Clinical trials: Urological Surgeries
Urinary Stress Incontinence
Transvaginal Tension Free Vaginal Tape-Obturator (TVT-O) Versus Transobturator Tape-Mentor (TOT) in the Management of Urodynamic Stress Urinary Incontinence
Urinary incontinence (involuntary leakage of urine) is an extremely common, distressing and socially disabling condition. It is known to affect up to 14 % of the adult female population in the United Kingdom.
- Trial name
- NCT00136071
- Testing
- Transobturator tape-ARIS, TVT-O
- Where
- United Kingdom
- Volunteers
- 230 people
- Sponsor
- South Glasgow University Hospitals NHS Trust
Stress Urinary Incontinence
Reducing Early Urinary Disorders After Stress Incontinence Surgery: The Role of Vaginal Wall Tension.
The progress in surgical procedures for treating female stress urinary incontinence has led to the development of tension-free techniques such as the trans-obturator tape (TOT).
- Trial name
- NCT06292702
- Testing
- Traditional Burch colposuspension, Modified Burch colposuspension
- Where
- Syria
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Damascus University
Cancer
Interest of a Geriatric Intervention Plan Associated to a Comprehensive Geriatric Assessment on Autonomy, Quality of Life and Survival of Patients Aged 70 Years Old and More Surgically Treated for a Resectable Cancer (Thoracic, Digestive or Urologic). Randomized Multicentric Study
The curative treatment of thoracic (lung and oesophagus), digestive (gastric, pancreatic, hepatic, colorectal), and urologic (renal, bladder, prostatic) cancers needs a surgical resection.
- Trial name
- epigac (NCT02000011)
- Testing
- comprehensive geriatric assessment (CGA), Geriatric intervention plan (GIP)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Urinary Incontinence,Stress
Tension Free Vaginal Tape Surgery - Follow up After 10 and 20 Years
Over the past 5-7 years there has been increasing concern about the use of polypropylene tapes in female incontinence surgery. There has been a special focus on pain in the vagina and lower abdomen and pain during sexual…
- Trial name
- TVTOPP (NCT04912830)
- Testing
- Tension-free vaginal tape
- Where
- Norway
- Volunteers
- 1,210 people
- Sponsor
- Norwegian University of Science and Technology
Urinary Incontinence, Obesity
BUDI (Bariatric UroDynamic Improvement)
In the population of obese women, the prevalence of urinary incontinence (UI) is around 70%. It was shown in the literature that weight loss by bariatric surgery allowed a significant improvement in the symptoms and impact on the…
- Conditions
- Urinary Incontinence, Obesity, Urodynamics, Quality of Life
- Trial name
- BUDI (NCT03509038)
- Testing
- Exploratory pathophysiology Study
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Caen
Urinary Bladder, Overactive, Pelvic Organ Prolapse
BOTOX® at the Time of Prolapse Surgery for OAB
The purpose of the study will be to assess the efficacy and safety of bladder BOTOX® for overactive bladder symptoms, such as urinary urgency and frequency, given at the time of prolapse surgery.
- Trial name
- NCT04807920
- Testing
- OnabotulinumtoxinA 100 UNT, Injectable saline
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Walter Reed National Military Medical Center
Benign Prostatic Hyperplasia
Transperineal Irreversible Electroporation for Benign Prostatic Hyperplasia
This clinical trial focuses on men with benign prostatic hyperplasia (BPH), a condition in which an enlarged prostate causes urinary problems.
- Trial name
- NCT06867315
- Testing
- Composite steep-pulse therapeutic device (CNP-III)
- Where
- 10 sites in China
- Volunteers
- 99 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Stress Urinary Incontinence, Urethral Sling Surgery
Trial Comparing Mini-Arc Precise Pro and the Trans Vaginal Obturator Tape for Stress Urinary Incontinence
Randomized comparison of two surgeries for the treatment of female stress urinary incontinence.
- Trial name
- NCT01799122
- Testing
- Mini Arc Precise Pro and Trans vaginal obturator sling (TVT-0)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Manitoba
Benign Prostatic Hyperplasia, Bladder Outlet Obstruction
Urinary CTGF in Benign Prostatic Obstruction
Benign prostatic obstruction (BPO) is one of the most common causes of bladder outlet obstruction (BOO) and may lead to progressive structural and functional alterations in the bladder over time.
- Conditions
- Benign Prostatic Hyperplasia, Bladder Outlet Obstruction, Lower Urinary Tract Symptom
- Trial name
- NCT07416981
- Volunteers
- 50 people
- Sponsor
- Tarik Emre Sener
Overactive Bladder
Combined Anticholinergic Medication and Sacral Neuromodulation to Treat Refractory Overactive Bladder
This study is a retrospective chart review including all patients who received surgical placement of a SNM device with Dr. Noblett from 2001 to the present.
