Clinical trials: Validation Studies
Glaucoma, Diabetic Retinopathy
Glaucoma Algorithm Validation Study in African Population - the MAGIC Study
Artificial Intelligence (AI) algorithms require validation in a variety of populations to ensure widespread clinical applicability.
- Trial name
- MAGIC (NCT06552247)
- Testing
- Fundus Picture AI testing
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Universitário Lisboa Norte
Healthy
Cardiac Linear and Torsional Contractility Measurements With a New Technology: Multi Dimensional Kineticardiography
This study aims to validate the possibility to track cardiac contractility changes with a new technology called 'Heart Kinetic' (HK). HK measurements will be realized and compared echocardiography.
- Trial name
- MultiKinVal (NCT03107351)
- Testing
- Cardiac contractility assessments with Kino-cardiograph, Cardiac assessment repeatability with Kino-cardiograph
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Chronic Kidney Diseases, Healthy
Multiparametric MRI in Healthy Volunteers and CKD Patients
Chronic kidney disease (CKD) is a global health concern because more than 10% of the world's population have it, its prevalence is increasing, and CKD is an important contributor to morbidity and mortality for this population.
- Trial name
- RESPECT (NCT05229263)
- Testing
- Non- contrast Enhanced Multiparametric Renal Magnetic Resonance
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Proximal Dental Caries
Evaluation of Reliability of the Near-infrared Imaging System (VistaCam iX Proxi) in Comparison With Digital Radiographic Findings and ICDAS-II in Detection of Approximal Carious Lesions.
The aim of this study is to evaluate the Clinical performance of the near-infrared imaging system VistaCam iX Proxi in comparison with digital radiographic findings and ICDAS-II in detection of approximal carious lesions.
- Trial name
- NCT03923192
- Testing
- Vistacam, Bitewing radiograph
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pre-diabetes
ELFI Health (e-Health for Empowerment by Lifestyle, Food Advice and Interaction)
In the present study the investigators will examine whether people living with prediabetes benefit from an e-health lifestyle intervention of three months.
- Trial name
- ELFI (NCT06236334)
- Testing
- ELFI lifestyle intervention
- Where
- Netherlands
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- TNO
Dental Caries, Caries Risk
Validation of a Digital Caries Risk Assessment Questionnaire Against the CAMBRA Protocol in an Egyptian Adult Population
This study is designed as a cross-sectional diagnostic agreement study conducted in accordance with the Standards for Reporting Diagnostic Accuracy Studies (STARD 2015) and the Guidelines for Reporting Agreement and Precision of…
- Trial name
- NCT07716254
- Testing
- Digital Caries Risk Assessment
- Where
- Egypt
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Validation Studies
d13C Added Sugar Intake Biomarker: Determining Validity in Children
Added sugars (AS) constitute a significant source (~ 16%) of the total daily calories consumed by youth. The role of AS in health is contentious, and the reliance on self-reported dietary data is an often-cited flaw in existing…
- Trial name
- NCT02455388
- Testing
- High added sugar diet, Low added sugar diet
- Where
- United States
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Type 1 Diabetes, Autoimmunity
Prospective Assessment in Newborns for Diabetes Autoimmunity
This is an observational study designed to help researchers understand the genetics and pathogenesis of type 1 diabetes, and to identify biomarkers for disease and disease complication prediction.
- Trial name
- PANDA (NCT00649246)
- Where
- 3 sites in United States
- Volunteers
- 25,055 people, healthy volunteers welcome
- Sponsor
- Augusta University
Cancer
a PROspective Case Control Study to Develop and Validate a Blood Test FOr mUlti-caNcers Early Detection（PROFOUND）
This study is a multi-center, case-control study aiming at developing and blinded testing machine learning-based multiple cancers early detection model by prospectively collecting blood samples from newly diagnosed cancer…
- Trial name
- PROFOUND (NCT06217900)
- Where
- 8 sites in China
- Volunteers
- 16,666 people, healthy volunteers welcome
- Sponsor
- Shanghai Weihe Medical Laboratory Co., Ltd.
Healthy
ContraTRAIN - a Validation Study of Contralateral Training Protocols
This study aims to validate the use of contralateral designs in studies of effects of resistance exercise. It will recruit healthy young (18-35 years) individuals, which will be allocated to 4 experimental groups.
- Trial name
- NCT03795025
- Testing
- Strength training 3x10RM + no training, Strength training 6x10RM + no training, 3x10RM + 6x10RM
- Where
- Norway
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Inland Norway University of Applied Sciences
Cardiac Arrhythmia
Validation Study: Extended Wear Performance of the Zio Monitor - SHASTA II
This trial assesses the wear performance of the Zio monitor, a long-term continuous ambulatory patch ECG monitor, in a representative population by evaluating (1) the wear duration (up to 30 days) of the device, (2) the…
- Trial name
- NCT07205367
- Testing
- Zio Monitor
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- iRhythm Technologies, Inc.
Blood Pressure
Clinical Trial of YuWell YE900 Electronic Sphygmomanometer
The purpose of this study is to evaluate the accuracy of the YuWell YE900 medical electronic blood pressure monitor for blood pressure measurements in adults and children according to the Association for the Advancement of…
- Trial name
- NCT04379323
- Testing
- YuWell YE900 Electronic Sphygmomanometer
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Nanjing Medical University
Periodontal Diseases, Periodontitis
Validity of a Self-reported Questionnaire for Periodontal Status in a Saudi Population
This observational study will evaluate the accuracy of a self-reported periodontal questionnaire in adults attending screening appointments in Abha, Saudi Arabia.
- Conditions
- Periodontal Diseases, Periodontitis, Gingivitis
- Trial name
- NCT07397104
- Testing
- Self-reported periodontal questionnaire and clinical periodontal examination (reference standard)
- Volunteers
- 291 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Validation of In-vitro Turbidometric Platelet Aggregation Assay
Study for Validation of In-vitro Turbidometric Platelet Aggregation Assay Using Human Blood in Healthy Volunteers
This study is designed for validation of in-vitro platelet aggregation assay using human blood in healthy volunteers. 32ml blood, 2ml for complete blood count test and 30ml for platelet aggregation assay, was collected from ten…
- Trial name
- NCT02071628
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Obstructive Sleep Apnea (OSA)
Level 3 Validation Study
This study will compare the output of a new Level 3 polysomnography system against in-laboratory polysomnography.
- Trial name
- NCT07688603
- Testing
- Comparison 1: Level 1 Polysomnography: Cadwell/Alice, Comparison 2: Level 3 Test: Berry Sleep Apnea Screening Monitor
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Windsor Sleep Disorders Clinic
Heart Failure, Congestive
A Method Validation Study for Evaluation of Novel Treatments Limiting Pulmonary Oedema in Cardiac Failure
Transient receptor potential vanilloid 4 (TRPV4) channel blockade may be promising in the treatment of pulmonary oedema and dyspnoea in heart failure (HF) and acute decompensated heart failure (ADHF) patients by re-establishing…
- Trial name
- NCT02135861
- Testing
- DCE-MRI scans, Gadobutrol
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Exercise, Validity
The Turkish Version of The Active-Q: Physical Activity Questionnaire
The investigators think that "The Active-Q: Physical Activity Questionnaire" will help physiotherapists and other health professionals in the field and in the field to evaluate individuals' physical activity by revealing their…
- Conditions
- Exercise, Validity, Reliability
- Trial name
- NCT04423705
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Testicular Appendix Torsion, Testicular Torsion
Deep Learning-Assisted Ultrasonic Diagnosis and Localization of Testicular Appendix Torsion
Ultrasound data were both retrospectively and prospectively collected from the primary center and six other sub-centers. Combined with clinical diagnostic outcomes, the data labeling was completed by physicians with extensive…
- Conditions
- Testicular Appendix Torsion, Testicular Torsion, Epididymitis
- Trial name
- NCT07301086
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Ying Jiang
Osteoarthritis of the Knee
Effect Of Meloxicam Versus Placebo In Mainland Chinese Patients With Osteoarthritis Of The Knee
This study is to validate the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) tool in mainland Chinese patients with osteoarthritis of the knee .
- Trial name
- NCT01430559
- Testing
- Meloxicam
- Where
- 25 sites in China
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Pfizer
BPH, BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms
BE Technologies Mobile Uroflowmetry Validation Study
This research study is studying MenHealth Mobile Uroflowmetry as a diagnostic tool for LUTS (lower urinary tract symptoms), a group of conditions involving the bladder, urinary sphincter, urethra and the prostate.
- Conditions
- BPH, BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms, BPH Without Urinary Obstruction, BPH Without Urinary Obstruction With Other Lower Urinary Tract Symptoms
- Trial name
- NCT04599283
- Testing
- MenHealth Uroflowmeter
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- BE Technologies Inc