Clinical trials: Use of Prescription Medications
Inappropriate Prescribing
Using a Mobile Application as a Support at the Prescription of Appropriate Medications for Elderly
Objective: To develop and evaluate the effectiveness of a mobile application to support decision making for prescription drugs to elderly patients.
- Trial name
- NCT02918643
- Testing
- Use of an application to for mobile devices like decision-making support for prescription drugs to elderly patients
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Bahia
Substance Use Disorders, Overdose
Smartphone Intervention for Overdose and COVID-19
This study will examine if the use of a smartphone application called Thrive4Life Connect can help people who use drugs lower their risk of overdose and learn more about COVID-19 vaccines.
- Conditions
- Substance Use Disorders, Overdose, COVID-19
- Trial name
- NCT05518461
- Testing
- iThrive WI Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Prescription Medication Understanding
Enhanced Prescription Drug Label to Improve Patient Understanding and Use
The overall objective of this study is to test the efficacy of an evidence-based, enhanced Rx container label design to improve patients' understanding of instructions for use.
- Trial name
- NCT00973180
- Testing
- Enhanced Label
- Where
- United States
- Volunteers
- 850 people
- Sponsor
- Northwestern University
Myocardial Infarction
Cardiovascular Medication Use Before First Myocardial Infarction
Large randomised trials have shown that cardiovascular medications prescribed to patients at high cardiovascular risk are effective in reducing the incidence of cardiovascular events.
- Trial name
- NCT01692795
- Where
- United Kingdom
- Volunteers
- 17,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Naloxone
Increasing Naloxone Access for Persons Who Use Opioids
Deaths relating to opioid overdose have rapidly increased over the past two decades. Due to the serious public health concern of the opioid epidemic, federal agencies recommend employing various harm reduction interventions.
- Trial name
- NCT04303000
- Testing
- Opioid Overdose Education with Naloxone Distribution, Opioid Overdose Education
- Where
- 4 sites in United States
- Volunteers
- 111 people
- Sponsor
- University of Alabama at Birmingham
Opioid-Related Disorders, Hepatitis C (HCV)
Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk
This study will test the effectiveness, implementation outcomes, and cost effectiveness of a locally-tailored, health kiosk to reduce overdose, hepatitis C, and HIV risk behavior and improve linkage to care in rural Appalachia.
- Conditions
- Opioid-Related Disorders, Hepatitis C (HCV), Human Immunodeficiency Virus (HIV), Drug Overdose
- Trial name
- NCT05657106
- Testing
- Health kiosk
- Where
- United States
- Volunteers
- 752 people, healthy volunteers welcome
- Sponsor
- April M Young
Drug Overdose
Pharmacokinetics and Pharmacodynamics of a New Formulation of Nasal Naloxone for Prehospital Use
Overdose with potential deadly outcome is a serious problem among opioid abusers, not least in Norway. The annual death toll from overdose is about 250, higher than road traffic accidents.
- Trial name
- OPI-14-001 (NCT02307721)
- Testing
- Intranasal naloxone, Intramuscular naloxone, Remifentanil
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Opioid Use Disorder, Bereavement
Community and Familial Impacts of the Opioid Crisis
This study aims to analyze the needs of those who have lost a loved one to opioid-related death and/or those currently supporting a loved one in treatment for Opioid Use Disorder.
- Conditions
- Opioid Use Disorder, Bereavement, Overdose of Opiate
- Trial name
- NCT05116852
- Testing
- Survey
- Where
- United States
- Volunteers
- 578 people
- Sponsor
- Cambridge Health Alliance
Opioid Use Disorder, Overdose
Pharmacist-Led Interventions to Increase Access to Medications for Opioid Use Disorders (PLI-MOUD)
The purpose of this study is to investigate the impact of a pharmacist-led intervention to expand access to medications for opioid use disorder (MOUD) on racial/ethnic differences in opioid-related overdose among individuals…
- Trial name
- PLI-MOUD (NCT05776823)
- Testing
- Pharmacist Narcan Training, BIRT, SMC
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- University of Arkansas
Accidental Overdose of Opiate
Rapid Self-Testing to Prevent Fentanyl Overdose Among Young People Who Use Drugs
The research team will enroll 100 young adults who use cocaine, heroin, inject drugs, or purchase prescription medications on the illicit market in a pilot study to be known as the Rhode Island Young Adult Prescription and…
- Trial name
- RAPiDS2 (NCT03373825)
- Testing
- Take home rapid drug test
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Brown University
Prescription Drug Abuse, Substance Abuse
A High School Program for Preventing Prescription Drug Misuse
This project will develop and evaluate a program to prevent prescription drug misuse in high school students
- Conditions
- Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
- Trial name
- NCT03219190
- Testing
- LST High School Hybrid
- Where
- United States
- Volunteers
- 1,804 people, healthy volunteers welcome
- Sponsor
- National Health Promotion Associates, Inc.
