Clinical trials: Vaginal Surgery
Wound Infection
A Comparison of Surgical Preparations and Wound Infection Rates for Elective Cesarean Sections
The purpose of this study is to find out if chlorhexidine gluconate solution is better at reducing the rate of wound infection after cesarean section compared to povidone-iodine.
- Trial name
- NCT00528008
- Testing
- povidone-iodine solution, chlorhexidine gluconate
- Where
- Canada
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Anal Melanoma, Bladder Melanoma
Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery
This phase II trial tests whether nivolumab in combination with cabozantinib works in patients with mucosal melanoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the…
- Conditions
- Anal Melanoma, Bladder Melanoma, Cervical Melanoma, Esophageal Melanoma
- Trial name
- NCT05111574
- Testing
- Biospecimen Collection, Bone Scan, Cabozantinib S-malate
- Where
- 146 sites in United States, Canada
- Volunteers
- 101 people
- Sponsor
- National Cancer Institute (NCI)
Sacrospinofixation, Apical Prolapse
Concordance of Pelvic Organ Mobility Measurements Between the Finite Element Model and the Dynamic Pelvic Floor MRI in Patients Undergoing a Sacrospinofixation Surgery
The primary objective of this study is to demonstrate the feasibility of using a Finite Element model of pelvic organs by evaluating the concordance of pelvic organ mobility measurements performed by this mechanical model…
- Trial name
- BiomécaRichter (NCT04551859)
- Testing
- Dynamic Pelvic Floor MRI
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pelvic Organ Prolapse
Comparing Postoperative Pain After Vessel Sealing Device Versus Conventional Suturing Methods for Vaginal Hysterectomy and Pelvic Reconstructive Surgery
This study will investigate pain outcomes for patients undergoing vaginal hysterectomy with pelvic reconstructive surgery using the LigasureTM vessel sealing device as compared to conventional clamping and suturing methods.
- Trial name
- NCT05192954
- Testing
- LigaSureTM vessel sealing device
- Where
- 2 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Marlana McDowell
Abnormal Uterine Bleeding, Uterine Bleeding
Outcomes on Abdominal Versus Vaginal Morcellation At Time of Hysterectomy
The purpose of the study is to investigate differences in perioperative and postoperative outcomes between the abdominal (AM) versus vaginal (VM) routes of contained morcellation in participants undergoing laparoscopic total…
- Conditions
- Abnormal Uterine Bleeding, Uterine Bleeding, Fibroid Uterus, Surgery
- Trial name
- NCT04434066
- Testing
- Total Laparoscopic Hysterectomy
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Vaginal Vault Prolapse
Prospective Study for Vaginal Vault Prolapse After Hysterectomy: Comparison of Two Surgical Methods
The study is carried out at the Sahlgrenska University Hospital and the patient population consists of women referred with symptomatic and bothersome post-hysterectomy vaginal vault prolapse at least 1 cm above or beyond the…
- Trial name
- NCT02290288
- Testing
- vaginal surgery, laparoscopic surgery
- Where
- Sweden
- Volunteers
- 138 people
- Sponsor
- Sahlgrenska University Hospital
Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse
Efficacy of Platelet Rich Plasma on Pelvic Floor Muscle Strength and Recurrence Rate in Pelvic Organ Prolapse Surgery
Pelvic organ prolapse (POP) is a common pelvic floor disorder associated with impaired quality of life and considerable postoperative recurrence following native tissue repair.
- Conditions
- Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse, Platelet Rich Plasma Injection
- Trial name
- NCT07746739
- Testing
- POP surgery adjunctive PRP
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Andalas University
Urinary Incontinence, Stress, Uterine Prolapse
Colpopexy and Urinary Reduction Efforts (CARE) Protocol
Pelvic organ prolapse occurs when the muscles holding pelvic organs (e.g., the uterus or bladder) weaken and the organs fall or slide down into the vagina. Pelvic organ prolapse can be corrected with surgery.
- Conditions
- Urinary Incontinence, Stress, Uterine Prolapse, Vaginal Prolapse
- Trial name
- CARE (NCT00065845)
- Testing
- Burch urethropexy at time of sacrocolpopexy
- Where
- 7 sites in United States
- Volunteers
- 322 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Vaginal Surgeries
Efficacy of Two Vaginal Solutions in Preoperative Use
This study is necessary in order to provide proof the effectiveness of Chlorhexidine gluconate and its safety.
- Trial name
- NCT03014778
- Testing
- The Chlorhexidine gluconate 0.05%, 10% Povidone iodine
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Urinary Retention
Duration of Stay After Urologic Surgery : Neuraxial Versus General Anesthesia
Outpatient midurethral surgery is a frequent surgery. It is performed either under general anesthesia or neuraxial anesthesia. A frequent complication is postoperative urinary retention requiring urinary catheterization, which…
- Trial name
- NCT03517202
- Where
- France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Strasbourg, France
First Trimester Pregnancy, Surgical Termination of Pregnancy
Misoprostol for Cervical Priming Prior to Vacuum Aspiration
Despite of the widespread use, and extensive studies, the optimal route of administration of misoprostol before surgical abortion remains to be defined.
