Clinical trials: Uterine Disease
Uterine Fibroids
Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 4)
The primary objective of this study was to show superiority of vilaprisan in the treatment of heavy menstrual bleeding (HMB) in subjects with uterine fibroids compared to placebo The secondary objectives of this study were to…
- Trial name
- NCT03400956
- Testing
- Vilaprisan (BAY1002670)
- Where
- 87 sites in United States, Czechia and 3 more
- Volunteers
- 103 people
- Sponsor
- Bayer
HPV Infection
Global Burden Estimation of Human Papillomavirus (GLOBE-HPV)
This study is a multi-country and multi-site project to estimate the point-prevalence of high-risk (HR) HPV genotype infections among representative samples of girls and women aged 9-50 years, and among specific sub-populations…
- Trial name
- HPV (NCT06129253)
- Testing
- Urine Sample Collection, Self-collected Vaginal Swab, Blood Samples
- Where
- 8 sites in Bangladesh, Democratic Republic of the Congo and 6 more
- Volunteers
- 29,750 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Endometritis, Vaginal Cleansing
Vaginal Cleansing With Chlorhexidine Versus Iodine for Prevention of Endometritis
Povidone has been approved for vaginal cleansing in the prevention of endometritis postcaesarean section. chlorhexidine solution which is cheap and readily available as shown to prevent endometritis.The aim of this study is to…
- Conditions
- Endometritis, Vaginal Cleansing, Post Caesarean
- Trial name
- NCT06936475
- Testing
- Povidone-Iodine, Chlorhexidine Gluconate
- Where
- Nigeria
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Federal Teaching Hospital Abakaliki
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Capecitabine in Treating Patients With Persistent or Recurrent Cervical Cancer
Phase II trial to study the effectiveness of capecitabine in treating patients who have persistent or recurrent cervical cancer.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Recurrent Cervical Carcinoma
- Trial name
- NCT00039442
- Testing
- Capecitabine, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Gynecologic Oncology Group
Levonorgestrel, Intrauterine Systems
Development of a Shared Decision Tool to Facilitate Uptake of the Levonorgestrel-releasing Intrauterine System for the Primary Prevention of Endometrial Cancer
To develop an educational tool to help patients and healthcare professionals make informed decisions about endometrial cancer and available prevention options for it (such as the use of a levonorgestrel-releasing intrauterine…
- Conditions
- Levonorgestrel, Intrauterine Systems, Prevention, Endometrial Cancer
- Trial name
- NCT07382583
- Testing
- Survey using a questionnaire
- Where
- 2 sites in United States
- Volunteers
- 270 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Carcinoma, Colon Carcinoma
Experimental PET Imaging Scans Before Cancer Surgery to Study the Amount of PET Tracer Accumulated in Normal and Cancer Tissues
This phase I trial studies a new imaging technique called FAPi PET/CT to determine where and to which degree the FAPI tracer (68Ga-FAPi-46) accumulate in normal and cancer tissues in patients with non-prostate cancer.
- Conditions
- Breast Carcinoma, Colon Carcinoma, Esophageal Carcinoma, Gastric Carcinoma
- Trial name
- NCT04147494
- Testing
- Computed Tomography, Gallium Ga 68 FAPi-46, Gallium Ga 68-labeled PSMA-11
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Twin; Complicating Pregnancy, Postpartum Hemorrhage
Prophylactic Methylergonovine for Twin Cesarean
Obstetrical hemorrhage (excessive bleeding related to pregnancy) is a leading cause of maternal morbidity (disease or symptom of disease) and mortality (death) worldwide with a significantly higher frequency and severity…
- Trial name
- NCT05772156
- Testing
- Methylergonovine
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Columbia University
Endometrial Cancer
Adaptive Daily MR-Guided Adjuvant Pelvic Therapy-Endometrial Cancer
To evaluate the safety, tolerability, and preliminary efficacy of moderately hypofractionated (15-fraction) MR-guided adaptive pelvic IMRT in patients with endometrial cancer.
- Trial name
- ADAPT-EC (NCT07643012)
- Testing
- MR-guided adaptive pelvic intensity-modulated radiation therapy (IMRT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rutgers, The State University of New Jersey
Advanced Solid Tumor, Lymphoma
Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy
Subjects who previously took part in the FT500-101 study and received allogeneic NK cell immunotherapy will take part in this long term follow-up study.
- Conditions
- Advanced Solid Tumor, Lymphoma, Gastric Cancer, Colorectal Cancer
- Trial name
- NCT04106167
- Testing
- Allogeneic natural killer (NK) cell
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Fate Therapeutics
Lung Cancer (Diagnosis), Osteochondroma
Clonal Hematopoiesis Chemotherapy and Radiation Effects Study
The goal of the Clonal Hematopoiesis Chemotherapy and Radiation Effects (CH CARE) Study is to understand how the presence or absence of clonal hematopoiesis (CH) influences outcomes in people receiving chemotherapy and radiation…
- Conditions
- Lung Cancer (Diagnosis), Osteochondroma, Spitz Nevus, Solid Cancers
- Trial name
- CH CARE (NCT07675967)
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Dana-Farber Cancer Institute
Vaginitis Bacterial, Cervicitis
Empiric Therapy of Mucopurulent Cervicitis (MPC)
Mucopurulent cervicitis (MPC) is a syndrome with associated symptoms including mucopurulent discharge (mucus and pus) from the cervix and other signs of inflammation such as easily induced cervical bleeding.
- Trial name
- NCT01072136
- Testing
- Azithromycin, Cefixime
- Where
- 4 sites in United States
- Volunteers
- 87 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cervical Cancer
Efficacy of Chemotherapy Alone in Patients With Poor-differentiated Early-stage Cervical Cancer
This study is aimed to enroll patients with early-stage cervical cancer (FIGO 2018 IB1-IB2) who undergo radical hysterectomy and the postoperative pathology doesn't meet Sedlis criteria or the "four-factor" model but with poorly…
- Trial name
- NCT05863377
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Preterm Birth Complication, Preterm Birth
Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities
The goal of this clinical trial is to learn if a personalized prenatal support program [(Personalized Toolkit Building a Comprehensive Approach to Resource optimization and Empowerment in Pregnancy \& Beyond, (PTBCARE+)] works to…
- Conditions
- Preterm Birth Complication, Preterm Birth, Preterm Birth Recurrence, Preeclampsia
- Trial name
- PTBCARE+ (NCT06915428)
- Testing
- Care coordination, Electronic massage, support gift #1
- Where
- United States
- Volunteers
- 1,228 people
- Sponsor
- University of North Carolina, Chapel Hill
Ovarian Cancer
The Exploration of Personalized ctDNA Based MRD in the Clinical Significance of Cervical Cancer
This study plans to enroll 80 patients with locally advanced cervical cancer (stage IB-ⅣA) confirmed by histology or cytology (according to the 2018 FIGO staging standard), who are expected to receive surgical resection or…
- Trial name
- NCT06283875
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Geneplus-Beijing Co. Ltd.
Abnormal Uterine Bleeding
Management of Abnormal Uterine Bleeding
Abnormal uterine bleeding "AUB" describes all abnormal forms of menstrual bleeding which may result from several causes including anovulation, problems related to pregnancy, infections, vaginal and cervical abnormalities, uterine…
- Trial name
- NCT06369012
- Testing
- Mefenamic acid 500 mg
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Egymedicalpedia
Uterine Fibroids, Adenomyosis
Effect of Addition of Steroids on Duration of Analgesia
The purpose of the study is to investigate the differences in post-procedural pain scores and narcotic use among patients who receive a Superior Hypogastric Nerve Block (SHNB) with and without corticosteroid performed as part of…
- Trial name
- NCT04126824
- Testing
- Triamcinolone, Bupivacaine, Iohexol contrast
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cervical Intraepithelial Neoplasia
A Study of VGX-3100 DNA Vaccine With Electroporation in Patients With Cervical Intraepithelial Neoplasia Grade 2/3 or 3
This is randomized, placebo controlled study to determine safety and efficacy of VGX-3100 DNA Vaccine delivered by Electroporation to adult women with biopsy-proven HPV 16 or 18 associated Cervical intraepithelial neoplasia grade…
- Trial name
- HPV-003 (NCT01304524)
- Testing
- VGX 3100, CELLECTRA™-5P
- Where
- 43 sites in United States, Australia and 7 more
- Volunteers
- 167 people
- Sponsor
- Inovio Pharmaceuticals
Uterine Atony, Hypotension
Oxytocin And Uterotonic Agent Use For Cesarean Delivery
The central objective of this study will be to evaluate a standardized, evidence-based regimen versus a conventional regimen for uterotonic drug dosing for elective cesarean delivery The investigators primary hypothesis is that…
- Trial name
- NCT01549223
- Testing
- Oxytocin Infusion, Oxytocin Bolus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus
Stellate Ganglion Block and Dexmedetomidine for Postoperative Sleep in Women Undergoing Laparoscopic Gynecologic Surgery
Study Objectives This study aims to investigate the effects of preoperative stellate ganglion block and intraoperative intravenous dexmedetomidine on postoperative sleep disturbance in patients undergoing laparoscopic gynecologic…
- Conditions
- Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus, Endometriosis, Endometrial Cancer
- Trial name
- NCT07860203
- Testing
- DEX 0.2 μg/kg/h., SGB
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Catherin Zhang
Cervical Cancer Treated with Pelvic Radiotherapy, Cervical Cancers
Establishment and Validation of Prediction Model of Simultaneous Chemoradiotherapy for Cervical Cancer Organoids
This is a single-arm, single-center, open-label, Phase II study aimed at assessing the efficacy of organoids in predicting the response to radiotherapy and chemotherapy in cervical cancer
- Trial name
- ECCO (NCT06786780)
- Testing
- Drug: Cisplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chongqing University Cancer Hospital
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