Clinical trials: Urinary Frequency/Urgency
Urinary Bladder, Overactive
Study to Test the Efficacy and Safety of YM178 in Subjects With Symptoms of Overactive Bladder
The study is intended to test efficacy, safety and tolerability of two doses of YM178 against placebo and tolterodine to treat patients with symptoms of over active bladder.
- Trial name
- Blossom (NCT01604928)
- Testing
- YM178, tolterodine
- Where
- 30 sites in Belgium, Czechia and 4 more
- Volunteers
- 260 people
- Sponsor
- Astellas Pharma Europe B.V.
Urinary Incontinence, Urge
CAN-Stim Compared to SNS in Treatment of Urinary Urgency Incontinence With Wireless Neuromodulation Technology
This is a prospective, randomized, controlled, multi-center, study in which 150 evaluable subjects will be randomized 1:1 to receive either a Protect CAN-Stim or SNS InterStim® system.
- Trial name
- PROTECT (NCT02577302)
- Testing
- CAN-Stim - Protect CAN-Stim System, SNS - InterStim® System
- Where
- 15 sites in United States
- Volunteers
- 200 people
- Sponsor
- Uro Medical Corporation
Overactive Bladder
Overactive Bladder Innovative Therapy Trial (OrBIT)
The purpose of this study is to compare percutaneous tibial nerve stimulation (PTNS) to drug therapy for the treatment of symptoms of overactive bladder (OAB).
- Trial name
- OrBIT (NCT00448175)
- Testing
- Urgent PC Neuromodulation System, Tolterodine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Uroplasty, Inc
Urgency Urinary Incontinence, Overactive Bladder
Repetitive Transcranial Magnetic Stimulation (rTMS) on Neurogenic Overactive Bladder in Stroke
Neurogenic overactive bladder (NOAB) presents with urgency incontinence. Existing NOAB management is expensive, lacks standardized regimens, or is invasive.
- Trial name
- NCT05557175
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Overactive Bladder, Urinary Urgency Incontinence
Sacral Neuromodulation for Male Overactive Bladder (MOAB)
To assess the post-market clinical outcomes of the Axonics SNM System for treatment of overactive bladder in male patients.
- Conditions
- Overactive Bladder, Urinary Urgency Incontinence, Benign Prostatic Hyperplasia, Prostate Cancer
- Trial name
- NCT06511141
- Testing
- Axonics SNM System
- Where
- 23 sites in United States
- Volunteers
- 150 people
- Sponsor
- Axonics, Inc.
Urinary Urge Incontinence
Comparison of Combination Therapy vs Single Agent Therapy for Treatment of Urge Incontinence.
This is a randomized double-blind placebo-controlled clinical trial of posterior tibial nerve stimulation (PTNS) plus extended release oxybutynin versus PTNS alone (placebo pills) in women undergoing treatment of urgency urinary…
- Trial name
- APP (NCT02176642)
- Testing
- Oxybutynin extended release, Posterior Tibial Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Duke University
Urgency Urinary Symptoms
Effect of Vibrator Use on Symptoms of Urgency Urinary Incontinence, Sexual Function, and Sleep
This study aims to understand if using a vibrator affects urgency related urinary incontinence. Insights from this study may open new recommendations for treating urinary urgency and incontinence.
- Trial name
- BLISS (NCT07569822)
- Testing
- Vibrator, Behavioral modification
- Volunteers
- 116 people
- Sponsor
- Albany Medical College
Urinary Urgency Incontinence
Examining Bladder Control Using Mindful Based Approach
Urgency Incontinence (where the bladder muscles contract suddenly, causing an immediate urge to urinate that is difficult to prevent) is commonly experienced in patients with overactive bladder.
- Trial name
- NCT01843543
- Testing
- Mindfulness Based Stress Reduction Course
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Urinary Bladder, Overactive
A Study of YM178 in Subjects With Symptoms of Overactive Bladder
This study is to assess the efficacy and safety of YM178 in patients with symptoms of overactive bladder.
- Trial name
- NCT01043666
- Testing
- YM178, tolterodine ER
- Where
- 35 sites in China, India and 2 more
- Volunteers
- 1,126 people
- Sponsor
- Astellas Pharma Inc
Urinary Bladder, Overactive
A Study to Assess Efficacy and Safety of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder
The study is intended to test the efficacy, safety and tolerability of two doses of mirabegron against placebo to treat patients with symptoms of overactive bladder
- Trial name
- ARIES (NCT00662909)
- Testing
- Mirabegron
- Where
- 125 sites in United States, Canada
- Volunteers
- 2,149 people
- Sponsor
- Astellas Pharma Inc
Bladder Pain Syndrome, Educational Behavioral Intervention
Mirogabalin Plus EBMP for IC/BPS
The goal of this clinical trial is to learn whether adding mirogabalin to educational-behavioral modification program (EBMP) improves symptoms and safety outcomes for adults living with interstitial cystitis/bladder pain syndrome…
- Conditions
- Bladder Pain Syndrome, Educational Behavioral Intervention, Urinary Urgency
- Trial name
- M-EBMP-IC/BPS (NCT07803393)
- Testing
- Behavioral: Educational and Behavioral Management Program (EBMP), Intervention
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
Urge Incontinence, Urinary Incontinence
Effect of Diaphragmatic Training on Urgency Urinary Incontinence in Postmenopausal Women
The purpose of this study was to determine the effect of diaphragmatic training on urgency urinary incontinence in postmenopausal women.
- Conditions
- Urge Incontinence, Urinary Incontinence, Postmenopausal Disorder
- Trial name
- NCT06521008
- Testing
- anti muscarinic drugs, Instructions including bladder training, pelvic floor muscle training (PFMT)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Overactive Bladder
Dose-Escalating Study of Propiverine Hydrochloride in Children Suffering From Overactive Bladder
The open-label dose-escalating two-centre study was designed to assess the pharmacokinetics as well as safety, tolerability and efficacy parameters of propiverine in patients 5-10 years of age suffering from…
- Trial name
- NCT00795925
- Testing
- propiverine hydrochloride
- Volunteers
- 30 people
- Sponsor
- APOGEPHA Arzneimittel GmbH
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia
Innovative Minimally Invasive Options in Treatment of Urinary Problems Related to Prostate Enlargement (BPH) in Men
For ageing men, Health related quality of life ( HRQoL) is challenged by two common issues: the onset of bothersome urinary symptoms attributable to prostate enlargement and diminishing ability to maintain normal sexual activity…
- Conditions
- Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia, Urinary Frequency/Urgency, Urinary Incontinence, Urge
- Trial name
- NCT03043222
- Testing
- UroLift as artifical device for prostatic urethral lift., Embospheres Microspheres as embolic agents for prostate artery embolization
- Where
- United States
- Sponsor
- St. Louis University
Urinary Urgency Incontinence
Post-Approval Study of the Neuspera Sacral Neuromodulation System
Prospective, multi-center, single-arm, post-approval study is designed to assess the long-term safety and efficacy data of the Neuspera Sacral Neuromodulation (SNM) System following commercial approval of the Neuspera SNM System.
- Trial name
- NSM-005 (NCT07144813)
- Testing
- Neuspera Implantable Sacral Neuromodulation System
- Where
- 20 sites in United States
- Volunteers
- 116 people
- Sponsor
- Neuspera Medical, Inc.
Urinary Incontinence
Physical Exercise and Bladder Training Program for Urinary Incontinence
The overall objective of this project is to reduce the risk of falls in elderly community dwelling women over 60 years of age with urgency urinary incontinence (UUI).
- Trial name
- NCT03869918
- Testing
- Exercise Program
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Pennsylvania
Mixed Incontinence, Urge and Stress
Mixed Urinary Incontinence Symptoms Before and After Treatment With Botox and Bulkamid
This study compares mixed urinary incontinence symptoms before and after a combined treatment with Botox and Bulkamid. Eligible for the study are adult females with a mixed urinary incontinence, having both urgency urinary…
- Trial name
- NCT02815046
- Testing
- Botulinum toxin type A, Polyacrylamide hydrogel
- Where
- Switzerland
- Volunteers
- 58 people
- Sponsor
- Prof. Dr. Volker Viereck
Urinary Frequency/Urgency
Development of Novel Cystometrics for Overactive Bladder
Urinary urgency is the key symptom of overactive bladder (OAB). A critical barrier in understanding OAB is the lack of a method to separate urgency that derives directly from bladder filling or what we term "tension sensor…
- Trial name
- NCT02060214
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Overactive Bladder
Procedural Discomfort Related to Number of Intradetrusor Botox Injections
Injection of intradetrusor OnabotulinumtoxinA (BTX-A) is a highly efficacious therapy with a reliable safety profile and demonstrable improvements in subjective and objective measures for overactive bladder (OAB) symptom control.
- Trial name
- BIND (NCT05652036)
- Testing
- Intradetrusor Botox Injections
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- The Methodist Hospital Research Institute
Overactive Bladder, Urgency-frequency Syndrome
OAB and the Microbiome
To determine differences in the urinary microbiomes, identified by polymerase change reaction (PCR) (UTIP™), of female patients with urgency and frequency syndrome with or without pelvic pain (Group A) compared to female controls…
- Trial name
- NCT04831801
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Miami