Clinical trials: Uterine Diseases
Endometrial Cancer
Postoperative Hypofractionated Intensity-modulated Radiotherapy Endometrial Cancer
To investigate the non-inferiority of disease-free survival in women who received hypofractionated intensity-modulated whole pelvic radiation therapy (2.5 Gy x 16 fractions) after curative surgery for stage III endometrial cancer.
- Trial name
- NCT05876130
- Testing
- POHIM_EM
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Samsung Medical Center
Intra-uterine Device Placement
Weighted Blankets for IUD Insertion
When having an intrauterine device placed in an outpatient clinic, patients frequently feel anxiety related to the procedure. This study is designed to determine if the use of a small, weighted blanket, placed over the patient's…
- Trial name
- NCT06969365
- Testing
- 10-pound weighted lap-pad, blanket
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Saint Luke's Health System
Uterine Cervical Neoplasms
Exclusion of Non-involved Uterus From the Target Volume in Locally Advanced Cervical Cancer
Both toxicity and local relapse are major concerns in the treatment of locally advanced cervical cancer. The purpose of this study is to ameliorate both by integrating modern imaging (diffusion weighted magnetic resonance…
- Trial name
- EXIT (NCT03542942)
- Testing
- treatment with EXIT-target volume
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Ghent
Anti-Mullerian Hormone Deficiency, Post Partum Hemorrhage
Anti-Mullerian Hormone (AMH) is a Marker for Ovarian Reserve. There Are Many Studies About AMH Changes in Ovarian Surgery, But Little is Known for Other Surgeries. We Seek to Investigate the Hormone Variations Before and After Uterine Artey Ligation for Postpartum Hemorrage (PPH)
Anti-Mullerian hormone (AMH) is a marker for ovarian reserve. There are many studies about AMH changes in ovarian surgery, but little is known for other surgeries.
- Trial name
- NCT03907605
- Testing
- anti- mullerian hormone
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Cervical Cancer
The Association of G9a Protein and the Outcome of Patients With Cervical Cancer
G9a protein was approved to be highly associated with recurrence of breast cancer, gastric cancer, hepatocellular cancer, prostate cancer and lung cancer.
- Trial name
- NCT01505751
- Where
- Taiwan
- Volunteers
- 69 people
- Sponsor
- Far Eastern Memorial Hospital
Endometrial Cancer
Ketohexokinase Isoforms in Endometrial Cancer.
Our preliminary analysis with clinical database suggested that, in patients with type I endometrial cancer, high ketohexokinase-expressing group have lower survival probabilities than low ketohexokinase-expressing group.
- Trial name
- NCT03931265
- Testing
- ketohexokinase
- Where
- Taiwan
- Volunteers
- 220 people
- Sponsor
- Far Eastern Memorial Hospital
Cervical Cancer
Spatially Fractionated Radiation Therapy for Locally Advanced Cervical Cancer
This randomized clinical trial will evaluate whether adding spatially fractionated radiation therapy (SFRT) to definitive chemoradiotherapy improves outcomes in patients with locally advanced cervical cancer.
- Trial name
- SFRT-LACC (NCT07781475)
- Testing
- Spatially Fractionated Radiation Therapy, standard of care
- Where
- China
- Volunteers
- 126 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Postpartum Hemorrhage
The Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Caesarean Section
This study seeks to determine if the using tranexamic acid prophylactically at caesarean section will prevent postpartum haemorrhage which is a major cause of maternal mortality in Zimbabwe and globally.
- Trial name
- ETAPPH (NCT04733157)
- Testing
- Tranexamic acid injection
- Where
- 2 sites in Zimbabwe
- Volunteers
- 1,226 people
- Sponsor
- University of Zimbabwe
Postmenopausal Women, Intrauterine Diseases
Office Hysteroscopy in Postmenopausal Women: A Randomized Trial of Cervical Preparation Strategies
The goal of this randomized controlled trial is to evaluate the effectiveness of different cervical preparation strategies before office hysteroscopy in postmenopausal women undergoing evaluation for intrauterine pathology.
- Conditions
- Postmenopausal Women, Intrauterine Diseases, Endometrial Pathology, Postmenopausal Bleeding
- Trial name
- NCT07697781
- Testing
- No Cervical Preparation, Misoprostol ( Cytotec) 200 microgram a tablet, Vaginal Estrogen (7-Day Regimen)
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Faculty of Medicine of Tunis
Non-small Cell Lung Cancer, Gastric Carcinoma
A Safety Study of SEA-TGT (SGN-TGT) in Advanced Cancer
This trial will look at a drug called SEA-TGT (also known as SGN-TGT) to find out whether it is safe for patients with solid tumors and lymphomas. It will study SEA-TGT to find out what its side effects are.
- Conditions
- Non-small Cell Lung Cancer, Gastric Carcinoma, Gastroesophageal Junction Carcinoma, Classical Hodgkin Lymphoma
- Trial name
- NCT04254107
- Testing
- SEA-TGT, sasanlimab, brentuximab vedotin
- Where
- 36 sites in United States, Canada and 4 more
- Volunteers
- 133 people
- Sponsor
- Seagen Inc.
Cesarean Delivery, Postpartum Hemorrhage (PPH)
Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery
The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo.
- Conditions
- Cesarean Delivery, Postpartum Hemorrhage (PPH), Intraoperative Blood Loss, Hemostasis
- Trial name
- NCT07362992
- Testing
- Tranexamic Acid (Topical)
- Where
- 4 sites in Israel
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Preterm Birth, Cervical Insufficiency
Nordic Randomized Trial on Laparoscopic Versus Vaginal Cerclage
Every year 15 million babies are born prematurely, which can lead to death or life-long disabilities. It is often caused by a dysfunction of the uterine cervix, which constitutes the narrow channel between the vagina and womb.
- Trial name
- NORACT (NCT06122506)
- Testing
- Laparoscopic cerclage, Vaginal cerclage
- Where
- 2 sites in Denmark
- Volunteers
- 188 people
- Sponsor
- University of Aarhus
Uterine Cervical Neoplasms
The Biomarker Analysis in Locally Advanced Cervical Cancer
Sonic hedgehog (Shh) signaling, including Gli1, is critical to treatment resistance. For optimizing cervical cancer treatment, the pathological prognostic factors determine whether to administer adjuvant therapy.
- Trial name
- NCT03635216
- Where
- Taiwan
- Volunteers
- 62 people
- Sponsor
- Mackay Memorial Hospital
Head and Neck Cancer, Gynecologic Cancer
Quality of Life Assessment of Radiotherapy in Recurrent Head and Neck Cancer
The purpose of this study is to examine the uses of a mobile health-based assessment and symptom monitoring platform.
- Conditions
- Head and Neck Cancer, Gynecologic Cancer, Cervical Cancer, Endometrial Cancer
- Trial name
- NCT05850663
- Testing
- Ecologic Momentary Assessment (EMA)
- Sponsor
- University of Oklahoma
Solid Tumors, Triple Negative Breast Cancer (TNBC)
A Study of ADRX-0706 in Select Advanced Solid Tumors
The primary purpose of this study is to assess the safety, tolerability, and pharmacokinetics, and to identify the optimal dose of ADRX-0706 in patients with select advanced solid tumors.
- Conditions
- Solid Tumors, Triple Negative Breast Cancer (TNBC), Urothelial Cancer, Cervical Cancer
- Trial name
- NCT06036121
- Testing
- ADRX-0706
- Where
- 21 sites in United States, China
- Volunteers
- 144 people
- Sponsor
- Adcentrx Therapeutics
Preterm Birth
Preventing Preterm Birth With a Pessary
The primary objective of this study, is to determine the effect of a Cup pessary, a device that is currently readily available in the USA and similar in design to the Arabin pessary, on the incidence of delivery prior to 37 weeks…
- Trial name
- PrePPy (NCT01380158)
- Testing
- Cup pessary (Bioteque America, Inc)
- Where
- 3 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Uterine Bleeding, Treatment Failures
Clinical Predictive Factors of Success of Hysteroscopic Endometrial Ablation/Resection
To determine the predictive factors of endometrial ablation failure in the management of uterine bleeding.
- Conditions
- Uterine Bleeding, Treatment Failures, Prognostic Factors
- Trial name
- NCT05483348
- Testing
- Endometrial Ablation, Repeated gynecological procedure
- Where
- Jordan
- Volunteers
- 95 people
- Sponsor
- Naser Al-Husban
Endometrial Cancer, Postmenopausal Bleeding
Patient's Experience and Choice Between Investigations for Endometrial Cancer in Postmenopausal Bleeding
Endometrial cancer is the most common malignancy of the female genital tract in Hong Kong. The aim in the evaluation of PMB is to exclude underlying malignancy.
- Trial name
- NCT03330015
- Where
- Hong Kong
- Volunteers
- 206 people
- Sponsor
- Chinese University of Hong Kong
Advanced Solid Tumors
A Study of INCB099280 in Combination With Axitinib in Adults With Advanced Solid Tumors
This study is being conducted to evaluate the safety and tolerability of INCB099280 in combination with axitinib and to assess the antitumor activity of INCB099280 in combination with axitinib.
- Trial name
- NCT05949632
- Testing
- INCB099280, axitinib
- Where
- 6 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- Incyte Corporation
Cervical Cancer
CINtec PLUS Triage in HPV Primary Screening
Prospective study which will recruit participants when they attend for a routine cervical screening. The study will evaluate the use of CINtec PLUS for triage of human papillomavirus (HPV) positive participants in HPV primary…
- Trial name
- NCT03721484
- Testing
- CINtec PLUS
- Where
- United Kingdom
- Volunteers
- 9,800 people, healthy volunteers welcome
- Sponsor
- Western Health and Social Care Trust
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