Clinical trials: Vagus Nerve Autonomic Disorder
Cerebral Palsy, Spastic
Nervus Vagus Stimulation and Cerebral Palsy
When the literature is reviewed, it is difficult to find direct research on the effects of auricular vagus nerve stimulation (aVNS) on the autonomic nervous system and spasticity in children with spastic cerebral palsy.
- Trial name
- NCT06880887
- Testing
- nervus vagus stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Istanbul Medipol University Hospital
Major Depressive Disorder
Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression
This study will identify the sex-dependent impact of expiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry and associated physiology in major depressive disorder (MDD).
- Trial name
- tVNS_MDD_Sex (NCT04448327)
- Testing
- active tVNS
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Primary Headache, Migraine in Adolescence
nVNS for the Prevention and Treatment of Primary Headache
This study is a single-center, single-arm study. All subjects will receive the same treatment. Children and adolescents (7-20 years old) with migraine who met the inclusion criteria will be enrolled as subjects in the…
- Conditions
- Primary Headache, Migraine in Adolescence, Migraine in Children, Cluster Headache
- Trial name
- NCT06277063
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Stress, Psychological Cumulative, Chronic Disease
Randomised Clinical Trial to Determine the Effect of Vagus Nerve Neurodynamics on the Neurovegetative Nerve System in People With Chronic Stress.
This unicentric, controlled clinical trial aims to evaluate the effects of vagus nerve neurodynamics and 6 bpm guided breathing, combined with manual therapy, on heart rate variability (HRV) in patients suffering from chronic…
- Conditions
- Stress, Psychological Cumulative, Chronic Disease, Heart Rate Variability, Vagal Nerve Stimulation
- Trial name
- VNN-HRV-CCS (NCT06499662)
- Testing
- Vagus Nerve Neurodynamics, Guided Breathing, Manual Therapy
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Marta de la Plaza
Systemic Lupus Erythematosus, Autonomic Dysfunction
Vagus Nerve Stimulation for Systemic Lupus Erythematous
This trial uses a double blinded, randomized 1:1 (active:sham) placebo controlled, parallel group design, investigating the effects of transcutaneous vagus nerve stimulation (tVNS) in patients with systemic lupus erythematosus…
- Conditions
- Systemic Lupus Erythematosus, Autonomic Dysfunction, Autonomic Neuropathy, Fatigue
- Trial name
- SLE-VNS (NCT05315739)
- Testing
- Non-invasive transcutaneous vagus nerve stimulation (tVNS)
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postural Orthostatic Tachycardia Syndrome (POTS), Post-acute COVID-19 Syndromes
Effects of Auricular Vagus Nerve Stimulation Combined With Slow-paced Breathing on Individuals With Postural Orthostatic Tachycardia Syndrome.
This study investigates a non-pharmacological treatment approach for Postural Orthostatic Tachycardia Syndrome (POTS), a disorder of the autonomic nervous system characterized by an excessive increase in heart rate upon standing.
- Trial name
- NCT06996314
- Testing
- TVNS + Slow-Paced Breathing (TVNS+SDB), TVNS without Breathing Training (TVNS+NB)
- Volunteers
- 100 people
- Sponsor
- Ali Kapan
Obesity, Bariatric Surgery
Preoperative Treatment With Noninvasive Intra-auricular Vagus Nerve Stimulation Pending Bariatric Surgery
Faced with the current obesity epidemic, new avenues of research into effective weight loss must be developed. Among the possible actions on obesity, vagus nerve stimulation has been shown in several studies to be effective in…
- Trial name
- OBESITE (NCT02648191)
- Testing
- NeuroCoach II Stim
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Functional Gastrointestinal Disorders, Vagus Nerve Autonomic Disorder
A Study of Randomized Sham-control Auricular TENS Unit Stimulation in Pediatric Functional Gastrointestinal Disorders
The purpose of this study is to see if using a micro-current through a device called a TENS (Transcutaneous Electrical Nerve Stimulator) unit helps to improve functional gastrointestinal disorder (FGID) symptoms in children by…
- Conditions
- Functional Gastrointestinal Disorders, Vagus Nerve Autonomic Disorder, Irritable Bowel Syndrome, Nausea
- Trial name
- NCT04247100
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Gisela Grotewold Chelimsky
Postural Orthostatic Tachycardia Syndrome
Vagus Nerve Stimulation in Treatment of Postural Orthostatic Tachycardia Syndrome
Postural orthostatic tachycardia (POTS) is characterized by abnormalities in the autonomic nervous system in the body. The autonomic nervous system controls and regulates body functions such as heart rate, breathing, digestion…
- Trial name
- POTS (NCT03930914)
- Testing
- Parasym (TM) Transcutaneous Electrical Nerve Stimulation (TENS) Device
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Oklahoma
Vasoconstriction Disorder of Extremities
Response of the Autonomic Nervous System to Auricular Stimulation of the Vagus Nerve (x)
While invasive vagal stimulation has proven its therapeutic effectiveness over the past 20 years, particularly in the treatment of epilepsy or depression, its implementation is hampered by the high cost, high technicality and…
- Trial name
- AURIX (NCT04130893)
- Testing
- stimulation of G13 then G15, stimulation of G15 then G13
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hôpital Européen Marseille
Post-COVID / Long-COVID, ME/CFS
Vagus Nerve Stimulation to the Ear to Improve Symptoms in Post-COVID-19 and ME/CFS
This study is testing whether a gentle electrical stimulation of a nerve in the ear, called the vagus nerve, can help reduce fatigue and improve symptoms in people with Post-COVID Syndrome or Myalgic Encephalomyelitis/Chronic…
- Trial name
- STIMPACT (NCT06968104)
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Luxembourg
- Volunteers
- 48 people
- Sponsor
- University of Luxembourg
Congestive Heart Failure
Autonomic Neural Regulation Therapy to Enhance Myocardial Function in Heart Failure (ANTHEM-HF) Study
The ANTHEM-HF Study is designed to demonstrate the safety and efficacy of vagus nerve stimulation (VNS) with the Cyberonics VNS Therapy System for the treatment of subjects with symptomatic heart failure.
- Trial name
- ANTHEM-HF (NCT01823887)
- Testing
- Vagus Nerve Stimulation (VNS)
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Cyberonics, Inc.
Stroke
Non-invasive Auricular Vagus Nerve Stimulation (taVNS) on Postural Control and Autonomic Responses in Stroke
This randomized controlled trial is conducted to determine the effects of transcutaneous auricular Vagus nerve stimulation (taVNS) on postural control in stroke patients (e.g., improvements in balance, mobility, and functional…
- Trial name
- NCT07629687
- Testing
- Vagus Nerve Stimulation combined with Balance Training Group, Balance Training Group
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Premature Ventricular Complexes, PVC - Premature Ventricular Contraction
Sustained Auricular Nerve Stimulation for PVC Suppression
Non-invasive vagus nerve stimulation has been clinically tested for the treatment cardiac arrhythmias. However, prior studies have shown mixed results-possibly in part due to inadequate stimulation duration.
- Conditions
- Premature Ventricular Complexes, PVC - Premature Ventricular Contraction, Auricular Vagus Nerve Stimulation
- Trial name
- SANS-PVC (NCT07093034)
- Testing
- Extended nocturnal use of auricular vagus nerve stimulator device
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Diego
Spinal Cord Injury (SCI)
Effect of Transauricular Vagal Stimulation on Cardiac Function After Spinal Cord Injury
The aim of this study is to investigate the effect of transauricular vagal nerve stimulation (taVNS) on cardiac autonomic functions in patients with spinal cord injury (SCI).
- Trial name
- NCT07007884
- Testing
- Active Transauricular Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Heart Failure, Heart Failure, Congestive
ANTHEM-HFrEF Pivotal Study
A multi-center randomized controlled clinical trial to evaluate Autonomic Regulation Therapy with the VITARIA system in patients with symptomatic heart failure and reduced ejection fraction.
- Conditions
- Heart Failure, Heart Failure, Congestive, Heart Failure, Systolic
- Trial name
- NCT03425422
- Testing
- VITARIA System
- Where
- 22 sites in United States
- Volunteers
- 533 people
- Sponsor
- LivaNova
Gastrointestinal Dysfunction, Diabetes Mellitus
Treatment of Complications to Diabetic Autonomic Neuropathy With Vagus Nerve Stimulation
The purpose of the DAN-VNS study is to investigate the effects of non-invasive vagal nerve stimulation on gastrointestinal symptoms such as nausea, vomiting, bloating, and diarrhea in people with diabetes.
- Trial name
- DAN-VNS (NCT04143269)
- Testing
- Non-invasive transcutaneous vagus nerve stimulation
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Aalborg University Hospital
Chronic Kidney Diseases
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Chronic Kidney Disease (CKD)
30 patients will participate in a prospective randomized clinical trial to test the safety, tolerability and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) for autonomic nervous system (ANS) dysfunction in…
- Trial name
- NCT06927024
- Testing
- Active taVNS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Fibromyalgia (FM) OR Fibromyalgia Syndrome, Manuel Therapy
Effects of Adding Vagal Neuromodulation to Manual Therapy in Women With Fibromyalgia
The aim of this study is to investigate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) added to manual therapy on pain, autonomic nervous system function, and illness perception in female patients…
- Conditions
- Fibromyalgia (FM) OR Fibromyalgia Syndrome, Manuel Therapy, Chronic Widespread Pain, Autonomic Nervous System Dysfunction
- Trial name
- NCT07894588
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Manual Therapy Program, Diaphragmatic Breathing and Stretching Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Hasan Kalyoncu University
Chronic Cluster Headache
Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care
Subjects enrolled into this 10 week study will for the first two weeks document the number of cluster headaches and the means of treating (medication) of these attacks. Subjects will then be randomized to into either two groups.
- Trial name
- NCT01701245
- Testing
- GammaCore
- Where
- 10 sites in Belgium, Germany and 2 more
- Volunteers
- 97 people
- Sponsor
- ElectroCore INC