Clinical trials: Urinary Bladder, Overactive
Overactive Bladder
Efficacy and Safety of Botulinum Toxin A for the Treatment of Refractory Overactive Bladder.
Overactive bladder induce urgency, urge incontinence, nocturia and pollakiuria. This condition is often resistant to anticholinergic drugs used as a first line treatment for this purpose.
- Trial name
- NCT00231491
- Testing
- Botulinum Toxin A (Botox )
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Overactive Bladder
The Efficacy of Solifenacin With or Without Tamsulosin in Adult Women With Overactive Bladder (OAB)
The aim of the study is to investigate if the combination therapy consisting of anticholinergics plus alpha-blockers could be beneficial for women suffering from Overactive Bladder (OAB).
- Trial name
- NCT01533597
- Testing
- Solifenacin, Solifenacin plus Tamsulosin
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Soonchunhyang University Hospital
Overactive Bladder, Incontinence
Investigation of the Effect of the Female Urinary Microbiome on Incontinence
This purpose of this study is to understand the types of bacteria that are in the bladder and vagina in patients with overactive bladder (OAB) symptoms and understand if the types of bacteria change when with the use of estrogen…
- Conditions
- Overactive Bladder, Incontinence, Nocturia
- Trial name
- FUM (NCT02835846)
- Testing
- Estrogen Cream
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Loyola University
Overactive Bladder
A Study to Evaluate the Effect of Mirabegron + Solifenacin in Overactive Bladder Patients
The purpose of this study was to evaluate the safety and efficacy of mirabegron as add-on therapy in patients with OAB treated with solifenacin.
- Trial name
- NCT01745094
- Testing
- mirabegron, solifenacin
- Where
- 5 sites in Japan
- Volunteers
- 223 people
- Sponsor
- Astellas Pharma Inc
Overactive Bladder
OnabotulinumtoxinA (BOTOX®) Treatment for Urinary Incontinence in Patients With Overactive Bladder
This is a study to evaluate the efficacy and safety of onabotulinumtoxinA (BOTOX®) compared with placebo, in achieving a 100% reduction in urinary incontinence in patients with overactive bladder (OAB) not properly managed with…
- Trial name
- COMFORT (NCT01945489)
- Testing
- onabotulinumtoxinA, Normal saline
- Where
- 40 sites in United States
- Volunteers
- 254 people
- Sponsor
- Allergan
Overactive Bladder
Reproducibility Study of Over Active Bladder Symptom Score [OABSS]
The purpose of this study is to evaluate the reproducibility of over active bladder symptom score (OABSS) in Asian countries.
- Trial name
- RESORT (NCT00901251)
- Where
- 5 sites in China
- Volunteers
- 50 people
- Sponsor
- Astellas Pharma Inc
Overactive Bladder, Urinary Incontinence
Botulinum-A Toxin Injection for Detrusor Hyperreflexia in Spinal Cord Injury: A Non-Surgical Approach.
The purpose of the study is to determine whether Botulinum-A toxin injected in the bladder muscle will help prevent the frequency and degree of urinary incontinence in Spinal Cord Injured and Multiple Sclerosis patients.
- Trial name
- NCT00262496
- Testing
- Botox
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Overactive Bladder Syndrome
Efficacy and Safety of Peroneal Electric Transcutaneous Neuromodulation in the Real-world Clinical Practice
The aim of the project is to study neuromodulation treatment in patients with idiopathic overactive bladder syndrome (OAB) in real clinical practice.
- Trial name
- NCT07796958
- Testing
- Peroneal eTNM
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- University Hospital Ostrava
Healthy
Pharmacologic Effects of Darifenacin and Tolterodine on Cardiovascular Parameters in Healthy Subjects
This study will evaluate the pharmacologic effects of exposure to darifenacin and tolterodine on cardiovascular parameters in healthy subjects 50 years of age and older
- Trial name
- NCT00413790
- Testing
- Darifenacin, Tolterodine
- Where
- 12 sites in United States
- Volunteers
- 162 people
- Sponsor
- Novartis
Overactive Bladder, Quality of Life
Information, Motivation, Behavioral Skills Model on Urinary Incontinence and Quality of Life in Men
Multiple studies have shown that education based on the IMB model is effective at bringing about health-related behavior change.
- Trial name
- NCT04068025
- Testing
- Assigned Interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Yildirim Beyazıt University
18-45 Range of Age, Cesarean Section
Is Elective Caesarean Sections for Predicting Post-spinal Hypotension Role of Overactive Bladder?
It is to predict postspinal hypotension that may develop in patients diagnosed with overactive bladder who will undergo elective cesarean section under spinal-epidural anesthesia.
- Conditions
- 18-45 Range of Age, Cesarean Section, Primigravid
- Trial name
- NCT05624671
- Testing
- bupivacaine,fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Overactive Bladder, Cardiovascular Disease
Specified Drug Use-results Survey of Betanis Tablets for Patients With Coexisting Cardiovascular Disease
This purpose of this study is to investigate the effects of mirabegron on the cardiovascular system in patients with overactive bladder with current or a history of cardiovascular disease.
- Trial name
- NCT02570035
- Testing
- Mirabegron
- Where
- 28 sites in Japan
- Volunteers
- 316 people
- Sponsor
- Astellas Pharma Inc
Urinary Incontinence
Feasibility Study Evaluating the ParaPatch System
A multi-center, open-label, prospective, feasibility study evaluating the ParaPatch System for the treatment of urinary incontinence and overactive bladder.
- Trial name
- NCT02278146
- Testing
- ParaPatch
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ParaPatch, Inc
Urinary Incontinence in Children
Efficacy of Solifenacin, Mirabegron and Combination Therapy in Children With Daytime Urinary Incontinence (BeDry)
The primary objective is to evaluate if (1) combination therapy of solifenacin and mirabegron in low doses is superior to monotherapy of solifenacin in high dose and if (2) combination therapy of mirabegron and solifenacin in low…
- Trial name
- NCT06551246
- Testing
- Solifenacin, Mirabegron
- Where
- 5 sites in Denmark
- Volunteers
- 236 people
- Sponsor
- University of Aarhus
Overactive Bladder
Neuromodulation Implantation Settings Variation for Overactive Bladder
Participants receiving neuromodulation treatment for overactive bladder symptoms will be routinely fitted with an impulse generator.
- Trial name
- NCT02112786
- Testing
- Intermittent or Continuous Setting RestorePrime Implanted Impulse Generator
- Where
- United States
- Sponsor
- Loma Linda University
Overactive Bladder
Does Bladder Training Improve the Efficacy of Nerve Stimulation in Women With Refractory Overactive Bladders
Overactive Bladder (OAB) is a chronic condition defined as urgency with or without incontinence usually associated with frequency and nocturia.
- Trial name
- NCT02107820
- Testing
- Bladder Training (BT), Percutaneous Tibial Nerve stimulation
- Where
- United Kingdom
- Volunteers
- 84 people
- Sponsor
- University Hospital Plymouth NHS Trust
BOTOX, Percutaneous Tibial Nerve Stimulation
IDB Injection Combined With PTNS for Managing Children With OAB Not Responding to Monotherapy
This study aimed to evaluate the outcome of simultaneous intradetrusor BOTOX (IDB) injection and Percutaneous tibial nerve stimulation (PTNS) for management of children with recurrent wetness since at least 6 months.
- Trial name
- NCT05911594
- Testing
- Solifenacin group, Percutaneous tibial nerve stimulation group, Intradetrusor BOTOX group
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Benha University
Urinary Incontinence, Urinary Incontinence, Urge
Safety and Performance of UCon Bar Electrode for the Treatment of Overactive Bladder (OAB) and Bowel Dysfunction (BD)
UCon is a medical device for treatment of the symptoms of overactive bladder (OAB) and bowel dysfunction (BD). It electrically stimulates the DGN through the skin to obtain modulated behaviour of the bladder/bowel musculature…
- Conditions
- Urinary Incontinence, Urinary Incontinence, Urge, Fecal Incontinence, Fecal Incontinence With Fecal Urgency
- Trial name
- NCT06091566
- Testing
- UCon-Bar
- Where
- 3 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- InnoCon Medical
Overactive Bladder, Overactive Bladder Syndrome
Yoga for Treatment of Overactive Bladder in Pediatric Patients
The goal of this pilot study is to assess the impact of yoga as a treatment modality in pediatric patients age 8-18 diagnosed with idiopathic overactive bladder as measured by validated questionnaires and urinary biomarkers.
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Overactive Detrusor
- Trial name
- NCT05895045
- Testing
- Yoga
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Healthy
Mapping of the Human Brainstem During Continence and Micturition: Noninvasive 7-T fMRI Study
The lower urinary tract (bladder, bladder neck, urethra and urethral sphincter) has two functions: Storage (Continence) and voiding (micturition).
- Trial name
- NCT04846387
- Testing
- Magnetic Resonance Imaging (MRI), Post-Void Residual, Uroflowmetry
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute