Clinical trials: Vaginosis
Bacterial Vaginosis, HIV
Effects of Contraceptive Ring on Vaginal Microbiota, HIV Shedding and Local Immunity
The investigators propose to explore the hypothesis-supported by limited data-that a contraceptive vaginal ring (CVR) that is commonly used in the United States, the NuvaRing, will enhance women's genital and reproductive health.
- Trial name
- NCT02445989
- Testing
- NuvaRing
- Where
- Kenya
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cervical Cancer, Vulvar Cancer
Long-term Follow-up of Bivalent Human Papillomavirus (HPV) Vaccine Study in Women
This extension study aims to evaluate the long-term protection and immune response of the bivalent HPV vaccine in women aged 18-30 who participated in a previous efficacy study (311-HPV-1003).
- Conditions
- Cervical Cancer, Vulvar Cancer, Vaginal Cancer, CIN - Cervical Intraepithelial Neoplasia
- Trial name
- NCT06776055
- Testing
- HPV-16/18 vaccine
- Where
- 9 sites in China
- Volunteers
- 5,372 people, healthy volunteers welcome
- Sponsor
- Shanghai Zerun Biotechnology Co.,Ltd
HPV Infections, Cervical Cancer
Evaluate the Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females
The study will evaluate the immunogenicity and safety of 9-valent HPV recombinant vaccine in Chinese healthy females16 to 26 years of age.
- Conditions
- HPV Infections, Cervical Cancer, Vulvar Cancer, Vaginal Cancer
- Trial name
- NCT05372016
- Testing
- Experimental: Experimental: 9-valent Human Papillomavirus (Types 6, 11, 16, 18, 31, 33, 45, 52, 58), Active Comparator: GARDASIL ®9
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Cervical Cancers, Vulvar Cancer
A Study of V503 (A Multivalent Human Papillomavirus [HPV] L1 Virus-Like Particle [VLP] Vaccine) in Preadolescents and Adolescents (V503-002)
This study will evaluate the immunogenicity and tolerability of V503 (a multivalent human papillomavirus [HPV] L1 virus-like particle [VLP] vaccine) in preadolescent and adolescent participants between 9 and 15 years old and…
- Conditions
- Cervical Cancers, Vulvar Cancer, Vaginal Cancer, Genital Lesions
- Trial name
- NCT00943722
- Testing
- V503
- Volunteers
- 3,074 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Vaginismus
Feasibility of Use of Vibrators With Vaginal Dilators for Vaginismus. (Vibrator Therapy and Dilators in Vaginismus)
The acceptability of vulvar vibration therapy has been evaluated in women with vulvodynia, and found to be acceptable, however has not been assessed in women with a primary complaint of vaginismus.
- Trial name
- ViTaDiVa (NCT04635345)
- Testing
- External Vibrator - patient-administered., Standard care
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Papillomavirus Infections
GARDASIL™ Study in Healthy Females Between 9 and 26 Years of Age in Sub-Saharan Africa (V501-046)
The study is designed to determine the safety, tolerability and immunogenicity of a 3-dose regimen of GARDASIL™ administered to healthy females between 9 and 26 years of age, in Sub-Saharan Africa.
- Trial name
- NCT01245764
- Testing
- Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine (GARDASIL™)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer
A Survivorship Care Plan for Gynaecological Cancer Patients
After treatment women surviving gynaecological cancer may experience lateeffects and longterm challenges specific to their disease and treatment resulting in functional deficits and a reduction in societal integration (Yabroff et…
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer, Endometrial Cancer, Esophageal Cancer
- Trial name
- NCT01582906
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer
Validation of a Nutrition Screening Tool
The objective of this study is to evaluate the sensitivity and specificity of two nutrition screening tools to identify inpatients with malnutrition or at risk of malnutrition.
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer, Endometrial Cancer, Esophageal Cancer
- Trial name
- NCT01851928
- Where
- United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Bacterial Vaginosis, Candidiasis
Vaginal Ecosystem and Network in the United States Study
The central premise of this study is that the intricate balance and diversity of the vaginal microbiome plays a pivotal role in the onset, progression, and severity of various gynecological conditions.
- Conditions
- Bacterial Vaginosis, Candidiasis, Urinary Tract Infections, Genitourinary Syndrome of Menopause
- Trial name
- VENUS (NCT06472765)
- Testing
- Vaginal Swab Collection
- Where
- 21 sites in United States, Canada
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Vaginal Biome Science
Vaginitis Gardnerella
Treatment of Gardnerella Vaginalis Vaginal Colonization With Amoxicillin
This is a randomized, double-blind, placebo-controlled Phase 2 study designed to determine if amoxicillin will eradicate vaginal colonization/infection with Gardnerella vaginalis (GV) when administered to women who are…
- Trial name
- NCT03211156
- Testing
- Amoxicillin
- Where
- 2 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Vaginosis, HIV Infections
Effect of Bacterial Vaginosis on HIV Susceptibility and Female Genital Immunology
A non-randomized, interventional, longitudinal clinical study to quantify the impact of bacterial vaginosis treatment on HIV susceptibility and genital immunology in Kenyan women.
- Trial name
- NCT02527941
- Testing
- Metronidazole
- Where
- Kenya
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Vaginal Discharge, Postcoital Vaginal Changes
In-Clinic Assessment of Vaginal Mucosal Safety Following Repetitive Use of the Livi Device
The goal of this clinical trial is to learn if the Livi postcoital tampon device is safe for repetitive use in sexually active women aged 18 years and older.
- Trial name
- NCT07445958
- Testing
- Livi Postcoital Tampon Device
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Bacterial Vaginosis Treatment
Vaginal Clindamycin Cream Plus Vaginal Probiotic for Bacterial Vaginosis
Vaginal Clindamycin Cream Plus Vaginal probiotic for treatment of Bacterial Vaginosis
- Trial name
- NCT03234517
- Testing
- Vaginal Clindamycin Cream, Vaginal Probiotic
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Vaginal Discharge, Dyspareunia
Evaluation of a Novel Female Hygiene Device for Postcoital Discomfort
Previous research has shown that semen deposition in the vagina after intercourse leads to dripping, discomfort, and vaginal odor.
- Conditions
- Vaginal Discharge, Dyspareunia, Female Sexual Dysfunction, Vaginitis
- Trial name
- NCT04885556
- Testing
- Tampon-like device for absorption of sexual fluids
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Bacterial Vaginoses
Effects of Lactobacillus Pentosus KCA1 on the Gut and Vaginal Microbiome of Women With Bacterial Vaginosis
Bacterial vaginosis (BV) is under-reported, misdiagnosed and inappropriately treated in Nigeria. Treatment option rely on antibiotics that eliminates both good and pathogenic bacteria, with gross impact on the gut and vaginal…
- Trial name
- NCT04329338
- Testing
- Lactobacillus pentosus KCA1
- Where
- Nigeria
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Nnamdi Azikiwe University
HIV-1-infection, Bacterial Vaginoses
Estrogen, Probiotics and Vaginal Health to Prevent HIV Infection in ACB Women
This study will enrol African, Caribbean and Black (ACB) women who are known to have a more diverse vaginal microbiome, higher rates of bacterial vaginosis with lower numbers of protective lactobacilli, and are at increased risk…
- Trial name
- NCT03837015
- Testing
- Estring Vaginal Ring, RepHresh Pro-B
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cervical Cancer, Vulvar Cancer
Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001)
The purpose of this study was to evaluate the safety, efficacy, and immunogenicity of V503 in comparison to GARDASIL. The primary hypotheses tested in the study were 1) V503 administered to 16- to 26-year-old adolescents and…
- Conditions
- Cervical Cancer, Vulvar Cancer, Vaginal Cancer, Genital Warts
- Trial name
- NCT00543543
- Testing
- Comparator: GARDASIL, Experimental: V503
- Volunteers
- 14,840 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Premature Birth, Bacterial Vaginosis
Effect of Probiotic Lactobacilli on Vaginal Flora of Pregnant Women at High Risk for Preterm Delivery
Purpose of the study is to determine the effect of probiotic lactobacilli on the vaginal flora and cytokine profile during pregnancy, and the incidence of preterm labour in women at high risk for preterm birth.
- Trial name
- NCT00217308
- Testing
- Lactobacilli GR-1 and RC-14
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Healthy
Pubic Hair and the Urinary and Vaginal Microbiome
This research study seeks to find if there is a connection between the presence of pubic hair and the type of bacteria that live in the vagina and bladder.
- Trial name
- NCT03272204
- Testing
- No pubic hair, Pubic Hair
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Margaret Mueller
Vulvovaginal Candidiasis
DeVEnIR: Defining Vulvovaginal Candidiasis - Elements of Infection and Remedy
Female-specific health conditions are underrepresented in research. The taboo felt by women to talk about intimate wellbeing is fed by this gender gap in scientific knowledge.
- Trial name
- DeVEnIR (NCT06397248)
- Testing
- No intervention
- Where
- 3 sites in Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp