Clinical trials: Urinary Frequency More Than Once at Night
Nocturia
Bioavailability of [14C]-SK-1404 ADME & IV Microtracer Study
The primary objectives of the study are: To determine the absolute bioavailability of SK-1404 To assess the mass balance recovery after a single oral (PO) dose of carbon-14 (14C)-SK-1404 To provide plasma, urine and faecal…
- Trial name
- NCT02878096
- Testing
- [14C]-SK-1404
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sanwa Kagaku Kenkyusho Co., Ltd.
Nocturia
VA106483 Dose Response Study in Elderly Males
The main purpose of the study is to evaluate the way VA106483 enters and leaves the blood and tissues over time and how the drug acts on and in the body at various dose levels compared to placebo in the same volunteer.
- Trial name
- NCT00922740
- Testing
- VA106483
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vantia Ltd
BPH, Nocturia
Use of Autologous Adipose-Derived Stem/Stromal Cells (AD-cSVF) in Symptomatic Benign Prostate Hypertrophy
Benign prostate hypertrophy (BPH) and inflammation are common non-cancerous enlargement of the prostate, which result in urinary interference and incomplete drainage of the bladder.
- Conditions
- BPH, Nocturia, BPH With Urinary Obstruction, Prostatism
- Trial name
- SVF-BPN (NCT02961114)
- Testing
- Microcannula Harvest Adipose, Centricyte 1000, IV Sterile Normal Saline
- Where
- 2 sites in United States
- Sponsor
- Robert W. Alexander, MD, FICS
Erectile Dysfunction, Nocturia, Short Term Insomnia, Obstructive Sleep Apnea
Effects of Nightshift Work and Sleep Disturbances on Erectile Function
We aim to observe the unwanted effects of nightshift work and short term insomnia on erectile function of men aged between 25 to 60 years.
- Trial name
- NCT04707807
- Testing
- IIEF-5
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Overactive Bladder
Acupuncture Combined With Mirabegron in the Treatment of OAB
Introduction: As conventional treatments for overactive bladder (OAB) have not yet shown satisfactory results, new approaches are needed.
- Trial name
- ACWMITTOOAB (NCT06181019)
- Testing
- 50 mg of mirabegron, acupuncture combined with mirabegron.
- Where
- China
- Volunteers
- 75 people
- Sponsor
- The Affiliated Ganzhou Hospital of Nanchang University
Nocturia
Investigation of the Superiority Effect of Desmopressin to Placebo in Terms of Night Voids Reduction in Nocturia Adult Female Patients
A multicenter, randomized, double-blind, placebo-controlled, parallel-group trial to investigate the safety and efficacy of desmopressin oral melt tablets against placebo during 3 months of treatment in adult females with…
- Trial name
- COMFORT (NCT01223937)
- Testing
- Desmopressin
- Where
- 45 sites in United States, Canada
- Volunteers
- 268 people
- Sponsor
- Ferring Pharmaceuticals
Prostatic Hyperplasia
The Impact of Alna® Ocas® on Nocturia in Patients With Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (LUTS/BPH)
Study to assess efficacy, tolerability and safety parameters of a three month ALNA®OCAS® -treatment with special respect to nocturia
- Trial name
- NCT02245542
- Testing
- ALNA®OCAS®
- Volunteers
- 5,775 people
- Sponsor
- Boehringer Ingelheim
Parkinson Disease, Parkinsonism
Head-up Tilt Sleeping to Alleviate Orthostatic Hypotension, Supine Hypertension and Nocturia in Parkinson's Disease
Autonomic dysfunction is common and often underrecognized in Parkinson's disease (PD). Orthostatic hypotension (OH) affects up to a third of PD patients and often coincides with supine hypertension.
- Trial name
- NCT05551377
- Testing
- Head-up tilt sleeping
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Nocturnal Polyuria
Desmopressin Melt Therapy in Patients With Nocturnal Polyuria: a Pharmacokinetic/Dynamic Study
The objective of this study is to find out what the pharmacokinetic/dynamic (PK/PD) characteristics of desmopressin melt are in nocturia patients (compared to healthy volunteers and children).
- Trial name
- NCT01435083
- Testing
- Desmopressin
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Ghent
Nocturnal Polyuria
A Cross-Functional, Population-Representative, Web-Based, Epidemiologic Study to Estimate the Prevalence and Burden of Nocturia Due to Nocturnal Polyuria in the US
To estimate the prevalence of nocturia due to nocturnal polyuria (NP) in the US and describe the demographic and clinical characteristics as well as the burden of illness in participants with nocturia due to NP.
- Trial name
- NCT04125186
- Testing
- Baseline EpiNP survey, Bladder diary, Testing of EpiNP baseline survey, bladder diary and a qualitative interview
- Where
- United States
- Volunteers
- 10,190 people
- Sponsor
- Ferring Pharmaceuticals
Nocturia
A Study of Minirin Melt in Patients With Nocturia
This is a confirmation of safety profile for Minirin Melt in clinical practice.
