Clinical trials: Vaginal Neoplasms
Bacterial Vaginosis, Candidiasis
Vaginal Ecosystem and Network in the United States Study
The central premise of this study is that the intricate balance and diversity of the vaginal microbiome plays a pivotal role in the onset, progression, and severity of various gynecological conditions.
- Conditions
- Bacterial Vaginosis, Candidiasis, Urinary Tract Infections, Genitourinary Syndrome of Menopause
- Trial name
- VENUS (NCT06472765)
- Testing
- Vaginal Swab Collection
- Where
- 21 sites in United States, Canada
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Vaginal Biome Science
Human Papillomavirus Infection, Self Sampling
HPV Typing Between Self- and Physician-sampled
Hygeia Touch Inc. developed a safe and comfortable vaginal self-sampling device "Hygeia Touch Self Sampling Kit for Women" to self-collect the vaginal discharge sample for high-risk Human Papillomavirus (hrHPV) detection.
- Conditions
- Human Papillomavirus Infection, Self Sampling, Vaginal Discharge
- Trial name
- NCT04472377
- Testing
- Self sampling kit for collecting discharge from vaginal fornix
- Where
- 3 sites in Taiwan
- Volunteers
- 1,210 people, healthy volunteers welcome
- Sponsor
- Hygeia Touch Inc.
Anxiety Disorder, Cervical Cancer
Scripted Sexual Health Informational Intervention in Improving Sexual Function in Patients With Gynecologic Cancer
This randomized pilot clinical trial studies the feasibility of a pre-operative and/or post-operative scripted sexual health informational intervention and how well it works in improving sexual function in patients with…
- Conditions
- Anxiety Disorder, Cervical Cancer, Endometrial Cancer, Female Reproductive Cancer
- Trial name
- NCT02096783
- Testing
- informational intervention, counseling intervention, questionnaire administration
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Wisconsin, Madison
Cervical Cancer
Vaginal Self-sampling for Non-attenders
Cervical cytology screening coverage in Northern Ireland (the proportion of eligible women, aged 25-64 years who have had a test result recorded in the previous five years) has increased steadily since 2005 to 78% in 2012/2013…
- Trial name
- NCT03252769
- Testing
- Self-sampling
- Where
- United Kingdom
- Volunteers
- 1,950 people, healthy volunteers welcome
- Sponsor
- Western Health and Social Care Trust
Rectal Tumors, Rectal Cancer
Organ-sparing With TraceIT® for Rectal Cancer Radiotherapy
For advanced rectal tumors, the standard of care is neoadjuvant radiotherapy (RT) +/- chemotherapy followed by surgery 8-10 weeks later.
- Conditions
- Rectal Tumors, Rectal Cancer, Advanced Cancer
- Trial name
- NCT03258541
- Testing
- TraceIT®, Volumetric Arc Therapy (VMAT), Surgery
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Thomas Zilli
HPV Infection
Treatment of HPV Infection in Perimenopausal and Postmenopausal Women
A randomized controlled study was conducted to determine the effects of vaginal estrogen and human interferon alpha 2b vaginal effervescent capsules on vaginal microecology in perimenopausal and postmenopausal women.
- Trial name
- NCT05863975
- Testing
- Human interferon alpha 2b vaginal Effervescent capsules
- Volunteers
- 150 people
- Sponsor
- Qianfoshan Hospital
Cervical Cancer, Endometrial Cancer
Phone or Email Reminder in Increasing Vaginal Dilator Use in Patients With Gynecologic Cancers Undergoing Brachytherapy
This randomized, pilot phase I trial studies whether phone or email reminders increases vaginal dilator use in patients with endometrial, cervical, or vaginal cancers after they undergo brachytherapy.
- Conditions
- Cervical Cancer, Endometrial Cancer, Radiation Toxicity, Vaginal Cancer
- Trial name
- NCT02058550
- Testing
- survey administration, computer-assisted intervention, telephone-based intervention
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Stanford University
Breast Cancer, Vaginal Dryness
Pilocarpine in Treating Vaginal Dryness in Patients With Breast Cancer
RATIONALE: Pilocarpine may decrease vaginal dryness and improve quality of life in patients with breast cancer It is not yet known whether pilocarpine is more effective than a placebo in treating vaginal dryness in patients with…
- Trial name
- NCT00343382
- Testing
- pilocarpine hydrochloride
- Where
- 192 sites in United States
- Volunteers
- 201 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cervical Cancer, Ovarian Cancer
Developing a Stepped Approach to Improving Sexual Function aFteR Treatment fOr gyNaecological Cancer
Women affected by gynaecologic cancers are often not aware of sexual consequences of cancer and its treatment. Most do not receive appropriate advice or help to recover sexual function, and the impact on their sexuality may be…
- Conditions
- Cervical Cancer, Ovarian Cancer, Uterine Cancer, Vaginal Cancer
- Trial name
- SAFFRON (NCT02458001)
- Testing
- SAFFRON stepped care
- Volunteers
- 100 people
- Sponsor
- University College, London
Cervical Carcinoma, Ovarian Carcinoma
Peer-to-Peer Support Program in Improving Quality of Life Outcomes in Patients With Gynecologic Cancer and Their Caregivers
This pilot clinical trial studies a peer-to-peer support program in improving quality of life outcomes in patients with gynecologic cancer and their caregivers.
