Clinical trials: Urologic Diseases
Hypogonadism, Malignant Urinary System Neoplasm
Perioperative Testosterone Replacement Therapy for the Improvement of Post-Operative Outcomes in Patients With Low Testosterone
This phase I trial investigates the safety of testosterone replacement therapy around the time of major urologic surgery (perioperative) in order to improve quality of life and post-operative outcomes such as decreased length of…
- Conditions
- Hypogonadism, Malignant Urinary System Neoplasm, Urinary System Disorder, Urinary System Neoplasm
- Trial name
- NCT04731376
- Testing
- Best Practice, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Emory University
Advanced Malignant Neoplasm, Castleman Disease
Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease
This phase I trial studies the side effects and best dose of bevacizumab and temsirolimus alone or in combination with valproic acid or cetuximab in treating patients with a malignancy that has spread to other places in the body…
- Conditions
- Advanced Malignant Neoplasm, Castleman Disease, Digestive System Carcinoma, Erdheim-Chester Disease
- Trial name
- NCT01552434
- Testing
- Bevacizumab, Cetuximab, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- M.D. Anderson Cancer Center
Bladder Cancer, Cancer of the Bladder, Recurrent
CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer
Bladder cancer is the most common urinary tract cancer and the 5th most common cancer in the US (1). Yet bladder cancer research is underfunded relative to other common cancers.
- Conditions
- Bladder Cancer, Cancer of the Bladder, Recurrent, Non-muscle Invasive Bladder Cancer
- Trial name
- CISTO (NCT03933826)
- Where
- 36 sites in United States
- Volunteers
- 570 people
- Sponsor
- University of Washington
Urologic Disorders
Telemedicine for Urologic Care in Rural Nigeria
Access to urologic care in rural Nigeria is not as robust as it needs to be given the size of the population. This study will employ two research groups in rural Northern Nigeria.
- Trial name
- NCT06976567
- Testing
- Telemedicine for urology consultations
- Where
- Nigeria
- Volunteers
- 220 people
- Sponsor
- University of California, San Francisco
Immunoglobulin A (IgA) Nephropathy
Clinical Trial to Assess Efficacy and Safety of the Human Anti-CD38 Antibody Felzartamab (MOR202) in IgA Nephropathy
Randomized, placebo-controlled, multi-center, double-blind, proof of concept phase IIa trial and dose evaluation trial of felzartamab in IgAN
- Trial name
- IGNAZ (NCT05065970)
- Testing
- Felzartamab
- Where
- 59 sites in United States, Australia and 13 more
- Volunteers
- 54 people
- Sponsor
- HI-Bio, A Biogen Company
Urologic Diseases, Urinary Tract Infections
Effect of Comprehensive Spa Care on Kidney and Urological Conditions: A Clinical Study in Adult Patients
This is a single-arm, pretest-posttest study evaluating the effects of a 21-day comprehensive spa care (Komplexní lázeňská léčebně rehabilitační péče, KLP) on patients with nephrological and urological conditions treated at a spa…
- Conditions
- Urologic Diseases, Urinary Tract Infections, Nephrolithiasis, Nephrocalcinosis
- Trial name
- Uro-Nefro (NCT07435844)
- Testing
- Comprehensive Spa Care, Exercise Therapy, Dietotherapy
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Institute of Spa and Balneology, public research institution
Urinary Incontinence, Daytime Wetting
Brain Activity Among Children With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children
The aim of this study is to investigate whether the activity in brain areas controlling the bladder is different among children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and…
- Conditions
- Urinary Incontinence, Daytime Wetting, Urination Disorders, Urination Involuntary
- Trial name
- NCT05989646
- Testing
- Sacral TENS
- Where
- 4 sites in Denmark
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Urinary Incontinence, Daytime Wetting
The Voided Urinary, Perineal, and Faecal Microbiota Among Children and Adolescents - the PpUF-study.
The aim of this study is to investigate whether the voided urinary, perineal/preputial, and the fecal microbiota are different between children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI)…
- Conditions
- Urinary Incontinence, Daytime Wetting, Urination Disorders, Urologic Diseases
- Trial name
- NCT07535619
- Where
- 4 sites in Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
IgA Nephropathy, Immunoglobulin A Nephropathy
A Study of Zigakibart in Adults With IgA Nephropathy
Safety and Efficacy of BION-1301 in Adults with IgA Nephropathy
- Trial name
- NCT05852938
- Testing
- BION-1301
- Where
- 200 sites in United States, Argentina and 21 more
- Volunteers
- 383 people
- Sponsor
- Novartis Pharmaceuticals
Conditions, Infections
Analysis of the Virtual Acute Care at Home Experience
The purpose of this study is to examine the implementation, intervention effectiveness, and dissemination of a digital acute care delivery model for improving selected health outcomes in the Hospital at Home population.
- Conditions
- Conditions, Infections, Heart Failure, Renal and Urinary Disorders
- Trial name
- HaH (NCT05952999)
- Testing
- Digital Care Solution as supportive personalized care, Traditional Hospital Level Care
- Where
- United States
- Volunteers
- 9,654 people
- Sponsor
- OSF Healthcare System
Urologic Diseases
Evaluation Patient Satisfaction After Passive Bladder Catheter Removal Compared to Active Removal
In usual practice, the removal of the bladder catheter is performed by a nurse a few days after the surgery. The nurse deflates the balloon and removes the catheter from the urethra by manual traction.
