Clinical trials: Uveitis, Anterior
Behcet Disease
Role of Regulatory B Cells in Behçet's Disease
There are limited data about the role of regulatory B cells in Behcet Disease. In this study we aimed to identify the proportions of total B lymphocytes and their regulatory subset in different Behcet Disease phenotype and…
- Trial name
- NCT04376411
- Testing
- Flow-cytometric assay, 2D Echocardiographic analysis, Two-Dimensional speckle tracking echocardiography
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Assiut University
Non-infectious Anterior Uveitis
A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis
This is a randomized, multi-center, investigator masked, comparator controlled study. The purpose of this study is to determine the efficacy and safety of NS2 in patients with non-infectious acute anterior uveitis.
- Trial name
- NCT02406209
- Testing
- NS2, Prednisolone acetate ophthalmic suspension (1%)
- Where
- 15 sites in United States
- Volunteers
- 45 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Uveitis
A Trial of the Efficacy and Safety of Izokibep in the Treatment of Non-anterior Uveitis
This is a multicenter, phase 2 trial to explore the efficacy and safety of Izokibep (ABY-035) in treating disease activity in patients with non-Infectious Intermediate, Posterior, Pan-Uveitis with significant disease activity at…
- Trial name
- LINNAEA (NCT04706741)
- Testing
- Izokibep, Prednisone/Prednisolone
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- ACELYRIN Inc.
Aneurysm, Behcet Syndrome, Vascular Type
Tocilizumab and Tofacitinib in the Treatment of Vascular Behçet's Syndrome
This project aims to evaluate the efficacy and safety of the combination of glucocorticoids with tocilizumab or tofacitinib, compared to the traditional combination of glucocorticoids with cyclophosphamide in the treatment of…
- Trial name
- NCT05845723
- Testing
- tocilizumab, tofacitinib, cyclophosphamide
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Peking Union Medical College Hospital
Metabolic Syndrome, Behcet Disease
Efficacy of Physical Activity Program in Metabolic-syndrome Females With Behcet Disease
metabolci syndrom is highly prevalent in behcet disorder females. usually physical activity is recommended to solve this problem
- Trial name
- NCT07702123
- Testing
- treadmill walking
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA)
Chinese Spondyloarthritis Inception Cohort (CESPIC)
The Chinese Spondyloarthritis Inception cohort (CESPIC) was started 2000 as a prospective, longitudinal, multicentre, nationwide study in China on patients with early SpA including ankylosing spondylitis (AS, also known as…
- Conditions
- Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA), Axial Psoriatic Arthritis (axPsA), Acute Anterior Uveitis (AAU)
- Trial name
- CESPIC (NCT05960864)
- Testing
- Celecoxib
- Volunteers
- 1,000 people
- Sponsor
- Southwest Hospital, China
Juvenile Idiopathic Arthritis Associated Uveitis, Uveitis, Anterior
Adalimumab Dose Adjustment for Pediatric Uveitis Treatment Trial
The goal of this clinical trial is to learn whether children and young adults with well-controlled juvenile idiopathic arthritis (JIA)-associated uveitis or chronic anterior uveitis can safely take adalimumab (or biosimilar)…
- Trial name
- ADAPT (NCT07699107)
- Testing
- Adalimumab/Biosimilar
- Where
- 18 sites in United States, Italy and 1 more
- Volunteers
- 160 people
- Sponsor
- Nisha Acharya
Anterior Uveitis
Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti
Background: Uveitis is an inflammatory condition in which the patient's own immune system attacks the eye, causing eye inflammation and vision loss.
- Trial name
- NCT00876434
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Uveitis, Iritis
Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications
Retinal optical coherence tomography (OCT) is an established technology which enables a detailed cross-sectional visualization of the retinal micro-anatomy, and an objective measurement of its thickness in-vivo.
- Conditions
- Uveitis, Iritis, Iridocyclitis, Anterior Uveitis
- Trial name
- NCT00476593
- Testing
- Diclofenac, Dexamethasone
- Where
- 2 sites in Norway
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Behcet Disease, Behcet Disease and Vascular Involvement
Immunosuppressive Therapy Alone Versus Plus Oral Anticoagulation in the Treatment of VT Associated With Behcet's Disease
This study is a Phase III, multicenter, prospective, randomized, double-blind, placebo-controlled clinical trial investigating the treatment of lower extremity venous thrombosis associated with Behçet's Disease.
- Conditions
- Behcet Disease, Behcet Disease and Vascular Involvement, Deep Venous Thromboses, Post Thrombotic Syndrome
- Trial name
- BETTER (NCT06925698)
- Testing
- Rivaroxaban plus immunosupression
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Marmara University
Behcet Disease
Phase III Study in Refractory Behcet's Disease
The purpose of this pivotal trial is to evaluate subcutaneous (SQ) AIN457 as an adjunctive therapy to reduce the rate of exacerbations of posterior uveitis or panuveitis secondary to Behçet's disease during the 24 weeks of study…
- Trial name
- SHIELD (NCT00995709)
- Testing
- AIN457
- Where
- 49 sites in United States, Egypt and 15 more
- Volunteers
- 118 people
- Sponsor
- Novartis Pharmaceuticals
Behcet Disease, Antineutrophil Cytoplasmic Antibody (ANCA) Positive Vasculitis
Armenian NAtionwide REGistry of Systemic Autoimmune and Autoinflammatory Diseases
Longitudinal prospective multicenter Armenian registry of systemic autoimmune, autoinflammatory diseases with constitution of bio-banking.
- Conditions
- Behcet Disease, Antineutrophil Cytoplasmic Antibody (ANCA) Positive Vasculitis, Takayasu Arteritis, Giant Cell Arteritis
- Trial name
- NAREG (NCT05904301)
- Testing
- Usual medical management of patients, additional blood and stool samples for biobanking
- Where
- 6 sites in Armenia
- Volunteers
- 800 people
- Sponsor
- Santé Arménie French-Armenian Research Center
Uveitis, Uveitis, Posterior
MAGNOLIA: Extension Study of Patients With Non-infectious Uveitis Who Participated in CLS1001-301
This study is a non-interventional, observational extension of the Parent study, CLS1001-301 (NCT02595398). The purpose of this study is to characterize the continued clinical benefit(s) regarding safety and efficacy of…
- Conditions
- Uveitis, Uveitis, Posterior, Uveitis, Anterior, Uveitis, Intermediate
- Trial name
- NCT02952001
- Testing
- 4 mg CLS-TA Suprachoriodal Injection
- Where
- 16 sites in United States, India
- Volunteers
- 33 people
- Sponsor
- Clearside Biomedical, Inc.
Spondylarthropathies, Spondylitis, Ankylosing
Methotrexate in the Treatment of Axial Spondyloarthritis
The goal of this study is to evaluate the efficacy of oral methotrexate for the treatment of active axial spondyloarthritis (early ankylosing spondylitis or spondyloarthritis with sacroiliitis).
- Trial name
- NCT00298012
- Testing
- Methotrexate
- Where
- 5 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Rheumatism Foundation Hospital
Anterior Uveitis, Panuveitis
Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis
The purpose of this phase 3 confirmatory study is to determine if difluprednate ophthalmic emulsion is effective in the treatment of treatment of uveitis.
- Trial name
- NCT00406887
- Testing
- Difluprednate Ophthalmic Emulsion
- Volunteers
- 140 people
- Sponsor
- Sirion Therapeutics, Inc.
Behçet's Syndrome, Behçet's Syndrome (BS)
Corticotropin for Behçet's Disease: A Multicenter Randomized Controlled TrialAcronym.
Adrenocorticotropic hormone (ACTH) is a polypeptide hormone secreted by the anterior pituitary gland. It can stimulate adrenal cortical hyperplasia and the secretion of glucocorticoids, thereby exerting anti-inflammatory…
- Trial name
- NCT07833163
- Testing
- Repository Corticotropin Injection (ACTH)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University People's Hospital
Anterior Uveitis (AU), Birdshot Chorioretinitis
Quantification & Classification of Inflammatory Cells in Uveitis Using OCT
The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of…
- Conditions
- Anterior Uveitis (AU), Birdshot Chorioretinitis, Behcet Disease, Herpes Simplex Virus
- Trial name
- NCT07065747
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP)
Phase 1b Long-term Extension Trial of RAY121 in Immunological Diseases (RAINBOW-LTE Trial)
This is a long-term extension trial of RAY121 in patients with immunological diseases such as antiphospholipid syndrome (APS), bullous pemphigoid (BP), Behçet's Syndrome (BS), dermatomyositis (DM), immune-mediated necrotizing…
- Conditions
- Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP), Behçet's Syndrome (BS), Dermatomyositis (DM)
- Trial name
- NCT06723106
- Testing
- RAY121
- Where
- 62 sites in Australia, Austria and 17 more
- Volunteers
- 144 people
- Sponsor
- Chugai Pharmaceutical
Behcet Disease, COVID
Familial Mediterranean Fever and Behçet: Analysis Before and After Covid19 Pandemic
Behcet' disease (BD) is a chronic inflammatory disease which is characterized by oral and genital ulcers, uveitis and skin lesions.
- Conditions
- Behcet Disease, COVID, FMF
- Trial name
- NCT04403438
- Testing
- ıt will be compared pain, sleep, fatigue, physical activity level and quality of life and questioning exercise habits before and after the covid-19 outbreak in patients with Behçet and FMF.
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University
Uveitis, Uveitis, Posterior
The Use of Two YUTIQ Versus Sham for Treatment of Chronic Non Infectious Intraocular Inflammation Affecting the Posterior Segment
The Use of Two YUTIQ versus Sham for Treatment of Chronic Non Infectious Intraocular Inflammation Affecting the Posterior Segment (TYNI Trial)
- Conditions
- Uveitis, Uveitis, Posterior, Uveitis, Anterior, Uveitis, Intermediate
- Trial name
- TYNI (NCT05486468)
- Testing
- Yutiq 0.18 MG Drug Implant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Texas Retina Associates