Clinical trials: Uterine Tone Disorders
Uterine Tone Disorders, Cesarean Section Complications
Durometer for Measuring Uterine Tone
This study will evaluate the use of a durometer to measure uterine tone in parturients undergoing cesarean delivery.
- Trial name
- NCT06284421
- Testing
- Shore durometer
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Post Partum Hemorrhage, Cesarean Section Complications
Oxytocin Pharmacokinetics and Pharmacodynamics
Oxytocin is the first-line drug to promote contraction of the uterus and prevent atony immediately after delivery. Nonetheless, unpredictable uterine atony refractory to oxytocin affects roughly 250,000 parturients annually in…
- Conditions
- Post Partum Hemorrhage, Cesarean Section Complications, Blood Loss
- Trial name
- NCT05488457
- Testing
- deuterated oxytocin (d5OT)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Post Partum Hemorrhage
Oxytocin in Cesarean Delivery
In this study the investigators hypothesize that infused combinations of oxytocin and ergometrine will exhibit fewer cardiac and neurological side effects than equipotent infusion of oxytocin alone.
- Trial name
- NCT01236482
- Testing
- Oxytocin versus oxytocin-ergometrine
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Hadassah Medical Organization
Pregnancy, Preeclampsia
The Impact of Pregnancy and Pregnancy-associated Hypertension on Human Uterine Myometrial Artery Reactivity
The investigators seek to describe the composition, architecture, and electrical conduction properties of the human uterine myometrial artery and their impact on vascular reactivity upon exposure to hypertensive stress.
- Conditions
- Pregnancy, Preeclampsia, Hypertension in Pregnancy
- Trial name
- NCT03888170
- Testing
- No intervention
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arizona
Adverse Effect of Oxytocic Drugs, Uterine Hemorrhage
Uterotonic Efficacy of Oxytocin 2.5 Versus 10 Units During Caesarean Section at Mulago Hospital
The purpose of the study was to determine whether 2.5 international units of oxytocin gives adequate uterine tone and is safe as compared to 10 international units of oxytocin following caesarean section delivery at Mulago…
- Conditions
- Adverse Effect of Oxytocic Drugs, Uterine Hemorrhage, Inappropriate Dose of Drug Administered
- Trial name
- NCT01726478
- Testing
- 2.5 units Oxytocin, 10 units Oxytocin
- Where
- Uganda
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Faculty of Medicine
Postpartum Hemorrhage (Primary)
Effect of Co-administration of Carbetocin and Calcium Chloride on Uterine Tone in Patients Undergoing Elective Cesarean Delivery
Postpartum hemorrhage (PPH) is a leading cause of maternal mortality, and its severity has been increasing globally, including in high-income countries.
- Trial name
- NCT07187544
- Testing
- Calcium Chloride, Carbetocin
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage, Uterine Atony
Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial
Background: Carbetocin is an established single-dose uterotonic agent for postpartum hemorrhage prophylaxis at elective cesarean delivery.
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Cesarean Section, Blood Loss, Surgical
- Trial name
- CARBOXY-RCT (NCT07636421)
- Testing
- Carbetocin, Oxytocin
- Where
- Saudi Arabia
- Volunteers
- 332 people
- Sponsor
- Mansoura University
Cesarean Section, Hypotension
Effect of Oxytocin Bolus Versus Slow Infusion on Haemodynamic Stability During Caesarean Section Under Spinal Anaesthesia
This study compares two standard ways of giving oxytocin (a medicine that helps the uterus contract) after the baby is born during a planned caesarean section performed under spinal anaesthesia.
- Conditions
- Cesarean Section, Hypotension, Postpartum Hemorrhage, Spinal Anesthesia
- Trial name
- NCT07784478
- Testing
- Oxytocin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Girls Medical College
Postpartum Hemorrhage, Uterine Atony
Exteriorization Versus In Situ Hysterotomy Repair During Cesarean: Effects on Uterine Tone
During standard cesarean deliveries, there are two ways that obstetricians repair the incision on the uterus (hysterotomy after delivery of the baby.
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Uterine Atony With Hemorrhage, Cesarean Section
- Trial name
- NCT07606846
- Testing
- Test Intervention: In Situ Repair, Comparator Intervention: Exteriorization
- Volunteers
- 60 people
- Sponsor
- Stanford University
Uterine Atony, Uterine Tone Disorders
Intravenous Versus Intramuscular Administration of Methylergonovine for Uterine Contraction in Cesarean Sections
Insufficient uterine tone resulting in atony can potentiate hemorrhage and adverse outcomes for the parturient. Oxytocin is the first pharmacologic agent used, followed by methylergonovine, carboprost, and misoprostol.
- Conditions
- Uterine Atony, Uterine Tone Disorders, Postpartum Hemorrhage
- Trial name
- NCT03303235
- Testing
- Methylergonovine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pregnancy Related
Effect of Using Virtual Glasses on Anxiety, Pain and Comfort During Uterine Tonus Assessment
This randomized controlled experimental study aimed to determine the effect of using virtual glasses during uterine tone assessment on anxiety, pain and comfort.
- Trial name
- Uterine Tone (NCT07545863)
- Testing
- Virtual reality (VR) glasses are used as a midwifery intervention to reduce anxiety, stress, comfort and pain by drawing the individual's attention in a different direction. VR glasses are a stress in
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Inonu University