Clinical trials: Uric Acid
Obesity, Dyslipidemia
Meta-analyses of the Effect of Sucrose Versus High Fructose Corn Syrup on Cardiometabolic Risk
The rise in high fructose corn syrup (HFCS) consumption over the past 40 years since its introduction as a popular sweetener in the United States has led to much concern regarding its contribution to the rise in obesity (1)…
- Conditions
- Obesity, Dyslipidemia, Prediabetes, Dysglycemia
- Trial name
- NCT02702479
- Testing
- High Fructose Corn Syrup, Sucrose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy, Diet Modification
Uric Acid Metabolism, Endothelial Function and Oxidative Stress in Vegans and Omnivores.
50 vegans and 50 omnivores will be recruited at the Erasme Hospital, Brussels. Hypothesis Relative induced-hyperuricemia by the vegan diet is not associated with impaired endothelial function if vitamin B12 and folic acid levels…
- Trial name
- NCT03849677
- Testing
- Endothelial function and inflammation
- Where
- Belgium
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Type 1 Diabetes Mellitus
The Effect of Uric Acid Lowering in Type 1 Diabetes
Patients with type 1 diabetes mellitus (T1DM) are at high risk of developing kidney complications potentially leading to end stage renal disease.
- Trial name
- NCT02344602
- Testing
- Febuxostat
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Hyperuricemia, Healthy
The Relationship Among, Serum Uric Acid, Left Ventricular Hypertrophy and Metabolic Syndrome
Hyperuricemia is associated with the prevalence of metabolic syndrome and cardiovascular risks in diverse of the population. Whether the dose-response effects on the prevalence of metabolic syndrome and cardiometabolic risks is…
- Trial name
- NCT03473951
- Testing
- Hyperuricemia
- Where
- Taiwan
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Diabetes Mellitus
Association Between Uric Acid / High Density Lipoprotein Ratio and Monocyte / High Density Lipoprotein Ratio With Diabetic Complications
Type 2 diabetes mellitus (T2DM) poses a formidable global health challenge, with complications arising in both the microvascular and macrovascular domains as glycemic control worsens.the aim of the study to evaluate uric acid /…
- Trial name
- NCT06754813
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gout
A Study to Determine the Safety, Tolerability, PK and Preliminary PD of SSS11 in Chinese Healthy Adult Volunteers
To evaluate the safety, tolerability, PK and preliminary PD of SSS11 for injection in chinese healthy adult volunteers.
- Trial name
- NCT04047394
- Testing
- PEGylated recombinant candida urate oxidase
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Gout; Hyperuricemia
Single Dose Study of SHR4640 in Healthy Subjects
The objective of the study is to assess the safety, tolerance, food effect, pharmacokinetic and pharmacodynamic properties of single dose adminstration of SHR4640 in healthy volunteers.
- Trial name
- NCT02815839
- Testing
- SHR4640
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Acute Coronary Syndrome
Association Between Uric Acid and Acute Coronary Syndrome
The aim of the study is to acess the association between admission serum uric acid level and in_hospital outcomes in patients with acute coronary syndromes
- Trial name
- NCT05770323
- Testing
- Uric acid level
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sohag University
Metabolic Syndrome
A Short Term Evaluation of a Structured Weight Loss Plan in Overweight and Obese Adults
The present study is designed to examine the effect of changes in body weight and related parameters associated with a commercially-available, low-carbohydrate diet plan.
- Trial name
- NCT02774668
- Testing
- "Grab-and-Go" meal plan, "Jump-Start" meal plan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hyperuricemia
Musculoskeletal Ultrasound in Asymptomatic Hyperuricemia
An observational study to evaluate the prevalence of US changes of gout in the joints and tendons of patients with different degrees of asymptomatic hyperuricemia.
- Trial name
- NCT02502565
- Testing
- Uric acid level
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Renal Function, Endothelial Function
Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function
The investigators hypothesize that, among non-hypertensive overweight and obese individuals, treatment of vitamin D deficiency and lowering uric acid concentrations (by either xanthine oxidase inhibition or increased renal…
- Conditions
- Renal Function, Endothelial Function, Blood Pressure, Overweight
- Trial name
- MODERATE (NCT01320722)
- Testing
- Vitamin D ergocalciferol, Probenecid, Allopurinol
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy
A Food-Drug Interaction Study of Serum Urate After Oral Inosine
The purpose of this study is to assess the effects of food on the amount of urate in the body after a single oral dose of inosine.
- Trial name
- NCT02614469
- Testing
- Inosine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Michael Alan Schwarzschild
Homocysteine Level and Interleukin- 17 in Lupus Nephritis Patients
Correlation Between Serum Uric Acid, Serum Homocysteine Level and Interleukin- 17 in Lupus Nephritis Patients
Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystem autoimmune disease characterized by pathogenic autoantibodies production against nuclear structures .
- Trial name
- NCT07017868
- Testing
- interleukin- 17
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sohag University
Obesity, PreDiabetes
Network Meta-analysis of Intermittent Fasting and Cardiometabolic Risk
Intermittent fasting is a method of restricting calories over a defined period of time and includes regimens such as whole-day fasting, alternate-day fasting, and time-restricted feeding.
- Conditions
- Obesity, PreDiabetes, Diabetes, Hypertension
- Trial name
- NCT05309057
- Testing
- Intermittent Fasting
- Where
- 2 sites in Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy Adults
Effect of Probiotic on the Gut Microbiota of Healthy Volunteers
The goal of this placebo-controlled randomized trial is to test the effect of intervention with Bifidobacterium animalis subsp. lactis BLa80 on the composition of the gut microbiota of healthy volunteers.
- Trial name
- NCT06103253
- Testing
- a Bla80 group
- Where
- China
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Chronic Kidney Diseases, Diabetes Mellitus, Type 2
Effect of Acute Fructose Load in Human
The metabolism of the monosaccharide fructose is less controlled than the metabolism of glucose, which will result in the metabolic product uric acid.
- Trial name
- NCT03157960
- Testing
- Blueberry drink, Blueberry and pizza, Soft beverage
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Acute Kidney Injury
Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers
Rehydration during and after physical exercise is essential to avoid acute kidney injury. Soft drinks are commonly used during exercise. High intake of carbohydrates is leading to obesity and metabolic disorders.
- Trial name
- NCT04310514
- Testing
- Fructose/glucose/xylitol/saccharose
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Gout
A Study to Evaluate ALN-XDH in Healthy Subjects and Patients With Gout
The purpose of this study is to: Part A: Evaluate the safety and tolerability of single ascending doses of ALN-XDH in healthy adult participants Part B: Evaluate the safety, tolerability and efficacy of ALN-XDH as monotherapy in…
- Trial name
- NCT05256810
- Testing
- ALN-XDH
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Alnylam Pharmaceuticals
Salt; Excess, Blood Pressure Disorders
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.
- Trial name
- PEPC3 (NCT04026776)
- Testing
- Allopurinol, Dietary Intervention
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Stable Angina, Unstable Angina
Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study
Serum uric acid level is a commonly measured biomarker. The association between serum uric acid level and the risk of developing cardiovascular diseases has been observed in some studies, while others showed controversial…
- Conditions
- Stable Angina, Unstable Angina, Myocardial Infarction, Unheralded Coronary Heart Disease Death
- Trial name
- NCT03425305
- Volunteers
- 180,000 people, healthy volunteers welcome
- Sponsor
- University College, London