- Trial name
- NCT01212224
- Where
- 81 sites in Czechia
- Volunteers
- 2,187 people
- Sponsor
- Ferring Pharmaceuticals
Urinary Bladder Overactive, Urinary Bladder Diseases\Urologic Diseases
This Was a Multinational Study Comparing the Efficacy and Safety of Two Medicines , Solifenacin Succinate and Mirabegron Taken Together, or Separately, or a Mock Treatment (Placebo) in Subjects With Symptoms of Overactive Bladder
The purpose of this study was to examine how well two medicines (solifenacin succinate and mirabegron) combined work compared to each medicine alone in the treatment of bladder problems.
- Conditions
- Urinary Bladder Overactive, Urinary Bladder Diseases\Urologic Diseases, Overactive Bladder, Urgency Incontinence
- Trial name
- SYNERGY (NCT01972841)
- Testing
- Solifenacin succinate, Mirabegron
- Where
- 435 sites in United States, Argentina and 40 more
- Volunteers
- 3,527 people
- Sponsor
- Astellas Pharma Europe B.V.
Obstructive Sleep Apnea, Nocturia
Mandibular Advancement Device and Changes in Nocturia
The main purpose of this study is to test is mandibular advancement device (MAD) use is associated with reductions in nocturia.
- Conditions
- Obstructive Sleep Apnea, Nocturia, OSA
- Trial name
- MAD (NCT05562388)
- Testing
- Somnodent Classic
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Isabel Moreno Hay
Urinary Bladder Overactive, Overactive Bladder
A Multinational Study Comparing the Long-term Efficacy and Safety of Two Medicines, Solifenacin Succinate and Mirabegron Taken Together, or Separately, in Subjects With Symptoms of Overactive Bladder
The purpose of this study was to examine how well the combination of two medicines (solifenacin succinate and mirabegron) worked compared to each medicine alone in the treatment of bladder problems, and how safe they were for…
- Conditions
- Urinary Bladder Overactive, Overactive Bladder, Urgency Incontinence, Urinary Bladder Diseases\Urologic Diseases
- Trial name
- SYNERGY II (NCT02045862)
- Testing
- Solifenacin succinate, Mirabegron
- Where
- 251 sites in United States, Australia and 30 more
- Volunteers
- 1,829 people
- Sponsor
- Astellas Pharma Europe B.V.
Pelvic Floor Disorders, Anxiety
Enhancing Behavioral Treatment for Women With Pelvic Floor Disorders
The purpose of this proposal is to test a novel behavioral treatment - Unified Protocol Cognitive-Behavior Therapy (UP-CBT)1 - to enhance quality of life in women with pelvic floor disorders.
- Conditions
- Pelvic Floor Disorders, Anxiety, Urinary Urgency, Urinary Incontinence
- Trial name
- NCT03623880
- Testing
- Unified Protocol, Supportive Therapy
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Northwestern University
Patients Who Had the Urine Volume at Nighttime More Than One Third of Total Daily Urine Volume (NPU) and Voided More Than Two Times at Nighttime (Nocturia)
Necessity for Repetitive Education of Behavioral Modification
Few studies have reported the efficacy of repetitive education for behavioral modification as the first-line therapy for patients with nocturnal polyuria (NPU).
- Trial name
- NCT01280279
- Testing
- education for behavioral modification
- Where
- South Korea
- Volunteers
- 104 people
- Sponsor
- Seoul National University Hospital
Nocturia, Venous Insufficiency of Leg
Discovering the Effect of Venous Insufficiency on Nocturia
With this prospective controlled trial, we hope to obtain more information about the coexistence between venous insufficiency and nocturia.
- Conditions
- Nocturia, Venous Insufficiency of Leg, Fluid Overload
- Trial name
- DEVINe (NCT04266496)
- Testing
- Questionnaires, Frequency Volume Chart, Collect urine during 1 day
- Where
- Belgium
- Volunteers
- 84 people
- Sponsor
- University Hospital, Ghent
Nocturia, Prostatic Hyperplasia
A Study of Silodosin 8 mg Daily for the Treatment of Nocturia in Men With Benign Prostatic Hyperplasia
Silodosin is compared to placebo to determine if it is safe and effective for the treatment of nighttime urination (nocturia) in men with BPH
- Trial name
- NCT00793819
- Testing
- silodosin
- Where
- 27 sites in United States
- Volunteers
- 215 people
- Sponsor
- Watson Pharmaceuticals
Nocturia
Treatment of Patients With Nocturia (Non-PK Study)
The purpose of this study is to evaluate a treatment of nocturia. The hypothesis is that SER120 will decrease the number of nocturic episodes compared to placebo.
- Trial name
- NCT00937378
- Testing
- SER120
- Where
- United States
- Volunteers
- 326 people
- Sponsor
- Serenity Pharmaceuticals, Inc.
Overactive Bladder
A Trial To Evaluate The Efficacy And Safety Of Fesoterodine In Patients With Symptoms Of Overactive Bladder Including Nocturnal Urinary Urgency
This study is designed to assess the efficacy of a flexible dose regimen of fesoterodine on micturition related nocturnal urgency episodes.
- Trial name
- NCT00911937
- Testing
- Fesoterodine
- Where
- 112 sites in United States
- Volunteers
- 963 people
- Sponsor
- Pfizer