Clinical trials: Urologic Injuries
Kidney Disease, Kidney Injury
Transgender Analysis of Nephrological Studies Focused on Renal Metrics
This study investigates how sex hormones affect kidney function in people undergoing gender-affirming hormone therapy (GAHT). We know men have a faster progression of kidney disease.
- Conditions
- Kidney Disease, Kidney Injury, Transgender Individuals
- Trial name
- TRANSFORM (NCT07542964)
- Testing
- P-aminohippurate clearance study, Iohexol infusion, Hyperinsulinemic clamp
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Amsterdam UMC, location VUmc
Kidney; Obstruction, Renal Obstruction
Contrast Enhanced Ultrasound for Renal Obstruction
This research is studying Definity ultrasound contrast agent, which is already approved by the Food and Drug Administration (FDA) for the ultrasound evaluation of the liver and heart.
- Trial name
- NCT05090800
- Testing
- Definity contrast during ultrasound
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
Acute Kidney Injury
Inferior Vena cavaCollapsibility Index in Patients With Acute Kidney Injury
This is an observational study that will examine the possibility of determining the type of Acute Kidney Injury (AKI) using bedside ultrasound machines.
- Trial name
- NCT02165072
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Texas Tech University Health Sciences Center
Acute Kidney Injury, Cardiac Surgery
Outcome of Patients Treated With RRT
Acute Kidney Injury (AKI) is a common serious complication after cardiac surgery. AKI not only prolongs the hospitalization time of patients undergoing cardiac surgery and increases the cost of treatment, but also is an…
- Trial name
- NCT04405830
- Testing
- Renal replacement therapy
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Nanjing Medical University
Acute Kidney Injury
Preventing Acute Kidney Injury
Acute kidney injury increases the risk for chronic kidney disease, length of stay, readmissions and mortality. Currently the only way to diagnose acute kidney injury is with a serum creatinine or drop in urine output.
- Trial name
- NCT04376619
- Testing
- remote ischemic preconditioning, KDIGO guidelines
- Volunteers
- healthy volunteers welcome
- Sponsor
- Atlantic Health System
Cardiac Disease, Blood Transfusion
Predicting CSA-AKI With ACTA-PORT Score
In the scope of this study, it will be determined whether the ACTA-PORT (Association of Cardiothoracic Anesthetists perioperative risk of blood transfusion) scoring system can predict the incidence of events in other organ…
- Conditions
- Cardiac Disease, Blood Transfusion, Acute Kidney Injury
- Trial name
- NCT06484907
- Where
- Turkey (Türkiye)
- Volunteers
- 467 people
- Sponsor
- Ankara City Hospital Bilkent
Acute Kidney Disease, Acute Kidney Injury
Impact of Different CRRT Modalities, Dosing Strategies, and Timing on Kidney Recovery and Prolonged Kidney Dysfunction
KARMA study is a hospital-based research study looking at how different ways of delivering kidney support therapy (CRRT) affect patients who are critically ill.
- Trial name
- KARMA (NCT07052617)
- Testing
- Continuos renal replacement therapy
- Volunteers
- 2,500 people
- Sponsor
- Croatian Society for Organ Support
Injury
Serum Vasopressin Levels and Severe Hemorrhagic Shock
The purpose of this study is to determine if vasopressin is used up by the body during traumatic shock (severe low blood pressure due to trauma).
- Trial name
- NCT01676454
- Where
- United States
- Sponsor
- Poudre Valley Health System
Acute Kidney Injury, Acute Kidney Failure
HEmoFiltration With Citric Acid Anticoagulation
Prospective observational study of all consecutive cardio-vascular surgical patients treated with post-dilution hemofiltration with regional citrate anticoagulation as first-choice anticoagulation method.
- Conditions
- Acute Kidney Injury, Acute Kidney Failure, Renal Replacement Therapy, Hemofiltration
- Trial name
- HEFCAA (NCT03836742)
- Testing
- Hemofiltration with regional citrate anticoagulation
- Where
- Poland
- Volunteers
- 54 people
- Sponsor
- Medical University of Gdansk
Prostate Cancer Metastatic, Radiotherapy Side Effect
Metastatic Prostate Cancer Men's Attitudes Towards Treatment of the Local Tumour and Metastasis Evaluative Research
Systemic therapy (i.e Androgen Deprivation Therapy with Docetaxel, Enzalutamide, Apalutamide or Abiraterone Acetate) has increased overall survival in men with hormone-sensitive metastatic prostate cancer.
- Conditions
- Prostate Cancer Metastatic, Radiotherapy Side Effect, Surgery, Urologic Cancer
- Trial name
- IP5-MATTER (NCT04590976)
- Testing
- Semi-Structured Interview Healthcare Professional, Semi-Structured Interview Patients, Think Aloud Interview Patients
- Where
- 35 sites in United Kingdom
- Volunteers
- 320 people
- Sponsor
- Imperial College London
Pre Eclampsia, Eclampsia, Antepartum
BH4 Blood Levels Variations in Pre Eclamptic Women
tetrahydrobiopterin (BH4) is degraded by several enzymes, including BH4 oxidase and peroxidases. Several factors can affect its synthesis and degradation.
- Conditions
- Pre Eclampsia, Eclampsia, Antepartum, HELLP Syndrome (HELLP), Unspecified Trimester, Acute Renal Failure
- Trial name
- BH4P (NCT05847361)
- Testing
- BH4 blood level
- Where
- Tunisia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Patient Acceptance of Health Care, Acute Renal Failure
DETECT-IP: a Clinical Decision Support System and Intelligent Procedures to Counter Some Adverse Drug Events in Older Hospital Patients
Current evidence shows that computerized decision support systems (CDSS) have shown to be insufficiently effective to prevent adverse drug reactions (ADRs) at large scale (e.g. whole hospital).
- Trial name
- DETECT-IP: (NCT05923983)
- Testing
- Clinical decision support, Will not receive Clinical Decision Support
- Where
- France
- Volunteers
- 783 people
- Sponsor
- University Hospital, Lille
Acute Kidney Injury
Acute Kidney Injury in Premature Infants
Our first Aim is to describe how common a sudden decrease in renal function happens in premature infants in a neonatal intensive care unit. We also want to see how a sudden loss of renal function affects survival.
- Trial name
- NCT00573079
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- University of Alabama at Birmingham
Post Operative Vasoplegic Syndrome, Acute Kidney Injury
POLECAT: Perioperative Delta Renin Concentration
We want to measure the amount of a hormone called renin in people's bodies before and after they have major abdominal surgery. We want to see if changes in renin levels are connected to problems with blood flow, unstable blood…
- Trial name
- POLECAT (NCT05942846)
- Volunteers
- 405 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Intraoperative Hypotension
Hypotension Prediction Index and Intraoperative Hypotension Incidence
This study aim to implement intraoperative hemodynamic monitoring and management guided with HPI algorithm in frail patients undergoing elective abdominal surgery.
- Trial name
- NCT06909786
- Testing
- HPI guided hemodynamic management, standard arterial line
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Acute Kidney Injury, Citrate
Citrate Versus Heparin in Continuous Renal Replacement Therapy :
This study is a prospective, multicenter, open-label randomized trial comparing regional citrate anticoagulation (RCA) with heparin-free protocol.
- Conditions
- Acute Kidney Injury, Citrate, Cytokines, Hemodynamic Responses
- Trial name
- NCT04865510
- Testing
- Regional citrate anticoagulation
- Where
- Thailand
- Volunteers
- 41 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Acute Kidney Injury
Safety & Efficacy of BCT197 in Patients Undergoing Cardiac Surgery
This study will assess the safety and efficacy of BCT197 on acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- NCT01336959
- Testing
- BCT197 Part A, BCT197 Part B
- Where
- 13 sites in United States, Israel and 1 more
- Volunteers
- 91 people
- Sponsor
- Mereo BioPharma
Acute Kidney Injury
Metabolic Complications Using a Low- Versus High Concentration Citrate Solution for Regional Anticoagulation in Continuous Kidney Replacement Therapy: A Pragmatic Randomized Trial.
This study is a pragmatic, randomized trial comparing two commercially available citrate solutions to determine their impact on metabolic complications in critically ill patients with acute kidney injury receiving continuous…
- Trial name
- LEON1 (NCT07751861)
- Testing
- low concentrated citrate solution (18 mmol/L), high concentrated citrate solution (136 mmol/L)
- Where
- Belgium
- Volunteers
- 176 people
- Sponsor
- University Hospital, Antwerp
Drug-Induced Nephropathy, Hypertension
Arginine in Treating Patients With Anti-VEGF Induced Kidney Injury
This phase II trial studies how well arginine works in treating patients with kidney injury caused by anti-VEGF drugs used in standard treatment for cancer.
- Conditions
- Drug-Induced Nephropathy, Hypertension, Proteinuria
- Trial name
- NCT02882373
- Testing
- Arginine
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Urological Injury, Gynecologic Disease
Urological Complications and Management After Gynecological Operations
OBJECTIVE: In the study, investigators aimed to evaluate the urological complications of gynecologic operations in a tertiary academic center and to evaluate the treatment methods of these complications.
- Trial name
- NCT04042129
- Testing
- gynecologic operations with urological complications
- Volunteers
- 1,754 people
- Sponsor
- Acibadem University