Clinical trials: Urinary Urge Incontinence
Overactive Bladder, Overactive Bladder Syndrome
Prophylactic Antibiotic Administration for Bladder OnabotulinumtoxinA Injection
The goal of this clinical trial is to evaluate the outcomes of differing durations of antibiotic prophylaxis with bladder onabotulinumtoxinA injection in patients with refractory overactive bladder.
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Urge Incontinence, Urinary Incontinence, Urge
- Trial name
- NCT05719285
- Testing
- Single-Dose Antibiotic, Multi-Dose Antibiotic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Urinary Bladder, Overactive, Urinary Incontinence, Urge
Efficacy of Animated Videos to Foster Healthy Bladder Behaviors in Community Women
In daily life, women are exposed to a wide range of challenging situations that can negatively affect toileting management and long-term bladder health.
- Trial name
- NCT06921915
- Testing
- eLearning
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kathleen O'Connell
Urinary Incontinence, Urinary Incontinence, Stress
Evaluation of a New Technology for the Treatment of Bladder Leakage in Women
Evaluation of a new technology for the treatment of bladder leakage in women. The objective is to compare quality of life and other incontinence associated outcomes between women receiving routine General Practitioner (GP)…
- Conditions
- Urinary Incontinence, Urinary Incontinence, Stress, Urinary Incontinence, Urge
- Trial name
- NCT04059653
- Testing
- Electrical stimulation, Treatment as usual
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Urge Urinary Incontinence
The Long Term Outcomes of Rehabilitation and Drug Treatment for in Urgency Urinary Incontinence
Urinary Urge Incontinence (UUI) is the involuntary urine loss associated with a strong sensation to void. UUI usually associated with reduced bladder capacity. The pathophysiology is unclear.
- Trial name
- UUI (NCT00498888)
- Testing
- tolterodine, bladder training, pelvic floor muscle training
- Where
- Israel
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Assuta Hospital Systems
Urinary Incontinence, Urge
An Experimental Protocol for the Study of Brain Functional Magnetic Resonance Imaging in Female With Urgent Urinary Incontinence
Background: Patients' life quality and physical and mental health are seriously affected by Urgent Urinary Incontinence(UUI). The cause is not clear at present.
- Trial name
- NCT04271852
- Testing
- bio-feedback treatment
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Urinary Urge Incontinence
RESTORE: An RCT to Evaluate the Efficacy of the Revi System
The Revi System is indicated for the treatment of patients with symptoms of urgency incontinence alone or in combination with urinary urgency.
- Trial name
- NCT06217328
- Testing
- Revi System Treatment, Revi System - Delayed Activation
- Where
- 19 sites in United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- BlueWind Medical
Urinary Incontinence, Stress Urinary Incontinence
Hybrid Fractional Laser Treatment for Symptoms of Urinary Incontinence
This multi-center clinical trial will evaluate the safety and long-term efficacy of hybrid fractional 2940 nm and 1470 lasers for improvement of symptoms of urinary incontinence.
- Conditions
- Urinary Incontinence, Stress Urinary Incontinence, Urge Incontinence
- Trial name
- NCT03180372
- Testing
- Hybrid Fractional Laser
- Where
- 5 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Sciton
Urge Incontinence, Urinary Incontinence, Urge
Treatment of Incontinence Without Memory Problems
An 8-week randomized, controlled, pilot clinical trial of Mirabegron compared to a standard anticholinergic therapy (Detrol LA) in elderly women with urgency urinary incontinence.
- Trial name
- TRIUMPH (NCT02436889)
- Testing
- Mirabegron, Tolterodine Tartrate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Overactive Bladder With Symptoms of Frequency, Urgency, and Urge Urinary Incontinence
The Effect Of Fluconazole On Pharmacokinetics Of Fesoterodine In Healthy Subjects
This study is designed to estimate the effect of fluconazole (200 mg BID for 2 days), a moderate CYP3A4 inhibitor on the pharmacokinetics of a single 8 mg oral dose of fesoterodine in healthy adult subjects.
- Trial name
- NCT00911235
- Testing
- Fesoterodine, fesoterodine plus fluconazole
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Females With Overactive Bladder Symptoms, Urgency & Urge Incontinence
Does Mirabegron Have a Positive Impact on Sexual Function in Females With Overactive Bladder
80 female patients evaluated for sexual function after receiving Mirabegron 50 mg once daily for 6 months for treatment of overactive bladder symptoms
- Trial name
- NCT04511273
- Testing
- Follow up of female sexual function
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Urge Incontinence, Urgency-frequency Syndrome
Percutaneous Nerve Evaluation Trial Time
Sacral neuromodulation (SNM) was approved by the Food and Drug Administration (FDA) for the treatment of urgency incontinence (UUI) in 1998.
- Conditions
- Urge Incontinence, Urgency-frequency Syndrome, Overactive Bladder
- Trial name
- NCT06226220
- Testing
- Sacral neuromodulation
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Overactive Bladder
Detrol Long Acting (LA) vs Estrace Vaginal Cream for the Treatment of Overactive Bladder Symptoms
The purpose of this study is to determine if long acting tolterodine confers more benefit than intravaginal low dose estrogen in the treatment of Overactive Bladder Syndrome at 12 weeks post-treatment initiation.
- Trial name
- DRIVE (NCT00465894)
- Testing
- Extended Release Tolterodine LA, Intra Vaginal Estradiol Cream
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Overactive Bladder, Dementia
Higher Neural Changes Following Anticholinergic, Beta 3 Agonist, or Placebo in Patients With Overactive Bladder
Women presenting with overactive bladder symptoms will be randomized to one of 3 arms (anticholinergic, beta-3 agonist, placebo). They will undergo baseline cognitive testing, functional MRI of the brain.
- Conditions
- Overactive Bladder, Dementia, Lower Urinary Tract Symptoms, Incontinence, Urge
- Trial name
- NCT03817931
- Testing
- Anticholinergic, Beta-3 Agonists, Adrenergic, Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Lower Urinary Tract Symptoms, Stress Urinary Incontinence
Pelvic Floor Disorder Symptoms in Women Seeking Weight Loss Therapy
The purpose of this study is to compare change in pelvic floor symptoms between patients receiving medical therapy for weight loss and surgical treatment for weight loss.
- Conditions
- Lower Urinary Tract Symptoms, Stress Urinary Incontinence, Urge Urinary Incontinence, Overactive Bladder
- Trial name
- NCT07175805
- Testing
- Bariatric Surgery, GLP1 receptor agonist
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hartford HealthCare
Urinary Incontinence, Urge
Brain-Centered Therapy Versus Medication for Urgency Urinary Incontinence : Hypnotherapy Or Pharmacotherapy
This study is randomized controlled trial in which urgency incontinent women (approximately 150-160) will be randomized to hypnotherapy or pharmacotherapy and evaluated at months 2, 6 \&12 Hypotheses: Among patients with urgency…
- Trial name
- Hyp-hOP (NCT01829425)
- Testing
- Anticholinergic medications, Hypnotherapy
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Overactive Bladder
Validation of Instruments for Pragmatic Clinical Trials for Overactive Bladder
A. Objectives \& Hypothesis Overactive bladder (OAB) affects over 10 million adults in the United States and each year substantial costs are incurred from private and public funds to test the efficacy of new and existing drugs…
- Trial name
- PfizerOABLUT (NCT01925456)
- Testing
- Toviaz
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Urge Urinary Incontinence
Incontinence & Intimate Partners: Assessing the Contribution of Treatment
Urge urinary incontinence (UUI) is a socially debilitating disease due to its inherently unpredictable nature and sometimes large volumes of urine loss.
- Trial name
- IIMPACT (NCT01559389)
- Testing
- Solifenacin
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Loyola University
Urinary Incontinence
Urge Incontinence Bladder Overactivity Study
Examine the efficacy and safety of duloxetine in subjects with symptoms of bladder overactivity due to pure detrusor instability or sensory urgency.
- Trial name
- NCT00475696
- Testing
- Duloxetine
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Urinary Incontinence
Functional Assessment and Muscle Evaluation Through Exercise Trial
The purpose of this study is to decrease rates of urinary incontinence in older women by building strength in the pelvic and lower body muscle through exercise and rehabilitation.
- Trial name
- FAME (NCT03166150)
- Testing
- Multi-modal rehabilitation program, Pelvic Floor Physical therapy
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Howard University
Urge Incontinence, Overactive Bladder
A Study of Transcutaneous Electrical Nerve Stimulation for Overactive Bladder
The purpose of the study is to compare patient centered- outcomes between Transcutaneous Electrical Nerve Stimulation (TENS) at three locations to treat urinary urge incontinence.
- Trial name
- NCT02922842
- Testing
- Transcutaneous Electrical Nerve Stimulation
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Rochester