Clinical trials: Uterine Leiomyomas
Uterine Fibroid, Pregnancy Complications
Pregnancy Outcomes Following Myomectomy
The most prevalent genital pathology, uterine fibroids have a detrimental impact on the health of women. Fibroid symptoms are typically more impactful on females and frequently require uterine excision.
- Conditions
- Uterine Fibroid, Pregnancy Complications, Reproductive Issues, Reproductive Sterility
- Trial name
- NCT06474065
- Testing
- Myomectomy
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centro di Ricerca Clinica Salentino
Uterine Fibroids, Endometriosis
Pharmacokinetics and Safety of Vilaprisan in Renal Impairment
The purpose of the study is to evaluate the pharmacokinetics of vilaprisan in subjects with moderate to severe renal impairment compared with matched subjects with normal renal function.
- Trial name
- NCT03411980
- Testing
- Vilaprisan (BAY1002670)
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Bayer
Uterine Leiomyomata (Fibroids)
Study Evaluating PRA-027 Multiple Ascending Doses In Cycling And Postmenopausal Women
This is the first multiple-dose study in humans with PRA-027. This study will provide an assessment of the safety, tolerability, pharmacokinetics (how the drug is absorbed, metabolized and excreted by the body) and…
- Trial name
- NCT00543790
- Testing
- PRA-027
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Uterine Fibroids, Adenomyosis
Ovarian Reserve Modification After Lps Hysterectomy With Bilateral Salpingectomy
The aim of this RCT of study is to compare the standard TLH with adnexal preservation with TLH plus prophylactic bilateral salpingectomy (PBS) in terms of ovarian reserve and surgical outcomes
- Conditions
- Uterine Fibroids, Adenomyosis, Pelvic Pain, Pelvic Prolapse
- Trial name
- NCT02086344
- Testing
- PBS, TLH _adnexal preservation
- Where
- Italy
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Leiomyoma, Uterine, Intraoperative Blood Loss
Intravenous Tranexamic Acid and Intramyometrial Desmopressin Effect on Blood Loss During Laparoscopic Myomectomy.
To evaluate the effect of intravenous tranexamic acid plus intramyometrial desmopressin administration on perioperative blood loss and blood transfusion need in laparoscopic myomectomy operation.
- Trial name
- NCT05517590
- Testing
- Tranexamic acid, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Fibroids
Endometrial and Myometrial Changes, With and Without Fibroids
fibroids are common among women in fertile age. the relation between fibroids and infertility is controversial. our goal is to claculate a ratio between uterine cavity - endometrium \& myometrium in normal uterine s and study the…
- Trial name
- NCT01671215
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Meir Medical Center
Leiomyoma (Uterine Fibroids)
Impact of Uterine Leiomyoma Location on Uterine Artery Doppler Velocimetry
Aim: Investigation of the impact of uterine leiomyoma location on uterine artery velocimetry Materials and Methods: It is a single-center prospective cohort study.
- Trial name
- ULLADS (NCT07186257)
- Where
- Turkey (Türkiye)
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Endometriosis of the Cul-de-sac, Chocolate Cyst of Ovary
Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions
Full conditioning of the peritoneal cavity during laparoscopic surgery will decrease post-operative pain, inflammation and adhesion formation.
- Conditions
- Endometriosis of the Cul-de-sac, Chocolate Cyst of Ovary, Fibroid/Myoma (Uterus/Cervix)
- Trial name
- NCT01344486
- Testing
- full conditioning, standard pneumoperitoneum
- Where
- Belgium
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Menorrhagia, Dysfunctional Uterine Bleeding
Study of Conventional Laparoscopic Hysterectomy Versus Robot-Assisted Laparoscopic Hysterectomy at a Teaching Institution
Approximately 600,000 women undergo hysterectomy each year in the United States, of which 12% are laparoscopic. The most common indications for hysterectomy are: symptomatic uterine leiomyomas (40.7%), endometriosis (17.7%), and…
- Conditions
- Menorrhagia, Dysfunctional Uterine Bleeding, Leiomyoma, Pelvic Pain
- Trial name
- NCT01581905
- Testing
- Conventional Laparoscopic Hysterectomy (LH), Robot Assisted Hysterectomy
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Leiomyoma, Uterine, Leiomyosarcoma Uterus
Accuracy of the Preoperative Molecular Diagnosis of Uterine Tumors by Liquid Biopsy
The development of precise and non-invasive diagnostic methods is a priority in areas such as gynaecology and oncology, and above all in improving the health of those patients with a surgical indication for hysterectomy…
- Trial name
- MYOSARCII (NCT04935333)
- Testing
- Collection of Leiomyoma samples, Collection of Leiomyosarcoma samples, Collection of control samples
- Where
- 21 sites in Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Igenomix
Uterine Fibroids, Adenomyosis
Effect of Addition of Steroids on Duration of Analgesia
The purpose of the study is to investigate the differences in post-procedural pain scores and narcotic use among patients who receive a Superior Hypogastric Nerve Block (SHNB) with and without corticosteroid performed as part of…
- Trial name
- NCT04126824
- Testing
- Triamcinolone, Bupivacaine, Iohexol contrast
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Vitamin D Deficiency, Leiomyoma
Correlation Between Serum Vitamin D3 and Incidence of Uterine Leiomyoma
The aim of the current study is to evaluate the association between low serum vitamin D level and incidence of uterine leiomyoma in Egyptian women as the research hypothesis that low serum vitamin D is considered a risk factor…
- Trial name
- NCT05151393
- Testing
- Measuring vitamin D3 level
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Heavy Menstrual Bleeding
Effectiveness of Truclear on Patient Quality of Life
This study aims to evaluate the quality of life in patients treated for submucosal leiomyomas using the Truclear hysteroscopic morcellator compared to women managed medically.
- Trial name
- HSCMyomecty (NCT02934789)
- Testing
- Hysteroscopic myomectomy with Truclear, Medical therapy
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- All For Women Healthcare, Illinois
Leiomyoma, Laparoscopy
Combined Vaginal Misoprostol and Perivascular Vasopressin
Injection of Vasopressin into the uterine tissue surrounding fibroids constricts blood vessels, and has been found to be beneficial by decreasing blood flow to fibroids, and thereby resulting in less bleeding with removal.
- Conditions
- Leiomyoma, Laparoscopy, Uterine Myomectomy
- Trial name
- NCT03815344
- Testing
- Standard, Standard-vaginal misoprostol
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Antonios Likourezos
Uterine Fibroid
Life Study: Lifestyle Intervention in Fibroid Elimination
The study will evaluate a lifestyle, nutrition, and exercise program to assess whether this program is acceptable and feasible for patients..Researchers will examine if the LIFE program can modify fibroid recurrence.
- Trial name
- NCT05416424
- Testing
- LIFE program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Abnormal Uterine Bleeding, Uterine Bleeding
Outcomes on Abdominal Versus Vaginal Morcellation At Time of Hysterectomy
The purpose of the study is to investigate differences in perioperative and postoperative outcomes between the abdominal (AM) versus vaginal (VM) routes of contained morcellation in participants undergoing laparoscopic total…
- Conditions
- Abnormal Uterine Bleeding, Uterine Bleeding, Fibroid Uterus, Surgery
- Trial name
- NCT04434066
- Testing
- Total Laparoscopic Hysterectomy
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Blood Loss, Surgical, Uterine Myoma
Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy
A total of 200 women for elective abdominal myomectomy were randomly allocated into two groups. 100 women in experimental group were administered 400ug Misoprostol (2 tablets of Prosotec®) through the rectal route prior to…
- Trial name
- NCT05108597
- Testing
- Misoprostol
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital
Leiomyoma, Uterine, Thrombosis
Are Uterine Fibroids Pro-thrombotic?
This study will investigate whether the presence of uterine fibroids is independently associated with a laboratory defined pro-thrombotic phenotype. VTE is associated with significant mortality and morbidity.
- Trial name
- NCT05607602
- Testing
- Comparison of blood samples between the two groups
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Uterine Fibroids, Menorrhagia, Endometriosis
Study Comparing Conventional vs. Robotic-assisted Laparoscopic Hysterectomy
The purpose of this study is to compare two ways of performing laparoscopic hysterectomy - robotic-assisted vs. conventional laparoscopy.
- Trial name
- NCT00485355
- Testing
- conventional laparoscopic hysterectomy, robotic assisted laparoscopic hysterectomy
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Leiomyoma, Incontinence
Uterine Artery Embolization and Pelvic Floor Symptoms
The objective of this study is to determine whether women who are already receiving treatment for their fibroids (ie. UAE) demonstrate improvement in urinary symptoms and sexual dysfunction as well.
- Conditions
- Leiomyoma, Incontinence, Prolapse
- Trial name
- NCT00827645
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center