Clinical trials: Valvular Heart Surgery
Cardiac Surgery
Effect of Preoperative Recombinant Human Erythropoietin on Transfusion Risk in Valvular Heart Surgery
The administration of rhEPO on the one day before cardiac surgery will be effective to decrease the bleeding due to the surgery.
- Trial name
- NCT00939978
- Testing
- rhEPO
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Yonsei University
Valvular Disease, Coronary Stenosis
The Scanner in the Coronary Evaluation
Conventional coronary angiography is the recommended procedure in detection of coronary stenosis in patients with heart valve disease referred for surgery.The aim of this prospective study is to assess diagnostic accuracy of…
- Trial name
- NCT00484380
- Testing
- Coronary scanner
- Where
- France
- Volunteers
- 66 people
- Sponsor
- French Cardiology Society
Heart; Dysfunction Postoperative, Cardiac Surgery
Clinical Assessment of Nonin 7600 Near Infrared Spectroscopy (NIRS) Tissue Oximetry During Cardiovascular Surgery
An observational study designed to evaluate the performance of a new Near Infrared Spectroscopy (NIRS) tissue oximeter device in the clinical setting, including a cerebral sensor and peripheral sensor.
- Trial name
- NCT01289470
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Nonin Medical, Inc
Heart Valve Diseases
Conventional Versus Mini-Sternotomy for Aortic Valve Surgery
Minimally-invasive operative techniques have been introduced in cardiac surgery. These techniques may have several advantages such as a decrease in post operative pain, lower morbidity and mortality, faster recovery, and a…
- Trial name
- NCT00221663
- Testing
- surgery techniques (sternotomy for aortic valve replacement)
- Where
- France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Bordeaux
Valvular Endocarditis
Surgical Management of Valvular Endocarditis
This study aims to achieve the following objectives objective 1 : To review the Investigators' experience of surgical management of infective endocarditis (IE) and analyze the outcomes and associated prognostic factors objective…
- Trial name
- NCT04572529
- Testing
- Cardiac Valve replacement
- Volunteers
- 50 people
- Sponsor
- Assiut University
Coronary Artery Disease, Valvular Heart Disease
Prehabilitation for Patients Undergoing Elective Cardiac Surgery
The objective of this clinical trial is to develop a novel rehabilitation model that, through the PRECICA program, will help to reduce perioperative and postoperative complications in the care process prior to planned cardiac…
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Chronic Thromboembolic Pulmonary Hypertension, Aortic Diseases
- Trial name
- PRECICA (NCT07704086)
- Testing
- Physical exercise, Educational program and respiration physiotherapy
- Where
- 2 sites in Spain
- Volunteers
- 86 people
- Sponsor
- Hospital Universitario 12 de Octubre
Valvulopathy, Cardiac Surgery
Non-interventional Study Exploring the Composition of the Valvular Microbiota of Patients Undergoing Cardiac Surgery
The prevalence of aortic valve disease is increasing, with these valvulopathies present in half of individuals over the age of 65. Oberbach A.
- Conditions
- Valvulopathy, Cardiac Surgery, Microbiota
- Trial name
- BIOVALV (NCT07075601)
- Testing
- Take 1 ml of blood, DNA sequencing, Valve collection (healthcare waste)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Toulouse
Coronary Bypass Graft Stenosis, Valvular Heart Disease
Comparison of Post-operation Cardiopulmonary Capacity of Patients Underwent Conventional and Robot-assisted Coronary Artery Bypass Graft and Valve Replacement Surgery
Robotic surgery is one of the most popular minimally invasive procedures for patients with coronary artery disease or valvular diseases.
- Trial name
- NCT05430568
- Testing
- robot-assisted surgery
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
Atrial Fibrillation, Atrial Flutter
Response to RSD1235 Compared to Placebo in Subjects With Atrial Arrhythmia After Heart Surgery
The purpose of this study is to demonstrate the safety and efficacy of RSD1235 compared to placebo in the conversion of atrial arrhythmia to sinus rhythm in subjects following valvular and/or coronary artery bypass graft surgery.
- Trial name
- NCT00125320
- Testing
- RSD1235
- Where
- 22 sites in United States, Argentina and 4 more
- Volunteers
- 190 people
- Sponsor
- Astellas Pharma Inc
Carotid Stenosis, Coronary Artery Disease
Simultaneous Cardiac Surgery and Micronet-covered Stent Carotid Revascularization in High Perioperative Stroke Risk Patients
Prospective, single-center, clinical registry of patients with symptomatic/critical carotid artery stenosis at risk of stroke coexisting with unstable or multivessel severe coronary artery disease and/or severe valvular heart…
- Conditions
- Carotid Stenosis, Coronary Artery Disease, Valvular Heart Disease, Myocardial Infarction
- Trial name
- SIM-GUARD (NCT04973579)
- Testing
- Simutaneous (single anaesthesia) carotid artery stenting with MicroNet covered stent (CGuard) and cardiac surgery (CABG or surgical valve replacement / repair procedure)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- John Paul II Hospital, Krakow
Valvular Heart Disease
Prehabilitation and Heart Valve Surgery
To evaluate the impact of prehabilitation on quality of recovery in heart valve surgery. To evaluate the effects of Mild to moderate valvular diseases with Newyork Heart Association (NYHA) grade I and II .
- Trial name
- NCT04993963
- Testing
- Cycle Ergometery Training (Prehabilitation), Control Standard Group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Atrial Fibrillation
Cardiac Surgical Treatment by Radiofrequency Ablation on Valvular Patients: Efficacy at 3 Months
The objective of the study is to evaluate the efficacy of the epicardial or endocardial radiofrequency ablation in the treatment of atrial fibrillation.
- Trial name
- NCT00259623
- Testing
- Radiofrequency ablation
- Where
- 5 sites in France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Toulouse
Coronary Artery Disease, Valvular Heart Disease
The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone
During induction for cardiac surgery, patient hemodynamic stability is achieved by using anesthetic drugs which least affects hemodynamics such as benzodiazepines, etomidate.
- Trial name
- NCT01495949
- Testing
- etomidate, thiopentone
- Where
- Thailand
- Volunteers
- 92 people
- Sponsor
- Mahidol University
Coronary Artery Disease, Valvular Heart Disease
Implementation of a Trimodal Prehabilitation Program as a Preoperative Optimization Strategy in Cardiac Surgery and Heart Transplant
Pre-habilitation programs that combine physical training, nutritional support and emotional reinforcement have demonstrated efficacy as presurgical optimization strategies in the context of digestive surgery.
- Trial name
- NCT03466606
- Testing
- pre-habilitation
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
Lung Ultrasound
Ultrasonographic Assessment of the Effect of CPB Acute Lung Injury
The study is designed to use the lung ultrasound to assess the effect of intermittent lung recruitment during cardiopulmonary bypass in cardiac surgeries on extra vascular lung water.
- Trial name
- CBP (NCT03619525)
- Testing
- lung recruitment
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Kidney Injury
The Effects of Dexmedetomidine on Postoperative Renal Function in Valvular Heart Surgery
The purpose of study is to compare the incidence of acute kidney injury in patients receiving perioperative dexmedetomidine or placebo undergoing valvular heart surgery.
- Trial name
- NCT01886079
- Testing
- dexmedetomidine, Saline
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Valvular Heart Disease
Role of High Mobility Group Box 1 as a Prognostic Biomarker in Patients Undergoing Valvular Heart Surgery
One of the most important factor that affects the post op complication of the cardiac surgery is systemic inflammation. Valvular heart surgery requires cardiopulmonary bypass and cardioplegic arrest, which can arouse the…
- Trial name
- NCT02490644
- Testing
- Blood sampling
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Yonsei University
Valvular Heart Disease, Coronary Artery Disease
Humanalbumin, Hydroxyethylstarch and Ringer Lactate During Cardiac Surgery
The aim of the study is to compare three different regimens for volume replacement during cardiac surgery, e.g. Albumin 5%, Hydroxyethylstarch 130/0.4 (HES) and Ringer-Lactate (RL).
- Trial name
- NCT01174719
- Testing
- volume replacement, Humanalbumin 5%
- Where
- Austria
- Volunteers
- 240 people
- Sponsor
- Medical University of Vienna
Patients Undergoing Valvular Heart Surgery
Impact of Preoperative Nutritional Status on the Postoperative Mortality and Morbidity in Patients Undergoing Valvular Heart Surgery
The investigators investigated the clinical impacts of preoperative nutritional status on mortality in patients undergoing valvular heart surgery.
- Trial name
- NCT04307732
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Yonsei University
Intensive Care Unit, Coronary Artery Bypass Grafting (CABG)
Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients
The MODIFY CSX study is a prospective, randomized, placebo-controlled trial conducted in heart centers in Germany and Italy. A total of 550 high-risk cardiac surgery patients will receive either 0.20 g fish oil/kg body weight…
- Conditions
- Intensive Care Unit, Coronary Artery Bypass Grafting (CABG), High Risk Patients, Cardiopulmonary Bypass
- Trial name
- MODIFY CSX (NCT06279793)
- Testing
- Fish Oil, Intravenous 0.9% Sodium Chloride
- Where
- 10 sites in Germany
- Volunteers
- 550 people
- Sponsor
- GCP-Service International West GmbH