- Conditions
- Cervical Carcinoma, Ovarian Carcinoma, Uterine Corpus Cancer, Vaginal Carcinoma
- Trial name
- NCT02412124
- Testing
- Supportive Care, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Endometrial Cancer
Frontline Immunotherapy Combined With Radiation and Chemotherapy in High Risk Endometrial Cancer
The purpose of this single arm, open label study is to evaluate the feasibility of pembrolizumab combined with radiation administered to the upper part of the vagina (vaginal cuff brachytherapy) followed by three cycles of…
- Trial name
- FIERCE (NCT03932409)
- Testing
- Pembrolizumab, Vaginal cuff brachytherapy (VCB), Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Oklahoma
Cervical Cancer, Uterine Cancer
Image-Guided Gynecologic Brachytherapy
Standard therapy for gynecologic cancers involves the use of brachytherapy, also called internal radiation therapy or implant radiation.
- Conditions
- Cervical Cancer, Uterine Cancer, Vaginal Cancer, Carcinoma of the Vulva
- Trial name
- AMIGO (NCT01399658)
- Testing
- Image-guided brachytherapy, 3'-Deoxy-3'-18f-Fluorothymidine
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Dana-Farber Cancer Institute
Bladder Cancer, Squamous Cell Carcinoma of the Lung
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas
The goal of this study is to evaluate the safety and effectiveness of EVOLVE104 in participants with advanced urothelial and squamous cell carcinomas who have previously taken standard treatment options, have declined or have…
- Conditions
- Bladder Cancer, Squamous Cell Carcinoma of the Lung, Esophageal Squamous Cell Carcinoma, Tongue Squamous Cell Carcinoma
- Trial name
- NCT07217171
- Testing
- EVOLVE104
- Where
- 16 sites in United States
- Volunteers
- 160 people
- Sponsor
- EvolveImmune United, Inc
Human Papillomavirus Infection
A Phase I Trial Evaluate the Safety and Tolerability Profile of HPV Vaccine
This study is to evaluate the safety and tolerability profile of Recombinant Nonavalent (Types 6/11/16/18/31/33/45/52/58) Human Papillomavirus (HPV) Vaccine (Escherichia Coli) in healthy women ages 18-45
- Trial name
- NCT05680454
- Testing
- Recombinant Nonavalent (Types 6/11/16/18/31/33/45/52/58) Human Papillomavirus (HPV) Vaccine (Escherichia Coli), Recombinant nonavalent Human Papillomavirus (Types 6,11,16,18,31,33,45,52,58) Vaccine
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Beijing Health Guard Biotechnology, Inc
Cervical Cancer
The Mechanism of Vaginal Flora and Its Metabolites in the Pathogenesis of Cervical Cancer
The disorder of vaginal microflora and its metabolites is considered to be a facilitating factor to human papillomavirus-mediated cervical cancer. However, the mechanism is still unclear.
- Trial name
- NCT05185713
- Testing
- This project is a clinical observational study. No additional medication or surgical interventions are performed on the subjects.
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cervical Intraepithelial Neoplasia
Vaginal Progesterone in the Treatment of Cervical Dysplasia Grade I and II
The investigators want to test whether treatment with a natural progesterone intravaginally increases the cure rate of cervical intraepithelial neoplasia grade I and II.
- Trial name
- NCT00247169
- Testing
- progesterone
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Uterine Fibroids, Uterine Leiomyoma
Vaginal vs. Laparoscopic Hysterectomy
Hysterectomy for benign indication is one of the most common surgical procedures in women. Numerous reviews and guidelines recommend the vaginal approach for benign hysterectomy, but the proportion of laparoscopic (and robotic)…
- Conditions
- Uterine Fibroids, Uterine Leiomyoma, Abnormal Uterine Bleeding, Unspecified
- Trial name
- NCT02059954
- Testing
- Hysterectomy
- Where
- 3 sites in Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Graz
Sexually Transmitted Infections, HIV Infections
Sexually Transmitted Infections Among African American Women Who Have Sex With Women
The purpose of this study is to determine the rates of sexually transmitted infections (STI) among a group of African American women who have sex with women (AA WSW).
- Trial name
- WSW (NCT01043081)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Mississippi Medical Center
Cervical Cancer Screening
The Use of a Novel Vaginal Speculum for Cervical Cancer Screening in Sunrise Community Health Patients
The specific aim of this research is to determine if the Bouquet Speculum TM , compared to the existing 2-bladed vaginal speculum, provides better visualization of the cervix, is easier for the provider to use and is more…
- Trial name
- NCT06496295
- Testing
- Vaginal Speculum Exam
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rocky Vista University, LLC