Clinical trials: Vaginal Stenosis
Gynecologic Cancer
Evaluation of a Brachytherapy Discharge Education Program to Improve Patient Care
Although brachytherapy is an effective treatment modality for gynecological cancer, a significant proportion of patients develop late treatment-related vaginal toxicity, negatively impacting their quality of life and limiting…
- Trial name
- BrachDEP (NCT04707937)
- Testing
- Online education, Regular standard of care education
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Cervical Cancer
Fat Grafting for Vaginal Stenosis in Gynaelogical Cancer
The GRASS study looks at performing a technique called "Fat Tissue Grafting" to assess whether it can reduce the side effects of vaginal stenosis effects and improve the sexual function of participants who wish to preserve…
- Trial name
- GRASS (NCT06015360)
- Testing
- Fat Graft
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Malignancies, Stenosis of Vagina
Longitudinal Evaluation Study of Vaginal Stenosis With and Without Pelvic Radiation Therapy
This study evaluates the effects of treatment with a vaginal dilator to reduce vaginal stenosis in women receiving pelvic radiation therapy for pelvic malignancies.
- Trial name
- NCT01404728
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Colorado, Denver
Vaginal Stenosis, Radiation Therapy
Feasibility of Hyivy Device Post-Radiation for Pelvic Malignancies
Vaginal dilator therapy (VDT) with static dilators is often prescribed to patients following vaginal or pelvic radiation therapy.
- Conditions
- Vaginal Stenosis, Radiation Therapy, Cancer, Pelvic Pain
- Trial name
- NCT05648253
- Testing
- Hyivy Intravaginal Device
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Hyivy Health Inc
Cancer Pain, Neck Cancer
Perineal Massage in Women With Gynecological Cancer
The high incidence of gynecological cancers, together with dyspareunia and vaginal stenosis, some of its most frequent sequelae, create the need to continue studying and researching oncological physiotherapy techniques that treat…
- Trial name
- NCT06432998
- Testing
- Perineal massage, Standard treatment
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- University of Alcala
Vaginal Stricture, Vaginal Stenosis
Quantifying Radiation Induced Vaginal Stenosis
Radiation (RT) affects the vagina by narrowing, tightening and scarring, termed vaginal stenosis (VS). VS occurs in up to 88% of patients treated with radiation for cervical cancer. VS is not well characterized in measurements.
- Trial name
- QRIVS (NCT05002751)
- Testing
- UCSD Vaginal Dilator Questionnaire, EORTC Sexual Health Questionnaire
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Relieves Vaginal Dryness / Improves Self-Lubrication, Improves Strength & Elasticity of Vagina (Aka Collagen and Elastin)
A Clinical Trial to Evaluate the Effects of the NeuEve Dryness Treatment Kit on Vaginal Health, Comfort, and Quality of Life in Postmenopausal Women
This is a decentralized, single-group, open-label clinical trial evaluating a 12-week regimen of the NeuEve Dryness Treatment Kit (comprising Feminine Moisture Support oral softgels, Bone Support oral capsules, NeuEve Salve…
- Conditions
- Relieves Vaginal Dryness / Improves Self-Lubrication, Improves Strength & Elasticity of Vagina (Aka Collagen and Elastin), Improves Vaginal Wall Thickness, Reduces Pain During Sex
- Trial name
- NCT07893795
- Testing
- Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NeuEve
Congenital Adrenal Hyperplasia
Surgical Evaluation of Using the Prepuce in Feminizing Genitoplasty
Background and Rationale: The vaginoplasty remains a challenge for the surgeon. The most commonly used techniques have been: the Y-V plasty described by fortunoff for low vagina, the pullthrough operation described by Hendren and…
- Trial name
- NCT03897504
- Testing
- feminizing genitoplasty using inner surface of the prepuce as pedicled tubularized flap
- Where
- Egypt
- Volunteers
- 5 people
- Sponsor
- Kasr El Aini Hospital
Vaginal Stricture
Newly Designed Vaginal Stent to Improve Patient Comfort and Healing Following Vaginal Surgery or Vaginal Radiation
Each year, females need surgery to create a vaginal canal or pelvic radiation to treat cancer. The result is often a narrowing or scarring of their vagina. To aid in healing a stent is often placed.
- Trial name
- NCT04807387
- Testing
- Vaginal Stent A, Vaginal Stent B, Vaginal Stent
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Pelvic Cancer, Cervical Cancer
Sexual Quality of Life of Patients With Gynecologic Cancer Treated With Brachytherapy.
Gynecologic cancer treatments (chemoradiotherapy, brachytherapy and surgery) greatly impact patients' sexual quality of life (QoL). Use of the vaginal dilators may reduce vaginal stenosis.
- Trial name
- Gyn&Co (NCT04184154)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 167 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Endometrial Cancer, Cervical Cancer
An Enhanced Vaginal Dilator to Reduce Radiation-Induced Vaginal Stenosis
This is a randomized control trial aimed to decreased radiation-induced vaginal stenosis in patients with endometrial or cervical cancer treated with post-operative external beam radiation therapy with or without brachytherapy.
- Conditions
- Endometrial Cancer, Cervical Cancer, Vaginal Stricture, Radiation Toxicity
- Trial name
- NCT03876860
- Testing
- Silicone Dilator, Standard Dilator
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Margaret Liotta
Gynecologic Cancer, Pathological Constriction
Pelvic Physiotherapy in the Prevention of Vaginal Stenosis Secondary to the Radiotherapy
Vaginal stenosis is one of the most prevalent side effects of pelvic radiation, affecting about one third of women. In this randomized controlled trial, the effect of a pelvic physiotherapy protocol on an incidence rate of…
- Trial name
- PPPVSSR (NCT03090217)
- Testing
- Pelvic Physiotherapy, Standard care (SC)
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Pelvic Radiotherapy, Vaginal Stenosis
Vaginal Dilator Therapy After Pelvic Radiation
This study is testing a new program to help women who have had pelvic radiation therapy to use vaginal dilators more regularly. Vaginal dilators are important tools that can help prevent or treat vaginal narrowing (called vaginal…
- Conditions
- Pelvic Radiotherapy, Vaginal Stenosis, Pelvic Cancer, Gynecologic Cancers
- Trial name
- NCT07216456
- Testing
- Improving Engagement with Vaginal Dilator Therapy after Pelvic Radiation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Duke University