Clinical trials: Uterine Leiomyomata (Fibroids)
Leiomyoma, Uterine, Leiomyosarcoma Uterus
Accuracy of the Preoperative Molecular Diagnosis of Uterine Tumors by Liquid Biopsy
The development of precise and non-invasive diagnostic methods is a priority in areas such as gynaecology and oncology, and above all in improving the health of those patients with a surgical indication for hysterectomy…
- Trial name
- MYOSARCII (NCT04935333)
- Testing
- Collection of Leiomyoma samples, Collection of Leiomyosarcoma samples, Collection of control samples
- Where
- 21 sites in Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Igenomix
Uterine Myoma
Does Preventive Uterine Artery Occlusion During Laparoscopic Myomectomy Impact on Ovarian Reserve Markers?
Hysterectomy is an effective treatment used as a first-line approach for uterine myomas. Several others alternatives to hysterectomy have been developed in recent years for women wishing to retain their uterus: myomectomy…
- Trial name
- ORAM (NCT02563392)
- Testing
- uterine myomectomy with preventive uterine arteries occlusion, laparoscopic uterine myomectomy without preventive uterine arteries occlusion
- Where
- Switzerland
- Volunteers
- 58 people
- Sponsor
- University Hospital, Geneva
Uterine Fibroids, Menorrhagia
Uterine Artery Embolization for Symptomatic Fibroids
This study will evaluate the safety, efficacy , quality of life and patient satisfaction of uterine artery embolization for the treatment of symptomatic uterine fibroids.
- Conditions
- Uterine Fibroids, Menorrhagia, Adenomyosis
- Trial name
- NCT00354471
- Testing
- Uterine Artery Embolization
- Where
- Canada
- Sponsor
- University of Manitoba
Low Back Pain, Uterine Fibroids (UF)
Comparative Effects of Kegel Versus Clamshell Exercises on Low Back Pain in Women With Uterine Fibroids: A Randomized Clinical Trial
Uterine fibroids represent a significant health concern for many women of reproductive age. Common symptoms include a tilted pelvis, heavy menstrual bleeding, and lower back pain (LBP).
- Trial name
- NCT07094633
- Testing
- Kegel Exercise Group, Clamshell Exercise Group
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Faisalabad
Uterine Myoma
Surgical Outcome of Two-port Laparoscopic Myomectomy
Study Objective: To evaluate the surgical outcome of laparoendoscopic two-sites myomectomy (LETS-M) and compare the difference between an experienced surgeon and three trainees. Design: A retrospective study.
- Trial name
- NCT04279626
- Testing
- LETS-M
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- National Taiwan University Hospital
Uterine Fibroid
Implementation of Uterine Fibroid Option Grid Patient Decision Aids Across Five Organizational Settings
UPFRONT is a study that aims to use two implementation frameworks - the Consolidated Framework for Implementation Research and the Normalization Process Theory - to guide the implementation of a uterine fibroid patient decision…
- Trial name
- UPFRONT (NCT03985449)
- Testing
- Uterine Fibroid Option Grid encounter patient decision aid (text only), Uterine Fibroid Option Grid encounter patient decision aid (text + Pictures), Uterine Fibroid Option Grid encounter patient decision aid (online)
- Where
- United States
- Volunteers
- 748 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Female Infertility, Female Infertility Due to Ovulatory Disorder
Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility
The study will describe the effectiveness of ovarian stimulation in correlation with female infertility causes in a Lebanese population: a comparative study using 5 protocols of ovulation induction (treatment with "A"…
- Conditions
- Female Infertility, Female Infertility Due to Ovulatory Disorder, Premature Ovarian Failure, Polycystic Ovary Syndrome
- Trial name
- CS-EOSP-ICSI (NCT04071574)
- Testing
- Human Chorionic Gonadotropin (hCG), Gonadotropins, GNRH-A Triptorelin
- Where
- Lebanon
- Volunteers
- 200 people
- Sponsor
- Lebanese University
Uterine Myoma
GnRH Agonist Pretreatment in Hysteroscopic Myomectomy
The primary outcome of this study is to assess if the GnRHa administration before cold loop hysteroscopic myomectomy contributes to accomplish the treatment in only one surgical procedure.
- Trial name
- NCT01873378
- Testing
- Triptorelin 3.75 mg
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Birth Defects, Pregnancy
Uterine Fibroid Pregnancy Registry
The Uterine Fibroid Pregnancy Registry is a USA and European-based registry designed to monitor pregnancies in women with uterine fibroids in order to 1.
- Conditions
- Birth Defects, Pregnancy, Uterine Fibroids
- Trial name
- NCT00232713
- Volunteers
- 2,360 people
- Sponsor
- Syneos Health
Uterine Myoma
Barbed Suture in Single-port Laparoscopic Myomectomy
The aim of this study is to test our hypothesis that the use of unidirectional knotless barbed suture in single-port laparoscopic myomectomy could facilitate the suture of uterine wall defect after myoma enucleation as multi-port…
- Trial name
- NCT01984632
- Testing
- Single-port laparoscopic myomectomy, Multi-port laparoscopic myomectomy
- Where
- 4 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- CHA University
Uterine Fibroids, Heavy Menstrual Bleeding
An Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids
This is an extension study for women who have already received six months of treatment in the phase III clinical trial M12-815 (NCT02654054) or M12-817 (NCT02691494), and will evaluate the long-term efficacy and safety of…
- Trial name
- NCT02925494
- Testing
- Estradiol/Norethindrone Acetate, Elagolix
- Where
- 124 sites in United States, Canada and 1 more
- Volunteers
- 433 people
- Sponsor
- AbbVie
Fibroid Uterus
Utility of Liposomal Bupivacaine Transversus Abdominal Plane Block for Open Myomectomy
The study team will be randomizing patients presenting for open myomectomy to either received transversus abdominal plane blocks with either liposomal bupivacaine or standard bupivacaine.
- Trial name
- NCT04272086
- Testing
- Bupivacaine, Bupivacaine liposome, normal saline
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Myoma;Uterus
Safety & Efficacy of Non-Invasive Procedures Using Ultrasound-Guided HIFU 'Sonotrip V20' in Symptomatic Uterine Fibroids
This is a single-arm clinical trial evaluating the safety and efficacy of ultrasound-guided HIFU (Sonotrip V20) for symptomatic uterine fibroids. 57 cases will be enrolled at a Korean institution.
- Trial name
- NCT05972642
- Testing
- HIFU-treatment
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Leiomyoma
A Long-Term Safety Study of Asoprisnil in the Treatment of Uterine Fibroids.
This study was designed to determine the long-term safety of asoprisnil 10 mg in women with one or more uterine fibroids after an initial 12 weeks in study M99-144.
- Trial name
- NCT00156182
- Testing
- Asoprisnil
- Volunteers
- 38 people
- Sponsor
- Abbott
Uterine Leiomyomata (Fibroids)
Study Evaluating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PRA-027 in Japanese Postmenopausal Women
The primary purpose of this study is to assess the safety and tolerability of ascending, multiple, oral doses of PRA-027 in Japanese postmenopausal women.
- Trial name
- NCT00826436
- Where
- Japan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Myoma;Uterus, Surgery
Myomectomy Operation and Fundus Incision, Energy Modalities and Methods of Extraction
Myomectomy operation due to myoma uteri is an operation that can cause serious blood loss. For some anatomical reasons, fundal myomas were removed, while a group of investigators recommended the initiation of a longitudinal…
- Trial name
- NCT03901404
- Testing
- Myomectomy Operation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Uterine Myoma
Radio Frequency Ablation (RFA STUDY )
The aim of this study is to investigate the safety and feasibility of a radiofrequency (RF) system employing RFITT (CelonProSurge) probes for the ablative treatment of uterine fibroids.
- Trial name
- RFA (NCT02631278)
- Testing
- Intraoperative radiofrequency ablation
- Where
- 2 sites in Italy
- Volunteers
- 10 people
- Sponsor
- Catholic University of the Sacred Heart
Myoma;Uterus, Polyp Uterus
Paracervical Block Versus Transcervical Block in Outpatient Procedural Hysteroscopy
Hysteroscopy is a minimally invasive, diagnostic and therapeutic gynecological surgical technique and the gold standard in the study of the uterine cavity.
- Trial name
- NCT05967936
- Testing
- Bupivacaine Injection
- Where
- Canada
- Volunteers
- 242 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Heavy Menstrual Bleeding, Uterine Fibroid
LIBERTY 2: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids
The purpose of this study is to determine the benefit of relugolix 40 milligrams (mg) once a day co-administered with estradiol (E2) 1 mg and norethindrone acetate (NETA) 0.5 mg compared with placebo for 24 weeks on heavy…
- Trial name
- NCT03103087
- Testing
- Relugolix, Estradiol/norethindrone acetate
- Where
- 127 sites in United States, Belgium and 6 more
- Volunteers
- 382 people
- Sponsor
- Myovant Sciences GmbH
Uterine Fibroids
Evaluation of Safety, Pharmacokinetics, and Efficacy of Proellex Administered Vaginally in Women With Uterine Fibroids
To determine the safety, pharmacokinetics and efficacy of 4 doses (3, 6, 12, 24 mg) of Proellex in premenopausal women with uterine fibroids confirmed by ultrasound. Drug will be administered vaginally.
- Trial name
- NCT01451424
- Testing
- Proellex
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Repros Therapeutics Inc.