Clinical trials: Uterine Diseases
Cervical Cancer, Endometrial Cancer
Intra-Operative Lymphatic Mapping in Patients With Invasive Carcinoma of the Cervix or Endometrial Carcinoma
The purpose of this study is to learn if a surgical technique called intraoperative lymphatic mapping can accurately identify the lymph node that is at greatest risk if endometrial or cervical cancer spreads to the lymph nodes.
- Conditions
- Cervical Cancer, Endometrial Cancer, Cervical Carcinoma
- Trial name
- NCT00595725
- Testing
- Lymphatic Mapping
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Endometrial Polyp., Malignant and Pre-malignant Changes in the Polyp
Incidence of Malignant and Premalignant Endometrial Polyp in Asymptomatic and Symptomatic Postmenopausal Women
The prevalence of endometrial polyp is 24% in the general population but is much higher in postmenopausal women. The incidence of malignant or pre-malignant findings in endometrial polyps ranges from 2 to 10% in menopausal women.
- Trial name
- NCT01203176
- Testing
- Hysteroscopic polypectomy
- Where
- Israel
- Volunteers
- 1,400 people
- Sponsor
- Arie Lissak, MD
Cervical Cancer, Acquired Immunodeficiency Syndrome
Cisplatin and Radiation Therapy in Treating Patients With HIV-Associated Locally Advanced Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01590017
- Testing
- cisplatin, external beam radiation therapy
- Where
- 2 sites in South Africa, Zimbabwe
- Volunteers
- 41 people
- Sponsor
- AIDS Malignancy Consortium
Endometriosis, Ovarian Cyst
PerClot Compared to Usual Care in Gynaecology Procedures
This study is a post market, multi-centre, randomised study evaluating PerClot compared to usual care. PerClot is a CE marked device and is currently used as a haemostat in gynaecological surgery throughout Europe.
- Conditions
- Endometriosis, Ovarian Cyst, Menorrhagia, Cancer
- Trial name
- NCT02835391
- Testing
- PerClot, Floseal, Surgicel, Surgiflo, Arista, Electrocautery/Diatermy
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- CryoLife Europa
Cervical Cancer
Cervical Carcinoma in Shatby University Hospital and Its Relation to Human Papilloma Virus
incidence of detection of carcinogenic types of human papilloma virus in 60 cases of cervical cancer
- Trial name
- NCT05539274
- Testing
- human papilloma virus testing and genotyping in cervical cancer cases
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Hossam Hassan Aly Hassan El Sokkary
Postpartum Hemorrhage, Tranexamic Acid
Tranexamic Acid in the Prevention of Postpartum Hemorrhage in Elective Caesarean Section
In obstetrics, postpartum haemorrhage (PPH) continues to be a major contributor to maternal morbidity and mortality worldwide. Uterine atony is the most common cause of PPH, and the prophylactic use of uterotonics, specifically…
- Trial name
- NCT04427618
- Testing
- Tranexamic acid, Normal saline
- Where
- Singapore
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Vaginal Bleeding, Uterine Cramping
Anticipatory Counseling on LNG-IUS Continuation, Utilization and Satisfaction
This study is a counseling intervention for new LNG-IUS users. The study explores the use of video technology to deliver anticipatory counseling on LNG-IUS side-effects, adjustment periods and bleeding changes to women newly…
- Trial name
- ACCCUSS (NCT02752282)
- Testing
- Anticipatory Counseling, Cancer Screening Guidelines
- Where
- 3 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of Washington
Advanced or Recurrent Endometrial Cancer
Efficacy Study of Chemotherapy to Treat Advanced or Recurrent Endometrial Cancer
The purpose of this study is to treat advanced or recurrent endometrial cancer, paclitaxel-containing regimen is the preferred chemotherapeutic regimen which is selected by most physicians.
- Trial name
- NCT01461759
- Testing
- Doctaxel, Cisplatin
- Where
- South Korea
- Volunteers
- 59 people
- Sponsor
- Asan Medical Center
Hypofractionated Radiotherapy, Intensity-modulated Radiotherapy
Adjuvant Moderately Hypofractionated Intensity-modulated Radiotherapy for Cervical Cancer
To investigate the safety and efficacy of moderately hypofractionated intensity-modulated radiotherapy in the treatment of postoperative cervical cancer
- Conditions
- Hypofractionated Radiotherapy, Intensity-modulated Radiotherapy, Cervical Cancers
- Trial name
- NCT07684508
- Testing
- Postoperative Radiotherapy
- Where
- 2 sites in China
- Volunteers
- 154 people
- Sponsor
- Manni Huang
Ovarian Neoplasms, Endometriosis
Acupuncture for Women's Health Conditions
The purpose of this study is to evaluate the safety and effectiveness of acupuncture in treating women's health conditions.
- Conditions
- Ovarian Neoplasms, Endometriosis, Pelvic Pain, Uterine Neoplasms
- Trial name
- NCT00090389
- Testing
- Chinese Acupuncture
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Cervical Carcinoma, Human Papillomavirus-Related Carcinoma
Prevention and Early Detection of Cervical Cancer Through Self-Administered Screening
This study examines prevention and early detection of cervical cancer through self-administration screening of patients in Western Uganda.
- Trial name
- NCT04927650
- Testing
- HPV testing, Questionnaire Administration
- Where
- Uganda
- Volunteers
- 2,556 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cervical Cancer, Cervical Precancer
Adherence to Preventive Care for Cervical Cancer
In the United States, the highest incidence of cervical cancer occurs in inner city urban centers, rural areas, the deep South, Appalachia and the U.S.-Mexico border.
- Conditions
- Cervical Cancer, Cervical Precancer, Adherence
- Trial name
- Adh-NYC-EP (NCT02406391)
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Brookdale University Hospital Medical Center
Endometrial Neoplasms, Ovarian Neoplasms
STELLA Trial: Transperitoneal vs. Extraperitoneal Approach for Laparoscopic Staging of Endometrial/Ovarian Cancer
The purpose of this study is to determine whether the extraperitoneal approach is better than the transperitoneal approach for laparoscopic aortic lymphadenectomy for the surgical staging of endometrial or ovarian cancer.
- Trial name
- STELLA (NCT01810874)
- Testing
- Transperitoneal laparoscopic aortic lymphadenectomy, Extraperitoneal laparoscopic aortic lymphadenectomy
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Advanced Malignancies, Metastatic Cancer
Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies
The purpose of this study is to determine the safety, tolerability, and efficacy of INCAGN01876 when given in combination with immune therapies in subjects with advanced or metastatic malignancies.
- Trial name
- NCT03126110
- Testing
- INCAGN01876, Nivolumab, Ipilimumab
- Where
- 38 sites in United States, Australia and 2 more
- Volunteers
- 145 people
- Sponsor
- Incyte Biosciences International Sàrl
Cervical Cancer
Altered Tumor Oxygenation by Metformin, a Potential Step in Overcoming Radiotherapy Resistance in LACC
Poor tumor oxygenation (hypoxia) is an established negative prognostic and predictive factor in locally advanced cervical cancer (LACC). Hypoxia-modifying measures implemented in the clinic are lacking.
- Trial name
- METOXY-LACC (NCT04275713)
- Testing
- Metformin, Cisplatin
- Where
- Norway
- Volunteers
- 41 people
- Sponsor
- Oslo University Hospital
Cervical Cancer, Cervical Intraepithelial Neoplasia Grade 2
Photodynamic Therapy Using Lutetium Texaphyrin in Treating Patients With Cervical Intraepithelial Neoplasia
Phase I trial to study the effectiveness of photodynamic therapy with lutetium texaphyrin in treating patients who have cervical intraepithelial neoplasia.
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasia Grade 2, Cervical Intraepithelial Neoplasia Grade 3
- Trial name
- NCT00005808
- Testing
- motexafin lutetium, photodynamic therapy, loop electrosurgical excision procedure
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer
Serplulimab for Locally Advanced Cervical Cancer
This study is a randomized, controlled, open-label, phase II clinical trial designed to enroll patients with previously untreated locally advanced cervical cancer.
- Trial name
- NCT07340489
- Testing
- Serplulimab, radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Cervical Cancer
Blood and Urine HPVDNA as Minimally Invasive Biomarkers for Cervical Cancer Detection and Surveillance Following Treatment
The purpose of this study is to determine if ctHPVDNA (circulating tumor HPV DNA) can be used as a non-invasive biomarker for identification and treatment monitoring of cervical cancer by characterizing correlation between plasma…
- Trial name
- NCT04743674
- Where
- 2 sites in United States, Malawi
- Volunteers
- 30 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Menorrhagia
Prevalence of Heavy Menstrual Bleeding in Female Population Living in Beijing
The purpose of the study is to estimate the prevalence of heavy menstrual bleeding (HMB) in females aged between 18 and 50 years old living in Bejing.
- Trial name
- NCT02304510
- Where
- China
- Volunteers
- 2,455 people
- Sponsor
- Peking University
Von Willebrand Disease (VWD), Heavy Menstrual Bleeding (HMB)
HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB
The purpose of this study is to evaluate the safety, tolerability, efficacy, and pharmacodynamics (PD) of multiple doses of ALN-6400 in adult and adolescent patients with VWD and HMB
- Trial name
- HMBeacon (NCT07575308)
- Testing
- ALN-6400
- Where
- 21 sites in United States, Netherlands and 3 more
- Volunteers
- 24 people
- Sponsor
- Alnylam Pharmaceuticals
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