Clinical trials: Urinary Tract Disease
Autosomal Dominant Polycystic Kidney Disease
8-Week Study of Tolvaptan Dose Forms in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
The purpose of this study is to compare the short-term effects of two tolvaptan formulations in patients with ADPKD.
- Trial name
- NOCTURNE (NCT01451827)
- Testing
- Tolvaptan MR, Tolvaptan IR
- Where
- 35 sites in United States
- Volunteers
- 178 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Healthy Subjects, Overactive Bladder
An Exploratory Study to Investigate Bladder Contractions in the Storage Phase and Related Bladder Sensations in Healthy Females and Females With Overactive Bladder (OAB) Using High Resolution and Conventional Urodynamics
This study aims to identify differences in bladder contractions during the storage phase (non voiding activities) between OAB subjects and healthy subjects, using high resolution urodynamics.
- Trial name
- NCT01540786
- Testing
- High resolution urodynamic assessment, Conventional urodynamic assessment
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe Ltd.
Stress Urinary Incontinence
The Outcome of the Transobturator Tape (TOT) Procedure
The aim of our study is to report the subjective and objective outcome of outside-in transobturator technique (TOT) (Monarc®) in long-term follow-up.
- Trial name
- NCT01532583
- Testing
- Gynaecological examination, a supine stress test, questionnaires
- Where
- Finland
- Volunteers
- 139 people
- Sponsor
- Turku University Hospital
Bladder Tumors, Spinal Anesthesia
Magnesium vs. Dexmedetomidine in TURBT Under Spinal Anesthesia
This randomized controlled trial evaluated the effects of intraoperative intravenous magnesium sulfate versus dexmedetomidine on postoperative pain, analgesic consumption, hemodynamic stability, and respiratory function in…
- Conditions
- Bladder Tumors, Spinal Anesthesia, Postoperative Pain, Magnesium Sulfate
- Trial name
- TURBT (NCT07445451)
- Testing
- magnesium sulfate, Dexmedetomidine, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Alcoholic Hepatitis, Alcoholic Liver Disease
Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone
Treatment of reference of severe alcoholic hepatitis is based on corticosteroids, given for 28 days. However, about 25-35% of patients do not take benefit from this treatment and die within the 6 months following the diagnosis.
- Trial name
- AntibioCor (NCT02281929)
- Testing
- Amoxicillin, Prednisolone
- Where
- 20 sites in France
- Volunteers
- 297 people
- Sponsor
- University Hospital, Lille
Bladder Cancer, Bladder Neoplasm
Bipolar Versus Mono-polar Needlescopic En Bloc TUR-BT
Non-muscle invasive bladder cancers (NMIBC) compose about 80% of bladder tumors. the stranded treatment of these tumors is TURBT. en bloc resection of NMIBC yields better mascularis propria with better oncological outcomes
- Trial name
- NCT04839029
- Testing
- Bipolar En bloc TURBT, Monopolar En bloc TURBT
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Benha University
Overactive Bladder, Parkinson Disease
Neurogenic Overactive Bladder Treatment on Parkinson's Disease Through Back Tibial Nerve Electrostimulation
Dysfunctions of the lower urinary tract are non-motor symptoms common engines in Parkinson's disease (PD). Urodynamic changes in PD include overactive bladder (OB), characterized by urgency with or without urge incontinence …
- Trial name
- NOVTPD (NCT02583529)
- Testing
- Back Tibial Nerve Electrostimulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Tatiane Gomes de Araujo
Recurrent Urinary Tract Infections
Probiotic Supplement for Recurrent UTIs in Healthy Women (L. Plantarum, L. Rhamnosus, B. Lactis)
This randomized, double-blind, placebo-controlled trial will evaluate the efficacy of a probiotic food supplement containing Lactiplantibacillus plantarum PBS067, Lacticaseibacillus rhamnosus LRH020, and Bifidobacterium animalis…
- Trial name
- BIO-RUTI-26 (NCT07884929)
- Testing
- Dietary Supplement containing probiotics
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Synbalance S.r.l.
Graft Rejection
Study of Alemtuzumab Versus Anti-thymocyte Globulin to Help Prevent Rejection in Kidney and Pancreas Transplantation
The purpose of this research study is to compare the effects of the two most commonly used anti-T cell induction agents(alemtuzumab and rabbit anti-thymocyte globulin) to prevent rejection in kidney and pancreas transplant…
- Trial name
- NCT00331162
- Testing
- Alemtuzumab, Anti-Thymocyte Globulin
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Wake Forest University Health Sciences
Dehydrated, Water-Electrolyte Imbalance, Malnutrition, Dehydration (Physiology)
Effects of Increased Water Intake on Hormonal Response, Hydration Status, and Physical Function in Low-drinking Older Adults
DrinkAge is a randomized controlled trial investigating whether increasing daily water intake can improve hydration and health-related outcomes in adults aged 60 years or older who habitually drink relatively little water.
- Trial name
- DrinkAge (NCT07892742)
- Testing
- Water
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Polytechnic University of Santarém
Interstitial Cystitis, Pelvic Pain
Intravesical Liposomes for Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS)
Interstitial cystitis/painful bladder syndrome (IC/PBS) is a poorly understood chronic disorder of unknown etiology consisting of irritative bladder symptoms and pelvic pain that dramatically affects quality of life.
- Trial name
- NCT01731470
- Testing
- Liposomes
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Kenneth Peters, MD
Prostate Cancer, Erectile Dysfunction
Efficacy and Toxicity of Bicalutamide and Dutasteride vs. Standard Care for Prostate Cytoreduction for Brachytherapy
The purpose of this study is to determine if a combination of neoadjuvant dutasteride and bicalutamide has the same efficacy and less toxicity than standard treatment with an LHRH agonist and bicalutamide for prostate…
- Conditions
- Prostate Cancer, Erectile Dysfunction, Lower Urinary Tract Symptoms
- Trial name
- NCT00866554
- Testing
- administration of a LHRH agonist and Bicalutamide, administration of Bicalutamide, Dutasteride and Tamoxifen
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- CHU de Quebec-Universite Laval
Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction
Radio-frequency (RF) Bladder Monitor
The goal of this pilot feasibility study is to evaluate a wearable microwave (MW)-based bladder monitoring system in adult volunteers and those with spinal cord injury (SCI) who use self-catheterization for bladder management.
- Conditions
- Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction, Neurogenic Bladder (NB)
- Trial name
- NCT07639541
- Testing
- Wearable microwave Bladder Monitoring System
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Urolithiasis, Shock Wave Lithotripsy
3D-CT vs Ellipsoid for JJ Stent Prediction Before ESWL
This prospective single-center study compares 3D-CT volumetry versus traditional ellipsoid formula to determine critical stone burden predicting JJ stent necessity before ESWL for 1-2 cm renal stones.
- Conditions
- Urolithiasis, Shock Wave Lithotripsy, Ureteral Stents
- Trial name
- NCT07337954
- Testing
- Extracorporeal shock wave lithotripter
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Ain Shams University
Lower Urinary Tract Symptoms
Prostatic Obstruction Investigation Team Multicenter Study
The present is a multicenter, observational study organized by the Prostatic Obstruction Investigation Team (POInT), with a main purpose of looking into the current status and symptom progression of male lower urinary tract…
- Trial name
- POInT (NCT03394651)
- Testing
- Oral medications to treat lower urinary tract symptoms, Minimal invasive transurethral prostate procedures
- Where
- China
- Volunteers
- 11,500 people
- Sponsor
- Changhai Hospital
Urinary Incontinence
Data Collection for Development of a Bladder Sensor During Urodynamics
This is an explorative, single-center, feasibility study using a prototype of a future Bladder Sensor to collect data during urodynamics.
- Trial name
- NCT05305846
- Testing
- TENA-PROTO2
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Essity Hygiene and Health AB
Kidney Transplant Rejection
Cellular Immunotherapy for Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney Transplants
The primary objective of this study is to demonstrate the safety and efficacy of cellular immunotherapy with MDR-103 for induction of functional immune tolerance in past recipients of human leukocyte antigen (HLA)-matched, living…
- Trial name
- NCT03606746
- Testing
- MDR-103
- Sponsor
- Medeor Therapeutics, Inc.
Obesity, Type 2 Diabetes
Lifestyle Management of CKD in Obese Diabetic Patients
The purpose of this randomized clinical trial is to evaluate the efficacy of 3 different technology-supported approaches to engaging 300 individuals with diabetes and concurrent chronic kidney disease in weight loss, dietary…
- Conditions
- Obesity, Type 2 Diabetes, Chronic Kidney Disease (CKD)
- Trial name
- NCT02276742
- Testing
- Social Cognitive Theory, Monitoring
- Where
- United States
- Volunteers
- 269 people
- Sponsor
- NYU Langone Health
Diuresis, Bladder Retention Volume
Effect of Preload on Bladder Retention Volume During Spinal Anesthesia
The purpose of this study is to assess the influence of different fluid infusions on the quantity of bladder retention after spinal anesthesia.
- Conditions
- Diuresis, Bladder Retention Volume, Hypotension
- Trial name
- NCT00550186
- Testing
- Ringers Lactate, HaemoHES 6%
- Where
- Netherlands
- Volunteers
- 144 people
- Sponsor
- Rijnstate Hospital
Overactive Bladder, Pharmacokinetics
A Clinical Study to Determine the Effect of YM178 on the Pharmacokinetics of Warfarin in Healthy Subjects
This study investigates whether YM178 has an effect on the pharmacokinetics of warfarin, to exclude any drug-drug interaction between YM178 and warfarin, and evaluates the safety and tolerability of warfarin alone and combined…
- Trial name
- NCT00856570
- Testing
- warfarin, YM178
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.