Clinical trials: Validity
Breast Cancer
Research on AI Models for Predicting Breast Cancer Treatment Effectiveness to Guide Her-2 Targeted ADC Therapy
This study aims to develop an AI-based predictive tool to help clinicians more accurately determine whether breast cancer patients can benefit from HER-2-targeted antibody-drug conjugate (T-DXd) therapy before treatment.
- Trial name
- NCT07689929
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Zhejiang Cancer Hospital
ICU Patients
Validation of PINI Score in ICU
Prospective, observational clinical monocentric study in ICU; Relationship between Pronostic Inflammatory and Nutritional Index (PINI) (and biomarkers related to PINI) and mortality, morbidity and nutrition in ICU
- Trial name
- NCT02742571
- Testing
- non applicable
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Clermont-Ferrand
Shock, Critically Ill
Validation of the Fluid Responsiveness Index in Critically Ill Patients
Fluid therapy is an important part of the management of patients with hemodynamic instability in the intensive care unit. By increasing cardiac preload, it aims at elevating cardiac output (CO) and thus restoring hemodynamic…
- Trial name
- FRI (NCT00894309)
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 80 people
- Sponsor
- Bicetre Hospital
Lung Cancer
Non-Invasive Biomarkers For Early Detection Of Lung Cancers
Recent studies have shown that low-dose chest CT scans can detect lung cancers in high-risk populations (age >50yo, >30 pack-years of tobacco use), and can lower cancer mortality.
- Trial name
- ISRUSAL01 (NCT01580332)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Douglas W. Johnson MD, FACR
Recurrent Non-Small Cell Lung Carcinoma, Stage IIIA Non-Small Cell Lung Cancer
Pemetrexed Disodium or Erlotinib Hydrochloride as Second-Line Therapy in Treating Patients With Advanced Non-small Cell Lung Cancer
This randomized phase III trial studies pemetrexed disodium to see how well it works compared with erlotinib hydrochloride as second-line therapy in treating patients with non-small cell lung cancer that has spread to other…
- Conditions
- Recurrent Non-Small Cell Lung Carcinoma, Stage IIIA Non-Small Cell Lung Cancer, Stage IIIB Non-Small Cell Lung Cancer, Stage IV Non-Small Cell Lung Cancer
- Trial name
- MARVEL (NCT00738881)
- Testing
- Erlotinib Hydrochloride, Pemetrexed Disodium
- Where
- 269 sites in United States, Canada
- Volunteers
- 23 people
- Sponsor
- National Cancer Institute (NCI)
Cardiovascular Diseases
VaLidation of the Simple Adaptation of the Kardia 6L ECG Recorder to Obtain Chest leAd equivaLents: a Multi-centre International (LOCAL-ECG) Study; on Behalf of the Africa Heart Rhythm Association Investigators
ECGs are routinely performed in cardiology. Recently handheld ECGs have shown promise in screening for heart rhythm disorders. These are quick to perform and do not require the preparation that is needed for 12 lead ECGs.
- Trial name
- LOCAL-ECG (NCT05324111)
- Testing
- Kardia 6L
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Ovarian Cancer
Quality-of-Life Assessment in Patients With Ovarian Cancer
RATIONALE: Quality-of-life assessment in patients undergoing cancer treatment may help determine the intermediate- and long-term effects of treatment.
- Trial name
- NCT00003772
- Testing
- quality-of-life assessment
- Where
- 4 sites in Austria, France and 2 more
- Volunteers
- 372 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Cervical Radiculopathy, Cervical Radicular Pain
Non-organic Signs to Predict Outcomes for Neck Pain
Neck pain is the 4th leading cause of disability in the world, with approximately 50% being neuropathic in nature. Epidural steroid injections (ESI) are one of the most commonly used treatments for cervical radiculopathy.
- Trial name
- NCT04320836
- Testing
- Cervical epidural steroid injection
- Where
- 3 sites in United States, South Korea
- Volunteers
- 78 people
- Sponsor
- Johns Hopkins University
Mood Disorders, Emotional Disorder
Validation of the Ontological Addiction Scale
Background: Bypassing a reductionist view of existing diagnostic categories, ontological addiction theory (OAT) is a new psychological model of human functioning and mental illness.
- Trial name
- OAS (NCT04137471)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Montpellier
Iron Absorption
Iron Long-Term Labelling Study Switzerland
Conventional indirect indicators of iron status, using serum and red blood cell biomarkers, are confounded by inflammation from common infections and are therefore of limited use in populations carrying a high burden of infection…
- Trial name
- NCT02979132
- Testing
- Eisensulfat LOMAPHARM 50 mg, Ferinject(R), iron fortified biscuits
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Prof. Michael B. Zimmermann
Healthy
Validity and Reliability of Tele-Assessment Based Core Performance and Functional Capacity Tests in Healthy Individuals
The COVID-19 pandemic process has created the need for social isolation and quarantine, and restrictions have occurred in access to healthcare services.
- Trial name
- NCT04899804
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Anemia
Spot-Check Noninvasive Pulse CO-Oximeter Validation
In this study, the accuracy of a noninvasive hemoglobin sensor(s) will be assessed by comparison to hemoglobin measurements from a laboratory analyzer.
- Trial name
- NCT02782806
- Testing
- Masimo Rad-67 Pulse Oximeter
- Where
- United States
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Perioperative Neurocognitive Disorders
The Reliability and Validity of Perioperative Cognitive Test Network Platform for Monitoring Neurocognitive Changes
This study aimed to analyze the reliability and validity of the results of the new designed perioperative cognitive test network platform, and to judge the reliability and scientific nature of the perioperative cognitive test.
- Trial name
- NCT06028568
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
IBD, Non Invasive Markers,IL6,Lactoferrin,Ferritin
The Validity of Novel Non-invasive Inflammatory Markers for Monitoring of Patients With Ulcerative Colitis
Ulcerative Colitis (UC) is a disease known for repeated relapses and remissions. So, meticulous follow-up is required to individualize treatment plans according to the status of each patient.
- Trial name
- NCT04670250
- Testing
- non invasive markers
- Volunteers
- 160 people
- Sponsor
- Assiut University
Atheroscleroses, Geriatric
Development and Validation of a Scale of Propensity for Change in Chronic Disease Prevention
Modifiable risk factors are estimated to account for 70% of cardiovascular diseases, 40% of Alzheimer's-type dementias, and 50% of type 2 diabetes cases.
- Trial name
- ProChange (NCT07765797)
- Testing
- Scale development phase, Beta testing phase, Validation phase
- Where
- France
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Pediatric Anesthesia
Turkish Validity and Reliability Study of Pediatric Anesthesia Satisfaction Scale
Strategies to increase patient satisfaction have a positive effect on clinical care. Therefore, evaluation of emotional and psychological satisfaction and satisfaction can increase the quality of anesthetic care.
- Trial name
- TVRPAS (NCT06121310)
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bozok University
Lung Cancer, Breast Cancer
Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis
The aim of this observational study is to comprehensively analyze the metabolites in plasma samples from multi-cancer patients using advanced mass spectrometry detection technology, in conjunction with metabolomics approaches.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT06363123
- Where
- 4 sites in China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Pulmonary Disease, Chronic Obstructive
Development and Validation of the GLORI-COPD Score
The objective of this study is to evaluate the diagnostic accuracy of the GLORI-COPD score in ambulatory care, to enable the screening of COPD patients at risk of complications, requiring early management
- Trial name
- GLORI-COPD (NCT04027296)
- Where
- France
- Volunteers
- 462 people
- Sponsor
- University of Paris 5 - Rene Descartes
Treatment Resistant Depression (TRD)
Ketamine Biomarker Validation
An EEG-based biomarker will be developed for the effects of ketamine infusion in patients with Depression. The effects of ketamine infusion on Depression symptoms and EEG signals will be analyzed.
- Trial name
- NCT07307768
- Testing
- Ketamine (0.25 mg/kg), Ketamine (0.5 mg/kg), Ketamine (0.75 mg/kg)
- Where
- United States
- Sponsor
- Soterix Medical
Delirium
DeltaScan Validation Study for the Assessment of Delirium in the ICU and on Wards
Rationale: Delirium is associated with prolonged hospitalization, an increased risk of dementia, institutionalization and mortality, as well as increased costs.
- Trial name
- Val3 (NCT03966274)
- Where
- Netherlands
- Volunteers
- 434 people
- Sponsor
- UMC Utrecht