Clinical trials: VA-ECMO
Cardiogenic Shock
Left Ventricular Unloading to Improve Outcome in Cardiogenic Shock Patients on VA-ECMO
Prospective, multi-center, randomized (1:1), controlled trial of Impella for active left ventricular unloading on top of veno-arterial extracorporeal membrane oxygenation vs.
- Trial name
- NCT05577195
- Testing
- Impella, VA-ECMO
- Where
- Germany
- Volunteers
- 198 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cardiogenic Shock
Evaluation of Early CRRT InTerventions in Patients With ECMO(ELITE)
Extracorporeal membrane oxygenation (ECMO) is of great value in supporting patients with cardiac shock. More than 80% ECMO patients will develop renal catastrophe that continuous renal replacement therapy (CRRT) is required.
- Trial name
- ELITE (NCT03549923)
- Testing
- Simultaneous CRRT, Conventional-indication CRRT, Esmolol
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Beijing Anzhen Hospital
Perfusion; Complications
Clinical Study of VA-ECMO Remote Limb Re-perfusion Monitoring Technology
Establish and verify the feasibility and effectiveness of VA-ECMO remote limb re-perfusion monitoring technology.
- Trial name
- NCT04929873
- Testing
- Closed transdyser, Routine monitor
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Venoarterial Extracorporeal Membrane Oxygenation, Renal Replacement Therapy
Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients
Extracorporeal membrane oxygenation (ECMO) is an extra-corporeal assistance used in case of respiratory or circulatory failure. In case of circulatory failure, ECMO is in the veno-arterial configuration (VA-ECMO).
- Conditions
- Venoarterial Extracorporeal Membrane Oxygenation, Renal Replacement Therapy, Acute Kidney Injury
- Trial name
- EPIC-ECMO (NCT06038162)
- Testing
- Parallel connection, Integrated connection
- Where
- 12 sites in France
- Volunteers
- 158 people
- Sponsor
- Hospices Civils de Lyon
Cardiopulmonary Arrest, VA-ECMO
Optimized CT-imaging Protocol in VA-ECMO Patients After CPR
Veno-arterial (VA) extracorporal membrane oxygenation (ECMO) is an increasingly applied method in patients under cardiopulmonary resuscitation (CPR), who are regularly examined with a contrast-enhanced computed tomography to…
- Trial name
- NCT05290805
- Testing
- ECMO flow rate reduction
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Cardiogenic Shock
Early Left Ventricular unLoading by Impella vs Intra-aortic Balloon Pump
Over the past decade, VA-ECMO has become the main mechanical support for cardiogenic shock (CS) unresponsive to medical therapy.
- Trial name
- ELLIPSE1 (NCT06645990)
- Testing
- Impella, IABP
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Cardiogenic Shock
Hemoperfusion in Extracorporeal Membrane Oxygenation (ECMO) Patients
Extracorporeal membrane oxygenation (ECMO) is a temporary mechanical circulatory support device for cardiogenic shock (CS) patients.
- Trial name
- NCT03729765
- Testing
- hemoperfusion
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Anzhen Hospital
Cardiogenic Shock Acute
Early Preventive Left Ventricle Unloading After VA-ECMO for Refractory Cardiogenic Shock
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used worldwide to treat severe cardiogenic shock.
- Trial name
- EULODIA (NCT07027202)
- Testing
- Early Left Ventricle unloading
- Where
- 12 sites in France
- Volunteers
- 298 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Extracorporeal Membrane Oxygenation, Nitric Oxide
Nitric Oxide in Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO)
This pilot study is designed to investigate the effect of inhaled nitric oxide on cardiac, pulmonary artery, and systemic hemodynamics at various time points during venoarterial extracorporeal membrane oxygenation (VA-ECMO)…
- Conditions
- Extracorporeal Membrane Oxygenation, Nitric Oxide, Shock, Cardiogenic
- Trial name
- NOVICE (NCT04224103)
- Testing
- Inhaled nitric oxide
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Filio Billia
Pulmonary Hypertension of the Newborn (PPHN)
Circulatory Changes During Venovenous (VV)- and Venoarterial (VA) Extracorporeal Membrane Oxygenation (ECMO)
Rationale: Persistent pulmonary hypertension of the newborn (PPHN) is a life threatening disease with a high mortality rate. Extracorporeal Membrane Oxygenation (ECMO) with veno-arterial (V-A) or veno-venous (V-V) cannulation can…
- Trial name
- ECMO (NCT00622492)
- Testing
- echocardiography Doppler sonography, blood and urine sampling
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Cardiac Arrest, Cardiopulmonary Arrest
ECMELLA vs. ECMO on 30-day Mortality
This international, multicenter cohort study aims to investigate outcomes after treatment with extracorporeal cardiopulmonary resuscitation (eCPR) during cardiac arrest.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Extracorporeal Membrane Oxygenation Complication, Cardiogenic Shock
- Trial name
- NCT05175898
- Testing
- VA-ECMO, ECMELLA
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Cardiogenic Shock
Establishing Physiologic Outcomes for Ventricular Unloading on VA ECMO
Aim 1: Prospective, observational analysis of the association between echocardiographic measures of cardiac function and left ventricular unloading on VA ECMO.
