Clinical trials: Uterine Disease
Menorrhagia
The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders
Many women have heavy periods and this can be associated with low blood, tiredness and inability to carry out normal activities. Approximately 10-30% of these women will have an underlying bleeding disorder.
- Trial name
- NCT00904709
- Testing
- tranexamic acid
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- K. Sue Robinson
Heavy Menstrual Bleeding
Quality of Life in Premenopausal Women With Heavy Menstrual Bleeding
Heavy menstrual bleeding or menorrhagia, is a common problem on women's lives and can burden both patients and health care systems. HMB is defined as cyclic heavy vaginal bleeding.
- Trial name
- NCT03368898
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Heavy Menstrual Bleeding, Menorrhagia
Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids
This is a randomized controlled trial (RCT) to assess the comparative effectiveness of Levonorgestrel Intrauterine System (LNG-IUS) to Tranexamic Acid (TA) for the treatment of heavy menstrual bleeding (HMB) in women with…
- Conditions
- Heavy Menstrual Bleeding, Menorrhagia, Uterine Fibroids
- Trial name
- NCT03317795
- Testing
- Levonorgestrel IUS, Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Shannon K. Laughlin-Tommaso
Cervical Cancer
A Clinical Study to Explore the Efficacy and Safety of Tislelizumab in Combination With Bevacizumab and Chemotherapy in Patients With Persistent, Recurrent, or Metastatic Cervical Cancer
Efficacy and safety of Tislelizumab combined with Bevacizumab and chemotherapy in patients with persistent, recurrent or metastatic cervical cancer.
- Trial name
- NCT05247619
- Testing
- Tislelizumab / Bevacizumab/Paclitaxel/Cisplatin/Carboplatin
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Zhejiang Cancer Hospital
Cervical Cancer
Delivery, Uptake and Acceptability of HPV Vaccination in Tanzanian Girls
The aims of this study are: 1. To determine feasibility of a school-based human papillomavirus (HPV) vaccination programme in Tanzania. 2.
- Trial name
- NCT01173900
- Testing
- Gardasil® HPV vaccine
- Where
- Tanzania
- Volunteers
- 5,532 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Ovarian Cancer, Endometrial Cancer
An Exploratory Study of Detection of Endometrial and Ovarian Cancers in Vaginal Samples Retrieved by the Ellele Sampling Device
An exploratory study of early detection and investigation of gynaecological diseases Throughout a woman's life, she may need tests that can feel uncomfortable, such as a smear test or a biopsy taken through the vagina.
- Trial name
- NCT07429799
- Testing
- Ellele Sampling Device
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ellele Health
Cervical Cancer, Cervical Intraepithelial Neoplasia
Study on Novel Strategies for Cervical Cancer Screening Using Photoelectric Detection and Epigenetic Procotol
A national multicenter, open randomized controlled study was conducted. It is planned to invite 30 multi-center units across the country to compete for enrollment, and each multi-center will enroll 140 patients meeting…
- Trial name
- CC-AZ (NCT06866392)
- Testing
- photoelectric detection
- Volunteers
- 4,200 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Cancer, Precancerous Condition
Vaccine Therapy With or Without Imiquimod in Treating Patients With Grade 3 Cervical Intraepithelial Neoplasia
RATIONALE: Vaccines made from DNA or a gene-modified virus may help the body build an effective immune response to kill tumor cells.
- Conditions
- Cervical Cancer, Precancerous Condition, HPV Disease, Human Papilomavirus
- Trial name
- NCT00788164
- Testing
- TA-HPV, pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine, imiquimod
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Endometrial Cancer
Evaluation of Outcomes in Women Undergoing Multimodality Treatment for Advanced Stage Endometrial Carcinoma
Patients with FIGO stage III endometrial carcinoma often require multimodality adjuvant therapy to improve survival and recurrence rates; however, the optimal adjuvant therapy sequence is yet to be established.
- Trial name
- NCT04743999
- Testing
- Quality of life questionnaire
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Postpartum Hemorrhage
Management of the Third Stage of Labor
To compare the efficacy of three different protocols of third stage management in preventing PPH.
- Trial name
- NCT02319707
- Testing
- Oxytocin, Oxytocin in 100 ml NaCl 0.9%
- Volunteers
- 500 people
- Sponsor
- Yariv yogev
Delivery Delayed, Mode of Delivery
Early Versus Delayed Oxytocin Infusion Following Amniotomy in Nulliparous Women
In UKM Medical Centre (UKMMC), delayed oxytocin augmentation at two hours following amniotomy is the routine obstetric practice in spontaneous or induced labour with intact membranes.
- Conditions
- Delivery Delayed, Mode of Delivery, Post Partum Hemorrhage, Uterine Hyperstimulation
- Trial name
- NCT04200599
- Testing
- duration of initiation of oxytocin
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Intrauterine Growth Restriction
Intra Uterine Growth Restriction
Intrauterine growth restriction (IUGR) is associated with an increase in perinatal mortality and morbidity, as well as longer-term neurological, cognitive, cardiovascular and endocrine complications.
- Trial name
- IUGR (NCT03866863)
- Testing
- Intrauterine growth restriction (IUGR)
- Where
- France
- Volunteers
- 31,052 people
- Sponsor
- Hospices Civils de Lyon
Cervical Cancer
Comparison of Cervical Cancer Screening Tests in HIV-infected Women in Lusaka, Zambia
This study will compare the test performance characteristics of visual inspection with acetic acid (VIA), Xpert HPV, and OncoE6 in HIV-infected women, to inform the possible inclusion of these molecular tests in future cervical…
- Trial name
- NCT02688816
- Testing
- Xpert HPV, OncoE6
- Where
- Zambia
- Volunteers
- 200 people
- Sponsor
- Carla Chibwesha, MD
Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors.
- Conditions
- Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck, HER2 Negative Breast Neoplasms, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT04389632
- Testing
- sigvotatug vedotin, pembrolizumab, cisplatin
- Where
- 158 sites in United States, France and 5 more
- Volunteers
- 1,006 people
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
Uterine Cavity, Conservative Management
Endometrial Cavity After Conservative Management of PAS Patients by Hysteroscopy
This study aimed to evaluate the endometrial cavity by hysteroscopy after different conservative management of placenta accrete spectrum (PAS), that has impact on the future fertility outcome and menstrual pattern of patients.
- Conditions
- Uterine Cavity, Conservative Management, Placenta Accreta
- Trial name
- NCT07662187
- Testing
- Resection and reconstruction, Cervical eversion and pouch closure, Anterior and posterior sutures
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Adenomyosis, Mifepristone
Long-term Use of Mifepristone in the Treatment of Adenomyosis
The design was a prospective, randomized, positive-control, parallel-group, multicenter clinical trial. The study included a randomized, parallel-group treatment for 24 weeks in 140 subjects from eight hospitals in seven cities…
- Trial name
- LUOMITTOA (NCT05151016)
- Testing
- mifepristone, Triptorelin Acetate
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Endometrial Cancer
From Fetal-maternal Interface Immune Tolerance to Endometrial Cancer Immune Escape: Potential Targets for Immunotherapy
Non-interventional retro-prospective study on Endometrial tissue samples taken from surgically treated patients.
- Trial name
- NCT06273878
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Regina Elena Cancer Institute
Ovarian Cancer, Endometrial Cancer
Weekly Paclitaxel/Carboplatin With Neupogen in Gynaecological Cancers
Rationale: The administration of prophylactic G-CSF may reduce the toxicity of a weekly paclitaxel/carboplatin regimen in gynaecological cancers.
- Conditions
- Ovarian Cancer, Endometrial Cancer, Uterine Cervical Cancer
- Trial name
- NCT01523678
- Testing
- Filgrastim, Paclitaxel, Carboplatin
- Where
- 17 sites in Belgium
- Volunteers
- 108 people
- Sponsor
- Belgian Gynaecological Oncology Group
Migraines, Bleeding
Prevention of Menstrual Migraines: Using Frovatriptan or Placebo During Hormone Free Intervals
This study will examine the combined effects of a continuous oral contraceptive (OC) regimen with supplemental frovatriptan therapy on headache severity and occurrence in subjects with documented Menstrually Associated Migraines…
- Conditions
- Migraines, Bleeding, Spotting
- Trial name
- MAM (NCT00700128)
- Testing
- frovatriptan
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Scott and White Hospital & Clinic
Colorectal Cancer, Bladder Cancer
Feasibility Testing of Patient Reported Outcomes - Informed Symptom Management System (PRISMS)
This is a proof-of-concept pilot randomized clinical trial to test the feasibility of the innovative Patient-Reported Outcomes-Informed Symptom Management System (PRISMS) to enhance personalized supportive care for cancer…
- Conditions
- Colorectal Cancer, Bladder Cancer, Ovarian Cancer, Cervical Cancer
- Trial name
- PRISMS (NCT04492007)
- Testing
- Patient-Reported Outcomes-Informed Symptom Management System (PRISMS)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
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