- Trial name
- NCT01933360
- Testing
- Misoprostol sublingual, 1h, Misoprostol sublingual, 3h, Misoprostol vaginal, 1h
- Where
- Sweden
- Volunteers
- 184 people
- Sponsor
- Karolinska Institutet
Surgery
Objective Structured Assessment of Technical Skills (OSATS) Evaluation of Delivery by Vacuum Extraction
In a prospective, randomized Trial, the investigators compare Hands-on teaching and frontal teaching using a Training Video for learning how to perform an assisted delivery by vacuum extraction on a pelvic Training model.
- Trial name
- VAC-OSATS (NCT02468427)
- Testing
- hands-on teaching, Frontal teaching
- Where
- Germany
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Unrecognized Condition
Different Surgical Techniques Used for Prolapse Repair in Elderly Patient
The investigator aimed to compare various pelvic floor repairs in female aged from 70 to 80 years old, to see which procedure in terms of treatment-related complications of SCP, VMR and NTR by comparing the operative and…
- Trial name
- NCT03445442
- Testing
- SCP, NTR, VMR
- Volunteers
- 214 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Vaginal Fistula
Non-inferiority of Short-term Catheterization Following Fistula Repair Surgery
This facility-based, multi-center randomized controlled trial (RCT) will test the non-inferiority of short-term (7 day) urethral catheterization compared to longer-term (14 day) urethral catheterization in terms of predicting…
- Trial name
- NCT01428830
- Testing
- 7-day catheterization following fistula repair surgery, 14 day catheterization
- Where
- 8 sites in Democratic Republic of the Congo, Ethiopia and 6 more
- Volunteers
- 524 people
- Sponsor
- EngenderHealth
Cesarean Section, Surgical Site Infection
Preoperative Application of Chlorhexidine to Reduce Infection With Cesarean Section After Labor
Surgical site infections (SSI) are the second most common cause of nosocomial infections accounting for 15% of all nosocomial infections among hospitalized patients and 38% of nosocomial infections in surgical patients.
- Conditions
- Cesarean Section, Surgical Site Infection, Nosocomial Infection
- Trial name
- PRACTICAL (NCT03423147)
- Testing
- 2% chlorhexidine gluconate cloth, 4% Chlorhexidine gluconate vaginal scrub
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Angela Bianco
Rectovaginal Fistula, Obstetric Complication
Musset's Surgical Technique: Evaluation of Long-term Results (LONGOMUSSET)
The surgical technique of Musset has shown its effectiveness for the cure of recto-vaginal fistulas. Recto-vaginal fistulas are mostly post-obstetric (88%).
- Trial name
- LONGOMUSSET (NCT05079139)
- Testing
- surgical technique of Musset
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Uterine Fibroids (UF), Abnormal Uterine Bleeding Unrelated to Menstrual Cycle
POPQ Associated With Total Laparoscopic Hysterectomy
The goal of this observational study is to evaluate the impact of different hysterectomy (removal of the uterus) techniques on the risk of pelvic organ prolapse (situation when one or more of your pelvic organs like your bladder…
- Conditions
- Uterine Fibroids (UF), Abnormal Uterine Bleeding Unrelated to Menstrual Cycle, Endometrial Hyperplasia, Pelvic Organ Prolapse (POP)
- Trial name
- POP-LAP (NCT07137299)
- Testing
- Questionnaire and Physical Exam
- Where
- 4 sites in Poland
- Volunteers
- 2,000 people
- Sponsor
- Medical University of Silesia
Vaginal Packing Following Pelvic Reconstructive Surgery
Does Vaginal Packing Influence Patient Outcomes Following Vaginal Reconstructive Surgery?
Vaginal packing is used routinely following vaginal reconstructive surgery. Despite little data to support the practice, purported benefits include reduced pelvic fluid accumulation or blood loss.
- Trial name
- NCT02000271
- Testing
- Vaginal packing, No vaginal packing
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Postoperative Care, Prolapse Genital
Postoperative Vaginal Compression After Prolapse Surgery - an RCT
The goal of this clinical trial is to learn if omitting postoperative vaginal compression (packing) can facilitate a more efficient recovery after elective surgery for uterovaginal prolapse.
- Conditions
- Postoperative Care, Prolapse Genital, Urogynecologic Surgery
- Trial name
- NCT07612202
- Testing
- No postoperative vaginal compression, Postoperative vaginal compression
- Where
- Denmark
- Volunteers
- 360 people
- Sponsor
- Christiane Marie Bourgin Folke Gam
Cervical Intraepithelial Neoplasia, Cervix Neoplasm
Comparing Two Techniques of Haemostasis After Cervical Conization
The LEEP conization is commonly used for cervical pathologies treatment. The techniques for hemostasis usually used are: cautery, Monsel's solution and vaginal pack.
- Trial name
- NCT03293628
- Testing
- Vaginal Packing
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Barretos Cancer Hospital