Clinical trials: Validation Studies
Validity and Safety
Flumatinib Efficacy and Safety for New Diagnosed Chronic Phase Chronic Myeloid Leukemia
The overall survival (OS)of Chronic myeloid leukemia (CML) has been significantly improved since the advent of Tyrosine kinase inhibitors (TKIs) .Nevertheless, there still exists a amount of patients who has poor response or…
- Trial name
- NCT04591197
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Colon Polyp
The Colon Endoscopic Bubble Scale (CEBuS); Validation Study
Colonoscopy is currently accepted as the gold standard in screening, surveillance and prevention for colorectal cancer (CRC), and therefore, its quality is a major priority.
- Trial name
- CEBuS (NCT04378088)
- Testing
- Validation of CEBuS
- Where
- Portugal
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Portuguese Oncology Institute, Coimbra
Musculoskeletal Diseases or Conditions
Digital Assessment Routing Tool (DART): Pilot Study
In the pilot study, we aim to explore trial design, assess procedures, and collect exploratory data to inform the design of a future Randomised Controlled Trial.
- Trial name
- NCT04904029
- Testing
- Digital Assessment Routing Tool [DART], Physiotherapy-led remote triage (usual care)
- Where
- United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Emergency Medicine
Development of a Natural Language Processing Tool to Enable Clinical Research in Emergency Medicine
The goal of this retrospective cohort study is to develop and validate a language model that can interpret the contents of emergency department electronic medical records and extract relevant information for research purposes in…
- Trial name
- NLP-DeVal (NCT06240572)
- Testing
- no intervention
- Where
- 8 sites in Italy
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Atopic Eczema
A Longitudinal Investigation of Skin Barrier Development From Birth and the Validation of Early Predictors of Atopic Eczema Risk: the Skin Testing for Atopic Eczema Risk (STAR) Study
Eczema is a chronic disease of the skin that is becoming more common worldwide for reasons unknown. Currently the best indicator that a baby will suffer from eczema is if either or both parents have the condition, although this…
- Trial name
- STAR (NCT03143504)
- Testing
- Skin Testing for Atopic eczema
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Public Health, Artificial Intelligence
Evaluating an AI-Generated Health Podcast
This study aims to explore a new way of delivering health information using an AI-generated podcast. The podcast, created with Google NotebookLM, uses verified content from the American Academy of Periodontology website to…
- Conditions
- Public Health, Artificial Intelligence, Feasibility Studies
- Trial name
- NCT06891495
- Testing
- Expert Evaluation of Adapted Questionnaire, AI-Generated Health Podcast Evaluation
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Qassim University
Rotator Cuff, Syndrome, Frozen Shoulder
Validation of a Kinematic Functional Shoulder Score Including Only Essential Movements
A lot of shoulder function evaluation scores exist but none has been universally accepted as a gold standard. Recent studies have demonstrated the potential of computerized movement analysis with embedded sensors for objective…
- Conditions
- Rotator Cuff, Syndrome, Frozen Shoulder, Humerus, Fracture, Other Instability of Joint, Shoulder Region
- Trial name
- NCT01431417
- Where
- Switzerland
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Haute Ecole de Santé Vaud
Periodontitis, Gingivitis and Periodontal Diseases
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)
This observational cross-sectional study investigates the levels of mitochondria-endoplasmic reticulum contact site (MERC) proteins in saliva and gingival crevicular fluid (GCF) of individuals with different periodontal…
- Conditions
- Periodontitis, Gingivitis and Periodontal Diseases, Biomarker Discovery and Validation, Pathways
- Trial name
- EKNMERC-GCF-SL (NCT07601685)
- Testing
- ELISA Biomarker Analysis, Calcium Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Inonu University
Breast Cancer
Multicentric Study for External Validation of a Deep Learning Model for Mammographic Breast Density Categorization
The correct categorization of breast density is essential to adapt the diagnostic examination to the needs of each patient. Assessment of breast density is performed visually by radiologists.
- Trial name
- NCT05021055
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Cross-Cultural Comparison, Validation Study
Italian Version of the Modified Barthel Index
This study aims to develop and validate the Italian version of the modified Barthel Index (mBI-Italian), through the following steps: translation of the mBI into Italian, by using the froward-backward translation approach, to…
- Conditions
- Cross-Cultural Comparison, Validation Study, Reliability and Validity, Disability Physical
- Trial name
- NCT05831215
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Aging, Physical Function
Movement and Behaviours Measurement Study
There are few studies that already have validated specific raw accelerometer cut-points for people over 65 years old. The purpose of the present study is to validate raw accelerometer cut points for general people over 65 years…
- Conditions
- Aging, Physical Function, Frailty Syndrome, Physical Disability
- Trial name
- MOBEMENTS (NCT04173715)
- Testing
- Older Adults Group., Low Physical Function Status Group, Medium Physical Function Status Group
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Pre-diabetes
ELFI Health (e-Health for Empowerment by Lifestyle, Food Advice and Interaction)
In the present study the investigators will examine whether people living with prediabetes benefit from an e-health lifestyle intervention of three months.
- Trial name
- ELFI (NCT06236334)
- Testing
- ELFI lifestyle intervention
- Where
- Netherlands
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- TNO
Diet Habit
Dietary Assessment Study Via Digital Images
The purpose of this investigation is to validate a passive image-assisted dietary assessment method using images taken by Sony Smarteyeglass and an automatic image analysis software, DietCam, to identify food items and estimate…
- Trial name
- NCT03267004
- Testing
- Dietary Assessment of Meal A using images taken by Sony Smarteyeglass, Dietary Assessment of Meal B using Images taken by Sony Smarteyeglass
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Asthma (Diagnosis), Children
Asthma Health Literacy Scale for Children (AHLSC) (Aged 8-12)
Asthma Health Literacy Scale for Children (AHLCS) (Ages 8-12): A Scale Development Study Objective: This study will be conducted using a methodological design to develop and examine the psychometric properties of the Asthma…
- Conditions
- Asthma (Diagnosis), Children, Health Literacy, Scale Reliability Validity
- Trial name
- NCT07295249
- Testing
- Asthma Health Literacy Scale for Children (AHLSC) (Aged 8-12): A Scale Development Study
- Where
- Turkey (Türkiye)
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Pregnant Women
Sleep Position Pattern Recording
The main goal of this study is to validate the accuracy of the body position detection by non-invasive wearable monitors (Skiin garments, Myant Medical Corp) during sleep in pregnant participants.
- Trial name
- NCT06286904
- Testing
- Skiin Garment system
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Myant Medical Corp.
Intubation, Intratracheal, Airway Management
A Novel Score for Procedural Difficulty During Videolaryngoscopic Intubation
Videolaryngoscopy generally improves the glottic view compared with direct laryngoscopy, yet a good view does not always translate into easy delivery of the tracheal tube.
- Conditions
- Intubation, Intratracheal, Airway Management, Videolaryngoscopy
- Trial name
- ZVL-DT (NCT07873138)
- Testing
- Videolaryngoscopic tracheal intubation
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Nagihan Emiroglu
Healthy
Study of the ANI Validity on Evaluation of Nociception in State of Hypnosis
Healthy subjects should assess pain on a numerical scale (EN), during painful skin stimuli of variable intensity delivered by a CO2 laser used at the power of 0.3 W, known for its safety.
- Trial name
- NCT02302313
- Testing
- CO2 laser and ANI monitor
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Opioid Use Disorder
Assessment of Methadone and Buprenorphine in Interstitial Fluid
The purpose of this research is to determine if common medications for opioid use disorder (i.e., buprenorphine/naloxone, buprenorphine, methadone) and their metabolites (norbuprenorphine [a metabolite of buprenorphine]…
- Trial name
- NCT05546229
- Testing
- Microneedle based interstitial fluid collection
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cari Health Inc.
ACL - Anterior Cruciate Ligament Deficiency
AI-Based Video Assessment of Anterior Knee Laxity
This prospective observational validation study aims to evaluate the accuracy and reliability of artificial intelligence-based video analysis for quantifying anterior knee laxity.
- Trial name
- AI-LAX (NCT07833605)
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- ASL Lecce
Urinary Sodium Excretion, Salt Intakes
Estimation Method of 24-hour Urinary Sodium Excretion by Using Spot Urine for Chinese Population
The accurate evaluation of daily salt or sodium intake is difficult to implement in clinical practice and large epidemiological studies.
- Trial name
- NCT03204422
- Testing
- No intervention
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Beijing Children's Hospital