Clinical trials: Urethral Stricture, Male
Urethral Stricture
Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy
The aim of this study is to evaluate the efficacy of local injected mitomycin C at the time of internal urethrotomy in order to prevent the recurrence of urethral strictures.
- Trial name
- NCT00918528
- Testing
- Internal urethrotomy, Mitomycin C - local injection
- Where
- Israel
- Sponsor
- Hillel Yaffe Medical Center
Urethral Stricture
9000 URETHRA STUDY: a Study About Urethroplasty for Urethral Stricture Disease
It has been demonstrated that urethroplasty should be considered the gold standard treatment for urethral stricture disease as it yields higher long-term success rates than endoscopic treatment options such as direct vision…
- Trial name
- NCT04071925
- Testing
- Urethroplasty
- Where
- 2 sites in Belgium
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Ghent
Urethral Stricture
Liquid Buccal Mucosa Graft Urethroplasty
Study Objectives The current definitive treatment options for urethral stricture disease include endoscopic urethrotomy known as Direct Vision Internal Urethrotomy (DVIU) or open reconstruction known as urethroplasty (1-6).
- Trial name
- LBMG (NCT03061344)
- Testing
- DVIU treated with liquid buccal mucosal graft
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- State University of New York - Upstate Medical University
Urethral Stricture, Male, Hormone Deficiency
Urethral Stricture After Transurethral Resection of the Prostate/Bladder: a Prospective Study of Risk Factors
There is currently no prognostic or predictive risk marker for this urethral stricture disease. The most conservative standard treatment for urethral stricture (internal urethrotomy) has a very high recurrence rate (greater than…
- Conditions
- Urethral Stricture, Male, Hormone Deficiency, Fibrosis
- Trial name
- STRICT-TURP (NCT04795570)
- Testing
- Transurethral resection of the prostate or bladder
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital Virgen de las Nieves
Urethral Stricture
A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty
The investigators propose a randomized non-blinded comparison of dorsal vs. ventral approach for buccal mucosa graft urethroplasty in the bulbar urethra. Buccal mucosa graft is a common method of repairing the strictured urethra.
- Trial name
- DvV (NCT02634619)
- Testing
- Ventral buccal mucosa onlay urethroplasty, Dorsal buccal mucosa onlay urethroplasty
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- University of California, San Francisco
Traumatic Urethral Stricture, Male, Overlapping Sites
Vessel-sparing Technique Versus Conventional Repair of PFUI: A Prospective Comparative Study
Pelvic fracture is associated with urethral injury in about 10% of patients . The common site of injury is at the bulbomembranous Junction and anastomotic urethroplasty with a tension free anastomosis remains the gold standard…
- Trial name
- NCT06248047
- Testing
- uretheroplasty
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Assiut University
Stricture Urethra
ROBUST I Pilot Study, Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease
Robust I study is a feasibility study for evaluating the safety and efficacy of DCB.
- Trial name
- ROBUST (NCT03014726)
- Testing
- Urotronic Drug Coated Balloon (DCB)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Urotronic Inc.
Anterior Urethral Stricture, Male
Pre-operative Assessment by Sonourethrography Only in Anterior Urethral Strictures.
The choice of the best surgical technique for urethral stricture repair depends on the stricture length. Estimating the length of urethral strictures is therefore of utmost importance.
- Trial name
- PASTIS (NCT04452890)
- Testing
- Sonourethrography
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Urethral Stricture, Male
Comparison Between Two Techniques Used in Treatment of Long Anterior Urethral Stricture
To evaluate dorsolateral and dorsal approach urethroplasty in treatment of anterior urethral stricture by using buccal mucosal graft as regard voiding and sexual outcomes.
- Trial name
- NCT05918315
- Testing
- Buccal mucosa substitution urethroplasty
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Urethral Stricture, Surgery
VeSpAR: Comparing Vessel-Sparing Anastomotic Repair and Transecting Anastomotic Repair in Isolated Short Bulbar Strictures.
The investigators want to verify whether the surgical outcome of vessel-sparing anastomotic repair in isolated short bulbar urethral strictures is not inferior to the surgical outcome of transecting anastomotic repair.
- Conditions
- Urethral Stricture, Surgery, Urologic Diseases
- Trial name
- VeSpAR (NCT03572348)
- Testing
- Transecting anastomotic repair (tAR), Vessel-sparing anastomotic repair (vsAR)
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Urethral Strictures
Efficiency of Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures
The purpose of this study is to determine whether laser internal urethrotomy (IU) is as efficient as cold knife internal urethrotomy for treatment of anterior urethral strictures regarding post operative urination outflow…
- Trial name
- IU (NCT01196572)
- Testing
- Internal Urethrotomy
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Urethral Stricture
Factors Predicting Urethral Stricture Recurrence After Dorsal Onlay Augmented, Buccal Mucosal Graft Urethroplasty
In this observational study, the investigators will evaluate potential risk factors associated with urethral stricture recurrence after augmentation anterior urethroplasty using dorsal onlay buccal mucosal Graft during the past…
- Trial name
- NCT04357080
- Testing
- Urethroplasty
- Where
- Egypt
- Volunteers
- 266 people
- Sponsor
- Al-Azhar University
Urethral Stricture, Male
Small Intestinal Submucosa Graft for Repair of Anterior Urethral Strictures
The field of research for this study is tissue engineering and the utilization of a small intestinal submucosa graft as a substitute biomaterial for conventional buccal mucosa in substitution urethroplasty of anterior urethral…
- Trial name
- NCT06192654
- Testing
- Small intestinal submucosa (SIS) graft urethroplasty, Autologous oral bucal mucosa graft urethroplasty
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xiaoyong Zeng
Urethral Stricture, Urethral Stricture, Anterior
Treatment of Bulbar Urethral Strictures With Optilume Drug-Coated Balloons in an Untreated Population
This randomized controlled trial investigates the effectiveness and safety of the Optilume® drug-coated balloon (DCB) compared to standard direct visual internal urethrotomy (DVIU) in the treatment of bulbar urethral strictures.
- Conditions
- Urethral Stricture, Urethral Stricture, Anterior, Urethral Stricture, Male, Urethral Stricture Less Than 2 cm
- Trial name
- FIRST-CARE (NCT06827210)
- Testing
- Optilume DCB, Standard Direct Visual Internal Urethrotomy (DVIU)
- Where
- 3 sites in Denmark
- Volunteers
- 140 people
- Sponsor
- Aalborg University Hospital
Urethral Stricture
Optilume PoST AppRoval Clinical Evaluation of Andrology ParaMeters
Single-arm, prospective study assessing semen quality after treatment with the Optilume Urethral DCB in men between 22 and 65 years of age.
- Trial name
- STREAM (NCT05383274)
- Testing
- Optilume Urethral DCB
- Where
- 9 sites in United States
- Volunteers
- 34 people
- Sponsor
- Urotronic Inc.
Urethral Stricture, Erectile Dysfunction
Comparison Between Excision And Primary Anastomosis Urethroplasty And Tunica Vaginalis Graft Urethroplasty.
Urethroplasty is considered the gold standard for the treatment of urethral stricture disease, with a success rate of more than 93% in terms of stricture recurrence.
- Trial name
- NCT07668973
- Testing
- Excision and Primary Anastomosis Urethroplasty, Tunica Vaginalis Graft Urethroplasty
- Volunteers
- 94 people
- Sponsor
- Sahiwal medical college sahiwal
Urethral Stricture
Urethral Resistive Index (URI): A New Parameter for Diagnosing Urethral Obstruction
This prospective observational study aims to evaluate the diagnostic accuracy of a new, non-invasive uroflowmetry parameter called the Urethral Resistive Index (URI) for detecting urethral stricture in men.
- Trial name
- URI (NCT07403786)
- Testing
- Uroflowmetry with URI Calculation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Urethral Stricture, Bladder (Urothelial, Transitional Cell) Cancer
The Impact of Age and Sex on Anticipated and Experienced Pain in First-Time Outpatient Flexible Cystoscopy
Cystoscopy is a procedure frequently performed in daily urological practice for the diagnosis of various urological conditions, including bladder tumors, benign prostatic hyperplasia, recurrent cystitis, and urethral strictures.
- Conditions
- Urethral Stricture, Bladder (Urothelial, Transitional Cell) Cancer, Benign Prostate Obstruction (BPO)
- Trial name
- PAINCYST (NCT07375641)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Kayseri Education and Research Hospital
Urethral Strictures in Males
Effectiveness and Safety of Autologous Adipose-Derived Regenerative Cells for the Treatment of Urethral Strictures
Autologous adipose-derived regenerative cells (ADRC) extracted using Celution 800/CRS System (Cytori Therapeutics Inc)from a portion of the fat harvested from the patient's front abdominal wall.
- Trial name
- NCT01889888
- Testing
- Submucosal injection of ADRC
- Where
- Russia
- Volunteers
- 12 people
- Sponsor
- Burnasyan Federal Medical Biophysical Center
Urethral Stricture Less Than 2 cm
Treatment of Urethral Stricture With Urethral Drug Ball
To evaluate the safety and efficacy of urethral drug balloon catheter in the treatment of urethral stricture.
- Trial name
- NCT05812482
- Testing
- Drug balloon dilatation, Direct vision internal urethrotomy (DVIU)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Lepu Medical Technology (Beijing) Co., Ltd.