Clinical trials: Urinary; Sepsis
Surgical Wound Infection, Cystitis
The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study
All surgical procedures carry with them the risk of infection. Even a minor infection can extend the hospitalization after cardiac surgery. The average minimum increase in length of stay for a single infection is three days.
- Conditions
- Surgical Wound Infection, Cystitis, Bacteremia, Pneumonia
- Trial name
- NCT00164099
- Testing
- Synbiotic 2000
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Medical Center
Pyelonephritis, Urinary Tract Infections
Treating Pyelonephritis an Urosepsis With Pivmecillinam
Febrile urinary tract infections and urosepsis are common and potentially serious infections that require effective antimicrobial treatment. The duration of parenteral treatment depends on oral alternatives.
- Trial name
- MePUr (NCT03282006)
- Testing
- pivmecillinam
- Where
- Norway
- Volunteers
- 53 people
- Sponsor
- Sykehuset i Vestfold HF
Respiratory Tract Infections, Urinary Tract Infections
HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections: a Multicenter Pilot Study
This study will analyze gene expression data (HostDx Sepsis test) from blood samples collected from participants with suspected infections.
- Conditions
- Respiratory Tract Infections, Urinary Tract Infections, Skin and Soft Tissue Infections, Intraabdominal Infections
- Trial name
- NCT03744741
- Testing
- HostDx Sepsis
- Where
- 7 sites in United States, Greece
- Volunteers
- 585 people
- Sponsor
- Inflammatix
Pneumonia, Urinary Tract Infections
BetaLACTA® Test for Early De-escalation of Empirical Carbapenems in Pulmonary, Urinary and Bloodstream Infections in ICU
The emergence and rapid worldwide spread of Extended- Spectrum Beta-Lactamase-producing enterobacteriaceae (ESBLE) both in hospital and community, led physicians, and notably intensivists, to prescribe more carbapenems…
- Conditions
- Pneumonia, Urinary Tract Infections, Bloodstream Infection
- Trial name
- BLUE-CarbA (NCT03147807)
- Testing
- betaLACTA® rapid diagnostic test
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hydronephrosis, Pyelonephritis
Bedside Ultrasonography in Acute Patients With Suspected Kidney Involvement
The aim of this study is to evaluate the accuracy and implications of the diagnoses and treatment determined by bedside ultrasonography (b-US) of the kidneys compared to current clinical assessment.
- Conditions
- Hydronephrosis, Pyelonephritis, Urosepsis
- Trial name
- NCT03873701
- Testing
- bedside ultrasonography
- Where
- Denmark
- Volunteers
- 153 people
- Sponsor
- Odense University Hospital
Infective Complications Post-transrectal Prostate Biopsy
Prostate Biopsy Antisepsis
During a prostate biopsy, a needle is guided through the rectum into the prostate. Although patients are given antibiotics before the biopsy, there is still a risk of bacteria getting from the rectum into the bladder, prostate…
- Trial name
- NCT00999427
- Testing
- Povidone-iodine
- Where
- 3 sites in Canada
- Volunteers
- 865 people
- Sponsor
- University of British Columbia
Bloodstream Infection, Pneumonia, Bacterial
Development of Risk Score Model and Decision Tree Algorithm for Predicting Infections With CRKp in Colonized Patients
DETERMINE trial is a prospective multicenter multinational cohort study. This study will be carried out to predict the risk of bloodstream infections (BSIs) or other types of invasive infection with carbapenem resistant…
- Conditions
- Bloodstream Infection, Pneumonia, Bacterial, Intra-abdominal Infection, Urinary Tract Infections
- Trial name
- DETERMINE (NCT04229511)
- Testing
- Detection of CRKp colonization
- Where
- Turkey (Türkiye)
- Volunteers
- 520 people
- Sponsor
- SCARE (Study group for carbapenem resistance)
Kidney Stone, Infection
Novel Antimicrobial Solution to Prevent Infections
Ureteroscopy is the most common surgical treatment for kidney stones. Although rare, sepsis after ureteroscopy can be a life-threatening complication, occuring in <3% of patients.
- Conditions
- Kidney Stone, Infection, Infection Associated With Catheter, Sepsis
- Trial name
- NCT07881822
- Testing
- antimicrobial irrigation
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Prostate Cancer, Prostate Biopsy
Administration of Antibiotic Prophylaxis for Transperineal Prostate Biopsy in Cipto Mangunkusumo Hospital
This randomized controlled trial aims to compare the rate of perioperative infection complications in transperineal prostate biopsy between the group that receives prophylactic antibiotic and the group that receives placebo.
- Conditions
- Prostate Cancer, Prostate Biopsy, Perioperative Complication, Bacteriuria
- Trial name
- NCT04985110
- Testing
- Cotrimoxazole
- Where
- Indonesia
- Volunteers
- 78 people
- Sponsor
- Universitas Indonesia
Critically Ill
Coated Devices to Decrease Infection in the Intensive Care Unit
Pilot explanatory, randomized, open label, controlled trial. Critically ill patients which will demand placement of invasive devices for organ support (endotracheal tube, central venous catheter and urinary Foley catheter) will…
- Trial name
- CRITIC (NCT03868241)
- Testing
- Coated devices, Control
- Where
- 6 sites in Brazil
- Volunteers
- 103 people
- Sponsor
- Hospital do Coracao
Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI)
Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens
This study is designed to provide evidence of efficacy of cefiderocol in the treatment of serious infections in adult patients caused by carbapenem-resistant Gram-negative pathogens.
- Conditions
- Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI), Hospital Acquired Pneumonia (HAP), Complicated Urinary Tract Infection (cUTI)
- Trial name
- CREDIBLE - CR (NCT02714595)
- Testing
- Cefiderocol, Best Available Therapy
- Where
- 85 sites in United States, Brazil and 14 more
- Volunteers
- 152 people
- Sponsor
- Shionogi
Bloodstream Infections (BSI) Due to CRE, Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE
A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)
This was a Phase 3 study containing a randomized open-label superiority cohort (Cohort 1) comparing the efficacy and safety of plazomicin with colistin when combined with a second antibiotic (either meropenem or tigecycline) in…
- Conditions
- Bloodstream Infections (BSI) Due to CRE, Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE, Ventilator-Associated Bacterial Pneumonia (VABP) Due to CRE, Complicated Urinary Tract Infection (cUTI) Due to CRE
- Trial name
- CARE (NCT01970371)
- Testing
- plazomicin, colistin, meropenem
- Volunteers
- 69 people
- Sponsor
- Achaogen, Inc.
Kidney Calculi, Urinary Tract Infections
Is it Necessary for Patients With a Positive Urine Culture to Achieve a Negative Result After Antimicrobial Treatment Before Undergoing Percutaneous Nephrolithotomy?
Objective: The current European Association of Urology (EAU) guidelines do not provide clear recommendations on whether patients with a positive urine culture(UC) should wait until the culture turns negative following…
- Conditions
- Kidney Calculi, Urinary Tract Infections, Sepsis
- Trial name
- NCT06210425
- Where
- China
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Junhao Zheng
Urinary Stone, Renal Colic
Radiomics and Image Segmentation of Urinary Stones by Artificial Intelligence
Kidney stone disease causes significant morbidity, and stones obstructing the ureter can have serious consequences. Imaging diagnostics with computed tomography (CT) are crucial for diagnosis, treatment selection, and follow-up.
- Conditions
- Urinary Stone, Renal Colic, Obstruction Ureter, Urosepsis
- Trial name
- RISUS_AI (NCT06412900)
- Where
- Norway
- Volunteers
- 522 people
- Sponsor
- Oslo University Hospital
Urinary Tract Infection Complicated, Acute Pyelonephritis
Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults
Vabomere™, (meropenem-vaborbactam) is being compared to the Best Available Therapy in the treatment of adults with selected serious infections due to Carbapenem Resistant Enterobacteriaceae
- Conditions
- Urinary Tract Infection Complicated, Acute Pyelonephritis, Hospital Acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia
- Trial name
- NCT02168946
- Testing
- Vabomere, Best Available Therapy
- Where
- 50 sites in United States, Argentina and 6 more
- Volunteers
- 77 people
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
Gram-Negative Bacterial Infections
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infants
The primary purpose of this study is to understand the pharmacokinetics (PK) of single and multiple doses of cefiderocol in children from birth to less than 3 months of age with suspected or confirmed aerobic Gram-negative…
- Trial name
- NCT06086626
- Testing
- Cefiderocol, Standard of Care
- Where
- 4 sites in United States, South Africa and 1 more
- Volunteers
- 30 people
- Sponsor
- Shionogi
Infant, Newborn, Infant, Low Birth Weight
Intravenous Immune Globulin (IVIG) to Prevent Neonatal Infection
A controlled clinical trial was conducted at eight participating centers between January 1, 1988, and March 31, 1991. Patients were randomly assigned to an intravenous immune globulin group or a control group.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- IVIG (NCT01203345)
- Testing
- IVIG
- Where
- 8 sites in United States
- Volunteers
- 2,416 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Community-Acquired Infections, Respiratory Tract Infections
Validation of Vital Signs and Symptoms for the Diagnosis of Serious Infections in Children in the Paediatric A&E.
Validation of Vital Signs and Symptoms for the Diagnosis of Serious Infections in Acutely Ill Children in a High Prevalent Setting: The Paediatric Accidents \& Emergencies through prospective observational data collection…
- Conditions
- Community-Acquired Infections, Respiratory Tract Infections, Sepsis, Urinary Tract Infections
- Trial name
- ERNIE3 (NCT01396798)
- Where
- Belgium
- Volunteers
- 1,500 people
- Sponsor
- KU Leuven
Respiratory Tract Infections, Urinary Tract Infections
Sepsis Prognosis and Diagnosis in the Emergency Department (SPEED)
This study aims to evaluate the diagnostic and prognostic performance of a novel mRNA diagnostic/prognostic classifier (interprets the expression of 29 host response mRNA biomarkers) from whole blood in adult patients presenting…
- Conditions
- Respiratory Tract Infections, Urinary Tract Infections, Intra-Abdominal Infections, Skin and Soft Tissue Infection
- Trial name
- NCT05639504
- Testing
- IMX-BVN-4 and IMX-SEV-4
- Sponsor
- Inflammatix
Urinary Tract Infections, Bacteremia
Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIs
To evaluate if the combination of pivmecillinam and clavulanic acid (PAC) is non-inferior to ciprofloxacin, trimethoprim-sulfamethoxazole or ertapenem as step down oral therapy in patients with febrile UTI caused by extended…
- Conditions
- Urinary Tract Infections, Bacteremia, Antibiotic Resistant Infection
- Trial name
- PACUTI (NCT05224401)
- Testing
- Pivmecillinam and amoxicillin/clavulanic acid, Standard treatment, ciprofloxacin, trimethoprim/sulfamethoxazole or ertapenem depending on susceptibility
- Where
- 5 sites in Sweden
- Volunteers
- 330 people
- Sponsor
- Lund University