Clinical trials: Vancomycin Dosage
Suspected Infection With Vancomycin Susceptible Bacterial Strains
Pharmacokinetics of Vancomycin in ICU Patients
Vancomycin is frequently under-dosed in ICU patients during the first 24-48 hours of treatment. Glomerular hyperfiltration syndrome, increased drug volume of distribution, vasopressor use, male sex and hypoalbuminemia are…
- Trial name
- PK-VANCO-ICU (NCT02844192)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Wound Infection, Abscess
Oritavancin Versus IV Vancomycin for the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infection
The purpose of this Phase 3 trial is to evaluate the efficacy, safety, and tolerability of oritavancin in ABSSSIs, including those caused by MRSA and to evaluate the potential economic benefit of oritavancin administered as a…
- Conditions
- Wound Infection, Abscess, Systemic Inflammation, Cellulitis
- Trial name
- SOLO II (NCT01252732)
- Testing
- Single-Dose IV Oritavancin Diphosphate, IV Vancomycin
- Where
- United States
- Volunteers
- 1,019 people
- Sponsor
- Melinta Therapeutics, Inc.
Bacterial Infections, Infection
Study Comparing the Safety and Efficacy of Two Doses of BC-3781 vs Vancomycin in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI)
This is a Phase II, multi-center, randomized, double-blind study comparing the safety and efficacy of two doses of BC-3781 versus vancomycin in patients with acute bacterial skin and skin structure infection.
- Trial name
- NCT01119105
- Testing
- BC-3781, Vancomycin
- Where
- 9 sites in United States
- Volunteers
- 210 people
- Sponsor
- Nabriva Therapeutics AG
Healthy Volunteers
First-in-human Study of VE303 in Healthy Adult Volunteers
This study was designed to evaluate safety and tolerability of a range of doses of VE303 in healthy adult volunteers. The study also evaluated pharmacokinetics of intestinal colonization by the VE303 strains and pharmacodynamics…
- Trial name
- NCT04236778
- Testing
- VE303, Oral Vancomycin
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Vedanta Biosciences, Inc.
Vancomycin Dosage
External Evaluation of Vancomycin Population Pharmacokinetic Models
All patients treated with vancomycin hospitalized outside of ICU in Brest University Hospital from 1rst january 2019 to 1rst january 2021 will be screened for inclusion.
- Trial name
- EOPMV (NCT05481788)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Vancomycin, Pharmacokinetics
First Time Right of Vancomycin
In 2020, only 16% of the Intensive Care Unit (ICU) patients achieved therapeutic drug concentrations after continuous administration of the first vancomycin dose.
- Trial name
- NCT05964114
- Testing
- Vancomycin
- Volunteers
- 134 people
- Sponsor
- Erasmus Medical Center
Infectious Disease
Loading Vancomycin Doses in the Emergency Department
In 2008, our ED administered an average of 245 doses of vancomycin per month. Currently there is no consistency in the ED practice in regards to vancomycin dosing.
- Trial name
- Loaded (NCT01162733)
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Christiana Care Health Services
Endocarditis, Bacterial, Infective Endocarditis
Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia
The overall goals of this study are to compare the safety and efficacy of daptomycin monotherapy 10 mg/kg/day and vancomycin monotherapy dosed to achieve vancomycin trough levels of 15 to 20 μg/mL for the treatment of…
- Trial name
- HDSAB (NCT00695903)
- Testing
- daptomycin, vancomycin
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Catheter-related Infection
Optimalisation of Therapeutic Drug Monitoring (TDM) of Vancomycin in Patients With Central Venous Port Devices
Recently, it was reported that when vancomycin levels are determined after port sampling, levels can be falsely increased potentially leading to wrong dose adjustments.
- Trial name
- NCT01661361
- Testing
- blood levels
- Volunteers
- 15 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Infection
Use of a Loading Dose of Vancomycin in Pediatric Dosing
Vancomycin is an antibiotic administered to children or adults for many types of infections. While it has been used to treat infections of children for more than 50 years we are still not completely certain about the best dose to…
- Trial name
- NCT01290237
- Testing
- vancomycin hydrocloride
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Boston Children's Hospital
Wound Infection, Abscess
Oritavancin Versus IV Vancomycin for the Treatment of Participants With Acute Bacterial Skin and Skin Structure Infection (SOLO I)
The purpose of this Phase 3 trial was to evaluate the efficacy, safety, and tolerability of oritavancin in acute bacterial skin and skin structure infections (ABSSSIs), including those caused by methicillin-resistant…
- Conditions
- Wound Infection, Abscess, Systemic Inflammation, Cellulitis
- Trial name
- SOLO I (NCT01252719)
- Testing
- Single-Dose IV Oritavancin Diphosphate, IV Vancomycin
- Where
- United States
- Volunteers
- 968 people
- Sponsor
- Melinta Therapeutics, Inc.
Sepsis, Vancomycin Treatment
A New Protocol for Continuous Vancomycin Infusion Dosing.
This observational study prospectively collect data on chosen dosing, renal function, measured plasma concentrations and adherence to the recommended clinical protocl for ICU patients treated with continuous vancomycin infusion.
- Trial name
- CVIP (NCT05143645)
- Testing
- Plasma vancoymcin measurements
- Where
- Sweden
- Volunteers
- 101 people
- Sponsor
- Karolinska University Hospital
Infection, Sepsis
Study of Obese Patients Comparing Two Vancomycin Loading Dose Regimens
Obesity alters the movement through the body of several antibiotics, including vancomycin. Based on literature to date, total body weight should be used to determine dosages and shorter dosing intervals may be needed.
- Conditions
- Infection, Sepsis, Obesity
- Trial name
- NCT02764359
- Testing
- IV vancomycin
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- CAMC Health System
Methicillin-resistant Staphylococcal Infections
Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children
Vancomycin is the standard first-line treatment for MRSA infections and a first-line empiric therapy. The relationship between exposure to vancomycin and efficacy is admitted but because of an important intersubject variability…
- Trial name
- OPTIBAYE (NCT02694458)
- Testing
- Early vancomycin monitoring and bayesian dosage adjustment, usual vancomycin dose and monitoring strategy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vancomycin Therapy
Dose Enhancement of Vancomycin IN Everyday Patients
Current Australian guidelines for vancomycin commonly underdoses individuals particularly in the first 48 hours. The aim of the trial is to compare two dosing regimens; the current Australian guidelines versus a more…
- Trial name
- DEVINE (NCT01427842)
- Testing
- DEVINE vancomycin regimen
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- The Canberra Hospital
Vancomycin, Hematologic Malignancies
Optimal Dosing of Vancomycin in an Adult Population of Hemato-oncology
This is a single-center prospective pharmacokinetic study. The principal objective is to collect new data among patients with hematologic cancer to develop a Bayesian population pharmacokinetic model and to improve dose…
- Conditions
- Vancomycin, Hematologic Malignancies, Febrile Neutropenia
- Trial name
- Hemato-Vanco (NCT04758442)
- Testing
- Additional blood sample
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Surgical Site Infection
Dose Escalation Trial of Intrasite Vancomycin Pharmacokinetics
Surgical wound infections remain a serious problem despite aseptic techniques and the use of prophylactic systemic antibiotics. Such infections can occur at rates up to ~20% in high-risk patients receiving long segment…
- Trial name
- NCT01764750
- Testing
- Intrasite Vancomycin, IV Vancomycin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Skin and Soft Tissue Infections
Evaluating the Use of Large-dose, Extended Interval Vancomycin Intravenous Administration for Skin and Soft Tissue Infections
Our hypothesis is that large-dose, extended-interval vancomycin (30 mg/kg IV q24h) administration provides non-inferior clinical efficacy and microbiological efficacy to standard vancomycin (15 mg/kg IV q12h) administration for…
- Trial name
- VOD (NCT01037192)
- Testing
- vancomycin
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Fraser Health
Healthy, Cystic Fibrosis
Inhaled Vancomycin Tolerability, Safety and Pharmacokinetics
The study is carried out to evaluate the safety, tolerability and pharmacokinetics of AeroVanc inhalation powder in healthy volunteers, and in patients with cystic fibrosis.
- Trial name
- NCT01537666
- Testing
- AeroVanc, IV vancomycin hydrochloride
- Where
- 2 sites in Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Savara Inc.
Methicillin-Resistant Staphylococcus Aureus
Vancomycin Dosage Adjustment for MRSA Infections
An open-label randomized controlled trial to compare two vancomycin dosage adjustment methods
- Trial name
- NCT03412500
- Testing
- Vancomycin equation-based method, Vancomycin trough concentration method
- Where
- Thailand
- Volunteers
- 114 people
- Sponsor
- Pinyo Rattanaumpawan