- Trial name
- NCT01047046
- Testing
- Retrospective chart review
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of California, Irvine
Postoperative Urinary Tract Infection, Pelvic Organ Prolapse
Gentamicin Intravesical Efficacy for Infection of Urinary Tract
Urinary tract infection (UTI) is a common problem after surgery for pelvic organ prolapse and stress urinary incontinence. This prospective, randomized, single-masked (subject), two-parallel armed study aims to determine the…
- Conditions
- Postoperative Urinary Tract Infection, Pelvic Organ Prolapse, Stress Urinary Incontinence
- Trial name
- GIVEIT (NCT04246996)
- Testing
- gentamicin sulfate, Catheter clamping only
- Where
- 2 sites in United States
- Volunteers
- 370 people
- Sponsor
- Kaiser Permanente
Stress Urinary Incontinence, Postmenopausal Disorder
ToT and Estrogen in Postmenopausal Females
To compare the subjective and objective outcomes of TVT-O procedure alone versus the same procedure followed by the use of premarin vaginal cream for 3 months in postmenopausal female with genuine stress incontinence.
- Trial name
- NCT03295487
- Testing
- TVT-O
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Kasr El Aini Hospital
Post Operative Pain
Comparison Between Bupivacaine and Bupivacaine With Dexmedetomidine in Caudal Block for Post Operative Pain Control
The aim of this study is to compare the duration of analgesia, sedation, and intra and postoperative hemodynamics. This drug is recently available in Pakistan.
- Trial name
- NCT05919173
- Testing
- Bupivacaine Hydrochloride 0.25% Injection Solution, Bupivacaine Hydrochloride 0.25% Injection plus Dexmedetomidine 1 microgram/kg body weight
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sindh Institute of Urology and Transplantation
Urinary Tract Infections
Nitrofurantoin and Urinary Tract Infections (UTIs)
Urinary tract infection (UTI) is the most common complication after surgery for prolapse or urinary incontinence. UTIs are painful and have the potential to turn into kidney infections.
- Trial name
- APPIC (NCT00678041)
- Testing
- Nitrofurantoin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pelvic Organ Prolapse, Stress Urinary Incontinence
Effect of a Risk Calculator on Patient Satisfaction With the Decision for Midurethral Sling During Prolapse Surgery
Pelvic organ prolapse occurs with descent of one or more pelvic structures: the uterus and/or cervix, bowel, bladder, or rectum.
- Conditions
- Pelvic Organ Prolapse, Stress Urinary Incontinence, Satisfaction
- Trial name
- NCT02111642
- Testing
- Online risk calculator
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Stress Urinary Incontinence, Urethral Hypermobility
Comparing Voiding Trials After Midurethral Sling for Stress Incontinence
Urinary incontinence is a prevalent health and quality of life concern affecting almost half of women over the age of 20. Urinary retention (abnormal holding of urine) is a concern of many surgeons who perform midurethral sling…
- Conditions
- Stress Urinary Incontinence, Urethral Hypermobility, Cystocele
- Trial name
- NCT02400034
- Testing
- Voiding trial
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Kidney Cancers
Photodynamic Diagnosis of Kidney Cancer Using Fluorescence Endoscopy and Oral 5-ALA
The goal of this prospective, single-arm feasibility study is to evaluate the safety and feasibility of using Gleolan® (5-aminolevulinic acid), an FDA-approved drug currently used during brain tumor surgery, in adults with…
- Trial name
- NCT07828704
- Testing
- 5-Aminolevulinic acid Hydrochloride (Gliolan®)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Henry Ford Health System
Lower Urinary Tract Symptoms, Gynecologic Malignancy
Prevalence of Lower Urinary Tract Symptoms in Women With Gynecologic Malignancy Planning to Undergo Surgical Management
This study is to determine the prevalence of lower urinary tract symptoms in women undergoing surgery for gynecologic malignancy.
- Trial name
- NCT00580697
- Where
- United States
- Sponsor
- University of California, Irvine
Stress Urinary Incontinence
Autologous Muscle Derived Cells Compared to Placebo for Urinary Sphincter Repair in Post-surgical Female Stress Incontinence
This study evaluates the efficacy and safety of Autologous Muscle Derived Cells for Urinary Sphincter Repair (AMDC-USR; generic name: iltamiocel) compared to a placebo in the reduction of stress incontinence episode frequency in…
- Trial name
- CELLEBRATE (NCT03104517)
- Testing
- AMDC-USR (iltamiocel)
- Where
- 21 sites in United States, United Kingdom
- Volunteers
- 96 people
- Sponsor
- Cook MyoSite
Hypospadias, Undescended Testis
Visual Guidelines and Tutoring in Pediatric Urological Surgery
The aim of this study is checking impact of visual guidelines (picture book) and tutoring in pediatric urologic surgery
- Conditions
- Hypospadias, Undescended Testis, Hydrocele, Ureteropelvic Junction Stenosis
- Trial name
- NCT02040389
- Testing
- Picture book, Standard preoperative education
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Shaare Zedek Medical Center