Clinical trials: Uterine Cervical Dysplasia
Cervical Intraepithelial Neoplasia
TMTP1-ICG Mapping in Colposcopy-directed Biopsy
Investigators aimed to determine the validity of the novel tumor targeted fluorescent TMTP1-ICG to increased accuracy of colposcopy-directed biopsy.
- Trial name
- NCT03321461
- Testing
- TMTP1, ICG
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huazhong University of Science and Technology
Human Papillomavirus (HPV), HPV Associated Cancers
C2001P-CS3: Testing the Feasibility of Different HPV Screening and Care Strategies for Women Living With HIV
The overall goal of this study is to inform the design and establish feasibility for a future clinical trial to determine the optimal management of women living with HIV (WLWH) with high-risk human papillomavirus (hrHPV) detected…
- Conditions
- Human Papillomavirus (HPV), HPV Associated Cancers, Cervical Cancer, Human Immunodeficiency Virus (HIV)
- Trial name
- NCT07576842
- Testing
- HPV DNA Testing (Abbott Alinity m HPV Assay), Visual Inspection with Acetic Acid, Cervical Histology (Biopsy Procedures)
- Where
- Botswana
- Volunteers
- 750 people
- Sponsor
- University of California, San Diego
Cervical Intraepithelial Neoplasia
Study of SOR007 Ointment for Cervical Intraepithelial Neoplasia (CIN)
This is a Phase 2, open-label, dose-rising study evaluating the safety, tolerability, and preliminary efficacy of three concentrations of SOR007 ointment (0.15%, 1.0%, and 2.0%) applied topically once per week for four weeks to…
- Trial name
- NCT03143491
- Testing
- SOR007 (Uncoated Nanoparticulate Paclitaxel) Ointment
- Sponsor
- DFB Soria, LLC
Herpes Genitalis, Genital Wart
Safety and Efficacy of Laser Therapy in Gynaecology
The aim of this study is to retrospectively evaluate the effectiveness and safety of Er:YAG laser for treatment of different gynecological indication, e.g.
- Conditions
- Herpes Genitalis, Genital Wart, Lichen Sclerosus, Cervical Intraepithelial Neoplasia
- Trial name
- NCT04073082
- Where
- Slovenia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Juna d.o.o.
Human Papilloma Virus, Cervical Cancer
Prevaccination Study of Cervical Human Papillomavirus Types in Yangtze River Delta Area, China
Human papilloma virus (HPV) infection contributes as a main causative factor to the development of invasive cervical cancer (ICC) and its precursors (cervical intraepithelial neoplasia, CIN).
- Conditions
- Human Papilloma Virus, Cervical Cancer, Cervical Intraepithelial Neoplasia
- Trial name
- NCT01487681
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Xing Xie, MD
Cervical Intraepithelial Neoplasia, HPV Infection
Effect of HPV Integration on Prognosis of Young Women With CIN2 in China
Clinically, cervical precancerous lesion is one of the important diseases that endanger the life safety and fertility of young women.
- Conditions
- Cervical Intraepithelial Neoplasia, HPV Infection, Virus Integration, HSIL, High Grade Squamous Intraepithelial Lesions
- Trial name
- NCT05282095
- Testing
- Follow up
- Where
- 20 sites in China
- Volunteers
- 300 people
- Sponsor
- Fujian Maternity and Child Health Hospital
Uterine Cervical Dysplasia
Music and Colposcopy in Women With Cervical Dysplasia.
To assess the effect of music during colposcopy on women´s anxiety.
- Trial name
- NCT03005795
- Testing
- Headphones, No Headphones
- Where
- 2 sites in Germany
- Volunteers
- 205 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Cervical Cancer Screening
Comparing Effectiveness of Physician-assisted Versus Self-assisted Pap Smear Collection
This purpose of this research study is to determine the effectiveness of the Personal Pap Smear Device™ to collect adequate cervical cell samples for cytology examination when compared with the Rover Cervex-Brush…
- Trial name
- NCT06229275
- Testing
- Pap smear collection using the Personal Pap Smear (PPS) Device, Active Comparator: Pap smear collection using the Rovers Cervex-Brush
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Cervical Intraepithelial Neoplasia, Cervix Neoplasm
Comparing Two Techniques of Haemostasis After Cervical Conization
The LEEP conization is commonly used for cervical pathologies treatment. The techniques for hemostasis usually used are: cautery, Monsel's solution and vaginal pack.
- Trial name
- NCT03293628
- Testing
- Vaginal Packing
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Barretos Cancer Hospital
Cervical Cancer
Spectroscopy Versus Standard Care in Cervical Cancer Patients
Primary objectives 1. To conduct a randomized clinical trial of the emerging technology fluorescence and reflectance spectroscopy, comparing colposcopy to colposcopy + spectroscopy in the diagnostic setting, stratifying patients…
- Trial name
- NCT00529464
- Testing
- Fluorescence Spectroscopy, Colposcopy, LEEP Procedure
- Where
- 3 sites in United States, Canada
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer, Precancerous Condition
Gene Expression Profiling of Cervical Cancer Progression in Biopsies and Tissue Samples
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- SAGE (NCT00629577)
- Testing
- microarray analysis, flow cytometry, biopsy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- British Columbia Cancer Agency
Cervical Intraepithelial Neoplasia (CIN)
Trial23 - A Method Study on Cervical Screening in Women Offered HPV-vaccination as Girls
In Denmark, the first birth cohorts of women offered HPV-vaccination as girls are entering the cervical screening program. These women are expected to be better protected against cervical cancer.
- Trial name
- NCT03049553
- Testing
- Cobas HPV-DNA test
- Where
- Denmark
- Volunteers
- 7,000 people
- Sponsor
- University of Copenhagen
Cervical Cancer, Cervical Intraepithelial Neoplasia
DNA PAX1 and JAM3 Methylation for Cervical Cancer Screening
Based on the previous study of NCT03961191 and NCT03960879, we performed this trial to further confirm the accuracy of host DNA PAX1 and JAM3 methylation for cervical cancer screening.
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasia, DNA Methylation, Cancer Screening
- Trial name
- NCT05290428
- Testing
- DNA methylation testing
- Where
- China
- Volunteers
- 459 people
- Sponsor
- Peking Union Medical College Hospital
Cancer of the Cervix, Cervical Intraepithelial Neoplasia
Compass - Randomised Controlled Trial of Primary HPV Testing for Cervical Screening in Australia
Compass is a randomised controlled trial of primary HPV testing for cervical cancer screening in Australia. A pilot study involving 5,000 women was carried out in 2013-2014.
- Trial name
- Compass (NCT02328872)
- Testing
- Molecular testing for HPV, Liquid Based Cytology
- Where
- Australia
- Volunteers
- 76,181 people, healthy volunteers welcome
- Sponsor
- VCS Foundation
Human Papilloma Virus, Vaginal Flora Imbalance
Vaginal Microbiome and HPV Pre-malignant and Cervical Dysplasia
In this study, the investigators will prospectively collect, analyze and integrate information regarding vaginal microbiome composition and HPV presence in women with cervical pathologies (high-grade CIN and CC) and controls, to…
- Conditions
- Human Papilloma Virus, Vaginal Flora Imbalance, Cancer Cervix Uterus, Cervical Dysplasia
- Trial name
- NCT05640700
- Where
- Israel
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Uterine Cervical Dysplasia
Hemostatic Procedure After Biopsy of the Cervix
Cytological abnormalities of the Cervix uteri need to be clarified by colposcopy biopsy. To avoid bleeding after biopsy, monsel´s paste is a common used Agent.
- Trial name
- NCT02486471
- Testing
- Monsel´s Paste, Wait and see
- Where
- 2 sites in Germany
- Volunteers
- 166 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Urothelial Carcinoma, Melanoma
SAbR Induced Innate Immunity in Urothelial Carcinoma, Melanoma, and Cervical Carcinoma
The study is an exploratory prospective, single center study with correlative endpoints. The study will investigate the association of tumor cGAS STING signaling with SAbR.
- Conditions
- Urothelial Carcinoma, Melanoma, Cervical Carcinoma in Situ
- Trial name
- NCT02986867
- Testing
- SAbR Treatment of Lesions
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Texas Southwestern Medical Center
Cervical Intraepithelial Neoplasia Grade 2/3
Validation of Human Papillomavirus Assays and Collection Devices for Self-samples and Urine Samples
The VALHUDES study is a Diagnostic Test Accuracy study that aims to document the clinical accuracy of hrHPV testing on urine samples, collected under standardised and optimised conditions, and on two types of vaginal self-samples…
- Trial name
- VALHUDES (NCT03064087)
- Testing
- Colli-Pee, Multi-Collect Swab, Evalyn Brush
- Where
- 5 sites in Belgium
- Volunteers
- 500 people
- Sponsor
- Marc Arbyn
Cervical Cancer, Precancerous Condition
Imiquimod in Preventing Cervical Cancer in Women With Cervical Neoplasia
RATIONALE: Chemoprevention therapy is the use of certain substances to try to prevent the development of cancer. Applying topical imiquimod before abnormal cervical cells are removed may be effective in preventing cervical…
- Trial name
- NCT00031759
- Testing
- imiquimod, Ablative or excisional therapy
- Where
- 8 sites in United States
- Volunteers
- 57 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Uterine Cervical Neoplasms, HIV/AIDS
Screening Test Accuracy of Gynocular™, HR-HPV Testing, VIA for Detection of Cervical Neoplastic Lesions, in Women Living With HIV
Cervical cancer in HIV-positive women is largely preventable through regular screening. The World Health Organization (WHO) recommends cervical screening for HIV-positive women every three years.
- Trial name
- NCT03931083
- Testing
- Screening for CIN2+/HSIL
- Where
- Zambia
- Volunteers
- 450 people
- Sponsor
- University of Bern