Clinical trials: Vaginal Surgery, open to volunteers
Pelvic Organ Prolapse
Comparison of V-NOTES and Laparoscopic Mesh-Free Sacrocolpopexy Techniques
This study aims to compare the surgical outcomes, safety profiles, and patient satisfaction between two minimally invasive techniques for pelvic organ prolapse repair: Vaginal Natural Orifice Transluminal Endoscopic Surgery…
- Trial name
- vnotes (NCT07082023)
- Testing
- V-NOTES Mesh-Free Sacrocolpopexy, Laparoscopic Mesh-Free Sacrocolpopexy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Havva Betül Bacak
Endometriosis Rectovaginal Septum
Laparoscopic Surgery for Severe Recto-vaginal Endometriosis
To determine the quality of life following the radical excision of recto-vaginal endometriosis.
- Trial name
- NCT02471443
- Testing
- Surgery for severe endometriosis
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery
Vaginal Mesh Surgery Versus Robotic-assisted Abdominal Mesh Surgery in the Treatment of Apical Prolapse - Prospective Randomized Non-inferiority Study
The goal of this study is to compare vaginal mesh surgery with abdominal robotic-assisted mesh surgery for the treatment of genital prolapse in women.
- Conditions
- Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery, Mesh Reinforcement, Vaginal Apex/Uterine Prolapse
- Trial name
- NCT07359755
- Testing
- Vaginal mesh surgery for apical prolapse, Robotic-assisted abdominal mesh surgery with Upsylon device (Boston Scientific - USA) for vaginal apical prolapse
- Where
- Brazil
- Volunteers
- 86 people
- Sponsor
- University of Sao Paulo General Hospital
Vaginal Prolapse
Prospective Observational Prolapse Study
The rationale of the study is to investigate the results of a prolapse treatment in adult women with a vaginal prolapse. The investigators will investigate this by taking questionnaires in women undergoing a surgical prolapse…
- Trial name
- NCT04701047
- Testing
- vaginal pessary, Vaginal prolapse surgery
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Ghent
Cesarean Section, Surgical Site Infection
Effect of Betadine Vaginal Cleansing Before Cesarean Section to Reduce Postoperative Infectious Morbidity
This randomized controlled trial aims to evaluate the efficacy of preoperative vaginal cleansing with 5% povidone-iodine in reducing postoperative infectious morbidity among women undergoing cesarean section.
- Conditions
- Cesarean Section, Surgical Site Infection, Endometritis
- Trial name
- NCT07715409
- Testing
- Povidone-iodine 5% solution
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mohamed Mousa Mohamed Mousa
CIN 2/3, HPV Infection
Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3)
This is a phase II double blind, placebo-controlled, randomized study of Artesunate vaginal inserts for the treatment of women who have cervical high grade intraepithelial neoplasia (CIN2/3).
- Conditions
- CIN 2/3, HPV Infection, Pre-Cancerous Dysplasia, Cervical Dysplasia
- Trial name
- ART-CIN_IIB (NCT04098744)
- Testing
- Artesunate vaginal insert
- Where
- 7 sites in United States
- Volunteers
- 78 people
- Sponsor
- Frantz Viral Therapeutics, LLC
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Prolapse Pelvic, Hysterectomy
Vaginal Natural Orifice Transluminal Endoscopic (vNOTE) Hysterectomy With Uterosacral Suspension
As the adoption of Vaginal natural orifice transluminal endoscopic surgery (vNOTES) expands, attention is shifting from feasibility studies to the refinement of surgical steps that optimize long-term pelvic health.
- Trial name
- VENUS (NCT07413861)
- Testing
- Uterosacral suspension, Hysterectomy by vNOTES approach
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Postoperative Care, Prolapse Genital
Postoperative Vaginal Compression After Prolapse Surgery - an RCT
The goal of this clinical trial is to learn if omitting postoperative vaginal compression (packing) can facilitate a more efficient recovery after elective surgery for uterovaginal prolapse.
- Conditions
- Postoperative Care, Prolapse Genital, Urogynecologic Surgery
- Trial name
- NCT07612202
- Testing
- No postoperative vaginal compression, Postoperative vaginal compression
- Where
- Denmark
- Volunteers
- 360 people
- Sponsor
- Christiane Marie Bourgin Folke Gam
Pelvic Organ Prolapse, Abnormal Uterine Bleeding
Evaluating Artisential Laparoscopic Instruments in Gynecologic Surgery
This study evaluates the efficacy and safety of Artisential laparoscopic instruments in minimally invasive gynecologic surgery.
- Conditions
- Pelvic Organ Prolapse, Abnormal Uterine Bleeding, Mesh Augmentation, Laparoscopic Surgery
- Trial name
- MIGS-ART (NCT06050161)
- Testing
- Articulating laparoscopic instrument, Conventional laparoscopic instrument, Robotic surgical instrument
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kern Medical Center
Hysterectomy, Natural Orifice Transluminal Endoscopic Surgery
Vaginal NOTES Hysterectomy Versus Vaginal Hysterectomy
Rationale: Natural orifice transluminal endoscopic surgery (NOTES) is a minimal invasive technique using the natural body orifices like stomach, oesophagus, bladder, rectum and vagina to access the human body for surgery.
- Conditions
- Hysterectomy, Natural Orifice Transluminal Endoscopic Surgery, Vaginal Hysterectomy
- Trial name
- VANH (NCT04886791)
- Testing
- Vaginal NOTES hysterectomy, Vaginal hysterectomy
- Where
- 2 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Zuyderland Medisch Centrum
Post-void Residual Volume, Recatheterization
Effect of Voiding Position (Standing in the Shower vs. Sitting) on Post-Void Residual Urine Volume (PVR) After Removal of Urinary Catheter in Women Following Benign Vaginal Gynecologic Surgery
The goal of this clinical trial is to learn if voiding in a standing position in the shower, rather than sitting on a toilet, may reduce pain associated with the act of voiding, thereby facilitating micturition and decreasing…
- Conditions
- Post-void Residual Volume, Recatheterization, Pain, UTI
- Trial name
- NCT07372547
- Testing
- Voiding position - Standing in the shower, Voiding position - Sitting on the toilet
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Assuta Ashdod Hospital
Pelvic Organ Prolapse, Pelvic Organ Prolapse (POP)
Accelerometer Measured Early Recovery After Prolapse Surgery
The AccelERate study will evaluate the physical recovery of patients who have undergone Pelvic Organ Prolapse (POP) surgery. This will be evaluated via a self-reported recovery questionnaire completed daily.
- Conditions
- Pelvic Organ Prolapse, Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse, Patient Education
- Trial name
- AccelERate (NCT07218016)
- Testing
- Postoperative Exercise regimen
- Where
- 7 sites in United States
- Volunteers
- 288 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Pelvic Organ Prolapse (POP)
Are There Benefits of Using Energy-based Devices for Opportunistic Salpingo-oophorectomy During Vaginal Hysterectomy Compared to a Standard Cold Approach?
This study compares two methods for removing the fallopian tubes and ovaries during vaginal hysterectomy for pelvic organ prolapse.
- Trial name
- NCT07379411
- Testing
- LigaSure MaryLand, Standard salpingo-oophorectomy technique
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Wolfson Medical Center
Perineal Injury, Pain Vulva
Improving Postoperative Recovery: A Study of Multimodal Perineal Analgesia Protocol (MPAP) After Vaginal Surgery
The purpose of this research is to determine if using perineal ice packs, medicated witch-hazel pads (MAJOR® Medi-Pads), and topical benzocaine spray (Dermoplast®) helps reduce perineal pain after perineorrhaphy and/or posterior…
- Conditions
- Perineal Injury, Pain Vulva, Perineum; Injury
- Trial name
- NCT07401134
- Testing
- Perineal ice packs, medicated witch-hazel pads, and topical benzocaine spray
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Pelvic Organ Prolapse Vaginal Surgery, Stress Urinary Incontinence in Women
The AMPER Study: Evaluation of the Efficacy of Human Amniotic Membrane Grafting in Preventing Mesh Exposure in Vaginal Reconstructive Surgery Using Polypropylene Mesh.
This study evaluates the efficacy of adding a human amniotic membrane graft to polypropylene mesh surgery for pelvic prolapse and stress urinary incontinence.
- Trial name
- AMPER (NCT07414849)
- Testing
- Sacrospinous Hysteropexy with Mesh, Retropubic Mid-urethral Sling (Bottom-Up), Transobturator Mid-urethral Sling (Out-In)
- Where
- Argentina
- Volunteers
- 330 people
- Sponsor
- Hospital General de Agudos J. M. Penna
Prolapse, Vaginal
Transperineal Ultrasound Evaluation of Vesicourethral Angle and de Novo SUI After Colpocleisis Surgery
This prospective observational study aims to evaluate changes in the vesicourethral angle using transperineal ultrasound before and after colpocleisis surgery, and to assess the relationship of these changes with the development…
- Trial name
- colpocleisis (NCT07071818)
- Testing
- Colpocleisis Group
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Pelvic Cancer, Anal Cancer
Assessment of Sexual Quality of Life Following Local Treatment (Radiotherapy With or Without Surgery) in Patients With HPV-positive Pelvic Cancer: a Descriptive Longitudinal Study
In patients with cancer associated with human papillomavirus (HPV), the physical effects of treatment, combined with the psychosexual impact linked to HPV status, can further impair the quality of sexual life.
- Conditions
- Pelvic Cancer, Anal Cancer, Vaginal Cancer
- Trial name
- SAPPHIRE (NCT07523152)
- Testing
- Assessment of sexual quality of life
- Volunteers
- 42 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Ectopic Pregnancy
Comparison of vNOTES and Laparoscopic Salpingectomy in the Surgical Treatment of Ectopic Pregnancy
This study compares vNOTES salpingectomy and laparoscopic salpingectomy in the treatment of ectopic pregnancy, focusing on outcomes such as operative time, postoperative pain, and recovery.
- Trial name
- vNOTES (NCT07057115)
- Testing
- vNOTES Salpingectomy Group., Laparoscopic Salpingectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Pelvic Organ Prolapse (POP)
Vaginal Estrogen for Improvement of Outcomes Following Pelvic Organ Prolapse Surgery
This open-label randomized control trial will study the use of vaginal estrogen in the first six weeks after pelvic organ prolapse (POP) repair surgery.
- Trial name
- VEPO (NCT07030426)
- Testing
- Vaginal Estrogen - Twice Weekly, Vaginal Estrogen - Daily
- Where
- 2 sites in Canada
- Volunteers
- 180 people
- Sponsor
- Sarah Wozney