Opioid-Use Disorder (OUD)
SafetyNet Program for Opioid Use Disorder (OUD)
The principal aim of this study is to determine whether a novel biopsychosocial intervention following opioid overdose (OD) affects 1) the frequency of secondary opioid OD events and 2) the proportion of individuals who remain…
- Trial name
- NCT04253782
- Testing
- Team Intervention
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Yale University
Health-Related Quality-of-Life, Social Capital
Cocreating Action to Improve Rationality in the Health System
Despite widespread recognition of social, economic, or environmental health determinants, health action remains heavily dominated by individual-level solutions (e.g., medication, patient counselling, vaccination).
- Conditions
- Health-Related Quality-of-Life, Social Capital, Health Literacy, Community Based Participatory Research
- Trial name
- CAIR (NCT07237971)
- Testing
- Cocreation process
- Where
- 2 sites in Spain
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Infectious Diseases, Metabolic Diseases
Drug Utilization Prevalence in a Pediatric Care Medical Center
One year prospective analysis of drug utilization and prescription point prevalence of medications in a pediatric tertiary care university medical center.
- Conditions
- Infectious Diseases, Metabolic Diseases, Cancer
- Trial name
- NCT00550706
- Where
- Israel
- Volunteers
- 567 people
- Sponsor
- Rambam Health Care Campus
Overdose, Opioid Use Disorder
Community-based Education, Navigation, and Support Intervention for Military Veterans
Military veterans in the U.S. represent one of the populations most disproportionately impacted by the current opioid crisis. Veterans who use opioids and are not connected to the VA healthcare system have high rates of…
- Conditions
- Overdose, Opioid Use Disorder, HIV Infections
- Trial name
- CENS (NCT05343169)
- Testing
- Overdose Education and Naloxone Distribution, Advanced Education in Safer Substance Use, Treatment, and Self-Care, Social Service and Health Navigation
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- New York University
Opioid Use Disorder, Opioid Use
Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data
The study is a quasi-experimental investigation of a sub-acute stabilization center (SASC) for people who have had or are at risk for having an opioid overdose and have an encounter with Seattle Fire Department emergency medical…
- Trial name
- NCT06768814
- Testing
- Sub-acute stabilization
- Where
- United States
- Volunteers
- 40,000 people
- Sponsor
- University of Washington
Inflammation, Gastroesophageal Reflux
Trial to Assess the Effectiveness of Educational Outreach in Prescription Guidelines
Background: The Portuguese National Health Directorate has issued clinical practice guidelines on prescription of anti-inflammatory drugs and COX-2 inhibitors, acid suppressive therapy and proton pump inhibitors, and…
- Conditions
- Inflammation, Gastroesophageal Reflux, Gastrointestinal Diseases, Cardiovascular Diseases
- Trial name
- TEP (NCT01984034)
- Testing
- Educational Outreach Visits, Passive Dissemination
- Where
- Portugal
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Opioid Use
Safely Disposing of Surplus Prescription Opioids
This study evaluates two interventions intended to increase the safe disposal of leftover prescription opioids, compared to no intervention.
- Trial name
- DISPOSE (NCT03855241)
- Testing
- Informational Sheet, DisposeRx Drug Disposal kit
- Where
- United States
- Volunteers
- 499 people
- Sponsor
- Johns Hopkins University
Cardiovascular Diseases
Implementation of a Pharmacy-Intervention to Enhance Prescription and Use of Lipid-Lowering Drugs
The purpose of this study is to determine the effectiveness of maximal support of community pharmacies to implement a pharmaceutical care model for improving underprescription and treatment persistence regarding lipid-lowering…
- Trial name
- NCT00509717
- Testing
- intensive implementation programme, control
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Radboud University Medical Center
Opioid Use, Pain, Musculoskeletal
Naloxone Education in Total Joint Patients
This study examines the efficacy of a brief pre-hospital naloxone education module added to the standard "Total Joint Class" curriculum on patient safety and experience.
- Conditions
- Opioid Use, Pain, Musculoskeletal, Surgery, Overdose of Opiate
- Trial name
- NCT04868552
- Testing
- Pre-hospital naloxone education
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Carilion Clinic