Clinical trials: Urogenital
Prostate Cancer
Phase 3, Multicenter, Randomized Study, Evaluating the Efficacy and Tolerability of Focused HIFU (High Intensity Focused Ultrasound) Therapy Compared to Active Surveillance in Patients With Significant Low Risk Prostate Cancer
The percentage of malignant prostate tumors detected very early is constantly increasing and the number of well differentiated tumors, with small volume and low risk of progression increases.
- Trial name
- HIFUSA (NCT03531099)
- Testing
- treatment with focal HIFU, PSA dosage, MRI
- Where
- 14 sites in France
- Volunteers
- 108 people
- Sponsor
- Hospices Civils de Lyon
Adult Solid Neoplasm, Peritoneal Carcinomatosis
Veliparib and Radiation Therapy in Treating Patients With Advanced Solid Malignancies With Peritoneal Carcinomatosis, Epithelial Ovarian, Fallopian, or Primary Peritoneal Cancer
This phase I trial studies the side effects and best dose of veliparib when given together with radiation therapy in treating patients with advanced solid malignancies (abnormal cells divide without control and can invade nearby…
- Conditions
- Adult Solid Neoplasm, Peritoneal Carcinomatosis, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma
- Trial name
- NCT01264432
- Testing
- Laboratory Biomarker Analysis, Quality-of-Life Assessment, Radiation Therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- National Cancer Institute (NCI)
HIV Infection
Healthy Choices to Promote Health and Reduce Risk in HIV-Infected Youth
Risk behaviors and their associated adverse health outcomes are becoming increasingly problematic among HIV-infected youth. This study is being conducted to test whether a brief motivational enhancement (ME) intervention will…
- Trial name
- NCT00103532
- Testing
- Healthy Choices - Motivational Enhancement Intervention, Standard care
- Where
- 6 sites in United States
- Volunteers
- 225 people
- Sponsor
- University of North Carolina, Chapel Hill
Bladder Cancer
Prospective Collection of Samples for Urothelial Cancer of Bladder
ProCSUCaB (Prospective Collection of Samples for Urothelial Cancer of Bladder) is a monocentric, non-interventional, prospective registry that will recruit newly diagnosed intermediate- and high-risk NMIBC patients in a tertiary…
- Trial name
- ProCSUCaB (NCT04167332)
- Volunteers
- 630 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Fallopian Tube Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma
YKL-40 in Serum Samples From Patients With Newly Diagnosed Stage III-IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer Receiving Chemotherapy
This research trial studies chitinase 3-like 1 (cartilage glycoprotein-39) (YKL-40) in serum samples from patients with newly diagnosed stage III-IV ovarian epithelial, primary peritoneal cavity, or fallopian tube cancer…
- Conditions
- Fallopian Tube Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma
- Trial name
- NCT00899093
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 131 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Gynecologic Oncology Group
Diabetes Mellitus, Diabetic Nephropathy
Role of Triglyceride-Glucose Index and Inflammatory Biomarkers as Prognostic Tools for Progression of Diabetic Nephropathy
This study aims to evaluate the prognostic value of the Triglyceride-Glucose (TyG) index alongside inflammatory biomarkers in predicting the progression of diabetic nephropathy, exploring their correlation with disease severity…
- Trial name
- NCT07813793
- Volunteers
- 105 people
- Sponsor
- Assiut University
Bladder Cancer, Benign Prostate Hyperplasia
The Effect of Preemptive Analgesia On The Comfort Of Patient and Doctor, in Cystoscopy
The study was designed as a prospective, randomized double-blind placebo controlled trial. According to power analysis in regards of previous studies in the literature with diclofenac sodium, using a total of 144 patients are…
- Conditions
- Bladder Cancer, Benign Prostate Hyperplasia, Hematuria, Pain
- Trial name
- NCT03831321
- Testing
- Diclofenac Sodium, Cystoscopy, Lubricant Gel
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people
- Sponsor
- Taha Uçar
Epithelial Ovarian Cancer, Fallopian Tube Cancer
Total/Subtotal Colectomy in Ovarian Cancer
The purpose of this study is to evaluate the safety and one year disease-free survival of total or subtotal colectomy and proctocolectomy in stage IIIc and stage IV epithelial ovarian, fallopian tube, and primary peritoneal…
- Conditions
- Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma, Secondary Malignant Neoplasm of Large Intestine
- Trial name
- NCT02595021
- Testing
- Total or Subtotal Colectomy, Other Bowel Resection
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Gynecologic Oncology Group
Gestational Diabetes Mellitus
Trial of Diet in Gestational Diabetes Mellitus: Metabolic Consequences to Mother and Offspring
The rapidly rising risk of gestational diabetes pregnant women demands that an effective diet strategy be developed due to the high risk of fetal overgrowth, which places the newborn at increased risk for childhood obesity and…
- Trial name
- CHOICE (NCT02244814)
- Testing
- Low Carbohydrate/Conventional, Choosing Healthy Options in Carbohydrate Energy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Colorado, Denver
Prematurity, Very Low Birth Weight
The Safety Evaluation of Silver Alginate (Algidex™) Dressing in Very Low Birth Weight (VLBW) Infants
The purpose of this study is to test the safety of silver alginate (Algidex™) dressing in VLBW infants in preparation for a large efficacy trial.
- Trial name
- NCT00593684
- Testing
- Silver Alginate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Hiv, Neurocognitive Dysfunction
Using Less Neurotoxic Drugs in Patients With HAND (MARAND-X)
Neurocognitive disorders are still highly prevalent in the HAART era; despite a dramatic reduction in dementia cases, 15-50% of patients may develop mild or asymptomatic neurocognitive disorders (HIV-associated neurocognitive…
- Trial name
- (MARAND-X) (NCT03163277)
- Testing
- emtricitabine, darunavir/cobicistat, maraviroc
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Giovanni Di Perri
Epithelial Ovarian Cancer, Ovarian Cancer
89Zr-DFO-Mirvetuximab PET/CT Imaging for Companion Diagnosis and Response Evaluation in Ovarian Cancer
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer-related death in women, with approximately 320,000 new cases and 200,000 deaths annually worldwide, and its incidence is rising.
- Trial name
- NCT07790939
- Testing
- 89Zr-DFO-Mirvetuximab PET/CT
- Volunteers
- 20 people
- Sponsor
- Peking University Cancer Hospital & Institute
Cervical Cancer, Cervical Cancer Stage
Non-Invasive Cervical Cancer Radiotherapy for Stage IB-IVB
The purpose of this study is to find out whether patients with cervical cancer treated with about a new radiation technique called "stereotactic body radiotherapy (SBRT) have less stress and anxiety compared to standard…
- Conditions
- Cervical Cancer, Cervical Cancer Stage, Cervical Cancer Stage IB2, Cervical Cancer Stage IB1
- Trial name
- NICER (NCT03146039)
- Testing
- Radiation Therapy
- Where
- United States
- Sponsor
- University of California, San Diego
Endometrial Cancer
Fasting InTervention for Endometrial Cancer
The goal of this study is to find out if it is safe for women with endometrial cancer who are going to have surgery to fast (not eat) overnight.
- Trial name
- FIT-ENDO (NCT07622901)
- Testing
- Prolonged Overnight Fasting (POF), Blood Specimen Collection, Blood Sugar Monitor
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Miami
Prostate Cancer
Imperial Prostate 9 - ATLAS (Approaches To Long-Term Active Surveillance)
The goal of this intervention study is for patients on active surveillance for prostate cancer, to demonstrate that use of regular MRI scans is better able to detect cancer progression over 5 years compared to the current NICE…
- Trial name
- IP9-ATLAS (NCT06280781)
- Testing
- MRI Scans
- Where
- 12 sites in United Kingdom
- Volunteers
- 1,263 people
- Sponsor
- Imperial College London
Autosomal Dominant Polycystic Kidney Disease
The Safety and Efficacy of Catheter-based Renal Denervation Using the Vessix™ Renal Denervation System in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients With Severe Debilitating Pain
This study will test the safety and efficacy of the Vessix Renal Denervation system in the reduction of pain in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).
- Trial name
- NCT02746419
- Testing
- Vessix
- Sponsor
- University of Chicago
Infective Endocarditis
Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery
Acute kidney injury is major complication after open heart surgery. The cause of acute kidney injury following open heart surgery is related to activation of sympathetic nervous system, decrease of renal blood flow…
- Trial name
- NCT02698930
- Testing
- dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Yonsei University
HIV Infections
Observational Cohort of HIV Infected Adults and Children in the PHPT Network Hospitals in Thailand
Since 2004, the Thai Ministry of Public Health has massively scaled up antiretroviral treatment programs to provide therapy to more than 80,000 patients with partial support of the Global Fund to fight AIDS, Tuberculosis and…
- Trial name
- NCT00433030
- Where
- 38 sites in Thailand
- Volunteers
- 2,816 people
- Sponsor
- Institut de Recherche pour le Developpement
Pre-Eclampsia
Role of Anti-C1q Autoantibodies in Pregnancy
Preeclampsia (PE) is a very frequent obstetric complication. C1q, the first recognition molecule of the classical pathway of complement system (C), represents a double-edged molecule in determining pregnancy outcomes.
- Trial name
- NCT06317467
- Testing
- Blood sampling
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- IRCCS Burlo Garofolo
Maternal Health, Pregnancy Complications
Wakobo-ti-Kodro: Improving Identification of Pregnancy at Risk of Obstetric Complications at Community Level
This project aims to improve maternal health indicators in a national context where the maternal mortality rate is one of the highest in the world.
- Trial name
- NCT06613867
- Testing
- Wakobotikodro
- Where
- Central African Republic
- Volunteers
- 1,857 people, healthy volunteers welcome
- Sponsor
- Alliance for International Medical Action
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