Clinical trials: Uterine Contraction
Healthy, Pregnant Women
Comparative Performance of INVU™ Versus Intrauterine Pressure Catheter (IUPC) in Uterine Contractions Monitoring of Pregnant Women.
The primary objective of this research is to assess the agreement between INVU™ and IUPC (the gold standard) during prenatal monitoring of uterine contractions and to assess the safety of INVU™.
- Trial name
- NCT03889405
- Testing
- INVU™, IUPC, TOCO
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nuvo-Group, Ltd.
Postpartum Hemorrhage
Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study
The goal of this study is to learn about how medication that is used to help treat low blood pressure during a Cesarean delivery (CD) can cause changes to the uterine muscle tissue and its ability to contract, in patients with…
- Trial name
- NCT06285396
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Where
- Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium
Poor uterine tone after the birth of a baby may cause serious bleeding (called postpartum hemorrhage or PPH). This is a major cause of maternal death worldwide. In the developed world the cesarean section rate is increasing.
- Trial name
- NCT03852797
- Testing
- Oxytocin, Ketamine, Propofol
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
Recovery of Oxytocin Responsiveness in Pregnant Human Myometrial Explants After Oxytocin-Induced Desensitization
Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide and is caused most commonly by poor uterine muscle tone after delivery.
- Trial name
- NCT02051231
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
The Relaxant Effect of Nitroglycerin on Oxytocin Desensitized Human Myometrium
Oxytocin causes myometrial contraction via the oxytocin receptor (OTR). Desensitization of the OTR after exposure to oxytocin has been demonstrated in previous studies.
- Trial name
- NCT03408054
- Testing
- Oxytocin, Nitroglycerin
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Cervical Assessment, Focal Myometrial Contractions
Focal Myometrial Contractions: Impact on Cervical Assessment and Association With Voiding
Focal myometrial (uterine) contractions occur in a substantial number of vaginal ultrasound examinations and can impede accurate cervical length measurement and placental location determination.
- Trial name
- NCT01513395
- Testing
- Interval bladder emptying
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Uterine Contraction, Pregnancy
Comparative Study of the Propagation of Uterine Electrical Activity (EHG) in Pregnant Women During Pregnancy and During Labour
The original aspect of the methodology proposed for this study concerns the use of as many as 16 electrodes to study the propagation and coordination (or synchronization) of uterine contraction.
- Conditions
- Uterine Contraction, Pregnancy, Delivery, Obstetric
- Trial name
- PropEHG (NCT02814344)
- Testing
- Electrohysterography
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens