Clinical trials: VOLUME OF FLUID
Major Abdominal Surgery, Duodenohemipancreatectomy
Intraoperative Haemodynamic Optimization Comparing Flow and Pressure Parameters
The purpose of the study is to confirm the hypothesis that flow treatment algorithm based on cardiac index trending by transesophageal Dopplerometry would result in reduced complications and reduced length of hospital stay in…
- Conditions
- Major Abdominal Surgery, Duodenohemipancreatectomy, Rectal Resection, Extensive Bowel Surgery
- Trial name
- Flow-press (NCT02104687)
- Testing
- Flow group, Press group
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- University Hospital Ostrava
Heat Exposure, Exercise Performance
Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution
The goal of this clinical trial is to learn whether creatine supplementation changes how the body adapts to repeated exercise in the heat in healthy recreationally active adults and varsity athletes.
- Conditions
- Heat Exposure, Exercise Performance, Hydration, Body Fluid Compartments
- Trial name
- NCT07593014
- Testing
- Creatine Monohydrate
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Windsor
Radical Cystectomy
The Stroke Volume Optimization of Goal Directed Fluid Therapy During Radical Cystectomy
Although fluid therapy is of paramount value in anesthetic practice, there is no guideline available for perioperative fluid management in major abdominal surgery.
- Trial name
- NCT03262480
- Testing
- stroke volume optimization
- Where
- Egypt
- Volunteers
- 172 people
- Sponsor
- Mansoura University
Surgery, Cardiac Output, Low
Reliability of a New Pulse Contour Technique for Diagnosing an Increase in Stroke Volume During a Fluid Challenge for Hemodynamic Optimization in Patients Scheduled for High-risk Abdominal Surgery: Comparison With Transthoracic Echocardiography: COMPARE Study
The present study aims at assessing the ability of a new pulse contour device for diagnosing a >15% stroke volume (SV) increase during patient hemodynamic optimization by fluid challenge in high risk abdominal surgery.
- Trial name
- COMPARE (NCT04871620)
- Testing
- >15% SV increase during fluid challenge
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Renal Failure, Chronic Kidney Diseases
Influence of Variable Inflow Volume, Dwell Duration and Glucose Concentration on Ultrafiltration Volume in APD Patients
The purpose of the current investigation is to provide proof of concept for a future approach to improve UF prediction accuracy.
- Trial name
- pPD (NCT06443021)
- Testing
- PD cycler
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Dehydration, Hydration
Oral Fluid Volume Expansion
When subjected to fluid loss or fluid deficiency irrespective of disease or environmental factors it is discussed how to rehydrate or how to hydrate prophylactic. In medical care it is common to give infusions.
- Trial name
- OFVEX (NCT01360333)
- Testing
- tap water, sodium chloride, carbohydrate rich fluid
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Septic Shock, Sepsis
The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock
The complexity of pediatric septic shock arise from its varied pathophysiology, which includes systemic inflammation, cardiovascular collapse, and multiple organ dysfunction.
- Trial name
- NCT06461390
- Testing
- Norepinephrine, Ringer's Lactate
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Indonesia
Mechanical Ventilation Complication, Actual Impaired Fluid Volume
Evaluation of the Effects of Fluid Therapy on Respiratory Mechanics
The investigators hypothesize that large doses of fluids used during intraoperative could affect lung parenchyma structure and, consequently, gas exchange and respiratory mechanics.
- Trial name
- NCT02071524
- Testing
- Group Colloid, Cristalloid administration
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università degli Studi di Ferrara
Blood Loss, Surgical, Fluid Retention
Impact of Hyperoncotic Albumin to Support Blood Loss Replacement
Fluid treatment is usually performed with either balanced crystalloid fluids or iso-oncotic colloids, (synthetic colloids, plasma and 5% albumin).
- Trial name
- HYPALB (NCT03848507)
- Testing
- albumin 20%
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Septic Shock, Hemodynamic Instability
Whether a Minimal Volume Could Predict Fluid Responsiveness Using Thermodilution by PAC in Septic Shock Patients
Assessment of fluid responsiveness (FR) is to detect whether patient could benefit from fluid therapy. Mini fluid challenge has been widely used in clinical practice to prevent patients from volume overload.
- Conditions
- Septic Shock, Hemodynamic Instability, Fluid Therapy
- Trial name
- NCT04515511
- Testing
- 4% gelatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Liver Transplantation (LT), End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL)
The goal of the REFIL-2 study is to evaluate the effectiveness of a low splanchnic blood volume restrictive fluid management strategy (a strategy that involves limiting fluid administration and prioritizing the use of medications…
- Trial name
- REFIL-2 (NCT07695363)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Phlebotomy, Optimized cardiac output liberal fluid management strategy
- Where
- 4 sites in Canada
- Volunteers
- 866 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Prostate Cancer Metastatic
Expression of Molecular Markers in Circulating Tumor Cells of Metastatic Castration-Resistant Prostate Cancer
As prostate cancer progresses into castration-resistant stage from initial hormone-sensitive status, the biological behavior of tumor cells that dissociated from primary lesions changed.
- Trial name
- NCT03089099
- Testing
- Blood drawing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Hemodynamic Instability
Impact of Fluid Management Within a Goal-directed Hemodynamic Protocol on Acid-base Balance in Elective Trauma Surgery
The purpose of this study is to determine whether the administration of a compound of balanced infusion solutions including 50% crystalloid and 50% colloid has a positive impact on acid-base balance in elective hip replacement…
- Trial name
- HIPSTER (NCT01117519)
- Testing
- Infusion Therapy
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Fluid Responsiveness
Accuracy of Pulse Pressure Variation and of Pleth Variability Index to Predict the Response to a Fluid Challenge
The aim of this study is to compare the accuracy of Pleth Variability Index (Radical 7 device) and of Pulse Pressure Variation (Nexfin device) with the Doppler measurement of stroke volume (esophageal Doppler) to detect the…
- Trial name
- Nexfin2 (NCT02040948)
- Testing
- - Nexfin (Pulse Pressure Variation) - Radical 7 (Pleth Variability Index) - CardioQ (stroke volume)
- Where
- 2 sites in France
- Volunteers
- 68 people
- Sponsor
- Hopital Foch
Plasma Volume, Tidal Volume
Effect of Tidal Volume Change on Pressure-based Prediction of Fluid Responsiveness in Children
This study evaluates predictability of fluid responsiveness of pressure-based dynamic variables such as pulse pressure variation and systolic pressure variation, according to tidal volume change in patients undergoing cardiac…
- Trial name
- NCT03963089
- Testing
- Tidal volume_6mL/kg, Tidal volume_10mL/kg, Tidal volume_14mL/kg
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Aneurysmal Subarachnoid Hemorrhage
Cerebrospinal Fluid (CSF) Drainage Study
When patients suffer a subarachnoid hemorrhage (bleeding around the brain), they often develop hydrocephalus. This is an enlargement of the fluid-filled spaces (ventricles) in the brain.
- Trial name
- NCT01420978
- Testing
- CSF Diversion
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Tetralogy of Fallot
Effects of Changes in Fluid Status on Right Ventricular Volumes and Function
The purpose of this study is to evaluate the correlation between fluid volume status and right ventricular volume and function, in those with free pulmonary valve insufficiency after Tetralogy of Fallot (TOF) repair.
- Trial name
- NCT02967315
- Testing
- Cardiac Magnetic Resonance Imaging (CMRI), Central venous line placement, Chest X-ray
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Wisconsin, Madison
Pulmonary Atelectasis, Postoperative
Ultrasound Evaluation of Preventive Measures for Postoperative Lung Atelectasis After Surgery
the aim of this prospective randomized blinded clinical study will be to assess the ultrasound evaluation of different preventive measures of post operative lung atelectasis in abdominal surgeries; these measures include…
- Trial name
- LUS/PEEP/RM (NCT06654778)
- Testing
- PEEP, PEEP/RM, PEEP/RM/RF
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Hemodynamic Monitoring
Starling/CRRT Observational Study
Hemodynamic optimization of critically ill patients is a goal for clinicians in order to afford the patient the best possible outcomes.
- Trial name
- NCT05729048
- Testing
- Starling
- Where
- United States
- Sponsor
- Baxter Healthcare Corporation
Stroke Volume Variation, SVV-FloTrac
A Comparison of Thoracic Electrical Bioimpedance and FloTrac/Vigileo
Stroke volume variation (SVV) is an indicator used to assess the patient's volume status. The FloTrac system (Edwards Lifesciences, Irvine, CA) continuously monitors cardiac output (CO) and SVV (SVV-FloTrac) by analyzing the…
- Conditions
- Stroke Volume Variation, SVV-FloTrac, Thoracic Electrical Bioimpedance, Fluid Responsiveness
- Trial name
- NCT06143111
- Testing
- Flotrac Group, BioZ Group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital