Clinical trials: Valve Stenoses, Aortic
Cardiomyopathy, Hypertrophic
A Study to Evaluate the Efficacy, Safety, and Tolerability of MYK-224 in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy
The purpose of this study is to characterize the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of MYK-224 in participants with obstructive Hypertrophic Cardiomyopathy (oHCM)
- Trial name
- MERCUTIO (NCT05556343)
- Testing
- MYK-224
- Where
- 25 sites in United States, Italy and 2 more
- Volunteers
- 18 people
- Sponsor
- Bristol-Myers Squibb
Hypertrophic Obstructive Cardiomyopathy, Stereotactic Body Radiotherapy
Safety and Efficacy of Stereotactic Body Radiotherapy in the Treatment of Hypertrophic Obstructive Cardiomyopathy
This study is designed to rigorously evaluate the safety and effectiveness of Stereotactic Body Radiotherapy (SBRT) as an innovative, non-invasive treatment for Hypertrophic Obstructive Cardiomyopathy (HOCM).
- Trial name
- SAFECARE (NCT06167876)
- Testing
- Stereotactic Body Radiotherapy (SBRT) Treatment
- Where
- 4 sites in China
- Volunteers
- 36 people
- Sponsor
- Second Xiangya Hospital of Central South University
Aortic Stenosis
A Clinical Trial of the Transcatheter Aortic Valve Implantation System With a Prospective, Multi-Center, One-Arm Approach to Evaluate the Efficacy and Safety in the Treatment of Patients With Severe Aortic Stenosis
A Clinical Trial of the Transcatheter Aortic Valve Implantation System with a Prospective, Multi-Center, One-Arm Approach to Evaluate the Efficacy and Safety in the Treatment of Patients with Severe Aortic Stenosis
- Trial name
- NCT05673525
- Testing
- Transcatheter Aortic Valve Implantation (KOKA-VALVE)
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Aortic Valve Stenosis, Mitral Regurgitation
Coronary Physiology Peri-Transcatheter Left-sided Valvular Interventions
Prospective, single-arm, observational study with invasive coronary physiology measurements before and after transcatheter left-sided valvular intervention.
- Conditions
- Aortic Valve Stenosis, Mitral Regurgitation, Coronary Artery Disease, Fractional Flow Reserve
- Trial name
- POTUS (NCT05374733)
- Testing
- Coronary Physiology assessment
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Erasmus Medical Center
Aortic Valve Stenosis
Exercise-based Cardiac Rehabilitation in Patients With Aortic Stenosis After Transcatheter Aortic Valve Implantation
Aortic valve stenosis (AS) is the most common valve disease among older individuals. In symptomatic AS, mortality is high, and the only treatment that improves prognosis and survival is transcatheter aortic valve implantation…
- Trial name
- TAVI (NCT06283940)
- Testing
- Physiotherapist-led exercise based cardiac rehabilitation (PT-X)
- Where
- Sweden
- Volunteers
- 135 people
- Sponsor
- Vastra Gotaland Region
Aortic Valve Stenosis
Clinical Value of Stress Echocardiography in Moderate Aortic Stenosis
The management of symptomatic patients with moderate Aortic Stenosis (AS) remains challenging and tests that would give more definitive answers are needed.
- Trial name
- NCT02792452
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- London North West Healthcare NHS Trust
Aortic Valve Stenosis
Cerebrovascular EveNts in Patients Undergoing TranscathetER Aortic Valve Implantation With Balloon-expandable Valves Versus Self-expandable Valves.
The aim of this collaborative analysis is to evaluate stroke rates and mortality in patients undergoing TAVI with the self-expandable MCV prosthesis compared to the balloon-expandable ES valve.
- Trial name
- CENTER (NCT03588247)
- Testing
- transcatheter aortic valve implantation
- Where
- Netherlands
- Volunteers
- 12,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Aortic Valve Stenosis, Remimazolam
Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVR
Anesthetic agents can cause hypotension, and be especially dangerous in patients with severe aortic stenosis, which can lead to even circulatory collapse. Remimazolam is known for its hemodynamic stability compared to propofol.
- Trial name
- NCT05864625
- Testing
- Remimazolam besylate, Propofol/ Sevoflurane
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Pusan National University Yangsan Hospital
Aortic Valve Stenosis, TAVI(Transcatheter Aortic Valve Implantation)
Portuguese Registry With Meril Myval THV Series - MyPORTuVal Registry
A prospective, single-arm, multi-centre registry to evaluate the safety and performance of Myval THV series using Transcatheter Aortic Valve Implantation (TAVI) procedure in patients with symptomatic severe native aortic valve…
- Trial name
- MyPORTuVal (NCT06818435)
- Testing
- Myval THV series
- Where
- 6 sites in Portugal
- Volunteers
- 150 people
- Sponsor
- Portuguese Association of Interventional Cardiology
Coronary Artery Disease, Aortic Stenosis
Aortic Valve and Root Measurements Under Real-Time 3-Dimensional Visualization During Angiography
The American College of Cardiology/American Heart Association guidelines place symptomatic severe Aortic Stenosis as a class I indication for aortic valve replacement.
- Trial name
- NCT02073617
- Testing
- Real-time 3-dimensional DynaCT
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- NYU Langone Health
Aortic Stenosis, Ascending Aortic Dilatation
Efficacy of Self-expandable and Balloon-expandable Valves in Patients With Ascending Aortic Dilation
This study evaluated the efficacy of self-expandable valves and balloon-expandable valves in patients with ascending aortic dilation who undergo transcatheter aortic valve replacement.
- Trial name
- NCT06743568
- Testing
- Transcatheter aortic valve replacement
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Hypertrophic Cardiomyopathy
OPIE in the Thin Interventricular Septum
This is a follow up investigation to our previous study entitled "On-pump intraoperative echocardiography (OPIE)" (clinicaltrials.gov NCT03094325) whereby we determined that left ventricular septal thickness as measured by the…
- Trial name
- NCT04050579
- Testing
- on-pump intracardiac echocardiography
- Where
- United States
- Sponsor
- NYU Langone Health
Aortic Valve Stenosis, Aortic Valve Calcification
ACURATE Enhance Post Market Study
The objective of the ACURATE Enhance study is to assess valve frame expansion and hemodynamics in a routine clinical setting when optimized procedural steps for valve implantation are followed.
- Conditions
- Aortic Valve Stenosis, Aortic Valve Calcification, Aortic Diseases
- Trial name
- NCT06959862
- Testing
- Transcatheter Aortic Valve Implantation/Replacement
- Sponsor
- Boston Scientific Corporation
Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy
Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Cardiomyopathies
- Trial name
- HiRO-HCM (NCT05100420)
- Where
- 17 sites in Canada
- Volunteers
- 2,000 people
- Sponsor
- Montreal Heart Institute
Aortic Valve Stenosis
Volume Challenge Added to DSE in the Diagnosis of Severe LFLGAS
The aim of this study is to test the diagnostic added value of Volume Challenge (VC) to low-dose dobutamine stress echocardiography (LDDSE) in patients with a low-flow, low-gradient aortic stenosis (LFLGAS).
- Trial name
- FLOW-AS (NCT03617406)
- Testing
- Volume Challenge
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypertrophic Cardiomyopathy, Hearing Loss
Refining Information Technology Support for Genetics in Medicine
The clinical use of genetic testing is expanding and, as a result, the number of variants identified in patients is growing. Knowledge of the clinical impact of these variants improves over time.
- Conditions
- Hypertrophic Cardiomyopathy, Hearing Loss, Cancer
- Trial name
- RISGIM (NCT01225978)
- Testing
- GeneInsight Clinic (GIC)
- Where
- 9 sites in United States, Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Aortic Valve Stenosis, Aortic Stenosis
CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material
The objective of this study is to demonstrate safety and efficacy of the EmStop Embolic Protection System when used as indicated to capture and remove thrombus/debris during self-expanding transcatheter aortic valve replacement…
- Conditions
- Aortic Valve Stenosis, Aortic Stenosis, Aortic Valve Disease
- Trial name
- NCT07276711
- Testing
- EmStop Embolic Protection System, Boston Scientific Sentinel
- Where
- 7 sites in United States
- Volunteers
- 663 people
- Sponsor
- EmStop Inc
Disparities in Treatment of Aortic Valve Stenosis, Aortic Valve Stenosis
Racial and Economic Disparities and Unmet Needs in Patients With Severe Aortic Valvular Disease
Common barriers to receiving appropriate guideline-driven care for patients with severe aortic stenosis include referral biases by primary care providers (lack of provider education), patient comorbidities (degree of fragility)…
- Trial name
- NCT04525937
- Testing
- Patient Questionnaire, Provider Questionnaire
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Minneapolis Heart Institute Foundation
Aortic Valve Stenosis, Heart Failure
ENAVOgliflozin Outcome Trial in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement
The goal of this trial is to to determine whether use of a novel SGLT2 inhibitor, Enavogliflozin 0.3 mg once daily is superior to placebo, when added to standard-of-care, in reducing the composite of major cardiovascular events…
- Trial name
- ENAVO-TAVR (NCT05672836)
- Testing
- Enavogliflozin, Standard-of-Care
- Where
- 31 sites in South Korea
- Volunteers
- 1,040 people
- Sponsor
- Duk-Woo Park, MD
Aortic Stenosis, Conduction Defect, Cardiac
Ventricular Pacing Rate in Follow-up of Patients Treated With Definitive PM Implantation Post TAVI
The goal of this observational study is to learn about the effective ventricular pacing rate in follow-up of patients who underwent a pacemaker (PM) implantation after transcatheter aortic valve implantation (TAVI).
- Trial name
- P-P-P-TAVI (NCT06499428)
- Where
- Italy
- Volunteers
- 67 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio