Clinical trials: Vaginal Delivery
Vaginal Birth After Cesarean
Vaginal Birth After Caesarean Section - Effect on Maternal Psychosocial Function
The incidence of caesarean section has reached 15-20% in most developed countries. Encouraging vaginal birth after caesareans section (VBAC) has been considered a key component of a strategy to reduce the caesarean section rate.
- Trial name
- NCT00294411
- Testing
- elective cesarean section
- Sponsor
- Chinese University of Hong Kong
Need of Episiotomy
Comparison of Never Performing Episiotomy to Performing it in a Selective Manor
The study hypothesis is that not performing never episiotomies is safe and results are equivalent to performing episiotomies ina selective manor.
- Trial name
- EPISIO (NCT02178111)
- Testing
- Never perform episiotomy, episiotomy
- Where
- Brazil
- Volunteers
- 237 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Human Microbiota, PreTerm Birth
The Reproductive Microbiome & Perinatal Health Outcomes
Pregnant African American women between 18 and 45 years of age will be enrolled at 20 weeks of gestation or less. Biological specimens (vaginal swabs, rectal swab) will be collected at enrollment, 23-24 weeks, at 28-29 weeks, and…
- Conditions
- Human Microbiota, PreTerm Birth, Human Gastrointestinal Microbiota, Metabolomics
- Trial name
- NCT02948192
- Testing
- Survey, Sample collection
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Labour, Induced, Vaginal Birth After Caesarean
Membrane Sweeping Versus Transcervical Foley Catheter for Induction of Labour in Women With Previous Caesarean Delivery
Nowadays, more and more women embark on pregnancy with previous Caesarean scar. One in five pregnancies requires induction of labour.
- Trial name
- NCT03326557
- Testing
- Membrane Sweeping versus Transcervical Foley Catheter for Induction of Labour in Women with Previous Caesarean Delivery
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Malaysia
Luteal Hormone Supplementation
A Phase III Study of FE 999913 in Japanese Female Patients Undergoing Fertility Treatment
The purposes of the study are to verify sufficient supplementation of luteal hormone after administrating FE999913 Vaginal Tablet twice a day (BID) or three times a day (TID) and to determine the efficacy and safety of FE999913…
- Trial name
- NCT01710514
- Testing
- FE 999913 vaginal tablet
- Where
- 6 sites in Japan
- Volunteers
- 108 people
- Sponsor
- Ferring Pharmaceuticals
Sexually Transmitted Infections (Not HIV or Hepatitis), Premature Birth
Genital Tract Infections, the Vaginal Microbiome and Gestational Age at Birth Among Pregnant Women in South Africa
This cohort study plans to investigate associations between the presence of multiple lower genital tract microorganisms in pregnancy and gestational age at birth.
- Conditions
- Sexually Transmitted Infections (Not HIV or Hepatitis), Premature Birth, Pregnancy; Infection, Microbial Colonization
- Trial name
- NCT06131749
- Testing
- No intervention
- Where
- South Africa
- Volunteers
- 603 people
- Sponsor
- University of Bern
Bacterial Vaginosis
Safety and Efficacy of a Vaginally Administered Probiotic Lactobacilli Delivery System.
The purpose of this study is to assess the safety and the efficacy of vaginally administered probiotic lactobacilli in combination with antibiotic therapy (metronidazole) in women with microbiologically defined bacterial…
- Trial name
- NCT00752193
- Testing
- Probiotic lactobacilli
- Where
- Belgium
- Volunteers
- 206 people
- Sponsor
- University Ghent
Maternal Care for Other Abnormalities of Cervix
Maternal Consequences of Membrane Stripping
This study aims to investigate the maternal effects of membrane stripping during vaginal birth. This study was designed as an experimental case-control study.
- Trial name
- NCT06373250
- Testing
- Membrane stripping group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Vaginal Delivery
Role of the Intrapartum Grobman Nomogram in the Indication of Attempted Vaginal Delivery After Cesarean Section
The rate of pregnant patients with a history of cesarean section is increasing. Caesarean section is a surgery which is not without risk and in particular concerning the risk of uterine rupture and malplacentation during a new…
- Trial name
- GPP (NCT06202768)
- Testing
- data collection
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Central Hospital, Nancy, France
Surgery
Objective Structured Assessment of Technical Skills (OSATS) Evaluation of Delivery by Vacuum Extraction
In a prospective, randomized Trial, the investigators compare Hands-on teaching and frontal teaching using a Training Video for learning how to perform an assisted delivery by vacuum extraction on a pelvic Training model.
- Trial name
- VAC-OSATS (NCT02468427)
- Testing
- hands-on teaching, Frontal teaching
- Where
- Germany
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Pregnancy
Effects of Antenatal Pelvic Floor Preparation Techniques for Childbirth
Perineal trauma during childbirth is an important etiological factor of various undesirable complications to women's health, with emphasis on pelvic floor dysfunction.
- Trial name
- EAPFPTC (NCT02582580)
- Testing
- Perineal massage, Vaginal Dilator, Pelvic floor muscles training
- Where
- Brazil
- Volunteers
- 63 people
- Sponsor
- Universidade Federal de Sao Carlos
Post Partum Hemorrhage, Blood Loss
Estimating Blood Loss Using TritonTM in Vaginal Deliveries: A Validation Trial
This study will be a prospective cohort study. Patients who meet criteria for inclusion in the study will be approached for participation at same day of admission.
- Conditions
- Post Partum Hemorrhage, Blood Loss, Vaginal Bleeding, Vaginal Delivery
- Trial name
- ELUSIVE (NCT04277962)
- Testing
- Triton L and D system for estimation of blood loss at time of vaginal delivery
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Quadratus Lumborum Nerve Block, Postpartum Cramping
Quadratus Lumborum Block Reduced Postpartum Uterine Pain After Virginal Childbirth
With the continuous advancement of ultrasonic technology, nerve block in which drugs are injected into the periphery of the target nerve through ultrasonic guidance has become the mainstream method for postoperative pain control.
- Conditions
- Quadratus Lumborum Nerve Block, Postpartum Cramping, Vaginal Delivery
- Trial name
- NCT05371015
- Testing
- quadratus lumborum nerve block (ropivacaine ), quadratus lumborum nerve block (normal saline)
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- Chang Gung Memorial Hospital
Abnormal Labor, Complication of Delivery
Clinical Application of Intrapartum Ultrasound
Intrapartum ultrasound monitoring is to be compared with conventional labor monitoring to clarify the accuracy of this technology, and then provide a basis for later related research.
- Trial name
- IPUS (NCT06442735)
- Testing
- intrapartum ultrasound, vaginal examination
- Where
- China
- Volunteers
- 455 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Uterine Atony, Postpartum Hemorrhage
Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT
This is a double-blind 3-arm randomized clinical trial to determine whether higher dose oxytocin regimens (compared to the standard regimen) reduce the frequency of uterine atony and postpartum hemorrhage after vaginal delivery.
- Trial name
- NCT00790062
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 1,798 people
- Sponsor
- University of Alabama at Birmingham
Pharmacokinetics
Expanded Use PK of Dapivirine Vaginal Ring
Study will evaluate the vaginal and blood pharmacokinetics of dapivirine from a vaginal ring containing 25 mg worn for 1, 2, 4, 8 or 12 months.
- Trial name
- NCT01952561
- Testing
- dapivirine ring
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
HIV, Contraception
The Quatro Study: Acceptability Study of (Placebo) Vaginal Delivery Forms for Preventing HIV and Unintended Pregnancy
The purpose of The Quatro Study is to assess the acceptability, preferences, user experience and effect on sexual behavior of four different vaginal microbicide or multi-purpose technology (MPT) delivery forms, using placebo…
- Trial name
- NCT02602366
- Where
- 2 sites in South Africa, Zimbabwe
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- CONRAD
Normal Vaginal Delivery, Perineal Episiotomy
Effect of Perineal Cryotherapy on Episiotomy
The present study aims to evaluate the effect of perineal cryotherapy on episiotomy- associated pain among postpartum women. The study hypothesis: Post-partum women who apply perineal cryotherapy have lower level of episiotomy…
- Trial name
- NCT06921200
- Testing
- Cryotherapy
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Twin Vaginal Delivery Skills
Recognition of Second Twin. Second Training vs Naive Performer. PROMPT Mannequin
Anterior foot identification in second twin delivery Two different population of resident in ObGyn Group 1 previous formal lecture on twin vaginal delivery followed by PROMPT mannequin scenario. Group 2 naive residents
- Trial name
- twin (NCT06127706)
- Testing
- twin vaginal delivery simulation
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Head and Neck Cancers, Lung and Esophagus Cancers
Adaptive Pet Study
The purpose of this study is to determine the benefit of using positron emission tomography (PET) in addition to the standard (computed tomography) CT to plan radiation therapy for cancer treatment.
- Conditions
- Head and Neck Cancers, Lung and Esophagus Cancers, Anal, Cervix, Vulvar, Vaginal, and Endometrium Cancers
- Trial name
- NCT01908504
- Testing
- PET-CT
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Duke University