Clinical trials: Vagus Nerve Stimulation
Healthy Adult
Vagal Nerve Stimulation for Interoception Modulation
Explore the effects of variable ingested volumes and auricular transcutaneous vagal nerve stimulation (taVNS) on brain and stomach outcomes in healthy adults.
- Trial name
- NCT03603730
- Testing
- taVNS
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Epilepsy
Transcutaneous Auricular Vagus Nerve Stimulation for Pediatric Epilepsy
The purpose of this study is to determine whether transcutaneous auricular vagus nerve stimulation as a complementary therapy is effective in the treatment of pediatric epilepsy.
- Trial name
- NCT02004340
- Testing
- ear vagus nerve stimulator
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- China Academy of Chinese Medical Sciences
Healthy Volunteers
Effect of Recording Duration on Heart Rate Variability During taVNS
This study aims to evaluate how different heart rate variability (HRV) recording durations reflect autonomic nervous system responses during transcutaneous auricular vagus nerve stimulation (taVNS) in healthy adults.
- Trial name
- taVNS-HRV (NCT07526415)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sinop University
Healthy, Sports Physical Therapy
The Effect of Vagus Nerve Stimulation on Cycling Ergometry and Recovery
It is aIt is aimed to examine the possible benefits and effects of the use of Transcutaneous Auricular Vagus Nerve Stimulation to be applied in healthy individuals for sportive purposes on recovery and sportive performance level.
- Conditions
- Healthy, Sports Physical Therapy, Activity, Motor
- Trial name
- TAVNSCER (NCT05778058)
- Testing
- Unilateral Stimulation, Bilateral Stimulation, Bicycle Ergometer Test
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sinop University
Vagus Nerve Stimulations
Comparison of the Acute Effects of Auricular Vagus Nerve Stimulation and Deep Breathing Exercise
The goal of this clinical trial is to investigate whether vagus stimulation and breathing exercises are more effective in healthy adults.
- Trial name
- NCT06740032
- Testing
- Transcutaneous vagus nerve stimulation, Deep breath exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Experimental Pain in Healthy Human Subjects
Tonic Pain and Transauricular Vagal Nerve Stimulation
This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception.
- Trial name
- NCT07325058
- Testing
- taVNS, Earlobe Stimulation
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Vagus Nerve Stimulation
Examining Transcutaneous Vagal Nerve Stimulation as a Facilitator of Social Bonding
This study aims to understand the role of the vagus nerve in promoting social bonding by using a non-invasive stimulation technique called transcutaneous vagal nerve stimulation (tVNS).
- Trial name
- CtVNS (NCT05899413)
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Efficacy, Self, Fatigue; Muscle, Heart
Neuromodulation of the Autonomic Nervous System in Athletes
There are few studies in the literature that have evaluated the effects of using percutaneous stimulation of the auricular branch of the vagus nerve for sports purposes (to accelerate recovery after physical exertion).
- Conditions
- Efficacy, Self, Fatigue; Muscle, Heart, Fatigue, Mental, Fatigue; Combat
- Trial name
- NANSA (NCT06281795)
- Testing
- tVNS
- Where
- Russia
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Anxiety
Is Auriculotherapy Responsible for Improvements on Anxiety Students' Prior and After Examinations?
As the investigators have shown before, there was a tendency for a reduction of anxiety levels on university students after 30 minutes, with auriculotherapy treatment before examinations have started.
- Trial name
- NCT05042778
- Testing
- Auriculotherapy
- Where
- Portugal
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Vagus Nerve Stimulation in Reward Learning
Pulsed tVNS Protocol and Reinforcement Learning
The aim of this study is to investigate the potential of a phasic taVNS stimulation protocol for reinforcement learning. The investigators will disentangle its effects on learning actions and outcomes through the administration…
- Trial name
- NCT06205108
- Testing
- taVNS stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Healthy
Mapping Auricular Vagus Nerve Circuitry
This study will determine how noninvasive nerve stimulation affects human brain, stomach, and autonomic activity.
- Trial name
- NCT00200889
- Testing
- active TEAS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Myocardial Injury
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Myocardial Injury in Elderly Patients Undergoing Thoracoscopic Surgery: a Prospective, Randomized Controlled Study
This research group plans to design a prospective, double-blind, randomized controlled study to explore the effect of taVNS on hs-cTnT in elderly patients undergoing thoracoscopic surgery, and to evaluate the effect on…
- Trial name
- NCT06759818
- Testing
- transcutaneous vagus nerve stimulation
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Jiaxing University
Motion Sickness
Evaluation of a Device to Reduce Motion Sickness and Spatial Disorientation
The purpose of this research study is to learn how a wearable nerve stimulation device, the Spark Biomedical's Sparrow Ascent System™, impacts the development of spatial disorientation and/or motion sickness in a healthy…
- Trial name
- NCT06892340
- Testing
- Transcutaneous Auricular Neurostimulation device
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Healthy Young Adults
Noninvasive Vagus Nerve Stimulation (VNS) for Neuromotor Adaptations
The study will examine how electrical stimulation of vagus nerve (i.e. nerve around the outer ear) from the skin surface during motor training influences a brain hormone (called norepinephrine), brain activity, and motor…
- Trial name
- NCT03628976
- Testing
- tVNS, Motor training
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Cognitive Function
The Effect of Transcutaneous Vagus Nerve Stimulation on Cognitive Function
Cognitive health is generally considered a key component of quality of life. Current evidence indicates that a large number of individuals are at a high risk for cognitive impairment from many causes as they age.
- Trial name
- NCT04070547
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- Czechia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Ostrava
Stroke
VNS-induced Corticospinal Plasticity
The goal of this study is to learn more about the connections between the brain, spinal cord, and muscles and how these connections can be strengthened after neurological injury.
- Trial name
- NCT04088565
- Testing
- Paired-Associative Stimulation (PAS), Vagus Nerve Stimulation (VNS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
No Condition Salivary Alpha Amylase
Salivary Alpha Amylase as a Biomarker of Transdermal Vagus Nerve Stimulation
The proposed project tests the hypothesis that salivary alpha amylase concentration is a reliable biomarker of the effect of transdermal vagus nerve stimulation (tVNS) in humans.
- Trial name
- NCT03854539
- Testing
- Transdermal Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Arkansas Tech University
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD)
Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations
This study plans to learn more about how stimulating the vagus nerve through gentle electrical stimulation applied to the ear can affect decision-making, problem-solving, and other thinking abilities.
- Conditions
- Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
- Trial name
- NCT07424365
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Epilepsy
Transcutaneous Vagal Nerve Stimulation: Influence on miRNA, Inflammation, Cerebral Resting State and Gastric Motility
Randomized, double-blind trial to investigate the influence of a single 4 hours episode of transcutaneous vagal nerve stimulation on the expression of microRNA, various cytokines, chemokines, neuropeptides, cerebral resting state…
- Trial name
- EpimiRNA_D (NCT02359188)
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Dyslexia
taVNS for Letter Learning in Dyslexia
This is a pilot study to establish feasibility of transcutaneous auricular vagus nerve stimulation (taVNS) for improving letter-learning in adolescents with dyslexia.
- Trial name
- NCT06127550
- Testing
- active taVNS
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Florida