Clinical trials: Urogenital Pathology
Pre-Eclampsia, Intrauterine Growth Restriction
PEPPI Study: Identification of Women at Risk for Placental Dysfunction
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a…
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Polycystic Ovary Syndrome, Iron-deficiency
- Trial name
- NCT06115122
- Testing
- Pre-eclampsia screening program
- Where
- Finland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Kidney Stones
Comparison of Multiple-, Single- and Zero-dose of Ciprofloxacin Prophylaxis in Retrograde Intrarenal Surgery
The purpose of this study is to compare the postoperative systemic inflammatory response syndrome (SIRS) rates undergoing retrograde intrarenal surgery (RIRS) after multiple-, single-, zero-dose of ceftriaxone prophylaxis in a…
- Trial name
- RIRS (NCT02304822)
- Testing
- Multiple-dose of Ciprofloxacin prophylaxis, Single-dose of Ciprofloxacin prophylaxis, Zero-dose of Ciprofloxacin prophylaxis
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Guohua Zeng
HPV Infection, Cervical Cancer Screening
Acceptability of HPV Self-sampling Among Canadian Women Aged 21 to 65
We propose a cross-sectional study to explore the acceptability and feasibility of HPV self-sampling among Quebec women. The study will invite eligible women to self-sample for HPV at home.
- Trial name
- CUTE-IPS (NCT05414929)
- Testing
- HPV self-sampling
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Urinary Incontinence
Urinary Incontinence Self-Screen for Healthy Aging
The purpose of this study is to increase awareness and timely treatment of urinary incontinence through a self-screening process.
- Trial name
- NCT03485872
- Testing
- Self-Screening and Referral Information, Standard Care
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Preeclampsia (PE), Intrauterine Growth Restriction (IUGR)
Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)
In pregnancies with placental insufficiency, the only available treatment is close monitoring to determine the point at which the risks of preterm birth for the baby are lower than the risks of continuing the pregnancy.
- Conditions
- Preeclampsia (PE), Intrauterine Growth Restriction (IUGR), Placental Insufficiency
- Trial name
- STATIN-PRE (NCT07098975)
- Testing
- Pravastatin 40 mg
- Where
- 2 sites in Spain
- Volunteers
- 154 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Post Partum Hemorrhage, Cesarean Section Complications
Oxytocin Pharmacokinetics and Pharmacodynamics
Oxytocin is the first-line drug to promote contraction of the uterus and prevent atony immediately after delivery. Nonetheless, unpredictable uterine atony refractory to oxytocin affects roughly 250,000 parturients annually in…
- Conditions
- Post Partum Hemorrhage, Cesarean Section Complications, Blood Loss
- Trial name
- NCT05488457
- Testing
- deuterated oxytocin (d5OT)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Kidney Disease, Chronic
An Observational Study of Mircera (Methoxy Polyethylene Glycol-epoetin Beta) in Patients With Chronic Kidney Disease Not On Dialysis
This observational, prospective, multicenter study will describe the mean dose of Mircera (methoxy polyethylene glycol-epoetin beta) and the hemoglobin levels in patients with chronic kidney disease.
- Trial name
- NCT01318512
- Where
- Czechia
- Volunteers
- 340 people
- Sponsor
- Hoffmann-La Roche
Vestibulodynia, Temporomandibular Disorder
Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments
Vestibulodynia (VBD) is a complex chronic vulvar pain condition that impairs the psychological, physical, and sexual health of 1 in 6 reproductive aged women in the United States.
- Conditions
- Vestibulodynia, Temporomandibular Disorder, Fibromyalgia Syndrome, Irritable Bowel Syndrome
- Trial name
- NCT03844412
- Testing
- 5% lidocaine/5 mg/ml 0.02% estradiol compound cream, Nortriptyline
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Duke University
Kidney Stone
Evaluation of Pain Before and After Removal of Non-obstructive Kidney Stones
Pain associated with renal stone disease is typically caused by an obstructing stone that obstructs the flow of urine, which results in renal collecting system dilatation.
- Trial name
- ENORC (NCT03657667)
- Testing
- Ureteroscopy
- Where
- 9 sites in United States, Canada
- Volunteers
- 43 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Endometriosis, Pelvic Pain
Hyivy Device as Non-hormonal Therapy in Endometriosis
This study seeks to address accessible management of endometriosis-associated chronic pelvic pain by evaluating a novel device used in the home.
- Trial name
- NCT05643131
- Testing
- Hyivy Intravaginal Device
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Hyivy Health Inc
Stress Urinary Incontinence, Incontinence, Urinary
Comparison Between a Telerehabilitation Program for Urinary Incontinence Versus a Conventional Face-to-face Program
Urinary incontinence (UI) is defined as any involuntary loss of urine. It affects a significant percentage of the population, mainly female, with a prevalence of 21.4% in Portuguese women, having a negative impact on quality of…
- Conditions
- Stress Urinary Incontinence, Incontinence, Urinary, Covid19, Pelvic Floor Muscle Weakness
- Trial name
- NCT05114395
- Testing
- Pelvic Floor Telerehabilitation Program, Pelvic Floor Face-to-Face Program
- Where
- 2 sites in Portugal
- Volunteers
- 39 people
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Advanced or Metastatic Solid Tumors
A Dose Escalation/Expansion Study of MDK-703 in Patients With Advanced or Metastatic Solid Tumors
This is an open-label, dose escalation and dose expansion study of MDK-703 as a monotherapy and in combination with other cancer therapies in adult study participants with advanced or metastatic solid tumors.
- Trial name
- ORCHID-1 (NCT05716295)
- Testing
- MDK-703, Checkpoint Inhibitor, Immune
- Where
- 6 sites in United States
- Volunteers
- 26 people
- Sponsor
- Medikine, Inc.
Locally Advanced/Metastatic or Recurrent Ovarian Cancer, Fallopian Tube Cancer,, Primary Peritoneal Cancer or Endometrial Cancer
A Study of MM-121 in Combination With Paclitaxel in Patients With Advanced Gynecologic and Breast Cancers
This study was a Phase 1 and pharmacologic open-labeled dose-escalation trial of MM-121 in combination with paclitaxel using a "3+3" design.
- Conditions
- Locally Advanced/Metastatic or Recurrent Ovarian Cancer, Fallopian Tube Cancer,, Primary Peritoneal Cancer or Endometrial Cancer, Locally Advanced/Metastatic Her2 Non Overexpressing Breast Cancer
- Trial name
- NCT01209195
- Testing
- MM-121, Paclitaxel
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Merrimack Pharmaceuticals
Chronic Kidney Diseases
Secondary Data Analysis of Patients at Risk for CKD to Inspect CKD Prevalence, Diagnosis Rates, Diagnostic Behaviour, Treatment Patterns and Patient Characteristics
This study is a national secondary data analysis to determine the prevalence of diagnosed and undiagnosed CKD in German primary care offices in a patient population at high risk for the development and progression of CKD.
- Trial name
- InspeCKD (NCT05953701)
- Where
- Germany
- Volunteers
- 800,211 people
- Sponsor
- AstraZeneca
Proteinuria, Kidney Injury
Inflammatory and Immune Profiling of Kidney Tissue Obtained From Patients With Newly Diagnosed Kidney Disease
This study will evaluate in patients with kidney disease, the role that certain inflammatory and immune mediators play in promoting kidney damage.
- Conditions
- Proteinuria, Kidney Injury, Chronic Kidney Disease
- Trial name
- NCT01156428
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- The Rogosin Institute
Stress Urinary Incontinence
Efficacy of Magnetic Stimulation for Stress Urinary Incontinence
The aim of the study is to investigate the effects of QRS®-1010 PelviCenter in female patients with stress urinary incontinence.
- Trial name
- NCT01924728
- Testing
- Magnetic stimulation
- Where
- Malaysia
- Volunteers
- 120 people
- Sponsor
- QRS Asia Sdn Bhd
End Stage Renal Disease
Conventional Hemodialysis vs. Short Daily Hemodialysis (6 Days / Week) and Mechanisms of Blood Pressure Control
More than 80% of patients with end stage renal disease have hypertension; 70% of whom are poorly controlled using conventional Hemodialysis therapy.
- Trial name
- NCT00759967
- Testing
- Microneurography, Bioimpedance testing
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Ottawa Hospital Research Institute
HIV Infections
The Effects of Illnesses on HIV Levels in the Body
To describe the magnitude and duration of changes in HIV-1 RNA levels during and after an acute febrile illness. To identify factors associated with increases, i.e., type of illness ultimately diagnosed (bacterial, viral…
- Trial name
- NCT00000900
- Where
- 14 sites in United States
- Volunteers
- 26 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Kidney Injury
Online Hemodiafiltration vs Conventional Hemodialysis in Acute Kidney Injury
Only limited data exist on the benefit of online hemodiafiltration in patient with Acute kidney injury. The objective of this pilot RCT is to assess the feasibility of a large multicentre RCT to determine whether, in patients…
- Trial name
- HDFAKI (NCT04525092)
- Testing
- Online Pre-dilution Hemodiafiltration, Conventional Hemodialysis, Online Post-dilution Hemodiafiltration
- Where
- 2 sites in Canada, Ireland
- Volunteers
- 45 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Polycystic Ovary Syndrome
The Effect of Polycystic Ovary Syndrome Treatment on Metabolomics
The aim of this study is to determine the effect of the treatment of polycystic ovary syndrome with two different oral contraceptives that contain cyproterone acetate and drospirenone
- Trial name
- NCT04831151
- Testing
- Yasmin, Diane-35
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Inonu University
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