Clinical trials: Valve Disease, Aortic
Hypertrophic Obstructive Cardiomyopathy
The Effect of TASH in Patients With HOCM
To examine patients with hypertrophic obstructive cardiomyopathy (HOCM) before and after septal alcohol ablation, to investigate the effect of the treatment in regards to changes in myocardial function, perfusion, invasive…
- Trial name
- Post-TASH (NCT04066777)
- Testing
- alcohol septal ablation
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steen Hvitfeldt Poulsen
Symptomatic Aortic Stenosis
Women's INternational Transcatheter Aortic Valve Implantation Registry
The study will evaluate all female patients with severe aortic stenosis undergoing transcatheter valve implantation with commercially available valves and delivery systems.
- Trial name
- WINTAVI (NCT01819181)
- Where
- 10 sites in United States, France and 4 more
- Volunteers
- 1,019 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Septal Hypertrophy, Obstructive Hypertrophic Cardiomyopathy
Use of Cryoenergy to Faciltate Myectomy in Hypertrophic Obstructive Cardiomyopathy: Comparison With the Classical Approach
In some patients, septal hypertrophy extends more distally, from the subaortic portion of the septum to the midventricular portion.
- Trial name
- NCT05726799
- Testing
- Cryo myectomy, Myectomy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Michele De Bonis
Aortic Valve Stenosis, Aortic Valve Insufficiency
The Italian Society of Invasive Cardiology Registry on Percutaneous Aortic Valve
The Italian Society of Invasive Cardiology Registry on Percutaneous Aortic Valve is a prospective Italian registry including several centers performing TAVI, collecting baseline, procedural and outcome data.
- Conditions
- Aortic Valve Stenosis, Aortic Valve Insufficiency, Transcatheter Aortic Valve Replacement
- Trial name
- NCT02713932
- Testing
- Transcatheter aortic valve implantation
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Aortic Valve Stenosis
Prospective, Multicenter, Randomized Controlled Clinical Study Evaluating the VitaFlow Liberty® Flex Transcatheter Aortic Valve Delivery System for the Treatment of Severe Aortic Stenosis Lesions
This is a prospective, multicenter, randomized controlled clinical study designed to evaluate the real-world performance of the VitaFlow Liberty® Flex Transcatheter Aortic Valve Retrievable and Steerable Delivery System…
- Trial name
- Flex-TAVR (NCT07145463)
- Testing
- Transcatheter Aortic Valve Replacement
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Shanghai Zhongshan Hospital
Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)
Prevalence and Characteristics of Transthyretin Amyloidosis in Patients With Left Ventricular Hypertrophy of Unknown Etiology
The main purpose of this study is to determine the prevalence of ATTR Cardiomyopathy among patients admitted due to Left Ventricular Hypertrophy (LVH) >15mm of unknown etiology by using a 99mTc-tracer scintigraphy based protocol
- Trial name
- TTRACK (NCT03842163)
- Testing
- Diagnosis of TTR amyloidosis cardiomyopathy
- Where
- 18 sites in Australia, Austria and 8 more
- Volunteers
- 812 people
- Sponsor
- Pfizer
Aortic Valve Stenosis
Clinical Evaluation of MDT-2111 in Subjects With Symptomatic Severe Aortic Stenosis
The primary objective of the present trial is to demonstrate the effectiveness and safety of the MDT-2111 in the treatment of symptomatic severe aortic stenosis in subjects deemed difficult for surgical operation.
- Trial name
- NCT01437098
- Testing
- MDT-2111 CoreValve for TAVI
- Where
- 4 sites in Japan
- Volunteers
- 55 people
- Sponsor
- Medtronic Cardiovascular
Complex Congenital Heart Defect, Dysfunctional RVOT Conduit
COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction
This study will demonstrate the safety and effectiveness of the Edwards Lifesciences SAPIEN 3/SAPIEN 3 Ultra RESILIA Transcatheter Heart Valve (THV) Systems in subjects with a dysfunctional right ventricular outflow tract (RVOT)…
- Conditions
- Complex Congenital Heart Defect, Dysfunctional RVOT Conduit, Pulmonary Valve Insufficiency, Pulmonary Valve Degeneration
- Trial name
- NCT02744677
- Testing
- SAPIEN 3/SAPIEN 3 Ultra RESILIA THV, SAPIEN 3 THV, SAPIEN 3 Ultra RESILIA THV
- Where
- 27 sites in United States
- Volunteers
- 108 people
- Sponsor
- Edwards Lifesciences
Cardiovascular Diseases, Heart Diseases
Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers
This study will determine the impact of highly active antiretroviral therapy (HAART) on the developing cardiovascular system, the evolution of HAART-associated cardiovascular changes over time, and the association between…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, HIV Infections
- Trial name
- CHAART-1 (NCT00253682)
- Where
- 5 sites in United States
- Volunteers
- 167 people
- Sponsor
- University of Miami
Obstructive Hypertrophic Cardiomyopathy
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
This registry evaluates patient characteristics, real-world treatment patterns, and short- and long-term outcomes in a population of patients in the United States and Europe with symptomatic obstructive hypertrophic…
- Trial name
- DISCOVER-HCM (NCT05489705)
- Testing
- Mavacamten, Non-mavacamten symptomatic oHCM therapy
- Where
- 101 sites in United States, Austria and 7 more
- Volunteers
- 1,700 people
- Sponsor
- Bristol-Myers Squibb
Aortic Valve Stenosis
VitaFlowTM II Transcatheter Aortic Valve System Study
A prospective, single arm clinical investigation evaluating safety and effectiveness/performance of the Microport CardioFlow VitaFlowTM II - Transcatheter Aortic Valve System for the treatment of symptomatic severe aortic…
- Trial name
- NCT03575039
- Testing
- VitaFlow II Transcatheter Aortic Valve System
- Volunteers
- 178 people
- Sponsor
- Shanghai MicroPort CardioFlow Medtech Co., Ltd.
Heart Valve Diseases
Conventional Versus Mini-Sternotomy for Aortic Valve Surgery
Minimally-invasive operative techniques have been introduced in cardiac surgery. These techniques may have several advantages such as a decrease in post operative pain, lower morbidity and mortality, faster recovery, and a…
- Trial name
- NCT00221663
- Testing
- surgery techniques (sternotomy for aortic valve replacement)
- Where
- France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Bordeaux
Aortic Valve Stenosis
Adjuvant Radiation in Aortic Valvuloplasty - ARAVA
This study will examine the effect of external beam radiation therapy in the prevention of restenosis following successful balloon aortic valvuloplasty in severe, symptomatic aortic stenosis.
- Trial name
- NCT00269165
- Testing
- Balloon Aortic Valvuloplasty, External Beam Radiation
- Volunteers
- 60 people
- Sponsor
- Medstar Health Research Institute
Hypertrophic Cardiomyopathy
Assessment of Wall Thickness in Hypertrophic Cardiomyopathy
Assessment of wall thickness in hypertrophic cardiomyopathy (HCM) is of diagnostic and prognostic importance given its known association with sudden cardiac death.
- Trial name
- NCT02234336
- Testing
- Noncontrast echocardiography, Contrast Echocardiography, Cardiac magnetic resonance imaging
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Mayo Clinic
Nonobstructive Hypertrophic Cardiomyopathy
ENavogliflozin DElivering Alleviation of Ventricular Diastolic Dysfunction in nonObstRuctive Hypertrophic CardioMyopathy
The primary objective of this study is to investigate the effect of enavogliflozin, an Sodium-glucose transporter 2 (SGLT2) inhibitor, compared with placebo on left ventricular diastolic function in patients with nonobstructive…
- Trial name
- NCT06580717
- Testing
- enavogliflozin 0.3mg
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Aortic Stenosis
Low-dose-contrast Cardiac Computed Tomography
Low-dose-contrast CCTA can effectively and safely assess the aortic valve apparatus, and effectively direct the trans-catheter heart valve (THV) size selection by providing accurate annulus sizing, and provide adequate…
- Trial name
- CCTA (NCT02146768)
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Baylor Research Institute
Severe Aortic Stenosis
Safety and Performance Study of the Optimum Transcatheter Aortic Valve
The TAVI (Thubrikar Aortic Valve, Inc.) -1 Study: Safety and Performance Study of the Optimum Transcatheter Aortic Valve- First-in-human study to assess feasibility and safety of the Optimum Aortic Valve Implant
- Trial name
- NCT04076150
- Testing
- Transcatheter Aortic Valve (TAV) Implantation With The Optimum TAV System
- Where
- Poland
- Volunteers
- 5 people
- Sponsor
- Thubrikar Aortic Valve, Inc.
Williams Syndrome, Duplication
Defining the Brain Phenotype of Children With Williams Syndrome
Background: Little is known about how the brain changes during childhood and adolescence, how genes affect this process, or how the brains of people with 7q11.23 genetic variation change during this period.
- Trial name
- NCT01132885
- Where
- United States
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Valvular Aortic Stenosis
Physical Activity in Patients After Aortic Valve Replacement (Valve-ex)
A structured and supervised, 3-month physical activity intervention in patients after aortic valve replacement due to severe stenosis, accompanied by examination of cardiac size and function, exercise capacity and endothelial…
- Trial name
- NCT00860678
- Testing
- Physical activity, no Intervention
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Heart Failure, Cardiac Surgery
Inotropic Treatment With Levosimendan (SimdaxR)in Heart Surgery
Hypothesis: Treatment with levosimendan will preserve myocardial function and hemodynamics after cardiac surgery and lead to reduced stay at intensive care unit
- Trial name
- NCT01221116
- Testing
- levosimendan
- Where
- Norway
- Volunteers
- 23 people
- Sponsor
- Ullevaal University Hospital
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