Clinical trials: Urine Albumin-creatinine Ratio
Type 2 Diabetes, Chronic Kidney Disease (CKD) Stages G2 to G3b
A Study to Learn More About How Well Finerenone Works in Real-world in People With Type 2 Diabetes and Chronic Kidney Disease in Primary Care (IMSS= Instituto Mexicano Del Seguro Social)
The main purpose of this study is to learn how treatment with finerenone affects the urinary albumin-to-creatinine ratio (uACR), a marker of kidney health, over time in adults with type 2 diabetes and chronic kidney disease who…
- Trial name
- FINE-IMSS-MX (NCT07841015)
- Testing
- Finerenone
- Where
- Mexico
- Volunteers
- 800 people
- Sponsor
- Bayer
Rheumatoid Arthritis, Renal Dysfunction
Subclinical Renal Dysfunction in Rheumatoid Arthritis
This comparative cross-sectional study aims to determine the prevalence of subclinical renal dysfunction in patients with rheumatoid arthritis and to evaluate its association with disease activity and inflammatory markers…
- Conditions
- Rheumatoid Arthritis, Renal Dysfunction, Chronic Kidney Diseases
- Trial name
- NCT07805109
- Volunteers
- 120 people
- Sponsor
- Assiut University
Type 2 Diabetes Mellitus (T2DM), Time Restricted Eating
Time Restricted Eating in Patients With Microalbuminuria
This is a clinical trial to assess how time-restricted eating (TRE) may improve kidney health and filtration patients with type 2 diabetes and increased protein content in their urine.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Time Restricted Eating, Microalbuminuria
- Trial name
- TREK (NCT06884059)
- Testing
- Time Restricted Eating
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Diego
T2DM (Type 2 Diabetes Mellitus), Metformin
Effect of Tofogliflozin on UACR Compared to Metformin Hydrochloride in Diabetic Kidney Disease (TRUTH-DKD)
This multicenter, randomized, open-label, controlled study will assess the efficacy of the SGLT2 inhibitor tofogliflozin on Urine Albumin-to-Creatinine Ratio (UACR) compared to metformin in patients with type 2 diabetes with…
- Conditions
- T2DM (Type 2 Diabetes Mellitus), Metformin, SGLT2-Inhibitors
- Trial name
- TRUTH-DKD (NCT05469659)
- Testing
- Tofogliflozin, Metformin
- Where
- Japan
- Volunteers
- 120 people
- Sponsor
- Shinshu University
Diabetic Nephropathy
A Study to Evaluate Pharmacodynamics, Safety, Tolerability and Pharmacokinetics of MT-3995 in Type II Diabetic Nephropathy Subjects With Albuminuria and Moderately Decreased GFR
The purpose of this study is to evaluate pharmacodynamics, safety, tolerability and pharmacokinetics of MT-3995 in Type II Diabetic Nephropathy Subjects with Albuminuria and Moderately Decreased GFR
- Trial name
- NCT01756716
- Testing
- MT-3995 Low, MT-3995 High
- Where
- 50 sites in Bulgaria, Czechia and 4 more
- Volunteers
- 49 people
- Sponsor
- Tanabe Pharma Corporation
Heart Failure, Chronic Kidney Disease
Efficacy, Safety and Tolerability of AZD9977 and Dapagliflozin in Participants With Heart Failure and Chronic Kidney Disease
The purpose of the study is to evaluate the efficacy and safety of AZD9977 in combination with dapagliflozin compared with dapagliflozin alone and to assess the dose-response relationship, dapagliflozin alone and 3 doses of…
- Trial name
- MIRACLE (NCT04595370)
- Testing
- AZD9977, Dapagliflozin
- Where
- 156 sites in United States, Belgium and 20 more
- Volunteers
- 153 people
- Sponsor
- AstraZeneca
Kidney Function Decline, Glomerular Filtration Rate
Rapid Kidney Function Decline in Older Adults
This observational study investigates whether a single set of GFR and urine albumin-to-creatinine ratio (ACR) thresholds can accurately screen for rapid kidney function decline in different elderly groups.
- Conditions
- Kidney Function Decline, Glomerular Filtration Rate, Urine Albumin-creatinine Ratio, Healthy Aging
- Trial name
- NCT06765811
- Where
- China
- Volunteers
- 1,539 people
- Sponsor
- Huashan Hospital
Microalbuminuria, Microalbuminuria /Creatinine Ratios ACR
Saxagliptin's Effects on Microalbuminuria Improvement in Type 2 Diabetic Patients
This study compare the effects on microalbuminuria improvement in type 2 diabetes mellitus (T2DM) treated with saxagliptin or glimepiride.All patients received metformin and/or acarbose, and randomly receive saxagliptin (5mg/d)…
- Trial name
- NCT02462369
- Testing
- Saxagliptin, glimepiride
- Volunteers
- 88 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Hypertension
VALERIA: Valsartan in Combination With Lisinopril in Hypertensive Patients With Microalbuminuria
The purpose of this study is to compare if the combination of valsartan 320 mg/lisinopril 20 mg versus the monotherapies of lisinopril 40 mg or valsartan 320 mg will result in a greater decrease of urinary albumin excretion…
- Trial name
- NCT00171067
- Testing
- valsartan, lisinopril
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 134 people
- Sponsor
- Novartis
Hypertension, Microalbuminuria
Community-based Microalbuminuria Screening in Patients With Hypertension
This study evaluates the effectiveness of different anti-hypertensive drugs on patients with hypertension and microalbuminuria.
- Trial name
- CMSIH (NCT03596840)
- Volunteers
- 3,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Diabetes, Kidney Disease
Improving Outcomes in Patients With Kidney Disease Due to Diabetes
Kidney disease affects about one out of three people with diabetes mellitus, a common medical problem. Treatment of kidney disease with medications that lower blood pressure can slow the kidney disease but there is no known cure.
- Conditions
- Diabetes, Kidney Disease, Hypertension
- Trial name
- NCT00381134
- Testing
- losartan 100 mg orally once daily, spironolactone 25 mg orally once daily
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Chronic Kidney Disease, Type 2 Diabetes
RAndomized EHR-based Prescribing to Improve Disease-modifying Therapies for Cardio-Kidney-Metabolic Care (RAPID-CKM)
The goal of this pragmatic randomized clinical trial is to determine whether an Epic-based clinician notification increases initiation of guideline-directed cardio-kidney-metabolic (CKM) therapies in adults with type 2 diabetes…
- Trial name
- NCT07605390
- Testing
- Epic-Based Clinician Notification, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- Baylor Research Institute
Albuminuria, Type 2 Diabetes Mellitus (T2DM)
Finerenone for Regression of Albuminuria in Type 2 Diabetes With Chronic Kidney Disease
This is a multicenter, randomized, double-blind, placebo-controlled clinical trial evaluating the efficacy and safety of finerenone, a nonsteroidal mineralocorticoid receptor antagonist, for the early regression of albuminuria in…
- Conditions
- Albuminuria, Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Diseases
- Trial name
- NCT07667517
- Testing
- Finerenone (BAY 94-8862)
- Where
- 13 sites in China
- Volunteers
- 148 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Diabetic Nephropathy
A Study to Evaluate Pharmacodynamics, Safety, Tolerability and Pharmacokinetics of MT-3995 in Type II Diabetic Nephropathy Subjects With Albuminuria
The purpose of this study is to evaluate pharmacodynamics, safety, tolerability and pharmacokinetics of MT-3995 in Type II Diabetic Nephropathy Subjects with Albuminuria
- Trial name
- NCT01756703
- Testing
- MT-3995 Low, MT-3995 High
- Where
- 43 sites in Bulgaria, Hungary and 3 more
- Volunteers
- 67 people
- Sponsor
- Tanabe Pharma Corporation
Chronic Kidney Diseases, Type2Diabetes
Decision Support for Detection of Chronic Kidney Disease in Type II Diabetes Mellitus
While data from the National Health and Nutrition Examination Survey (NHANES) estimate that 36.9% of patients with diabetes have CKD, only approximately 10% of patients are aware of their kidney disease.
- Trial name
- CKD-DETECT (NCT05342545)
- Testing
- Alert-based computerized decision support
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Brigham and Women's Hospital
Type 2 Diabetes Mellitus
A Study to Evaluate the Renal Protective Effect (Urine Albumin-to-Creatinine Ratio (UACR)), Efficacy and Safety of Ipragliflozin in Type 2 Diabetes Mellitus Patients With Albuminuria
The primary purpose of this study is to assess the renal protective effect of ipragliflozin in combination with metformin on the percent change of UACR from baseline to 24 weeks against glimepiride in combination with metformin…
- Trial name
- NCT03118713
- Testing
- metformin, ipragliflozin, glimepiride
- Where
- 8 sites in South Korea
- Volunteers
- 33 people
- Sponsor
- Astellas Pharma Korea, Inc.
Cardiovascular Health Status, Smoking Status
Effectiveness and Implementation Evaluation of NeoMayor for Improving Cardiovascular Health in Chilean Older Adults
This study aims to evaluate the effectiveness and implementation of NeoMayor, a mobile health (mHealth) intervention designed to improve cardiovascular health among older adults at elevated cardiovascular risk in Chile.
- Conditions
- Cardiovascular Health Status, Smoking Status, Physical Activity, Diet Quality
- Trial name
- NEOMAYOR (NCT07633392)
- Testing
- NeoMayor App, Wearable Device Support, Human Health Coach Support
- Where
- 2 sites in Chile
- Volunteers
- 240 people
- Sponsor
- University of Chile
Type 2 Diabetes, Microalbuminuria
Use of Sitagliptin to Decrease Microalbuminuria
The people being asked to participate in this study have type 2 diabetes and abnormal levels of protein in their urine. This indicates that they are starting to develop diabetic kidney disease.
- Trial name
- NCT02048904
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Missouri-Columbia
Lupus Nephritis
Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy of Lupus Nephritis
This study is designed to compare the safety and efficacy of Mycocep Capsules (Mycophenolate Mofetil) and a marketed Azathioprine formulation, Imuran Azathioprine Tablets, in the maintenance therapy of lupus nephritis.
- Trial name
- NCT02949349
- Testing
- Mycophenolate mofetil, Azathioprine, Prednisolone
- Volunteers
- 32 people
- Sponsor
- Genovate Biotechnology Co., Ltd.,
No Condition, Health Young Males
Stable Versus Unstable Resistance Training Effects on Physical Fitness and Physiological Biomarkers of Untrained Male University Students
The goal of this clinical trial is to learn the effects of stable and unstable resistance training on physical fitness, kidney function and blood lipid tests in healthy young male volunteers.
- Trial name
- NCT07349342
- Testing
- resistance training
- Where
- Ethiopia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Addis Ababa University