- Trial name
- NCT05658276
- Where
- 2 sites in United States, Canada
- Sponsor
- University of Utah
VA-ECMO
Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO
The aim of this study is to characterize ventilation/perfusion (V/Q) matching in adult patients receiving peripheral VA ECMO support while on mechanical ventilation, and to evaluate the impact of PEEP titration guided by…
- Trial name
- ECMO-VP (NCT07141524)
- Testing
- Physiology measurements
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Beth Israel Deaconess Medical Center
ECMO, Mplementation of a Veno-venous VV or Veno-arterial VA
EVOLUTION OF D-DIMER AS A MARKER OF BLEEDING RISK ON ECMO
ECMO (extracorporeal membrane oxygenation) is a life-saving device, used in intensive care to treat severe respiratory or cardiac failure. However, it carries a high risk of serious life-threatening bleeding.
- Conditions
- ECMO, Mplementation of a Veno-venous VV or Veno-arterial VA, INTENSIVE CARE
- Trial name
- ECMOstase2 (NCT07039513)
- Testing
- Blood sampling collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Cardiogenic Shock, Post-cardiac Surgery
Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients
The use of antibiotic therapy is common in intensive care units and primarily involves beta-lactams. Its optimal implementation is made difficult by the pharmacokinetic changes inherent in critically ill patients.
- Conditions
- Cardiogenic Shock, Post-cardiac Surgery, Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
- Trial name
- KAMELOT (NCT06338345)
- Testing
- Therapeutic drug monitoring of beta-lactam
- Where
- 5 sites in France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Grenoble
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Efficacy and Safety of Synchronized Cardiac Support in Cardiogenic Shock Patients
The study aims to investigate the safety and efficacy of the Synchronized Cardiac Support treatment wit the icor kit and the Xenios console with modified sensor box ECG and Software Version 3.2.4
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, ECLS, VA ECMO
- Trial name
- PulseSE (NCT05106491)
- Testing
- Synchronized Cardiac Support with the icor kit
- Where
- 2 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Xenios AG
Cardiac Arrest, Pulmonary Injury
Pulmonary Physiologic Assessment of Patients on Veno-arterial Extracorporeal Membrane Oxygenation (VA ECMO)
There is limited data on the respiratory system mechanics and ideal mode of ventilation for patients on veno-arterial extra-corporeal membrane oxygenation (VA ECMO) post cardiac arrest.
- Trial name
- NCT04739007
- Testing
- Veno-arterial extracorporeal membrane oxygenation (VA-ECMO), Electrical Impedance Tomography (EIT)
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Out-Of-Hospital Cardiac Arrest
Rapid Response VA-ECMO in Refractory Out-of-hospital Cardiac Arrest
A selected group of patients with refractory cardiac arrest may benefit from inhospital treatment and this may warrant transfer to the hospital with ongoing CPR.
- Trial name
- RESuSCITATe (NCT03658759)
- Testing
- Extracorporeal Cardiopulmonary Resuscitation
- Where
- Netherlands
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) - "HemodynamECMOnitoring-VA Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593756
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Cardiogenic Shock
Evaluation of Speckle Tracking Parameters as Predictors of Successful VA SPECKLE ECMO
Purpose of this study is to assess whether measurements obtained through speckle tracking (LV longitudinal and circumferential strain, RV longitudinal strain) can give additional information in identifying patients who develop…
- Trial name
- SPECKLE-ECMO (NCT03532529)
- Testing
- not applicable, it is an observational study
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust