Functional Outcomes of Ejaculation-preserving Partial Trans Urethral Resection of the Prostate With Complete Trans Urethral Resection of the Prostate for Benign Prostatic Obstruction
It has been demonstrated that sexual activity was common in the majority of men over 50 years old and was an important component of overall quality of life (QoL).
- Trial name
- PARTURP (NCT05574244)
- Testing
- Partial surgery preserving the prostatic apex, Conventional endoscopic prostatic surgery
- Where
- 17 sites in France
- Volunteers
- 336 people
- Sponsor
- University Hospital, Bordeaux
Benign Prostate Hyperplasia, Bladder Outlet Obstruction
En-bloc With Early Apical Release Versus Lobe-by-lobe LASER Enucleation of the Prostate
Since its introduction in 1998 , and through numerous level 1a evidence, Holmium Laser enucleation of the prostate (HoLEP) has come to be considered a size-independent golden standard treatment for management of bladder outlet…
- Trial name
- NCT07014969
- Testing
- En-bloc HoLEP
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Mansoura University
Urethral Stricture
Bioengineered Collagen Implant for Urethral Stricture Repair
The field of research for this study is tissue engineering and the utilization of a bioengineered collagen implant as a substitute biomaterial for conventional buccal mucosa in substitution urethroplasty of distal urethral…
- Trial name
- NCT05463991
- Testing
- Bioengineered collagen implant
- Where
- Malaysia
- Volunteers
- 5 people
- Sponsor
- Regenosca SA
Bladder Cancer, Bladder Outlet Obstruction
Day-case Endourology; Enablers, Barriers, Unexpected Outcomes
A qualitative research study conducted in hospitals across England, in which staff members will be interviewed. We will interview staff who are directly or indirectly involved in delivering care for patients undergoing the…
- Conditions
- Bladder Cancer, Bladder Outlet Obstruction, Urolithiasis
- Trial name
- NCT06152666
- Testing
- None - qualitative interviews
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Benign Prostatic Hyperplasia, Bladder Outlet Obstruction
Bipolar Transurethral Enucleation (BipolEP) vs Bipolar Transurethral Resection of the Prostate
The aim of this study is to compare two different surgical methods for treating benign prostatic obstruction (BPO). The investigators are going to compare the risks and benefits of bipolar transurethral resection of the prostate…
- Trial name
- NCT03503721
- Testing
- BipolEP, bipolarTURP
- Where
- 2 sites in Austria, Switzerland
- Volunteers
- 84 people
- Sponsor
- Salzburger Landeskliniken
Urethral Stricture, Surgery
VeSpAR: Comparing Vessel-Sparing Anastomotic Repair and Transecting Anastomotic Repair in Isolated Short Bulbar Strictures.
The investigators want to verify whether the surgical outcome of vessel-sparing anastomotic repair in isolated short bulbar urethral strictures is not inferior to the surgical outcome of transecting anastomotic repair.
- Conditions
- Urethral Stricture, Surgery, Urologic Diseases
- Trial name
- VeSpAR (NCT03572348)
- Testing
- Transecting anastomotic repair (tAR), Vessel-sparing anastomotic repair (vsAR)
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Bladder Outlet Obstruction
Bladder Outlet Obstruction Observation Using Dynamic Urine Vibration "Holter"
Current gold standard of bladder outlet diagnosis is pressure flow study. This study is invasive time consuming and requires expensive and complex set-up.
- Trial name
- NCT01779349
- Testing
- Dynamic Urine Vibration "Holter"
- Where
- 2 sites in Israel
- Volunteers
- 45 people
- Sponsor
- P. Square Medical Ltd
Lower Urinary Tract Symptoms, Bladder Outlet Obstruction
A Study of Mirabegron (YM178) in Men With Lower Urinary Tract Symptoms (LUTS) and Bladder Outlet Obstruction (BOO)
This study examined the safety, tolerability, and efficacy of mirabegron (YM178) compared to placebo.
- Trial name
- NCT00410514
- Testing
- Mirabegron
- Where
- 27 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Astellas Pharma Inc
Bladder Neck Obstruction, Benign Prostate Hyperplasia
Assessing Safety & Efficacy of MediTate Temporary Implant in Subjects With Benign Prostate Hyperplasia
The purpose of this study is to assess the safety and efficacy of MediTate Temporary Implantable Nitinol Device (TIND) used to alleviate symptoms of Bladder Outlet Obstruction (BOO) secondary to Benign Prostate Hyperplasia…
- Trial name
- NCT01436877
- Testing
- Insertion of Temporary Implantable Nitinol Device (TIND)
- Where
- Israel
- Volunteers
- 32 people
- Sponsor
- Medi-Tate Ltd.
Hypospadias
Effect of Caudal and Penile Block on Hypospadias Repair Complications
Hypospadias is one of the most common genitourinary (GU) malformations, seen in approximately 1 of 250 male live births. Common methods of local anesthesia administration for hypospadias surgery include caudal and dorsal penile…
- Trial name
- NCT02851290
- Testing
- Caudal block anesthesia, Dorsal penile nerve block anesthesia
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Baylor College of Medicine
Urethral Stricture
Role of Uttarbasti in the Management of Mutra Marga Sankoch (Urethral Stricture)
Uttarbasti is per urethral administration of medicated oil which has been recommended by Sushrut for urinary track disorders. As far as conventional surgery is concerned urethral stricture still remains a challenge due to post…
- Trial name
- NCT00535717
- Testing
- uttarbasti (per urethral administration of medicated oil )
- Volunteers
- healthy volunteers welcome
- Sponsor
- Maharashtra University of Health Sciences
Bladder Outlet Obstruction, BPH
High Intensity Focused Ultrasound (HIFU) Ablation for Treatment of Prostate Tissue in Bladder Outlet Obstruction
Objectives: To assess the efficacy of HIFU therapy for benign prostatic tissue ablation in patients with lower urinary tract symptoms (LUTS) due to bladder outlet obstruction (BOO) that caused by Benign prostatic hyperplasia…
- Trial name
- HIFU for BOO (NCT07194187)
- Testing
- High Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pediatric Disorder, Hydronephrosis in Children
Effect of Concomitant Bladder Neck Incision and Urethral Valve Ablation on Surgical Re-intervention Rate for Patients With Posterior Urethral Valve
To determine the short-term effects of concurrent valve ablation and bladder neck incision on re-intervention rate for patients with posterior urethral valve.
- Conditions
- Pediatric Disorder, Hydronephrosis in Children, Hydronephrosis, Secondary, Hydronephrosis Congenital
- Trial name
- NCT05087537
- Testing
- Valve ablation, Valve ablation and bladder neck incision
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Mansoura University