Clinical trials: Uterine Hemorrhage
Von Willebrand Disease, Menorrhagia
The Effect of the Nutraceutical "Hemofix" on the Coagulation System
Hemofix is a herbal formula based on traditional Jewish and far eastern medicine created to assist in wound healing and bleeding arrest. It contains herbs such as Red Clover, Liquorice, Raspberry, Ginger and more.
- Trial name
- NCT01651468
- Testing
- HEMOFIX
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Post Partum Hemorrhage
Prevention of Postpartum Hemorrhage With Tranexamic Acid
In part 1 of the study, the investigators conducted a prospective, open-label, dose finding pharmacokinetic (PK) study in 43 pregnant 3rd trimester women scheduled for non-emergent cesarean section.
- Trial name
- Optimum OB-TXA (NCT05370820)
- Testing
- Tranexamic acid, No intervention
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Vaginal Bleeding, Uterine Cramping
Anticipatory Counseling on LNG-IUS Continuation, Utilization and Satisfaction
This study is a counseling intervention for new LNG-IUS users. The study explores the use of video technology to deliver anticipatory counseling on LNG-IUS side-effects, adjustment periods and bleeding changes to women newly…
- Trial name
- ACCCUSS (NCT02752282)
- Testing
- Anticipatory Counseling, Cancer Screening Guidelines
- Where
- 3 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of Washington
Heavy Menstrual Bleeding
IUB SEAD RED (Revolutionary Endometrial Ablation Device Study
One of the AUB symptoms, heavy menstrual bleeding (HMB), can lead to iron deficiency and iron deficiency anemia and in acute and severe cases, can necessitate emergency medical care.
- Trial name
- HMB (NCT04959396)
- Testing
- IUB SEAD
- Where
- 9 sites in Georgia, Israel
- Volunteers
- 30 people
- Sponsor
- Ocon Medical Ltd.
Leiomyoma, Uterine Fibroids
Safety and Effectiveness Study of RF Ablation of Uterine Fibroids to Reduce Menstrual Bleeding: the Fibroid Ablation Study
The primary objective of this study is to test the hypothesis that a minimum 75% volume radiofrequency ablation of fibroids associated with menorrhagia results in reduction of menstrual bleeding.
- Conditions
- Leiomyoma, Uterine Fibroids, Menorrhagia
- Trial name
- FAST (NCT00768742)
- Testing
- VizAblate Intrauterine Ultrasound-Guided RF Ablation
- Where
- 3 sites in Canada
- Sponsor
- Gynesonics
Menorrhagia, Dysmenorrhea
Menorrhagia, Dysmenorrhea and Iron Deficiency Among Young Women Soldiers and Effect on Activity
As combat women soldiers are required to more intensive daily activity the investigators believe that the impact of menorrhagia, dysmenorrhea and its clinical consequence (as characterized by, anemia iron deficiency and reduced…
- Conditions
- Menorrhagia, Dysmenorrhea, Iron Deficiency Anemia
- Trial name
- NCT02685501
- Testing
- no intervention
- Where
- 2 sites in Israel
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Postpartum Hemorrhage, Delivery Complication
Trends in the Administration of Tranexamic Acid for Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the global leading cause of maternal death, with 20-30% of maternal deaths in Thailand linked to hemorrhage.
- Conditions
- Postpartum Hemorrhage, Delivery Complication, Cesarean Section Complications, Perinatal Problems
- Trial name
- NCT07278037
- Testing
- Tranexamic acid
- Where
- Thailand
- Volunteers
- 648 people
- Sponsor
- Mahidol University
Heavy Menstrual Bleeding, Uterine Fibroids
A Study to Assess Patient-Reported Quality of Life and Effectiveness on Control of Bleeding in Adult Participants With Heavy Menstrual Bleeding Due to Uterine Fibroids Taking Oral Oriahnn Capsules
Uterine Fibroids (UF) are noncancerous (benign) tumors that commonly occur in up to 80% of women of reproductive age. Symptoms can include heavy menstrual bleeding (HMB), low back pain, urinary frequency and urgency…
- Trial name
- REACH (NCT05026502)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- AbbVie
Heavy Menstrual Bleeding, Menorrhagia
Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids
This is a randomized controlled trial (RCT) to assess the comparative effectiveness of Levonorgestrel Intrauterine System (LNG-IUS) to Tranexamic Acid (TA) for the treatment of heavy menstrual bleeding (HMB) in women with…
- Conditions
- Heavy Menstrual Bleeding, Menorrhagia, Uterine Fibroids
- Trial name
- NCT03317795
- Testing
- Levonorgestrel IUS, Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Shannon K. Laughlin-Tommaso
Post Partum Hemorrhage
Recombinant Factor VII for Intractable Postpartum Haemorrhage
Postpartum haemorrhage remains at the top of the causes of maternal deaths in both developed and developing countries .
- Trial name
- NCT05298826
- Testing
- recombinant factor VIIa
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Aljazeera Hospital
Infertility Unexplained, Abnormal Uterine Bleeding
Diagnostics of Chronic Endometritis in Infertility
Chronic endometritis (CE) is characterized by the presence of atypical plasma cell infiltrates (CD138 positive) in the endometrial stroma.
- Conditions
- Infertility Unexplained, Abnormal Uterine Bleeding, Intrauterine Disorder
- Trial name
- NCT05946655
- Testing
- Ofloxacin + Metronidazole
- Where
- Poland
- Volunteers
- 102 people
- Sponsor
- Jagiellonian University
Uterine Leiomyoma, Uterine Fibroid
ABSOLUTELY: A Temporary Uterine Blood Supply Occlusion for Laparoscopic Myomectomy in Patients With UTErine LeiomYoma
A phase 3 multicenter unblinded randomized controlled trial comparing the temporary uterine blood supply occlusion with conventional approach during laparoscopic myomectomy in patients with uterine leiomyoma.
- Conditions
- Uterine Leiomyoma, Uterine Fibroid, Leiomyoma, Uterine, Myoma;Uterus
- Trial name
- NCT04519593
- Testing
- Laparoscopic myomectomy with prior temporary uterine blood supply occlusion, Conventional laparoscopic myomectomy
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Mother and Child Clinic Saint-Petersburg
Post Partum Haemorrhage
Improving Management of Post-partum Haemorrhage With Quantra® System
Post partum haemorrhage is a concerning situation in maternity wards, though it is not the first cause of maternal mortality anymore.
- Trial name
- Quantralab (NCT05336838)
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Abnormal Uterine Bleeding
Comparison Efficiency of Oral Etoricoxib Versus Intravenous Fentanyl on Post Operative Pain in Curettage Under TIVA
Comparison of the efficiency of oral Etoricoxib versus intravenous Fentanyl on post operative Pain in curettage under TIVA: A randomized controlled trial
- Trial name
- NCT03697733
- Testing
- fractional curettage
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Blood Loss, Surgical
Ergot and Oxytocin During Cesarean Delivery Following Failure to Progress in Labour
Despite of marked improvements in clinical management, early postpartum hemorrhage(PPH)remains a significant contributor to maternal morbidity and mortality both in developing countries and in hospitals equipped with all that…
- Trial name
- NCT00481533
- Testing
- Methyl-Ergonovine-Oxytocin, Oxytocin
- Where
- Canada
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
Investigating the Effect of Pulsatile Administration of Oxytocin on the Desensitization of Human Myometrium In-vitro
Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide and is caused most commonly by poor uterine muscle (myometrium) tone after delivery.
- Trial name
- NCT02338089
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Leiomyoma, Laparoscopy
Combined Vaginal Misoprostol and Perivascular Vasopressin
Injection of Vasopressin into the uterine tissue surrounding fibroids constricts blood vessels, and has been found to be beneficial by decreasing blood flow to fibroids, and thereby resulting in less bleeding with removal.
- Conditions
- Leiomyoma, Laparoscopy, Uterine Myomectomy
- Trial name
- NCT03815344
- Testing
- Standard, Standard-vaginal misoprostol
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Antonios Likourezos
Bleeding, Anemia
Carbetocin Versus Oxytocin and Ergometrine for the Prevention of Postpartum Haemorrhage Following Caesarean Section
The investigators compare the effectiveness and adverse effects of I.V carbetocin versus oxytocin \& ergometrine I.V for prevention of postpartum haemorrhage following cesarean section.
- Trial name
- NCT02101567
- Testing
- Pabal 100 mcg iv infusion over 1 minute given after delivery of fetal head, Oxytocin 5 IU iv infusion and Methtergine 0.2 mg iv
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
Postpartum Haemorrhage
PCC and Fibrinogen Compared With FFP in PPH
The purpose of the study is to find out if the regimen of prothrombin complex concentrate (PCC) together with fibrinogen concentrate is as efficient as fresh frozen plasma (FFP) (plus fibrinogen if needed) during the early stages…
- Trial name
- NCT01910675
- Testing
- PCC, FFP
- Where
- Finland
- Sponsor
- Helsinki University Central Hospital
Postpartum Bleeding, Oxytocin
Comparing Intra-Umbilical Versus Intravenous Oxytocin in Women During the Third Stage of Labor for Reducing Blood Loss
The goal of this clinical trial is to determine whether giving oxytocin through the umbilical cord is more effective than giving it through a vein in reducing blood loss during the third stage of labor.
- Conditions
- Postpartum Bleeding, Oxytocin, Third Stage of Labour
- Trial name
- NCT07566455
- Testing
- Oxytocin after delivery, Intraumbilical oxytocin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- CMH Multan Institute of Medical Sciences