Clinical trials: Vagal Nerve Stimulation
Health People, Physical Activity
The Effect of Auricular Vagus Nerve Stimulation and Controlled Breathing Exercises on Performance and Autonomic Nervous System
There are many studies in the literature on transcutaneous vagus nerve stimulation (VNS) and controlled breathing exercises (CBE), but there are limited studies examining the effects of both interventions on performance and the…
- Conditions
- Health People, Physical Activity, Autonomic Nerveus System, Vagus Nerve Stimulations
- Trial name
- NCT06796101
- Testing
- Vagus Nerve Stimulation, Controlled breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Type 2 Diabetes, Obesity
Vagal Nerve Stimulation and Glucose Metabolism
The overall aim of this application is to determine the mechanism(s) by which common bariatric surgical procedures alter carbohydrate metabolism.
- Conditions
- Type 2 Diabetes, Obesity, Gastric Emptying
- Trial name
- NCT01117311
- Testing
- VNB on, VNB off
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Parkinson Disease
The Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Anxiety in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients with anxiety.
- Trial name
- NCT05950347
- Testing
- Active Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Major Depressive Disorder
Effects of Respiratory-Gated Transcutaneous Vagal Nerve Stimulation in Major Depression (Phase 1)
This study will evaluate the short term effects of respiratory-gated transcutaneous vagus nerve stimulation on the regulation of cardiovagal activity, depressive symptomatology and immune function in subjects with major…
- Trial name
- NCT04607226
- Testing
- Active transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Stress Response
Transcutaneous Vagus Nerve Stimulation (tVNS) and Stress Regulation During Performance Tasks
This study examines how individuals respond to performance-related tasks and whether a non-invasive ear stimulation device influences stress responses during those tasks.
- Trial name
- NCT07470229
- Testing
- Transcutaneous Vagus Nerve Stimulation (tVNS), Evaluative Stress Task
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Florida
Stress, Sleep
Effects of Transcranial Electrical Stimulation in Chronic Stress
This clinical trial aims to determine if Transcranial electrical stimulation by direct current (tDCS) and transauricular Vagus Nerve Stimulation (tVNS) treatments are effective in reducing stress symptoms, distress and improving…
- Trial name
- NEUROSTIM (NCT06813209)
- Testing
- tDCS, tVNS
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Crohn's Disease
Vagus Nerve Stimulation in Crohn's Disease
This is an open label interventional study using an implantable vagus nerve stimulation device in patients with Crohn's disease who have active disease despite treatment with a tumor necrosis factor (TNF) antagonist drug.
- Trial name
- NCT02311660
- Testing
- Vagus Nerve Stimulation Device
- Where
- 4 sites in Croatia, Italy and 2 more
- Volunteers
- 15 people
- Sponsor
- SetPoint Medical Corporation
Health, Subjective
Investigation of the Effect of Unilateral Right, Unilateral Left and Bilateral Applications of Transcutaneous Auricular Vagus Nerve Stimulation on Autonomic Nervous System Activity in Healthy People
The vagus nerve is one of the main components of the parasympathetic nervous system, which oversees a wide variety of important bodily functions, including mood control, immune response, digestion, and heart rate.
- Trial name
- NCT05370027
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Stroke
Effect of Non-invasive Vagus Nerve Stimulation on Cerebrovascular Reactivity and Cognition in Chronic Stroke Patients
This study will be conducted to assess the effect of non-invasive vagus nerve stimulation on cerebrovascular reactivity and cognition in chronic stroke patients
- Trial name
- NCT07626242
- Testing
- Trans-auricular vagus nerve stimulation, Conventional physical therapy, Computer based cognitive rehabilitation training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Psychiatric Disorder
Pilot Study on the Acceptability of Auricular Vagus Nerve Neurostimulation in Adolescents
Non-suicidal self-injury (NSSI) are acts defined by the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders 5) as intentional and deliberate, occurring outside a psychotic state and directly causing moderate injury.
- Trial name
- NEUROMUTE (NCT06433583)
- Testing
- transcutaneous auricular vagal nerve stimulation
- Where
- 2 sites in France
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Stroke, Dysphagia
Auricular Vagus Nerve Stimulation and Post-Stroke Dysphagia in Older Adults
This study investigates the effect of non-invasive transcutaneous auricular vagus nerve stimulation (tVNS-E) on swallowing rehabilitation in patients over 70 years old after stroke.
- Trial name
- SVA-DPA (NCT07428590)
- Testing
- tVNS-E active device, tVNS-E inactive device
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Stroke, Vagus Nerve Stimulation
Vagal Stimulation in Individuals With Stroke
The aim of this study is to investigate the effects of manual vagus nerve stimulation (VNS) on motor, autonomic, and cognitive functions in individuals with chronic stroke.
- Conditions
- Stroke, Vagus Nerve Stimulation, Motor Function, Otonomic Function
- Trial name
- NCT07822854
- Testing
- vagus nerve stimulation, classic rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Nermin KART
Breast Cancer
MindVybe tVNS/APS for Wellbeing in Breast Cancer Survivors
This study tests whether a gentle, non-invasive device called mindvybe can help improve feelings of wellbeing in people who have had breast cancer.
- Trial name
- NCT07782866
- Testing
- Transcutaneous vagus nerve and acupuncture point stimulation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The Healing Consciousness Foundation
Persistent Post-concussive Symptoms
Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms
Persistent post-concussive symptoms (PPCS) affect a significant proportion of individuals following a concussion, leading to debilitating impacts on their quality of life and work capacity.
- Trial name
- taVNS-PPCS (NCT07017257)
- Testing
- Active taVNS
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- University of Liege
Parkinson Disease, Upper Extremity Dysfunction
Effectiveness of Noninvasive Vagus Stimulation for Upper Extremity in Parkinson's Disease
Vagus nerve stimulation in the treatment of PD is a non-pharmacological intervention with the potential to improve gait, cognition, fatigue, and autonomic functions, but more evidence is needed for VSS in the treatment of PD.
- Conditions
- Parkinson Disease, Upper Extremity Dysfunction, Tremor
- Trial name
- NCT05456451
- Testing
- noninvasive vagus nerve srimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 5 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Functional Neurological Disorder, Motor Symptoms
Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND)
This clinical study will test if adding a non-invasive stimulation of the vagus nerve through the ear during physiotherapy brings an improvement to FND (Functional Neurological Disorder) patients with motor symptoms.
- Trial name
- TMS-VNS (NCT07710677)
- Testing
- Vagial Nerve Stimulation (VNS) active stimulation
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Central Auditory Disease, Auditory Processing Disorder, Central
taVNS Effect on Central Auditory Processing
The behavioral effects of vagus nerve stimulation (VNS) and observed activation in the auditory cortex with transcutaneous auricular VNS (taVNS) raise questions about their potential impact on auditory processing.
- Conditions
- Central Auditory Disease, Auditory Processing Disorder, Central, Auditory Processing Disorders, Vagus Nerve Stimulation
- Trial name
- NCT06970444
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medipol University
Healthy, Activity, Motor
The Effect Of Transcutaneous Auricular Vagus Nerve Stimulation On Sports Performance And Physiological Parameters
OBJECTIVE: The aim of this study is to investigate the effect of non-invasive auricular VNS (Vagus Nerve Stimulation) on sportive performance and physiological parameters in healthy individuals.
- Trial name
- VNS001 (NCT04768738)
- Testing
- Auricular Vagus Nerve Stimulation Level Of Above Threshold, Auricular Vagus Nerve Stimulation Level Of Subthreshold, 5 Minutes Bicycle Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Sinop University
Older Adults Without Any Specific Clinical Condition, Autonomic Nervous System Imbalance
Effects of Transcutaneous Vagus Nerve Stimulation in Older Adults
The autonomic nervous system consists of two branches, the sympathetic and the parasympathetic, which must work in balance. Its functioning can be measured indirectly by heart rate variability, which is the time between…
- Conditions
- Older Adults Without Any Specific Clinical Condition, Autonomic Nervous System Imbalance, Transcutaneous Vagus Nerve Stimulation
- Trial name
- tVNS_older (NCT07292623)
- Testing
- Active location tVNS
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Transcutaneous Vagal Nerve Stimulation (tVNS), Diabetic Polyneuropathy
Effect of Vagus Nerve Stimulation on Pain Intensity, Nerve Conduction Studies and Functional Outcomes in Diabetic Peripheral Neuropathy Patients
To evaluate the efficacy of vagus nerve stimulation in reducing neuropathic pain, symptom severity, electrophysiological studies and functional outcomes in patients with diabetic peripheral neuropathy.
- Trial name
- NCT07405021
- Testing
- Conventional physical therapy program, Transcutaneous auricular vagus nerve stimulation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University