- Trial name
- IDESONDE (NCT05313945)
- Testing
- Passive indwelling urinary catheter removal, Active indwelling catheter removal by a nurse
- Where
- 2 sites in France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Spinal Cord Injuries, Bowel Dysfunction
Noninvasive Spinal Cord Stimulation for Early SCI
The investigators are looking to determine the safety and efficacy of non-invasive transcutaneous spinal cord stimulation (TSCS) in promoting recovery of lower urinary tract (LUT), bowel, sexual, and cardiovascular function, as…
- Conditions
- Spinal Cord Injuries, Bowel Dysfunction, Sexual Dysfunction, Autonomic Dysfunction
- Trial name
- NCT06587841
- Testing
- Spinal COrd NEuromodulation™ (SCONE™) for transcutaneous spinal cord stimulation (TSCS)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Urologic Diseases, Hematuria
A Study of Ward Admissions for Haematuria
This multicenter, prospective observational study will evaluate national and international practice variations (if present) in the emergency management of patients admitted to hospital with haematuria, inform a consensus…
- Conditions
- Urologic Diseases, Hematuria, Hematuria; Benign, Bladder Cancer
- Trial name
- WASHOUT (NCT07395037)
- Testing
- Inpatient work-up and management
- Where
- United Kingdom
- Volunteers
- 1,050 people
- Sponsor
- British Urology Researchers in Surgical Training
Urologic Diseases
Evaluation of AI Large Models for Diagnosis and Treatment in Real-World Cases: Multicenter Retrospective Study
This multicenter retrospective study aims to evaluate the diagnostic and therapeutic performance of three large language models-ChatGPT, Gemini and Deepseek-using 800 archived inpatient medical records from urology departments…
- Trial name
- NCT07378358
- Testing
- Large Language Model Assessment (ChatGPT, Gemini, DeepSeek)
- Where
- China
- Volunteers
- 800 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Infections, Heart Failure
Advancing Health Information Exchange (HIE) During Inter-hospital Transfer (IHT) to Improve Patient Outcomes
Sub-optimal transfer of clinical information during inter-hospital transfer (IHT, the transfer of patients between acute care hospitals) is common and can lead to patient harm.
- Conditions
- Infections, Heart Failure, COPD Exacerbation, Asthma
- Trial name
- NCT05443321
- Testing
- Health Information Exchange (HIE) platform
- Where
- United States
- Volunteers
- 1,006 people
- Sponsor
- Brigham and Women's Hospital
Urologic Diseases, Prostate Biopsy
VIrtual Reality Induced Pain and anxiEty Relief in Outpatient UROlogical Procedures
Though the efficacy of VRH is documented in various outpatient urological procedures and has provided promising preliminary information in prostate biopsy, its systematic use in urology remains poorly studied.
- Conditions
- Urologic Diseases, Prostate Biopsy, Flexible Cystoscopy, Circumcision
- Trial name
- NCT07338292
- Testing
- REALICA, Clinical Practice
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Urinary Tract Infections, Recurrent
Bovine Colostrum for Prophylaxis Against Recurrent Urinary Tract Infection in Children
Prebiotics as bovine colostrum are considered as a valuable supplement in the prevention of upper respiratory tract infections, gastrointestinal tract infections and neonatal sepsis.
- Conditions
- Urinary Tract Infections, Recurrent, Child, Prevention & Control
- Trial name
- NCT06164600
- Testing
- Bovine colostrum
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Urologic Surgical Procedures, Urinary Bladder, Neurogenic
Pediatric Urology Recovery After Surgery Endeavor (PURSUE)
The purpose of this research study is to evaluate an Enhanced Recovery After Surgery (ERAS) protocol in children and young adults undergoing urologic reconstructive surgery.
- Conditions
- Urologic Surgical Procedures, Urinary Bladder, Neurogenic, Urinary Bladder Diseases
- Trial name
- NCT03245242
- Testing
- Enhanced Recovery after Surgery, Historical usual surgical care
- Where
- 7 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Urinary Tract Disease
Antibiotic Strategy and Asymptomatic Bacteriuria in the Context of Intra-vesical Botulinum Toxin A Injections.
The study aims to demonstrate that the "thrifty antibiotic strategy" applied to MS or SCI patients with asymptomatic bacteriuria prior to BoNTA intravesical injections does not increase the rate of symptomatic post-injection UTIs…
- Trial name
- ANTIBIOBONTA (NCT05534399)
- Testing
- Intra-vesical BoNTA injections
- Where
- France
- Volunteers
- 526 people
- Sponsor
- University Hospital, Lille
Lupus Nephritis
A Study to Assess Effectiveness and Safety of Efgartigimod in Chinese Patients With Lupus Nephritis (ZL-1103-013)
The purpose of the study is to evaluate the efficacy and safety of efgartigimod IV in Chinese patients with active lupus nephritis (LN).
- Trial name
- NCT05810948
- Testing
- efgartigimod IV
- Where
- 31 sites in China
- Volunteers
- 73 people
- Sponsor
- argenx